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The map label for this gene is ubiB [C]

Identifier: 110680879

GI number: 110680879

Start: 3603081

End: 3604406

Strand: Direct

Name: ubiB [C]

Synonym: RD1_3730

Alternate gene names: 110680879

Gene position: 3603081-3604406 (Clockwise)

Preceding gene: 110680878

Following gene: 110680880

Centisome position: 87.18

GC content: 55.58

Gene sequence:

>1326_bases
ATGATTGATAGAGCTGACGATCCCCGCGCCTTGGCCGTCCCGTCAGGGCGTATCGCCCGTTTGGGCCGTCTGAGTTCCAT
GACAGCCGGCGTGGCCGGGAGTATGGCCGTAAACGGCTTGGCGCAGCTCGGCCAAGGTCAGCGCCCTTCGATGCGGGATC
TGTTGCTTACACCGCAGAATGTCACGCGCGTTGCCAATCAACTGGCAAAGATGCGCGGCGCCGCGATGAAAATCGGTCAA
TTGATGTCAATGGATACGGGTGATGTTTTGCCACCTGAACTCGCGCAGATCATGGCTCGACTGCAAGATGATGCACATTT
CATGCCGCCGGCACAACTCAAACAGGTACTTGCTGCAAATTGGCCTGAAGGCTGGCTGCAAAAATACAAGAAATTCGACG
TCCGCCCCATTGCCGCGGCGTCCATCGGGCAAGTGCATCGTGCGCAACTGAAAGACGGGCGTGATCTTGCAATCAAAGTG
CAGTACCCCGGTGTCGCAAGGAGCATTGACAGCGATGTGGCAAATGTCGGCGTTCTGATGCGGATGTCAGGCCTTTTGCC
GAAAGGCTTCGAACTCGCCCCTTATCTGGAAGAAGCGCGCAAACAACTGCATGATGAAACCGATTACGTATTGGAAGGCG
CGCAACTGATGCGTTTTGGCACACTGCTGCGCAATGATCCGGCCTTCATCATACCGGAACTATACCGCGATTGGACAACA
GCCGGCATTCTTGCCATGAGCTATGTCGAAGGCGAACCCATCGAAAGCGCGCAGGATGCGCCGCAGGAGACGCGCAACCG
GATTGCGAAACATCTGATTGAATTGACGTTGAAAGAACTCTTCGAGTTTGGTTTGATGCAAACCGATCCGAATTTCGCAA
ACTATCGATATCAGCCTGACACGGGCCAAGTCGTCTTGCTTGACTTTGGCGCAACGCGCACGCTCGATCCGGTCGTCGTG
CAACAATACCGTGTGTTGATGCGCGCCGGGTTGCAGGACGACACAGCCGCGATCTTTCAAACGGCACAGGACATTGGCTT
TTTTGCCGCCGACACGCCGGAGGTACACAAAAATCGGATCGTGAAGATGATCCGGCTCGCCTTTGGCGCCCTGCGCGACA
GCACAGAGTTTGAATTTGCCGCAACCGACCTGTCGCAACAGATGCAAACCGAAGGCATGGCACTGGCCCAGGAGGGGTTC
GTACCGCCGCCCTTGCCAATTGATGTCCTGTTGTTGCAGCGAAAATTTAGCGGCGTCTTCCTGCTTTGCGGACGCTTGGG
GGCCAAGGTCGATTTGTCATCTCTTTGGGAGGCTTATGTTACGTAA

Upstream 100 bases:

>100_bases
GAACGTTTTTCTCGCACCCGTTACCCGCACTCCCGCTCAGTCACGCTAAAATGGCACGAACCTCCATTGCCGTGCGGTAC
TTGCCACCTACGTCAAGCCC

Downstream 100 bases:

>100_bases
GCGCAAATGCAAAAGGCGTTGCCGGACTGGGATGCCTGGGAGCGATCCGACGCAGAGGTCAAGACAAATAATGCTTAAAT
GTTGGAACCGGGTATTATGG

Product: ABC1 family protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MIDRADDPRALAVPSGRIARLGRLSSMTAGVAGSMAVNGLAQLGQGQRPSMRDLLLTPQNVTRVANQLAKMRGAAMKIGQ
LMSMDTGDVLPPELAQIMARLQDDAHFMPPAQLKQVLAANWPEGWLQKYKKFDVRPIAAASIGQVHRAQLKDGRDLAIKV
QYPGVARSIDSDVANVGVLMRMSGLLPKGFELAPYLEEARKQLHDETDYVLEGAQLMRFGTLLRNDPAFIIPELYRDWTT
AGILAMSYVEGEPIESAQDAPQETRNRIAKHLIELTLKELFEFGLMQTDPNFANYRYQPDTGQVVLLDFGATRTLDPVVV
QQYRVLMRAGLQDDTAAIFQTAQDIGFFAADTPEVHKNRIVKMIRLAFGALRDSTEFEFAATDLSQQMQTEGMALAQEGF
VPPPLPIDVLLLQRKFSGVFLLCGRLGAKVDLSSLWEAYVT

Sequences:

>Translated_441_residues
MIDRADDPRALAVPSGRIARLGRLSSMTAGVAGSMAVNGLAQLGQGQRPSMRDLLLTPQNVTRVANQLAKMRGAAMKIGQ
LMSMDTGDVLPPELAQIMARLQDDAHFMPPAQLKQVLAANWPEGWLQKYKKFDVRPIAAASIGQVHRAQLKDGRDLAIKV
QYPGVARSIDSDVANVGVLMRMSGLLPKGFELAPYLEEARKQLHDETDYVLEGAQLMRFGTLLRNDPAFIIPELYRDWTT
AGILAMSYVEGEPIESAQDAPQETRNRIAKHLIELTLKELFEFGLMQTDPNFANYRYQPDTGQVVLLDFGATRTLDPVVV
QQYRVLMRAGLQDDTAAIFQTAQDIGFFAADTPEVHKNRIVKMIRLAFGALRDSTEFEFAATDLSQQMQTEGMALAQEGF
VPPPLPIDVLLLQRKFSGVFLLCGRLGAKVDLSSLWEAYVT
>Mature_441_residues
MIDRADDPRALAVPSGRIARLGRLSSMTAGVAGSMAVNGLAQLGQGQRPSMRDLLLTPQNVTRVANQLAKMRGAAMKIGQ
LMSMDTGDVLPPELAQIMARLQDDAHFMPPAQLKQVLAANWPEGWLQKYKKFDVRPIAAASIGQVHRAQLKDGRDLAIKV
QYPGVARSIDSDVANVGVLMRMSGLLPKGFELAPYLEEARKQLHDETDYVLEGAQLMRFGTLLRNDPAFIIPELYRDWTT
AGILAMSYVEGEPIESAQDAPQETRNRIAKHLIELTLKELFEFGLMQTDPNFANYRYQPDTGQVVLLDFGATRTLDPVVV
QQYRVLMRAGLQDDTAAIFQTAQDIGFFAADTPEVHKNRIVKMIRLAFGALRDSTEFEFAATDLSQQMQTEGMALAQEGF
VPPPLPIDVLLLQRKFSGVFLLCGRLGAKVDLSSLWEAYVT

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI34147522, Length=440, Percent_Identity=33.6363636363636, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI27363457, Length=450, Percent_Identity=32, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI217416386, Length=368, Percent_Identity=33.4239130434783, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI40254938, Length=292, Percent_Identity=28.0821917808219, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI217035081, Length=225, Percent_Identity=29.7777777777778, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI41393593, Length=373, Percent_Identity=27.3458445040214, Blast_Score=99, Evalue=1e-20,
Organism=Escherichia coli, GI2367309, Length=255, Percent_Identity=27.843137254902, Blast_Score=89, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI32565180, Length=442, Percent_Identity=33.4841628959276, Blast_Score=259, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17559152, Length=370, Percent_Identity=25.4054054054054, Blast_Score=88, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321319, Length=437, Percent_Identity=37.2997711670481, Blast_Score=315, Evalue=7e-87,
Organism=Drosophila melanogaster, GI18859849, Length=430, Percent_Identity=33.2558139534884, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI22024280, Length=284, Percent_Identity=26.4084507042254, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24662575, Length=267, Percent_Identity=24.3445692883895, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 48773; Mature: 48773

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDRADDPRALAVPSGRIARLGRLSSMTAGVAGSMAVNGLAQLGQGQRPSMRDLLLTPQN
CCCCCCCCCEEECCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCHHHHCCCCHH
VTRVANQLAKMRGAAMKIGQLMSMDTGDVLPPELAQIMARLQDDAHFMPPAQLKQVLAAN
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCC
WPEGWLQKYKKFDVRPIAAASIGQVHRAQLKDGRDLAIKVQYPGVARSIDSDVANVGVLM
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHH
RMSGLLPKGFELAPYLEEARKQLHDETDYVLEGAQLMRFGTLLRNDPAFIIPELYRDWTT
HHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHH
AGILAMSYVEGEPIESAQDAPQETRNRIAKHLIELTLKELFEFGLMQTDPNFANYRYQPD
HHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCC
TGQVVLLDFGATRTLDPVVVQQYRVLMRAGLQDDTAAIFQTAQDIGFFAADTPEVHKNRI
CCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCEEECCCCHHHHHHH
VKMIRLAFGALRDSTEFEFAATDLSQQMQTEGMALAQEGFVPPPLPIDVLLLQRKFSGVF
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHH
LLCGRLGAKVDLSSLWEAYVT
HHHHHCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MIDRADDPRALAVPSGRIARLGRLSSMTAGVAGSMAVNGLAQLGQGQRPSMRDLLLTPQN
CCCCCCCCCEEECCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCHHHHCCCCHH
VTRVANQLAKMRGAAMKIGQLMSMDTGDVLPPELAQIMARLQDDAHFMPPAQLKQVLAAN
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCC
WPEGWLQKYKKFDVRPIAAASIGQVHRAQLKDGRDLAIKVQYPGVARSIDSDVANVGVLM
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHH
RMSGLLPKGFELAPYLEEARKQLHDETDYVLEGAQLMRFGTLLRNDPAFIIPELYRDWTT
HHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHH
AGILAMSYVEGEPIESAQDAPQETRNRIAKHLIELTLKELFEFGLMQTDPNFANYRYQPD
HHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCC
TGQVVLLDFGATRTLDPVVVQQYRVLMRAGLQDDTAAIFQTAQDIGFFAADTPEVHKNRI
CCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCEEECCCCHHHHHHH
VKMIRLAFGALRDSTEFEFAATDLSQQMQTEGMALAQEGFVPPPLPIDVLLLQRKFSGVF
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHH
LLCGRLGAKVDLSSLWEAYVT
HHHHHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]