Click here to switch to the map view.

The map label for this gene is lon [H]

Identifier: 109946692

GI number: 109946692

Start: 56846

End: 59341

Strand: Reverse

Name: lon [H]

Synonym: Hac_0059

Alternate gene names: 109946692

Gene position: 59341-56846 (Counterclockwise)

Preceding gene: 109946693

Following gene: 109946691

Centisome position: 3.82

GC content: 40.1

Gene sequence:

>2496_bases
ATGACTGAATATTTTCCTAGAATTCTGCCCGTGTTGGTAGAAGAAGACACTTTTTTATACCCCTTTATGATAGCCCCTAT
TTTTTTGCAAAATAATGCGAGTATCAAGGCGGTGGCTTACGCTAAAAGCAACAAATCATTAGTCTTTATTGCATGCCAAA
AAGACAAATTGAACGACAATGAAGCCCCTTATTATGATGTGGGGGTGATTGGCTCTATCATGCGCGAAGCGGACATGCCT
AATGGACGCGTGAAATTGCTTTTTAATGGTATCGCTAAAGGGCGTATTTTAGAGCCCGCTAAAGAAAATGAGCAAGGCTT
TTTGGAAGCTCAAATAAGCCCTATTGAATATTTAGAATACGATAAAGAAAACATTCAAGCTATCGTGGAAGTGTTGAAAG
AAAAAGTGATCACTCTAGCGAATGTAAGCTCGCTCTTCCCCCCAGATTTGATCAAAGCTTTAGAAGACAATGACGATCCC
AACCGCATCGCTGATTTAATCGCAGCGGCTTTGCGCTTGAAAAAAGATCAAGCGTATTCCCTTTTTGCTAACAACAACAC
CGAGCAACGCTTATTGGATTTGATTGATATTGTGATAGAAGAGACTAAAACCCAAAAACTCCAAAAAGAAATCAAATCCA
AAGTCCATCAAAAAATGGAGCAAGTCAATAAGGAATATTTCTTAAAAGAGCAGCTCAAACAAATCCAAAAAGAGCTTGGC
ACAGACAAGCAACGAGATGAGGATTTAAACCAATACTACCAAAAATTAGAAAGCATCAAGCCTTTTTTAAAAGAAGAAGC
GTTTAAAGAAATCAAAAAACAAATTGACCGATTAAGCCGAACCCATGTGGATAGCTCTGATAGTGCGACTTTGCAAAGCT
ATATTGAAACTATGTTGGATGTGCCTTTTGGTCAATATGGGAAAAAAGCGTTAGACATTAAGCATGTTAGAGAACAATTG
AATAAGGATCATTATTCCTTGAAAAAACCTAAAGAGCGCATTGTGGAATACTTTGCCACCATGCAGCTTTTAGAAATGCG
CCAAAAGAAAAAACAAGAGCTACAACCAAACAAAAAAGACAAAACCAAAGGCACTATTTTGTGTTTTTATGGGCCTCCTG
GCGTAGGTAAAACAAGCCTAGCCAATTCCATTGCTAAAGCGATAGAGCACCCATTAGTTCGGATCGCTTTAGGGGGATTA
GAGGATGTGAATGAATTAAGAGGTCATCGGCGCACTTATGTAGGCTCAATGCCTGGGCGCATTGTCCAAGGGCTTATTGA
AGCTAAAAAAATGGATCCGGTCATGGTTTTAGATGAAATTGATAAAGTGGATAGGAGCGTTAGGGGTGATCCAACGAGCG
CTTTGTTAGAGATTTTAGACCCTGAGCAAAATGTTGCTTTTAGGGATCATTATGCGAATTTTAGCATTGATTTGTCGCAA
GTGATTTTTATCGCCACCGCCAACAATGTGGATAGAATCCCAGCTCCTTTAAGAGACAGAATGGAATTTATTAGCGTGTC
TAGCTACACGCCTAGTGAAAAAGAAGAAATCGCTAAAAACTACCTTATCCCCCAAGAATTAGAAAAGCATGCCTTAAAAC
CTAGCGAGGTTAAGATTAGCCAGGCGTGTTTGAAGCTCATTATTGAAAAATACACCAGAGAAGCGGGCGTTAGGGATTTA
CGAAGACAAATCGCAACGATTATGCGCAAGGTGGCTTTAAAATACCTAGAGGATAATCCGCACAAAAAAGGGCGAGCCAA
AAAAGACGAAAATGAAGAAGATGAAAATAAAAAAGGCGAAAATAAAGATTTTTGTGTCTCTATCACGCCTAATAACCTTA
AAGAGTATTTAGAACGCACGGTGTTTGAAATTGACCCCATAGATAAAGAAAATAAAATCGGTATTGTCAATGGCTTGGCA
TGGACGCCAGTAGGCGGCGATGTGCTTAAAATTGAAGCGCTTAAGATTAGGGGTAAAGGGGAATTGAAACTCACGGGAAG
CTTAGGCGATGTGATGAAAGAATCCGCTTTGATCGCTTTTTCTGTCGTTAAAGTCTTGTTGGATGAAGAAAAATTAAAAG
CCCCCAAAATCCCTAGCGAGACCCTTAAAGACACAGAGGGTAAGAAAAAGAAAAAAGCGCTTAAGGTTTATAACGCTTAC
GATTTGCATTTGCATGTCCCTGAAGGAGCCACGCCTAAAGATGGGCCAAGCGCTGGAATCGCTATGGCGAGCGTGATTGC
GAGTATTTTGTGCGACAAAGCCACAAGAAGCGATGTGGCAATGACGGGCGAACTGACTTTGAGTGGGGAAGTTTTACCCA
TAGGAGGGTTGAAAGAAAAATTGATCGCTGCTTTTAAAGCCGGCATTAAAACCGCTCTCATTCCTGTCAAAAATTACGAA
AGGGATTTAGATGAAATCCCTGCTGAAGTGCTAGAGAATTTAAAAATCGTTGCGGTGAAAAACATCGCTGAAGTGTTGGA
AAAAACCTTACTTTAA

Upstream 100 bases:

>100_bases
AAAGAGACTAAACCCAAACCATCACACATGCCTTGGTATGTGTTGATTTTTGATTGGTAGGATATTTCAAACCATACAAA
CCATAACAGAGAGATGAAAA

Downstream 100 bases:

>100_bases
AATGCAAGCCGGAATCATTGGTTTAGGGCTTATGGGAGGCAGTTTGGGATTGGCTTTGCAAGAATTAGGGCGTTTTAAAA
GCGTTATAGGCTATGATCAT

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 831; Mature: 830

Protein sequence:

>831_residues
MTEYFPRILPVLVEEDTFLYPFMIAPIFLQNNASIKAVAYAKSNKSLVFIACQKDKLNDNEAPYYDVGVIGSIMREADMP
NGRVKLLFNGIAKGRILEPAKENEQGFLEAQISPIEYLEYDKENIQAIVEVLKEKVITLANVSSLFPPDLIKALEDNDDP
NRIADLIAAALRLKKDQAYSLFANNNTEQRLLDLIDIVIEETKTQKLQKEIKSKVHQKMEQVNKEYFLKEQLKQIQKELG
TDKQRDEDLNQYYQKLESIKPFLKEEAFKEIKKQIDRLSRTHVDSSDSATLQSYIETMLDVPFGQYGKKALDIKHVREQL
NKDHYSLKKPKERIVEYFATMQLLEMRQKKKQELQPNKKDKTKGTILCFYGPPGVGKTSLANSIAKAIEHPLVRIALGGL
EDVNELRGHRRTYVGSMPGRIVQGLIEAKKMDPVMVLDEIDKVDRSVRGDPTSALLEILDPEQNVAFRDHYANFSIDLSQ
VIFIATANNVDRIPAPLRDRMEFISVSSYTPSEKEEIAKNYLIPQELEKHALKPSEVKISQACLKLIIEKYTREAGVRDL
RRQIATIMRKVALKYLEDNPHKKGRAKKDENEEDENKKGENKDFCVSITPNNLKEYLERTVFEIDPIDKENKIGIVNGLA
WTPVGGDVLKIEALKIRGKGELKLTGSLGDVMKESALIAFSVVKVLLDEEKLKAPKIPSETLKDTEGKKKKKALKVYNAY
DLHLHVPEGATPKDGPSAGIAMASVIASILCDKATRSDVAMTGELTLSGEVLPIGGLKEKLIAAFKAGIKTALIPVKNYE
RDLDEIPAEVLENLKIVAVKNIAEVLEKTLL

Sequences:

>Translated_831_residues
MTEYFPRILPVLVEEDTFLYPFMIAPIFLQNNASIKAVAYAKSNKSLVFIACQKDKLNDNEAPYYDVGVIGSIMREADMP
NGRVKLLFNGIAKGRILEPAKENEQGFLEAQISPIEYLEYDKENIQAIVEVLKEKVITLANVSSLFPPDLIKALEDNDDP
NRIADLIAAALRLKKDQAYSLFANNNTEQRLLDLIDIVIEETKTQKLQKEIKSKVHQKMEQVNKEYFLKEQLKQIQKELG
TDKQRDEDLNQYYQKLESIKPFLKEEAFKEIKKQIDRLSRTHVDSSDSATLQSYIETMLDVPFGQYGKKALDIKHVREQL
NKDHYSLKKPKERIVEYFATMQLLEMRQKKKQELQPNKKDKTKGTILCFYGPPGVGKTSLANSIAKAIEHPLVRIALGGL
EDVNELRGHRRTYVGSMPGRIVQGLIEAKKMDPVMVLDEIDKVDRSVRGDPTSALLEILDPEQNVAFRDHYANFSIDLSQ
VIFIATANNVDRIPAPLRDRMEFISVSSYTPSEKEEIAKNYLIPQELEKHALKPSEVKISQACLKLIIEKYTREAGVRDL
RRQIATIMRKVALKYLEDNPHKKGRAKKDENEEDENKKGENKDFCVSITPNNLKEYLERTVFEIDPIDKENKIGIVNGLA
WTPVGGDVLKIEALKIRGKGELKLTGSLGDVMKESALIAFSVVKVLLDEEKLKAPKIPSETLKDTEGKKKKKALKVYNAY
DLHLHVPEGATPKDGPSAGIAMASVIASILCDKATRSDVAMTGELTLSGEVLPIGGLKEKLIAAFKAGIKTALIPVKNYE
RDLDEIPAEVLENLKIVAVKNIAEVLEKTLL
>Mature_830_residues
TEYFPRILPVLVEEDTFLYPFMIAPIFLQNNASIKAVAYAKSNKSLVFIACQKDKLNDNEAPYYDVGVIGSIMREADMPN
GRVKLLFNGIAKGRILEPAKENEQGFLEAQISPIEYLEYDKENIQAIVEVLKEKVITLANVSSLFPPDLIKALEDNDDPN
RIADLIAAALRLKKDQAYSLFANNNTEQRLLDLIDIVIEETKTQKLQKEIKSKVHQKMEQVNKEYFLKEQLKQIQKELGT
DKQRDEDLNQYYQKLESIKPFLKEEAFKEIKKQIDRLSRTHVDSSDSATLQSYIETMLDVPFGQYGKKALDIKHVREQLN
KDHYSLKKPKERIVEYFATMQLLEMRQKKKQELQPNKKDKTKGTILCFYGPPGVGKTSLANSIAKAIEHPLVRIALGGLE
DVNELRGHRRTYVGSMPGRIVQGLIEAKKMDPVMVLDEIDKVDRSVRGDPTSALLEILDPEQNVAFRDHYANFSIDLSQV
IFIATANNVDRIPAPLRDRMEFISVSSYTPSEKEEIAKNYLIPQELEKHALKPSEVKISQACLKLIIEKYTREAGVRDLR
RQIATIMRKVALKYLEDNPHKKGRAKKDENEEDENKKGENKDFCVSITPNNLKEYLERTVFEIDPIDKENKIGIVNGLAW
TPVGGDVLKIEALKIRGKGELKLTGSLGDVMKESALIAFSVVKVLLDEEKLKAPKIPSETLKDTEGKKKKKALKVYNAYD
LHLHVPEGATPKDGPSAGIAMASVIASILCDKATRSDVAMTGELTLSGEVLPIGGLKEKLIAAFKAGIKTALIPVKNYER
DLDEIPAEVLENLKIVAVKNIAEVLEKTLL

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=588, Percent_Identity=42.687074829932, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI21396489, Length=680, Percent_Identity=36.7647058823529, Blast_Score=457, Evalue=1e-128,
Organism=Escherichia coli, GI1786643, Length=828, Percent_Identity=40.0966183574879, Blast_Score=565, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI17505831, Length=701, Percent_Identity=36.8045649072753, Blast_Score=422, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17556486, Length=692, Percent_Identity=32.514450867052, Blast_Score=356, Evalue=2e-98,
Organism=Saccharomyces cerevisiae, GI6319449, Length=708, Percent_Identity=36.2994350282486, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI24666867, Length=707, Percent_Identity=36.7751060820368, Blast_Score=448, Evalue=1e-126,
Organism=Drosophila melanogaster, GI221513036, Length=707, Percent_Identity=36.7751060820368, Blast_Score=447, Evalue=1e-125,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 93764; Mature: 93632

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEYFPRILPVLVEEDTFLYPFMIAPIFLQNNASIKAVAYAKSNKSLVFIACQKDKLNDN
CCCHHHHHHHHHCCCCCEEHHHHHHHHHEECCCCEEEEEEECCCCCEEEEEEECCCCCCC
EAPYYDVGVIGSIMREADMPNGRVKLLFNGIAKGRILEPAKENEQGFLEAQISPIEYLEY
CCCEEHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEECCHHHHHHC
DKENIQAIVEVLKEKVITLANVSSLFPPDLIKALEDNDDPNRIADLIAAALRLKKDQAYS
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEE
LFANNNTEQRLLDLIDIVIEETKTQKLQKEIKSKVHQKMEQVNKEYFLKEQLKQIQKELG
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TDKQRDEDLNQYYQKLESIKPFLKEEAFKEIKKQIDRLSRTHVDSSDSATLQSYIETMLD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
VPFGQYGKKALDIKHVREQLNKDHYSLKKPKERIVEYFATMQLLEMRQKKKQELQPNKKD
CCCCCCCCHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
KTKGTILCFYGPPGVGKTSLANSIAKAIEHPLVRIALGGLEDVNELRGHRRTYVGSMPGR
CCCCEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHCCCCCHH
IVQGLIEAKKMDPVMVLDEIDKVDRSVRGDPTSALLEILDPEQNVAFRDHYANFSIDLSQ
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHCCCCEEEHHH
VIFIATANNVDRIPAPLRDRMEFISVSSYTPSEKEEIAKNYLIPQELEKHALKPSEVKIS
EEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHCCCCCHHHHH
QACLKLIIEKYTREAGVRDLRRQIATIMRKVALKYLEDNPHKKGRAKKDENEEDENKKGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCC
NKDFCVSITPNNLKEYLERTVFEIDPIDKENKIGIVNGLAWTPVGGDVLKIEALKIRGKG
CCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCEEEEECCEECCCCCCEEEEEEEEECCCC
ELKLTGSLGDVMKESALIAFSVVKVLLDEEKLKAPKIPSETLKDTEGKKKKKALKVYNAY
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHCCEE
DLHLHVPEGATPKDGPSAGIAMASVIASILCDKATRSDVAMTGELTLSGEVLPIGGLKEK
EEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCEEECCCHHHH
LIAAFKAGIKTALIPVKNYERDLDEIPAEVLENLKIVAVKNIAEVLEKTLL
HHHHHHHCHHHEEEECHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHCC
>Mature Secondary Structure 
TEYFPRILPVLVEEDTFLYPFMIAPIFLQNNASIKAVAYAKSNKSLVFIACQKDKLNDN
CCHHHHHHHHHCCCCCEEHHHHHHHHHEECCCCEEEEEEECCCCCEEEEEEECCCCCCC
EAPYYDVGVIGSIMREADMPNGRVKLLFNGIAKGRILEPAKENEQGFLEAQISPIEYLEY
CCCEEHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEECCHHHHHHC
DKENIQAIVEVLKEKVITLANVSSLFPPDLIKALEDNDDPNRIADLIAAALRLKKDQAYS
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEE
LFANNNTEQRLLDLIDIVIEETKTQKLQKEIKSKVHQKMEQVNKEYFLKEQLKQIQKELG
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TDKQRDEDLNQYYQKLESIKPFLKEEAFKEIKKQIDRLSRTHVDSSDSATLQSYIETMLD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
VPFGQYGKKALDIKHVREQLNKDHYSLKKPKERIVEYFATMQLLEMRQKKKQELQPNKKD
CCCCCCCCHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
KTKGTILCFYGPPGVGKTSLANSIAKAIEHPLVRIALGGLEDVNELRGHRRTYVGSMPGR
CCCCEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHCCCCCHH
IVQGLIEAKKMDPVMVLDEIDKVDRSVRGDPTSALLEILDPEQNVAFRDHYANFSIDLSQ
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHCCCCEEEHHH
VIFIATANNVDRIPAPLRDRMEFISVSSYTPSEKEEIAKNYLIPQELEKHALKPSEVKIS
EEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHHCCCCCHHHHH
QACLKLIIEKYTREAGVRDLRRQIATIMRKVALKYLEDNPHKKGRAKKDENEEDENKKGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCC
NKDFCVSITPNNLKEYLERTVFEIDPIDKENKIGIVNGLAWTPVGGDVLKIEALKIRGKG
CCCEEEEECCHHHHHHHHHHHHCCCCCCCCCCEEEEECCEECCCCCCEEEEEEEEECCCC
ELKLTGSLGDVMKESALIAFSVVKVLLDEEKLKAPKIPSETLKDTEGKKKKKALKVYNAY
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHCCEE
DLHLHVPEGATPKDGPSAGIAMASVIASILCDKATRSDVAMTGELTLSGEVLPIGGLKEK
EEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCEEECCCHHHH
LIAAFKAGIKTALIPVKNYERDLDEIPAEVLENLKIVAVKNIAEVLEKTLL
HHHHHHHCHHHEEEECHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9252185 [H]