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The map label for this gene is ilvD [H]

Identifier: 110680844

GI number: 110680844

Start: 3556550

End: 3558283

Strand: Direct

Name: ilvD [H]

Synonym: RD1_3693

Alternate gene names: 110680844

Gene position: 3556550-3558283 (Clockwise)

Preceding gene: 110680842

Following gene: 110680845

Centisome position: 86.05

GC content: 60.96

Gene sequence:

>1734_bases
ATGCACAAGAAACCATATGATCAATTCCGCTCCGCGCGCTGGTTTGGGCCGGACGATCTGCGGTCCTTCGGCCACCGCTC
GCGCGCGATGCAGATGGGGCTGTCGCGCGAGGATTGGGAGGGTAAACCGGTCATCGCCATCCTCAATACATGGTCCGAGT
TGCAACCCTGCCACATGCATTTCAAGGACCGGGTCGCCTTCGTCAAAAAGGGCGTGCTTCAGGCAGGCGGCATGCCGGTG
GAAATCCCGGTCCATTCACTGGGCGAGCAATTGTTGAAACCAACCGCCATGCTGTACCGCAATATGGTGGCGATGGAGGT
CGAAGAAGTCCTGCGCGCGAACCCGGTCGATGGCGCGGTGCTGATGGGCGGCTGCGATAAATCCACGCCCGCGCTTGTGA
TGGGCGCGGTGTCCATGGGCCTTCCCTTCATCTACCTGCCCGCAGGTCCGATGTTGCGGGGCAATTATGCCGGAAAGGTG
CTGGGGTCCGGGGCCGATGCATGGAAATACTGGGATGAGCGGCGCGCGGGGCACATCTCCAAAGAGGAATGGCAAGGGCT
CGAAGGGGGCATCGCGCGGTCCTATGGGCATTGCATGACCATGGGCACGGCCAGCACCATGACGGCCATCGCCGAAGGGC
TTGGCCTCTGTCTGCCGGGGGCGTCGTCCATCCCGGCCCCTGACGTGAACCACCAGCGCATGAGTGCCGCCTGCGGGCGA
CGCATCGTCGATATGGTCTGGCAGGACCTGACGCCGGATCAGATCATCACCCAAAGCAGTGTCGCGAACGCCGTGACCGT
TGCCATGGCCACCGGCTGTTCCACCAATGCGATCATTCACCTGATTGCCATGGCACGCAGGTCCGGGGTGCCTCTGACGC
TTGATGATCTGGACGCAATCGGAAGAACGACGCCCGTGATTGCCAATATCCGACCCTCCGGAAAGGACTACCTGATGGAG
GATTTCTTTTATGCGGGGGGCTTGCCCGCGCTGATGAAAGAACTGGGCGACAAGCTGGATTTGGACGCAATGACCGTTTC
GGGGCGCACGGTCGGCCAGAACATCGCGGGTGCCACGAATTACAACAGCGATGTGATCCGCAGCTTGCGCAACCCGGTCT
ACGGCGAAGGGTCGCTGGCGGTGCTCAAGGGCAATCTGGCACCGGATGGCGCGGTCATCAAACCCGCTGCGATGGATGCG
AAGTTCATGACACATCGCGGGCCTGCGATGGTGGCAAATTCCTATGCCGAACTGAAGTCGATCATAGATGACCCGCAGGC
GGACATTACCGCCGACCACGTTCTGATCCTGCGCAACGCGGGTCCTCAGGGCGGGCCCGGCATGCCCGAATGGGGCATGA
TCCCCATGCCACAAAAGCTGCTGAACGAAGGGCACCGGGACATGGTGCGCCTGTCCGATGCGCGCATGAGCGGCACGAGT
TACGGAGCCTGTATCCTGCATGTGGCGCCTGAGGCATTTGTGGGCGGGCCGCTCGCGCTGATCGAAACCGGAGATATGAT
CTCGCTCGACATTCCGAACCGCCGCCTCGACGTGGAATTGACCGAAGAGCAACTGGCAAAGCGGCGGCAAAACTGGGTGC
CGCCCAAACCGCACTATGAACGCGGCTATGGCTGGATGTTTCTCAAACACATCGAACAGGCGGACAAAGGGTGTGATTTT
GACTTCCTGCGCACGGAATTCGGCGCATCCGTACCAGAACCAGAGATCAATTGA

Upstream 100 bases:

>100_bases
CCTTGCAATGGGTATGCAGCGCATCAAAAGACAGGCACCCCATGGAAACCGCCGCTTATTTGGCGCTATGCTCCCGGCAG
TCGCAAGGGAACAGCGGTAG

Downstream 100 bases:

>100_bases
TTAAAGACGCCCGGCGGAGATATGATCCGGTGCGAGGGCACAGCCAGGTTTGGAGAGCGCGCATGAACAACGACGAGGAC
AAGATCGCCGGGCGCCTGCA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 577; Mature: 577

Protein sequence:

>577_residues
MHKKPYDQFRSARWFGPDDLRSFGHRSRAMQMGLSREDWEGKPVIAILNTWSELQPCHMHFKDRVAFVKKGVLQAGGMPV
EIPVHSLGEQLLKPTAMLYRNMVAMEVEEVLRANPVDGAVLMGGCDKSTPALVMGAVSMGLPFIYLPAGPMLRGNYAGKV
LGSGADAWKYWDERRAGHISKEEWQGLEGGIARSYGHCMTMGTASTMTAIAEGLGLCLPGASSIPAPDVNHQRMSAACGR
RIVDMVWQDLTPDQIITQSSVANAVTVAMATGCSTNAIIHLIAMARRSGVPLTLDDLDAIGRTTPVIANIRPSGKDYLME
DFFYAGGLPALMKELGDKLDLDAMTVSGRTVGQNIAGATNYNSDVIRSLRNPVYGEGSLAVLKGNLAPDGAVIKPAAMDA
KFMTHRGPAMVANSYAELKSIIDDPQADITADHVLILRNAGPQGGPGMPEWGMIPMPQKLLNEGHRDMVRLSDARMSGTS
YGACILHVAPEAFVGGPLALIETGDMISLDIPNRRLDVELTEEQLAKRRQNWVPPKPHYERGYGWMFLKHIEQADKGCDF
DFLRTEFGASVPEPEIN

Sequences:

>Translated_577_residues
MHKKPYDQFRSARWFGPDDLRSFGHRSRAMQMGLSREDWEGKPVIAILNTWSELQPCHMHFKDRVAFVKKGVLQAGGMPV
EIPVHSLGEQLLKPTAMLYRNMVAMEVEEVLRANPVDGAVLMGGCDKSTPALVMGAVSMGLPFIYLPAGPMLRGNYAGKV
LGSGADAWKYWDERRAGHISKEEWQGLEGGIARSYGHCMTMGTASTMTAIAEGLGLCLPGASSIPAPDVNHQRMSAACGR
RIVDMVWQDLTPDQIITQSSVANAVTVAMATGCSTNAIIHLIAMARRSGVPLTLDDLDAIGRTTPVIANIRPSGKDYLME
DFFYAGGLPALMKELGDKLDLDAMTVSGRTVGQNIAGATNYNSDVIRSLRNPVYGEGSLAVLKGNLAPDGAVIKPAAMDA
KFMTHRGPAMVANSYAELKSIIDDPQADITADHVLILRNAGPQGGPGMPEWGMIPMPQKLLNEGHRDMVRLSDARMSGTS
YGACILHVAPEAFVGGPLALIETGDMISLDIPNRRLDVELTEEQLAKRRQNWVPPKPHYERGYGWMFLKHIEQADKGCDF
DFLRTEFGASVPEPEIN
>Mature_577_residues
MHKKPYDQFRSARWFGPDDLRSFGHRSRAMQMGLSREDWEGKPVIAILNTWSELQPCHMHFKDRVAFVKKGVLQAGGMPV
EIPVHSLGEQLLKPTAMLYRNMVAMEVEEVLRANPVDGAVLMGGCDKSTPALVMGAVSMGLPFIYLPAGPMLRGNYAGKV
LGSGADAWKYWDERRAGHISKEEWQGLEGGIARSYGHCMTMGTASTMTAIAEGLGLCLPGASSIPAPDVNHQRMSAACGR
RIVDMVWQDLTPDQIITQSSVANAVTVAMATGCSTNAIIHLIAMARRSGVPLTLDDLDAIGRTTPVIANIRPSGKDYLME
DFFYAGGLPALMKELGDKLDLDAMTVSGRTVGQNIAGATNYNSDVIRSLRNPVYGEGSLAVLKGNLAPDGAVIKPAAMDA
KFMTHRGPAMVANSYAELKSIIDDPQADITADHVLILRNAGPQGGPGMPEWGMIPMPQKLLNEGHRDMVRLSDARMSGTS
YGACILHVAPEAFVGGPLALIETGDMISLDIPNRRLDVELTEEQLAKRRQNWVPPKPHYERGYGWMFLKHIEQADKGCDF
DFLRTEFGASVPEPEIN

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=598, Percent_Identity=28.9297658862876, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI2367371, Length=474, Percent_Identity=31.4345991561181, Blast_Score=176, Evalue=4e-45,
Organism=Escherichia coli, GI1788157, Length=518, Percent_Identity=28.5714285714286, Blast_Score=171, Evalue=8e-44,
Organism=Escherichia coli, GI1786464, Length=519, Percent_Identity=29.6724470134875, Blast_Score=156, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6322476, Length=550, Percent_Identity=31.0909090909091, Blast_Score=256, Evalue=9e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 62781; Mature: 62781

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKKPYDQFRSARWFGPDDLRSFGHRSRAMQMGLSREDWEGKPVIAILNTWSELQPCHMH
CCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHCCHHHHH
FKDRVAFVKKGVLQAGGMPVEIPVHSLGEQLLKPTAMLYRNMVAMEVEEVLRANPVDGAV
HHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
LMGGCDKSTPALVMGAVSMGLPFIYLPAGPMLRGNYAGKVLGSGADAWKYWDERRAGHIS
EECCCCCCCCHHHHHHHHHCCCEEEECCCCEEECCCCCCEECCCCHHHHHHHHHHCCCCC
KEEWQGLEGGIARSYGHCMTMGTASTMTAIAEGLGLCLPGASSIPAPDVNHQRMSAACGR
HHHHCCCCCCHHHHCCCEEECCCHHHHHHHHHHHCEECCCCCCCCCCCCCHHHHHHHHHH
RIVDMVWQDLTPDQIITQSSVANAVTVAMATGCSTNAIIHLIAMARRSGVPLTLDDLDAI
HHHHHHHHCCCHHHHHHHHHHHHHEEEHHCCCCCHHHHHHHHHHHHHCCCCEEHHHHHHC
GRTTPVIANIRPSGKDYLMEDFFYAGGLPALMKELGDKLDLDAMTVSGRTVGQNIAGATN
CCCCCEEEECCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEECCCHHCCCCCCCCC
YNSDVIRSLRNPVYGEGSLAVLKGNLAPDGAVIKPAAMDAKFMTHRGPAMVANSYAELKS
CCHHHHHHHCCCCCCCCCEEEEECCCCCCCCEECCHHCCCHHHHCCCCHHHHHHHHHHHH
IIDDPQADITADHVLILRNAGPQGGPGMPEWGMIPMPQKLLNEGHRDMVRLSDARMSGTS
HHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHCCCCC
YGACILHVAPEAFVGGPLALIETGDMISLDIPNRRLDVELTEEQLAKRRQNWVPPKPHYE
CCEEEEEECCHHHCCCCEEEEECCCEEEEECCCCEEEEEECHHHHHHHHHCCCCCCCCCC
RGYGWMFLKHIEQADKGCDFDFLRTEFGASVPEPEIN
CCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MHKKPYDQFRSARWFGPDDLRSFGHRSRAMQMGLSREDWEGKPVIAILNTWSELQPCHMH
CCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHCCHHHHH
FKDRVAFVKKGVLQAGGMPVEIPVHSLGEQLLKPTAMLYRNMVAMEVEEVLRANPVDGAV
HHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
LMGGCDKSTPALVMGAVSMGLPFIYLPAGPMLRGNYAGKVLGSGADAWKYWDERRAGHIS
EECCCCCCCCHHHHHHHHHCCCEEEECCCCEEECCCCCCEECCCCHHHHHHHHHHCCCCC
KEEWQGLEGGIARSYGHCMTMGTASTMTAIAEGLGLCLPGASSIPAPDVNHQRMSAACGR
HHHHCCCCCCHHHHCCCEEECCCHHHHHHHHHHHCEECCCCCCCCCCCCCHHHHHHHHHH
RIVDMVWQDLTPDQIITQSSVANAVTVAMATGCSTNAIIHLIAMARRSGVPLTLDDLDAI
HHHHHHHHCCCHHHHHHHHHHHHHEEEHHCCCCCHHHHHHHHHHHHHCCCCEEHHHHHHC
GRTTPVIANIRPSGKDYLMEDFFYAGGLPALMKELGDKLDLDAMTVSGRTVGQNIAGATN
CCCCCEEEECCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEECCCHHCCCCCCCCC
YNSDVIRSLRNPVYGEGSLAVLKGNLAPDGAVIKPAAMDAKFMTHRGPAMVANSYAELKS
CCHHHHHHHCCCCCCCCCEEEEECCCCCCCCEECCHHCCCHHHHCCCCHHHHHHHHHHHH
IIDDPQADITADHVLILRNAGPQGGPGMPEWGMIPMPQKLLNEGHRDMVRLSDARMSGTS
HHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHCCCCC
YGACILHVAPEAFVGGPLALIETGDMISLDIPNRRLDVELTEEQLAKRRQNWVPPKPHYE
CCEEEEEECCHHHCCCCEEEEECCCEEEEECCCCEEEEEECHHHHHHHHHCCCCCCCCCC
RGYGWMFLKHIEQADKGCDFDFLRTEFGASVPEPEIN
CCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA