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The map label for this gene is nuoH

Identifier: 109946838

GI number: 109946838

Start: 186813

End: 187802

Strand: Reverse

Name: nuoH

Synonym: Hac_0217

Alternate gene names: 109946838

Gene position: 187802-186813 (Counterclockwise)

Preceding gene: 109946839

Following gene: 109946837

Centisome position: 12.09

GC content: 41.62

Gene sequence:

>990_bases
ATGAGCGCTTATATCATTGAAACTTTGATTAAAATTTTGATTTTAGTCGCTGTTTTTTCGGCTTTAGGGGGTTTTGCCAC
CTATATCGAAAGGAAAGTGTTAGCCTATTTCCAACGCCGTTTAGGGCCTTCTTATGTGGGGCCTTTTGGGCTTTTACAAG
TCGCAGCAGATGGCATTAAGCTTTTCACCAAAGAAGACATTATCCCCCAAGGCGCGAATAAGTTGATTTTCACCCTAGCG
CCCATTATTGCGATGGTGAGTGCATTTGTGTCCATGGCGCCTATCCCCTTTTTCCCTAATTTCACTCTGTTTGGCTATGA
GATCAAGCCCATTATTTCTGACATTAACATTGGCTTTTTATTTTTCTTAGCCGTGGGTGCAGCAGGGATTTATGCACCCA
TTTTAGCTGGGCTTGCTTCTAATAATAAATACTCTTTAATTGGATCAGCAAGAGCGACGATCCAACTGCTCAGCTTTGAA
GTGGTAAGCACCTTAACCATTCTAGCCCCTTTAATGGTGGTAGGATCGCTTTCTTTAGTAGAGATCAATAATTACCAAAG
CGGTGGGTTTTTAGACTGGCTTGTTTTCAAGCAACCTTTAGCGTTTATTTTATTTTTGATCGCAAGCTATGCTGAATTGA
ATCGAACGCCCTTTGACTTGCTAGAGCATGAAGCCGAGATCGTAGCTGGGTATTGCACCGAATACAGCGGTTTGAAATGG
GGCATGTTCTTTTTGGCAGAATACGCGCATTTATTCGCTTTTTCTTTTGTGATTTCTATCGTGTTTTTTGGTGGGTTTAA
CGCATGGGGCTTTATCCCTGGAGGCATAGCGATTTTGATTAAAGTAAGCTTTTTTGTCTTTTTGTCCATGTGGGTTAGAG
CGACTTACCCGCATGTGCGCCCAGACCAACTGATGAACATGTGTTGGAAAATCATGTTGCCTTTAGCGCTATTGAACATT
GTGCTAACAGGCGTTATTATTTTAATTTAA

Upstream 100 bases:

>100_bases
TGGATCAAGAGGTGTTTGTTGTTTCGCCTTCTCTTTTAGGGAATGGTTCTAACTTTTTTAAAGAGAGCGTGTTTGATAGC
GTGGATTTAAAGGAGCAAGC

Downstream 100 bases:

>100_bases
GGAGGTTTTATGGCTAAACAAGAATACAAACAACTTCCTAAACGAGCCGAAATCCATAGCGCGACAGAGCAATTTAAAGA
CACCATTAAAACAAGCTTGG

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MSAYIIETLIKILILVAVFSALGGFATYIERKVLAYFQRRLGPSYVGPFGLLQVAADGIKLFTKEDIIPQGANKLIFTLA
PIIAMVSAFVSMAPIPFFPNFTLFGYEIKPIISDINIGFLFFLAVGAAGIYAPILAGLASNNKYSLIGSARATIQLLSFE
VVSTLTILAPLMVVGSLSLVEINNYQSGGFLDWLVFKQPLAFILFLIASYAELNRTPFDLLEHEAEIVAGYCTEYSGLKW
GMFFLAEYAHLFAFSFVISIVFFGGFNAWGFIPGGIAILIKVSFFVFLSMWVRATYPHVRPDQLMNMCWKIMLPLALLNI
VLTGVIILI

Sequences:

>Translated_329_residues
MSAYIIETLIKILILVAVFSALGGFATYIERKVLAYFQRRLGPSYVGPFGLLQVAADGIKLFTKEDIIPQGANKLIFTLA
PIIAMVSAFVSMAPIPFFPNFTLFGYEIKPIISDINIGFLFFLAVGAAGIYAPILAGLASNNKYSLIGSARATIQLLSFE
VVSTLTILAPLMVVGSLSLVEINNYQSGGFLDWLVFKQPLAFILFLIASYAELNRTPFDLLEHEAEIVAGYCTEYSGLKW
GMFFLAEYAHLFAFSFVISIVFFGGFNAWGFIPGGIAILIKVSFFVFLSMWVRATYPHVRPDQLMNMCWKIMLPLALLNI
VLTGVIILI
>Mature_328_residues
SAYIIETLIKILILVAVFSALGGFATYIERKVLAYFQRRLGPSYVGPFGLLQVAADGIKLFTKEDIIPQGANKLIFTLAP
IIAMVSAFVSMAPIPFFPNFTLFGYEIKPIISDINIGFLFFLAVGAAGIYAPILAGLASNNKYSLIGSARATIQLLSFEV
VSTLTILAPLMVVGSLSLVEINNYQSGGFLDWLVFKQPLAFILFLIASYAELNRTPFDLLEHEAEIVAGYCTEYSGLKWG
MFFLAEYAHLFAFSFVISIVFFGGFNAWGFIPGGIAILIKVSFFVFLSMWVRATYPHVRPDQLMNMCWKIMLPLALLNIV
LTGVIILI

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=295, Percent_Identity=35.5932203389831, Blast_Score=175, Evalue=4e-44,
Organism=Escherichia coli, GI1788618, Length=324, Percent_Identity=40.1234567901235, Blast_Score=231, Evalue=7e-62,
Organism=Escherichia coli, GI87082115, Length=227, Percent_Identity=27.7533039647577, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_HELAH (Q17Z59)

Other databases:

- EMBL:   AM260522
- RefSeq:   YP_664066.1
- STRING:   Q17Z59
- GeneID:   4176454
- GenomeReviews:   AM260522_GR
- KEGG:   hac:Hac_0217
- NMPDR:   fig|382638.8.peg.211
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   NMCWKIM
- PhylomeDB:   Q17Z59
- ProtClustDB:   PRK06076
- BioCyc:   HACI382638:HAC_0217-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 36314; Mature: 36183

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x129b2d00)-; HASH(0x118bb08c)-; HASH(0x11d073b8)-; HASH(0x118c62d0)-; HASH(0x12988a34)-; HASH(0x12667b18)-; HASH(0x127e22e8)-; HASH(0x11d07190)-; HASH(0x127e22dc)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAYIIETLIKILILVAVFSALGGFATYIERKVLAYFQRRLGPSYVGPFGLLQVAADGIK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LFTKEDIIPQGANKLIFTLAPIIAMVSAFVSMAPIPFFPNFTLFGYEIKPIISDINIGFL
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECEEHHHHHHHHHHHHH
FFLAVGAAGIYAPILAGLASNNKYSLIGSARATIQLLSFEVVSTLTILAPLMVVGSLSLV
HHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
EINNYQSGGFLDWLVFKQPLAFILFLIASYAELNRTPFDLLEHEAEIVAGYCTEYSGLKW
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHH
GMFFLAEYAHLFAFSFVISIVFFGGFNAWGFIPGGIAILIKVSFFVFLSMWVRATYPHVR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
PDQLMNMCWKIMLPLALLNIVLTGVIILI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHH
>Mature Secondary Structure 
SAYIIETLIKILILVAVFSALGGFATYIERKVLAYFQRRLGPSYVGPFGLLQVAADGIK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LFTKEDIIPQGANKLIFTLAPIIAMVSAFVSMAPIPFFPNFTLFGYEIKPIISDINIGFL
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECEEHHHHHHHHHHHHH
FFLAVGAAGIYAPILAGLASNNKYSLIGSARATIQLLSFEVVSTLTILAPLMVVGSLSLV
HHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
EINNYQSGGFLDWLVFKQPLAFILFLIASYAELNRTPFDLLEHEAEIVAGYCTEYSGLKW
EECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHH
GMFFLAEYAHLFAFSFVISIVFFGGFNAWGFIPGGIAILIKVSFFVFLSMWVRATYPHVR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
PDQLMNMCWKIMLPLALLNIVLTGVIILI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA