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The map label for this gene is trpS [H]

Identifier: 109946852

GI number: 109946852

Start: 198540

End: 199532

Strand: Direct

Name: trpS [H]

Synonym: Hac_0232

Alternate gene names: 109946852

Gene position: 198540-199532 (Clockwise)

Preceding gene: 109946851

Following gene: 109946853

Centisome position: 12.78

GC content: 38.57

Gene sequence:

>993_bases
ATGAGAAATAACATGCAAAAAAAACGAGTCTTTTCAGGCATTCAACCAACAGGGCAAATCCATTTGGGCAACTATCTAGG
AGCGATCAAACACTGGGTAAAAATGCAAGATGAATATGAAAACCTTTTTTGTGTCGTCAATTCGCATGCGATCACTCTCC
CCATAGACCCTAAAATTTTACAATCTCAAAGTTATGATCTCGTTAAATTGCTTTTAGCTTGTGGGATTAGTCCCAAGCAA
TCTGGGTTATTCATCCAAAGTGAAGTTGATGAGCATCCGGCTTTAGCATGGCTATTAGATTGTCAAGTGTCTATGGGGGA
AATGCAACGAATGACGCAATTTAAAGACAAGTCTTTAAAAAACCCTAAAAGCGTGAATGTGGGGCTTTTCAATTACCCTA
TTTTAATGGCGTCAGACATTTTATTATACCAGAGCGATTTAGTGCCAGTGGGCGAAGATCAAAAACAGCATTTAGAGCTC
ACACGAAACATTGCAGAAAAATTTAACAGGGATTTTGGAGACTGCTTTAAAGTCCCTGAGCCTTTGATCGCTAAAGTAGG
GGCAAGGGTTATGGGGCTAGATGAACCGCAAGTGAAGATGAGTAAATCGCATAAGGGGGTTAATCATGCGATCTTTCTTT
TAGATGAACCAGATATTATTGTAAGAAAAATCAAAAAAGCGACCACGGATTCCATAGGCACTATTCAATTTGATGCGGCA
AGAGAGGGGATTTTTAATCTTTTAAATATCTACATGCTTTTAAGCGGTGAAAGTCAAGAAAACATAGAAGAGCGTTTCAG
AAATAAAGGCTATGGGGATTTTAAAAAAGAATTGGCTGAAGTGATCATTCAAGCTTTAAAACCCATCCAAGAAAGATACA
AAGAAATCAGCGATGATGAAGTGAAAGCCATTTTAAATCATGGCGTAGAAAAAGCCAAGCCTTTAGCGAGGGCGACTTAC
CAAAAAGCTAAAGAATTGATGGGGTTGGTTTAG

Upstream 100 bases:

>100_bases
GAGTTATGAAGTGTTACTATTTTCGGGGATTAGGCGCTCTTAAAAACTAAAATCAATCAATATTAAAATTAGATGGTTAC
AATGGCATTAATCTAAATGA

Downstream 100 bases:

>100_bases
ATGAAAATTTTAGGCTTATGGTTAGGGGTTTTTGTTTTCTTAAGGCTACACCTTAATTTATACTTGGGTGAAGAGCCCAA
ATACAAAGACAATTTCACGC

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MRNNMQKKRVFSGIQPTGQIHLGNYLGAIKHWVKMQDEYENLFCVVNSHAITLPIDPKILQSQSYDLVKLLLACGISPKQ
SGLFIQSEVDEHPALAWLLDCQVSMGEMQRMTQFKDKSLKNPKSVNVGLFNYPILMASDILLYQSDLVPVGEDQKQHLEL
TRNIAEKFNRDFGDCFKVPEPLIAKVGARVMGLDEPQVKMSKSHKGVNHAIFLLDEPDIIVRKIKKATTDSIGTIQFDAA
REGIFNLLNIYMLLSGESQENIEERFRNKGYGDFKKELAEVIIQALKPIQERYKEISDDEVKAILNHGVEKAKPLARATY
QKAKELMGLV

Sequences:

>Translated_330_residues
MRNNMQKKRVFSGIQPTGQIHLGNYLGAIKHWVKMQDEYENLFCVVNSHAITLPIDPKILQSQSYDLVKLLLACGISPKQ
SGLFIQSEVDEHPALAWLLDCQVSMGEMQRMTQFKDKSLKNPKSVNVGLFNYPILMASDILLYQSDLVPVGEDQKQHLEL
TRNIAEKFNRDFGDCFKVPEPLIAKVGARVMGLDEPQVKMSKSHKGVNHAIFLLDEPDIIVRKIKKATTDSIGTIQFDAA
REGIFNLLNIYMLLSGESQENIEERFRNKGYGDFKKELAEVIIQALKPIQERYKEISDDEVKAILNHGVEKAKPLARATY
QKAKELMGLV
>Mature_330_residues
MRNNMQKKRVFSGIQPTGQIHLGNYLGAIKHWVKMQDEYENLFCVVNSHAITLPIDPKILQSQSYDLVKLLLACGISPKQ
SGLFIQSEVDEHPALAWLLDCQVSMGEMQRMTQFKDKSLKNPKSVNVGLFNYPILMASDILLYQSDLVPVGEDQKQHLEL
TRNIAEKFNRDFGDCFKVPEPLIAKVGARVMGLDEPQVKMSKSHKGVNHAIFLLDEPDIIVRKIKKATTDSIGTIQFDAA
REGIFNLLNIYMLLSGESQENIEERFRNKGYGDFKKELAEVIIQALKPIQERYKEISDDEVKAILNHGVEKAKPLARATY
QKAKELMGLV

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=328, Percent_Identity=41.7682926829268, Blast_Score=273, Evalue=1e-73,
Organism=Homo sapiens, GI41352700, Length=179, Percent_Identity=52.5139664804469, Blast_Score=208, Evalue=4e-54,
Organism=Escherichia coli, GI1789786, Length=331, Percent_Identity=48.036253776435, Blast_Score=326, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI71982800, Length=329, Percent_Identity=33.7386018237082, Blast_Score=201, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI71982793, Length=329, Percent_Identity=33.7386018237082, Blast_Score=200, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6320474, Length=346, Percent_Identity=41.0404624277457, Blast_Score=216, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24666151, Length=332, Percent_Identity=39.1566265060241, Blast_Score=249, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 37401; Mature: 37401

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNNMQKKRVFSGIQPTGQIHLGNYLGAIKHWVKMQDEYENLFCVVNSHAITLPIDPKIL
CCCCHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCEEEEEECCEEEECCCHHHH
QSQSYDLVKLLLACGISPKQSGLFIQSEVDEHPALAWLLDCQVSMGEMQRMTQFKDKSLK
HCCCHHHHHHHHHCCCCCCCCCEEEECCCCCCCCEEEHHHHHHCHHHHHHHHHHHHHHCC
NPKSVNVGLFNYPILMASDILLYQSDLVPVGEDQKQHLELTRNIAEKFNRDFGDCFKVPE
CCCCCCCCHHHCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCH
PLIAKVGARVMGLDEPQVKMSKSHKGVNHAIFLLDEPDIIVRKIKKATTDSIGTIQFDAA
HHHHHHCCHHCCCCCCHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCEEEEHHH
REGIFNLLNIYMLLSGESQENIEERFRNKGYGDFKKELAEVIIQALKPIQERYKEISDDE
HHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VKAILNHGVEKAKPLARATYQKAKELMGLV
HHHHHHCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRNNMQKKRVFSGIQPTGQIHLGNYLGAIKHWVKMQDEYENLFCVVNSHAITLPIDPKIL
CCCCHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCEEEEEECCEEEECCCHHHH
QSQSYDLVKLLLACGISPKQSGLFIQSEVDEHPALAWLLDCQVSMGEMQRMTQFKDKSLK
HCCCHHHHHHHHHCCCCCCCCCEEEECCCCCCCCEEEHHHHHHCHHHHHHHHHHHHHHCC
NPKSVNVGLFNYPILMASDILLYQSDLVPVGEDQKQHLELTRNIAEKFNRDFGDCFKVPE
CCCCCCCCHHHCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCH
PLIAKVGARVMGLDEPQVKMSKSHKGVNHAIFLLDEPDIIVRKIKKATTDSIGTIQFDAA
HHHHHHCCHHCCCCCCHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCEEEEHHH
REGIFNLLNIYMLLSGESQENIEERFRNKGYGDFKKELAEVIIQALKPIQERYKEISDDE
HHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VKAILNHGVEKAKPLARATYQKAKELMGLV
HHHHHHCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]