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The map label for this gene is pyrD [H]

Identifier: 110681094

GI number: 110681094

Start: 3820037

End: 3821089

Strand: Direct

Name: pyrD [H]

Synonym: RD1_3961

Alternate gene names: 110681094

Gene position: 3820037-3821089 (Clockwise)

Preceding gene: 110681093

Following gene: 110681098

Centisome position: 92.43

GC content: 64.67

Gene sequence:

>1053_bases
ATGAAACGGCTTGCCGAAAAGGCAGGCCTCGCGGTTTTGCAAAGCATGGACCCGGAAAGGGCACACGGCCTTGCGCTTGC
AGCGCTCAATGCGGGGCTTGCCGGTCAACCGGGGCCGATCAAATCGGACCGTTTGCGCGTGCGCTTGGCAGGCATGGATC
TGGCAAATCCGGTCGGGCTGGCGGCGGGCTTTGACAAGAATGCCCAAGCCGTTGGCCCGCTTGGCAAGGCTGGTTTCGGG
TTCATTGAGGTGGGCGCGGCCACGCCCCTGCCCCAACCCGGCAACCCAAAGCCACGCCTGTTCCGCCTCAAGCAAGACGC
CGCCGCCATCAACCGGTTCGGGTTCAACAACGACGGTATGGACGCCATCGCCGGGCGACTGGCAGGGGCGGCGTGCGCGG
TGCCTGTAGGCATCAATCTCGGCGCGAACAAGACCAGCGAGGACCGCGCCGCCGATTTCGCCGTTGTGATGCAGCGCTTC
AAAGGGCATGTGTCTTTCGCGACGGTCAATGTCTCCTCGCCCAACACCGAAAAACTGCGCGACCTGCAAGGGCCCGCCGC
CCTTGCCGCGCTGCTTGACGGCGTGATGCAGGTGCGGGGCAACACACCGGTGTTTCTGAAAATCGCGCCGGACCTGACCC
TGCCCGAGATCAGCGATATTGCCACGGTCGCGCAGAATGCTGGCGTGGACGGGATCATCGCAACCAATACCACGCTGGAT
CGTGATGGGTTGCATGGGCCCCATAAGACGCAGGCGGGCGGGCTGTCCGGCCAGCCTCTGTTTGAGAAATCAACGCGCGT
GCTCGCGCAGCTTTCCGCAGCAACCGACCTGCCGCTGATCGGTGTGGGCGGTGTCGCCAGTGGCGCGCAGGCCTATGCCA
AAATCCGCGCGGGTGCCACGGCGGTGCAGCTTTACACAGGGTTGGTCTATGGCGGGCTGTCACTGGTGGGCGACATCATC
CGTGACCTGGGTGATCTGCTGGAACGGGACGGCTTTGCGTCGGTGGCCGAAGCCTGCGGCACGGATCGCGACCGCTGGCT
CAACGCGGCCTAA

Upstream 100 bases:

>100_bases
TCTATCGCAAGCTGCGCCTTGATGATGTCCTCTGGGCGGTGCCGCTGCCCCTCGTGGATGGTGTACACCAGTTTCCGGCC
GGGCTGGACGAGGCCTGCGC

Downstream 100 bases:

>100_bases
CCTGCCTTGCTCGCGTGGCGTTCAAGGGCCGGGTACCGCGCGCCCAACGTAATGCCACGCACGGCAAAAGAGATCAGCAA
AGCCACCCACAGCCCGTGAT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MKRLAEKAGLAVLQSMDPERAHGLALAALNAGLAGQPGPIKSDRLRVRLAGMDLANPVGLAAGFDKNAQAVGPLGKAGFG
FIEVGAATPLPQPGNPKPRLFRLKQDAAAINRFGFNNDGMDAIAGRLAGAACAVPVGINLGANKTSEDRAADFAVVMQRF
KGHVSFATVNVSSPNTEKLRDLQGPAALAALLDGVMQVRGNTPVFLKIAPDLTLPEISDIATVAQNAGVDGIIATNTTLD
RDGLHGPHKTQAGGLSGQPLFEKSTRVLAQLSAATDLPLIGVGGVASGAQAYAKIRAGATAVQLYTGLVYGGLSLVGDII
RDLGDLLERDGFASVAEACGTDRDRWLNAA

Sequences:

>Translated_350_residues
MKRLAEKAGLAVLQSMDPERAHGLALAALNAGLAGQPGPIKSDRLRVRLAGMDLANPVGLAAGFDKNAQAVGPLGKAGFG
FIEVGAATPLPQPGNPKPRLFRLKQDAAAINRFGFNNDGMDAIAGRLAGAACAVPVGINLGANKTSEDRAADFAVVMQRF
KGHVSFATVNVSSPNTEKLRDLQGPAALAALLDGVMQVRGNTPVFLKIAPDLTLPEISDIATVAQNAGVDGIIATNTTLD
RDGLHGPHKTQAGGLSGQPLFEKSTRVLAQLSAATDLPLIGVGGVASGAQAYAKIRAGATAVQLYTGLVYGGLSLVGDII
RDLGDLLERDGFASVAEACGTDRDRWLNAA
>Mature_350_residues
MKRLAEKAGLAVLQSMDPERAHGLALAALNAGLAGQPGPIKSDRLRVRLAGMDLANPVGLAAGFDKNAQAVGPLGKAGFG
FIEVGAATPLPQPGNPKPRLFRLKQDAAAINRFGFNNDGMDAIAGRLAGAACAVPVGINLGANKTSEDRAADFAVVMQRF
KGHVSFATVNVSSPNTEKLRDLQGPAALAALLDGVMQVRGNTPVFLKIAPDLTLPEISDIATVAQNAGVDGIIATNTTLD
RDGLHGPHKTQAGGLSGQPLFEKSTRVLAQLSAATDLPLIGVGGVASGAQAYAKIRAGATAVQLYTGLVYGGLSLVGDII
RDLGDLLERDGFASVAEACGTDRDRWLNAA

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=347, Percent_Identity=46.9740634005764, Blast_Score=284, Evalue=7e-77,
Organism=Escherichia coli, GI1787177, Length=331, Percent_Identity=40.1812688821752, Blast_Score=220, Evalue=8e-59,
Organism=Caenorhabditis elegans, GI17509475, Length=352, Percent_Identity=44.8863636363636, Blast_Score=279, Evalue=1e-75,
Organism=Drosophila melanogaster, GI281361352, Length=344, Percent_Identity=44.1860465116279, Blast_Score=260, Evalue=9e-70,
Organism=Drosophila melanogaster, GI17137316, Length=344, Percent_Identity=44.1860465116279, Blast_Score=260, Evalue=9e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 35938; Mature: 35938

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLAEKAGLAVLQSMDPERAHGLALAALNAGLAGQPGPIKSDRLRVRLAGMDLANPVGL
CCHHHHHHHHHHHHHCCCHHHHCEEHEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCC
AAGFDKNAQAVGPLGKAGFGFIEVGAATPLPQPGNPKPRLFRLKQDAAAINRFGFNNDGM
CCCCCCCCHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCH
DAIAGRLAGAACAVPVGINLGANKTSEDRAADFAVVMQRFKGHVSFATVNVSSPNTEKLR
HHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHH
DLQGPAALAALLDGVMQVRGNTPVFLKIAPDLTLPEISDIATVAQNAGVDGIIATNTTLD
HHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCEEEECCCEEC
RDGLHGPHKTQAGGLSGQPLFEKSTRVLAQLSAATDLPLIGVGGVASGAQAYAKIRAGAT
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCH
AVQLYTGLVYGGLSLVGDIIRDLGDLLERDGFASVAEACGTDRDRWLNAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHCCCC
>Mature Secondary Structure
MKRLAEKAGLAVLQSMDPERAHGLALAALNAGLAGQPGPIKSDRLRVRLAGMDLANPVGL
CCHHHHHHHHHHHHHCCCHHHHCEEHEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCC
AAGFDKNAQAVGPLGKAGFGFIEVGAATPLPQPGNPKPRLFRLKQDAAAINRFGFNNDGM
CCCCCCCCHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCH
DAIAGRLAGAACAVPVGINLGANKTSEDRAADFAVVMQRFKGHVSFATVNVSSPNTEKLR
HHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHH
DLQGPAALAALLDGVMQVRGNTPVFLKIAPDLTLPEISDIATVAQNAGVDGIIATNTTLD
HHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCEEEECCCEEC
RDGLHGPHKTQAGGLSGQPLFEKSTRVLAQLSAATDLPLIGVGGVASGAQAYAKIRAGAT
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCH
AVQLYTGLVYGGLSLVGDIIRDLGDLLERDGFASVAEACGTDRDRWLNAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA