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The map label for this gene is tetA [H]

Identifier: 110681071

GI number: 110681071

Start: 3797388

End: 3798593

Strand: Direct

Name: tetA [H]

Synonym: RD1_3936

Alternate gene names: 110681071

Gene position: 3797388-3798593 (Clockwise)

Preceding gene: 110681070

Following gene: 110681072

Centisome position: 91.88

GC content: 61.69

Gene sequence:

>1206_bases
GTGAAACCCGCCGTCGTTTTCATCCTGATGACCATGATGATTGATGCGATGGGCATCGGGCTGATCATCCCCGTCATGCC
CGACCTGTTCCAGGAGGTGGGCGCGGGCGATCTGGGCACCGCAGCGCTCTGGGGCGGGATATTGGCCACGGCATTTGCGG
TCATGCAGTTCTTCTTTGGGCCCGTGATCGGCGGTCTGTCAGATCGCTTTGGGCGCAGGCCAATCCTGCTGGTATCACTG
TTTGTGATGATGCTGGATTACCTCGTCATGGCGCTGGCAGGCAGCATCTGGCTGTTGCTGATCGGGCGCATGATCGGCGG
GGTCACGGCTGCGACACAGGCAACGGCCAATGCCTATATGGCGGACATTTCGGCCCCGCAGGACCGGGCCGCGAACTTCG
GCCTGATCGGTGCGGCTTTCGGTGTCGGCTTCGTGCTTGGCCCCCTGATTGGCGGCCTGCTGGCTGAATTCGGAACCCGC
GCCCCGTTTTATGCCGCTGCCGCCTGCGCCGGGTTGAATGCGATCTTCGGCTATTTCGTGCTCAAGGAAACGCTGCCCGC
CAGCAAACGGCGCCCTTTCGAGTGGCGGCGCGCCAACCCTTTCGGCAGTTTTCGCCACCTCAGCAAACTGCATGCGCTGG
GGCCGTTCCTGATCGTATTTTTTCTCTATCAGGTGGCATTCGCCGTTTACCCCGCCATCTGGTCCTTCTTTGGCAAGGAA
CGGTTCGGTTGGGAACCTGCGACCATCGGGCTGAGCCTTGCGCTGTTCGGCATCATGATGGCCATCGTGCAGGGCGGTCT
GATCCGCCCCGTGATGCGTCTGCTGGGCGCGCGTGGCACGGTCGTTTATGGCCATATTTTTGACATCTGTGTATTTCTGG
CCCTCGCCTTTGTCACCAGTGGCACCATCGCCCTGATCCTGACACCGCTCGCAGCCCTCGCCGCTGTGATCACCCCAGCC
CTGCAAGGCATCATGTCCAAATCCGTCGGACCCGACGCGCAGGGCGAGTTGCAAGGCGCGCTCACCTCGCTCAGCGCACT
TGCGATGATCCTGTCACCACTGGTCATGACGGGCACTTTCGCAGCCTTCACCGGCCCGGATGCGCCCATTTACGCGCCGG
GCGCGCCTTTCATCCTGTCGGCTGGATTGATCGTCATCGGTCTGACCATTTTCATCACACGCGGGCGCGCCGCATCGTTT
TCCTGA

Upstream 100 bases:

>100_bases
ACCCCCACCTGCCGCAGACCTTATTTCAGGCCGGGCATCAGCTTGGTCAGGCCCCGGAAGAGGCGCGGGCCTTTGCCGCG
CGCATCATGAGCATGGCCAA

Downstream 100 bases:

>100_bases
CGGCACCAGTTGGCTTTCGTCGCGTTCGGGCTTGCGCATGACCCGGCATTTAGTAACGCTGGCCAGACAGAAACAGGAAG
CACCGGGGAGATCACCAGAT

Product: tetracycline resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: TetA(C) [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MKPAVVFILMTMMIDAMGIGLIIPVMPDLFQEVGAGDLGTAALWGGILATAFAVMQFFFGPVIGGLSDRFGRRPILLVSL
FVMMLDYLVMALAGSIWLLLIGRMIGGVTAATQATANAYMADISAPQDRAANFGLIGAAFGVGFVLGPLIGGLLAEFGTR
APFYAAAACAGLNAIFGYFVLKETLPASKRRPFEWRRANPFGSFRHLSKLHALGPFLIVFFLYQVAFAVYPAIWSFFGKE
RFGWEPATIGLSLALFGIMMAIVQGGLIRPVMRLLGARGTVVYGHIFDICVFLALAFVTSGTIALILTPLAALAAVITPA
LQGIMSKSVGPDAQGELQGALTSLSALAMILSPLVMTGTFAAFTGPDAPIYAPGAPFILSAGLIVIGLTIFITRGRAASF
S

Sequences:

>Translated_401_residues
MKPAVVFILMTMMIDAMGIGLIIPVMPDLFQEVGAGDLGTAALWGGILATAFAVMQFFFGPVIGGLSDRFGRRPILLVSL
FVMMLDYLVMALAGSIWLLLIGRMIGGVTAATQATANAYMADISAPQDRAANFGLIGAAFGVGFVLGPLIGGLLAEFGTR
APFYAAAACAGLNAIFGYFVLKETLPASKRRPFEWRRANPFGSFRHLSKLHALGPFLIVFFLYQVAFAVYPAIWSFFGKE
RFGWEPATIGLSLALFGIMMAIVQGGLIRPVMRLLGARGTVVYGHIFDICVFLALAFVTSGTIALILTPLAALAAVITPA
LQGIMSKSVGPDAQGELQGALTSLSALAMILSPLVMTGTFAAFTGPDAPIYAPGAPFILSAGLIVIGLTIFITRGRAASF
S
>Mature_401_residues
MKPAVVFILMTMMIDAMGIGLIIPVMPDLFQEVGAGDLGTAALWGGILATAFAVMQFFFGPVIGGLSDRFGRRPILLVSL
FVMMLDYLVMALAGSIWLLLIGRMIGGVTAATQATANAYMADISAPQDRAANFGLIGAAFGVGFVLGPLIGGLLAEFGTR
APFYAAAACAGLNAIFGYFVLKETLPASKRRPFEWRRANPFGSFRHLSKLHALGPFLIVFFLYQVAFAVYPAIWSFFGKE
RFGWEPATIGLSLALFGIMMAIVQGGLIRPVMRLLGARGTVVYGHIFDICVFLALAFVTSGTIALILTPLAALAAVITPA
LQGIMSKSVGPDAQGELQGALTSLSALAMILSPLVMTGTFAAFTGPDAPIYAPGAPFILSAGLIVIGLTIFITRGRAASF
S

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI225703104, Length=343, Percent_Identity=30.6122448979592, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI225703102, Length=343, Percent_Identity=30.6122448979592, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI39753965, Length=317, Percent_Identity=26.4984227129338, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI94721311, Length=424, Percent_Identity=25.7075471698113, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI217416366, Length=383, Percent_Identity=23.4986945169713, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71996331, Length=320, Percent_Identity=23.4375, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17551570, Length=356, Percent_Identity=23.0337078651685, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17738085, Length=367, Percent_Identity=26.4305177111717, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21357569, Length=430, Percent_Identity=25.5813953488372, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI161080926, Length=430, Percent_Identity=25.5813953488372, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI161080924, Length=430, Percent_Identity=25.5813953488372, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24656463, Length=430, Percent_Identity=25.5813953488372, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24656468, Length=430, Percent_Identity=25.5813953488372, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI221513297, Length=358, Percent_Identity=24.3016759776536, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42221; Mature: 42221

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure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HHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 383387; 6337373; 6307828; 1517220 [H]