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The map label for this gene is pyrE

Identifier: 109946848

GI number: 109946848

Start: 195911

End: 196516

Strand: Reverse

Name: pyrE

Synonym: Hac_0228

Alternate gene names: 109946848

Gene position: 196516-195911 (Counterclockwise)

Preceding gene: 109946849

Following gene: 109946847

Centisome position: 12.65

GC content: 42.57

Gene sequence:

>606_bases
ATGGATGTCAAAGCATGTTATCAAAACGCTAAAGCGTTGTTGGAGGGGCATTTCTTACTCAGTAGCGGGTTTCATTCTAA
CTACTATTTGCAATCTGCTAAAGTGTTGGAAAACCCTAAATTAGCCGAACAATTAGCGCTAGAATTAGCCAAACAAATTC
AAAACGCTCGTTTAAACATTGAATGCGTGTGCTCGCCTGCCATTGGGGGGATTTTAGCCGGGTATGAGCTTGCAAGGGCT
TTGGGTGTGCGTTTTATTTTTACCGAAAGAGTGAATGGCGTTATGGCGTTAAGGCGTGGTTTTGAAGTCAAGCCAAATGA
AAAAATTTTAGTGTGTGAAGACATTATCACTACAGGAAAATCCGCTATGGAATGCGCTAAAGTTTTAGAAGAAAAGGGTG
CTCACATCGTGGCTTTTGCCGCTCTAGCTAATCGGGGTATTTGCAAACGCACCCATTCTTCTTTAAAGGCTCAAGAGGAT
GCATGTTTGCCTAGCGAACTGCCTCTTTTTGCTTTAGAAGATTTTGTTTTTGACATGCATGAGCCTAAGCATTGCCCTTT
ATGTACCACTAGCGTTGCTATCAAACCGGGAAGTCGTGGCAACTAA

Upstream 100 bases:

>100_bases
GAAAGCCCAAGAACAGGTGCAAAAAATCACCGATGAAGCCATTAAAAAAATTGATGAAAGCGTGAAAAACAAAGAAGATG
CGATTTTAAAGGTCTAAACA

Downstream 100 bases:

>100_bases
AAAAAATAAAACCCTAGAAAAAAAACAAGCGTTAGAAAGCCCCTTAAAAGGGCTGAATCTCTCTTTACGCTTAAAGGCCT
TTATCACCGATATTTTTATG

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MDVKACYQNAKALLEGHFLLSSGFHSNYYLQSAKVLENPKLAEQLALELAKQIQNARLNIECVCSPAIGGILAGYELARA
LGVRFIFTERVNGVMALRRGFEVKPNEKILVCEDIITTGKSAMECAKVLEEKGAHIVAFAALANRGICKRTHSSLKAQED
ACLPSELPLFALEDFVFDMHEPKHCPLCTTSVAIKPGSRGN

Sequences:

>Translated_201_residues
MDVKACYQNAKALLEGHFLLSSGFHSNYYLQSAKVLENPKLAEQLALELAKQIQNARLNIECVCSPAIGGILAGYELARA
LGVRFIFTERVNGVMALRRGFEVKPNEKILVCEDIITTGKSAMECAKVLEEKGAHIVAFAALANRGICKRTHSSLKAQED
ACLPSELPLFALEDFVFDMHEPKHCPLCTTSVAIKPGSRGN
>Mature_201_residues
MDVKACYQNAKALLEGHFLLSSGFHSNYYLQSAKVLENPKLAEQLALELAKQIQNARLNIECVCSPAIGGILAGYELARA
LGVRFIFTERVNGVMALRRGFEVKPNEKILVCEDIITTGKSAMECAKVLEEKGAHIVAFAALANRGICKRTHSSLKAQED
ACLPSELPLFALEDFVFDMHEPKHCPLCTTSVAIKPGSRGN

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRE_HELAH (Q17Z49)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_664076.1
- ProteinModelPortal:   Q17Z49
- STRING:   Q17Z49
- GeneID:   4177753
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_0228
- NMPDR:   fig|382638.8.peg.221
- eggNOG:   COG0461
- HOGENOM:   HBG404341
- OMA:   ILHGHFV
- ProtClustDB:   PRK00455
- BioCyc:   HACI382638:HAC_0228-MONOMER
- HAMAP:   MF_01208
- InterPro:   IPR023031
- InterPro:   IPR006273
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01367

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.10

Molecular weight: Translated: 21977; Mature: 21977

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 117-117 BINDING 145-145

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
4.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVKACYQNAKALLEGHFLLSSGFHSNYYLQSAKVLENPKLAEQLALELAKQIQNARLNI
CCHHHHHHHHHHHHHHHHHEECCCCCCEEEHHHHHHCCCHHHHHHHHHHHHHHHHCCCCE
ECVCSPAIGGILAGYELARALGVRFIFTERVNGVMALRRGFEVKPNEKILVCEDIITTGK
EEEECCHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHCCH
SAMECAKVLEEKGAHIVAFAALANRGICKRTHSSLKAQEDACLPSELPLFALEDFVFDMH
HHHHHHHHHHHCCCEEEEEHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
EPKHCPLCTTSVAIKPGSRGN
CCCCCCCEECEEEECCCCCCC
>Mature Secondary Structure
MDVKACYQNAKALLEGHFLLSSGFHSNYYLQSAKVLENPKLAEQLALELAKQIQNARLNI
CCHHHHHHHHHHHHHHHHHEECCCCCCEEEHHHHHHCCCHHHHHHHHHHHHHHHHCCCCE
ECVCSPAIGGILAGYELARALGVRFIFTERVNGVMALRRGFEVKPNEKILVCEDIITTGK
EEEECCHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHCCH
SAMECAKVLEEKGAHIVAFAALANRGICKRTHSSLKAQEDACLPSELPLFALEDFVFDMH
HHHHHHHHHHHCCCEEEEEHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
EPKHCPLCTTSVAIKPGSRGN
CCCCCCCEECEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA