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The map label for this gene is hutH

Identifier: 110680830

GI number: 110680830

Start: 3544689

End: 3546230

Strand: Direct

Name: hutH

Synonym: RD1_3678

Alternate gene names: 110680830

Gene position: 3544689-3546230 (Clockwise)

Preceding gene: 110680829

Following gene: 110680831

Centisome position: 85.76

GC content: 64.33

Gene sequence:

>1542_bases
ATGACACTCACGCTGACACCGGGTGCGGCAACGCTCGCGCAATTGCAGGATATCTGGGCGAACAATCGCGCTGTCACACT
GTGCCCCTCGGCCCATGCCGGGATCAAAGCGGCGCAGGCGCTTGTGGCAAAGGCCGCCGCCGGTGATGACGCGGTCTATG
GCGTGAACACCGGCTTTGGCAAGCTGGCCAGCGTCAAGATCGCCGCCAAGGATGTCGCCACCCTGCAGCGCAACCTGATC
CTGTCGCATTGCTGCGGCGTGGGTGAGCCGCTGGATGCAGCGACCACCCGGTTAATGATGGTGCTGAAACTTCTGTCCTT
GGGCCGTGGCGCATCCGGCGTGGCCATGACGACCCTTGAAATCATTGAAAACATGCTCGCGCGCGGCGTCACGCCGGTGA
TCCCCAGCCAAGGGTCGGTCGGTGCATCGGGCGATCTGGCTCCGCTGGCGCATATGGCCGCAGCCATGATCGGTGAAGGT
GAGGCCGTTTTCGAAGGCACACGCATGGCCGCAGGTGACGCCCTGCGCCGCGCGGGCATCACCCCCATCGTGCTGGGCGC
GAAAGAAGGTCTGGCGCTGATCAACGGCACGCAGTTTTCAACCGCCTGCGCGCTTGTCGGCCTGTGGGGCGCGTGGCGCA
ATGCGGCGACCTGCGTGCTGACCTGCGCCTTGTCCACCGATGCGATCATGGGGTCCACCGCACCCTTGCAGGATGCAATC
CATACCCTGCGCGGGCACGCGGGTCAGATTGCCGTGGCGCGCGCGCAACGGGCGCTGATGGCAGGCTCGCAAATCCGAGA
AAGCCATGTGGAGGGCGACACGCGGGTTCAGGACCCCTATTGCATCCGCTGCCAGCCGCAGGTGACCGGTGCCGCGATGG
ATATTCTGCATTTTGCAGGCAGAACACTCGAAATCGAGGCCAACGCCGTCACCGATAACCCGCTGGTGCTGGTGGAGGAC
GAGTTGATCGTTTCGGGGGGGAACTTCCACGCCGAACCCGTGGGCTTTGCCGCCGATCAGATCGCCGTGGCCGTGTCGGA
ACTGGGCGCGATTGCGCAGCGGCGCGTCGCACTCATGGTCGACCCGACACTGTCCTTTGATCTGCCACCCTTTCTGACGC
CTGATCCGGGCCTCAACTCCGGCCTGATGATCGCCGAAGTGACCACCGCCGCGCTGATGAGCGAAAACAAACATCTCGCC
AATCCCTGCACGACCGACAGCACCCCGACCTCCGCCAATCAGGAAGACCACGTAAGCATGGCAGCCCACGCTGCCCGGCG
CCTTTTGCGGATGAACGCGAACCTGAATGTGATCCTTGGCGTTGAGGCGATGTGCGGCGCGCAGGGCATCGAATTCCGCG
CCCCTCTGGAAACCAGCGCCCCGCTCAAGGCCGCGATGGCCGTTTTGCGCGCGCATGTGCCAACGATTGCCGAAGACCGC
TACATGGCACCCTCTATCGAAGCCGCCAGCGCCTTGGTTGCAAACGGCACGCTGGCGGCATGCGTGGATCTGCCTGCCTT
CGTCAAGGGAGAGGCCGCATGA

Upstream 100 bases:

>100_bases
CGCGCGCCGATCTGTGCGTCTGGAACGCGCAGCATCCAAGCGAATTGGCTTATCGCATCGGGTTCAACCCGCTGCATCAG
CGCATCTTCAAGGGGGCGAT

Downstream 100 bases:

>100_bases
CCCCCGTCAGCGTTCATCAGGGCAGCAGCCCCATCGTTCTTGGCTTTCCCCATACGGGTACGTATGTGCCCGATGATATT
GCCGCAAGACTGAACGATAA

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MTLTLTPGAATLAQLQDIWANNRAVTLCPSAHAGIKAAQALVAKAAAGDDAVYGVNTGFGKLASVKIAAKDVATLQRNLI
LSHCCGVGEPLDAATTRLMMVLKLLSLGRGASGVAMTTLEIIENMLARGVTPVIPSQGSVGASGDLAPLAHMAAAMIGEG
EAVFEGTRMAAGDALRRAGITPIVLGAKEGLALINGTQFSTACALVGLWGAWRNAATCVLTCALSTDAIMGSTAPLQDAI
HTLRGHAGQIAVARAQRALMAGSQIRESHVEGDTRVQDPYCIRCQPQVTGAAMDILHFAGRTLEIEANAVTDNPLVLVED
ELIVSGGNFHAEPVGFAADQIAVAVSELGAIAQRRVALMVDPTLSFDLPPFLTPDPGLNSGLMIAEVTTAALMSENKHLA
NPCTTDSTPTSANQEDHVSMAAHAARRLLRMNANLNVILGVEAMCGAQGIEFRAPLETSAPLKAAMAVLRAHVPTIAEDR
YMAPSIEAASALVANGTLAACVDLPAFVKGEAA

Sequences:

>Translated_513_residues
MTLTLTPGAATLAQLQDIWANNRAVTLCPSAHAGIKAAQALVAKAAAGDDAVYGVNTGFGKLASVKIAAKDVATLQRNLI
LSHCCGVGEPLDAATTRLMMVLKLLSLGRGASGVAMTTLEIIENMLARGVTPVIPSQGSVGASGDLAPLAHMAAAMIGEG
EAVFEGTRMAAGDALRRAGITPIVLGAKEGLALINGTQFSTACALVGLWGAWRNAATCVLTCALSTDAIMGSTAPLQDAI
HTLRGHAGQIAVARAQRALMAGSQIRESHVEGDTRVQDPYCIRCQPQVTGAAMDILHFAGRTLEIEANAVTDNPLVLVED
ELIVSGGNFHAEPVGFAADQIAVAVSELGAIAQRRVALMVDPTLSFDLPPFLTPDPGLNSGLMIAEVTTAALMSENKHLA
NPCTTDSTPTSANQEDHVSMAAHAARRLLRMNANLNVILGVEAMCGAQGIEFRAPLETSAPLKAAMAVLRAHVPTIAEDR
YMAPSIEAASALVANGTLAACVDLPAFVKGEAA
>Mature_512_residues
TLTLTPGAATLAQLQDIWANNRAVTLCPSAHAGIKAAQALVAKAAAGDDAVYGVNTGFGKLASVKIAAKDVATLQRNLIL
SHCCGVGEPLDAATTRLMMVLKLLSLGRGASGVAMTTLEIIENMLARGVTPVIPSQGSVGASGDLAPLAHMAAAMIGEGE
AVFEGTRMAAGDALRRAGITPIVLGAKEGLALINGTQFSTACALVGLWGAWRNAATCVLTCALSTDAIMGSTAPLQDAIH
TLRGHAGQIAVARAQRALMAGSQIRESHVEGDTRVQDPYCIRCQPQVTGAAMDILHFAGRTLEIEANAVTDNPLVLVEDE
LIVSGGNFHAEPVGFAADQIAVAVSELGAIAQRRVALMVDPTLSFDLPPFLTPDPGLNSGLMIAEVTTAALMSENKHLAN
PCTTDSTPTSANQEDHVSMAAHAARRLLRMNANLNVILGVEAMCGAQGIEFRAPLETSAPLKAAMAVLRAHVPTIAEDRY
MAPSIEAASALVANGTLAACVDLPAFVKGEAA

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family

Homologues:

Organism=Homo sapiens, GI4504333, Length=488, Percent_Identity=40.3688524590164, Blast_Score=348, Evalue=7e-96,
Organism=Caenorhabditis elegans, GI17567831, Length=494, Percent_Identity=41.0931174089069, Blast_Score=328, Evalue=3e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTH_ROSDO (Q162E2)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_683837.1
- ProteinModelPortal:   Q162E2
- SMR:   Q162E2
- STRING:   Q162E2
- GeneID:   4194957
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_3678
- NMPDR:   fig|375451.6.peg.3421
- eggNOG:   COG2986
- HOGENOM:   HBG510887
- OMA:   QKGQIDS
- ProtClustDB:   PRK09367
- BioCyc:   RDEN375451:RD1_3678-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00229
- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313
- TIGRFAMs:   TIGR01225

Pfam domain/function: PF00221 PAL; SSF48557 L-Aspartase-like

EC number: =4.3.1.3

Molecular weight: Translated: 52833; Mature: 52701

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTLTPGAATLAQLQDIWANNRAVTLCPSAHAGIKAAQALVAKAAAGDDAVYGVNTGFG
CEEEECCCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCC
KLASVKIAAKDVATLQRNLILSHCCGVGEPLDAATTRLMMVLKLLSLGRGASGVAMTTLE
CCEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
IIENMLARGVTPVIPSQGSVGASGDLAPLAHMAAAMIGEGEAVFEGTRMAAGDALRRAGI
HHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHCCC
TPIVLGAKEGLALINGTQFSTACALVGLWGAWRNAATCVLTCALSTDAIMGSTAPLQDAI
CEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHCCCCCCHHHHH
HTLRGHAGQIAVARAQRALMAGSQIRESHVEGDTRVQDPYCIRCQPQVTGAAMDILHFAG
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHCC
RTLEIEANAVTDNPLVLVEDELIVSGGNFHAEPVGFAADQIAVAVSELGAIAQRRVALMV
CEEEEEEEEECCCCEEEEECCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEE
DPTLSFDLPPFLTPDPGLNSGLMIAEVTTAALMSENKHLANPCTTDSTPTSANQEDHVSM
CCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHH
AAHAARRLLRMNANLNVILGVEAMCGAQGIEFRAPLETSAPLKAAMAVLRAHVPTIAEDR
HHHHHHHHHHHCCCCEEEEECHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCC
YMAPSIEAASALVANGTLAACVDLPAFVKGEAA
CCCCCHHHHHHHHCCCCEEEECCCCHHHCCCCC
>Mature Secondary Structure 
TLTLTPGAATLAQLQDIWANNRAVTLCPSAHAGIKAAQALVAKAAAGDDAVYGVNTGFG
EEEECCCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCC
KLASVKIAAKDVATLQRNLILSHCCGVGEPLDAATTRLMMVLKLLSLGRGASGVAMTTLE
CCEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
IIENMLARGVTPVIPSQGSVGASGDLAPLAHMAAAMIGEGEAVFEGTRMAAGDALRRAGI
HHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHCCC
TPIVLGAKEGLALINGTQFSTACALVGLWGAWRNAATCVLTCALSTDAIMGSTAPLQDAI
CEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHCCCCCCHHHHH
HTLRGHAGQIAVARAQRALMAGSQIRESHVEGDTRVQDPYCIRCQPQVTGAAMDILHFAG
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHCC
RTLEIEANAVTDNPLVLVEDELIVSGGNFHAEPVGFAADQIAVAVSELGAIAQRRVALMV
CEEEEEEEEECCCCEEEEECCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEE
DPTLSFDLPPFLTPDPGLNSGLMIAEVTTAALMSENKHLANPCTTDSTPTSANQEDHVSM
CCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHH
AAHAARRLLRMNANLNVILGVEAMCGAQGIEFRAPLETSAPLKAAMAVLRAHVPTIAEDR
HHHHHHHHHHHCCCCEEEEECHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCC
YMAPSIEAASALVANGTLAACVDLPAFVKGEAA
CCCCCHHHHHHHHCCCCEEEECCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA