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The map label for this gene is fahA

Identifier: 110680806

GI number: 110680806

Start: 3516406

End: 3517656

Strand: Direct

Name: fahA

Synonym: RD1_3653

Alternate gene names: NA

Gene position: 3516406-3517656 (Clockwise)

Preceding gene: 110680805

Following gene: 110680807

Centisome position: 85.08

GC content: 61.87

Gene sequence:

>1251_bases
ATGACACAACTTCTCCGCTCTTGGGTCGAAAGCGCCAATGCGCCCGACACCGACTTCCCGCTCAACAACCTGCCCTATGG
GGCTTTCCGTGTCGGTGACAGCGACCTGCATGCAGGTGTCGCGATTGGCGCGCGCATCCTCGATGTAACCGCCCTTGTAC
AGGCCGGTCTGCTTGACCTGCCCGAAACCGGCGTTTTTGCCCGTGGCACATGGAATGACTTCATGGCACTGGGTTCGGAT
GTCTGGGCCAGTTTCCGTGCGCACCTGACGGCCGCTCTGGCAGAAGGTGCGGCGCAGCAATCGGACCTTGAGCCACATTT
GGTTGCCATGGCCGATGCCAAGCTCGAGATGCCCTTCATCGTGACGGAATTCACCGACTTCTATGCGGGACGTCACCATG
CGTTCAACGTCGGATCGCTGTTCCGCGATCCGGCCAATGCCCTGCCGCCCAACTGGTTGCATATCCCGATCGGGTATAAC
GGTCGCGCATCGTCGGTCGTGGTCAGCGGCACGGACATCACCCGCCCCAACGGACAGTTGAAAGCACCGGACGCGGAGAT
GCCGGTGTTCGAGGCGTCCAAGCGCTTCGATCTGGAACTTGAGATGGGCGCGATTGTTGGCAAGCCCTCGAAAGGTCGCG
TCAGCGTGCAAGAGGCCGACGACATGATCTTCGGCTACGTTCTTCTCAACGACTGGTCCGCGCGCGACATTCAGGCCTGG
GAATACCAGCCGCTTGGCCCGTTTCAGGCCAAGGCAACCGCGACCACCATCAGCCCGTGGATCGTGACCAAAGCCGCACT
TGAGCCCTTCCGCGCCTCGACCCCGCCGCGCGAAAAGGAACTGCTGCCATACCTCGCAGAAACGGGCCCGATGCTCTATG
ATATCGACCTCGAAGTGGGCCTCGCCCCAGAAGGCAAATCGGAAACCATCCTGTCGCGCACGAATTACAACGTGATGTAT
TACTCCGCAGCCCAGCAACTGACCCACCACACCACCAGCGGCTGCCCGATGCGGGTTGGCGATCTGCTCGGTTCCGGCAC
GATTTCCGGCCCTGAAAAGGAAAACCGCGGCAGCCTGCTGGAACTGAGCTGGGCGGGTAAGGAACCGCTGACGCTGGACA
CGGGCGAGACCCGCACGTTTCTGGAAGACGGAGACACGCTGACCCTGCGCGGTGCCGCCAAAGGCGACGGATACCGGATC
GGCTTTGGCGACTGCACAGGCACCCTGCGCCCAGCATCCGCGCTGGATTGA

Upstream 100 bases:

>100_bases
TTTGCCCGCCTGCTTGAGATCGAAGAACAGGCCCTGAAACTGCCGGCTTTCGATGCCGCACGCCCCGAAAACCAGCCAGA
CGCCACCTGAAGGACAAACG

Downstream 100 bases:

>100_bases
AACGACGCGCCGACCCGCGCGACGCCGTCCGACGAGACAGTGCTCGGTGGTCGCAAGCCCACCGCGCGCTACCCGTTTAA
CAAACCCGCATGACGCCGAC

Product: fumarylacetoacetase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Hydroxylase; 2-Hydroxyhepta-2 4-Diene-1 7-Dioate Isomerase; Fumarylacetoacetate Hydrolase Family Protein; Fumarylacetoacetase Hydrolase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MTQLLRSWVESANAPDTDFPLNNLPYGAFRVGDSDLHAGVAIGARILDVTALVQAGLLDLPETGVFARGTWNDFMALGSD
VWASFRAHLTAALAEGAAQQSDLEPHLVAMADAKLEMPFIVTEFTDFYAGRHHAFNVGSLFRDPANALPPNWLHIPIGYN
GRASSVVVSGTDITRPNGQLKAPDAEMPVFEASKRFDLELEMGAIVGKPSKGRVSVQEADDMIFGYVLLNDWSARDIQAW
EYQPLGPFQAKATATTISPWIVTKAALEPFRASTPPREKELLPYLAETGPMLYDIDLEVGLAPEGKSETILSRTNYNVMY
YSAAQQLTHHTTSGCPMRVGDLLGSGTISGPEKENRGSLLELSWAGKEPLTLDTGETRTFLEDGDTLTLRGAAKGDGYRI
GFGDCTGTLRPASALD

Sequences:

>Translated_416_residues
MTQLLRSWVESANAPDTDFPLNNLPYGAFRVGDSDLHAGVAIGARILDVTALVQAGLLDLPETGVFARGTWNDFMALGSD
VWASFRAHLTAALAEGAAQQSDLEPHLVAMADAKLEMPFIVTEFTDFYAGRHHAFNVGSLFRDPANALPPNWLHIPIGYN
GRASSVVVSGTDITRPNGQLKAPDAEMPVFEASKRFDLELEMGAIVGKPSKGRVSVQEADDMIFGYVLLNDWSARDIQAW
EYQPLGPFQAKATATTISPWIVTKAALEPFRASTPPREKELLPYLAETGPMLYDIDLEVGLAPEGKSETILSRTNYNVMY
YSAAQQLTHHTTSGCPMRVGDLLGSGTISGPEKENRGSLLELSWAGKEPLTLDTGETRTFLEDGDTLTLRGAAKGDGYRI
GFGDCTGTLRPASALD
>Mature_415_residues
TQLLRSWVESANAPDTDFPLNNLPYGAFRVGDSDLHAGVAIGARILDVTALVQAGLLDLPETGVFARGTWNDFMALGSDV
WASFRAHLTAALAEGAAQQSDLEPHLVAMADAKLEMPFIVTEFTDFYAGRHHAFNVGSLFRDPANALPPNWLHIPIGYNG
RASSVVVSGTDITRPNGQLKAPDAEMPVFEASKRFDLELEMGAIVGKPSKGRVSVQEADDMIFGYVLLNDWSARDIQAWE
YQPLGPFQAKATATTISPWIVTKAALEPFRASTPPREKELLPYLAETGPMLYDIDLEVGLAPEGKSETILSRTNYNVMYY
SAAQQLTHHTTSGCPMRVGDLLGSGTISGPEKENRGSLLELSWAGKEPLTLDTGETRTFLEDGDTLTLRGAAKGDGYRIG
FGDCTGTLRPASALD

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=409, Percent_Identity=48.4107579462103, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17568863, Length=411, Percent_Identity=48.9051094890511, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24657182, Length=406, Percent_Identity=46.0591133004926, Blast_Score=364, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 45006; Mature: 44875

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLLRSWVESANAPDTDFPLNNLPYGAFRVGDSDLHAGVAIGARILDVTALVQAGLLDL
CHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCC
PETGVFARGTWNDFMALGSDVWASFRAHLTAALAEGAAQQSDLEPHLVAMADAKLEMPFI
CCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEEEECCCCCCCEE
VTEFTDFYAGRHHAFNVGSLFRDPANALPPNWLHIPIGYNGRASSVVVSGTDITRPNGQL
EEEHHHHHCCCCCEEEHHHHHCCCHHCCCCCEEEEECCCCCCCCEEEEECCEEECCCCCE
KAPDAEMPVFEASKRFDLELEMGAIVGKPSKGRVSVQEADDMIFGYVLLNDWSARDIQAW
ECCCCCCCCCCCCCCEEEEEEECEEECCCCCCEEEEECCCCEEEEEEEEECCCCCCCCCE
EYQPLGPFQAKATATTISPWIVTKAALEPFRASTPPREKELLPYLAETGPMLYDIDLEVG
ECCCCCCCCCCCEEEECCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEEEEEEE
LAPEGKSETILSRTNYNVMYYSAAQQLTHHTTSGCPMRVGDLLGSGTISGPEKENRGSLL
CCCCCCCCEEEEECCCEEEEEEHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCCEE
ELSWAGKEPLTLDTGETRTFLEDGDTLTLRGAAKGDGYRIGFGDCTGTLRPASALD
EEEECCCCCEEECCCCCEEEEECCCEEEEEECCCCCCEEEEECCCCCCCCCHHCCC
>Mature Secondary Structure 
TQLLRSWVESANAPDTDFPLNNLPYGAFRVGDSDLHAGVAIGARILDVTALVQAGLLDL
HHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCC
PETGVFARGTWNDFMALGSDVWASFRAHLTAALAEGAAQQSDLEPHLVAMADAKLEMPFI
CCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCEEEEEECCCCCCCEE
VTEFTDFYAGRHHAFNVGSLFRDPANALPPNWLHIPIGYNGRASSVVVSGTDITRPNGQL
EEEHHHHHCCCCCEEEHHHHHCCCHHCCCCCEEEEECCCCCCCCEEEEECCEEECCCCCE
KAPDAEMPVFEASKRFDLELEMGAIVGKPSKGRVSVQEADDMIFGYVLLNDWSARDIQAW
ECCCCCCCCCCCCCCEEEEEEECEEECCCCCCEEEEECCCCEEEEEEEEECCCCCCCCCE
EYQPLGPFQAKATATTISPWIVTKAALEPFRASTPPREKELLPYLAETGPMLYDIDLEVG
ECCCCCCCCCCCEEEECCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEEEEEEE
LAPEGKSETILSRTNYNVMYYSAAQQLTHHTTSGCPMRVGDLLGSGTISGPEKENRGSLL
CCCCCCCCEEEEECCCEEEEEEHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCCCEE
ELSWAGKEPLTLDTGETRTFLEDGDTLTLRGAAKGDGYRIGFGDCTGTLRPASALD
EEEECCCCCEEECCCCCEEEEECCCEEEEEECCCCCCEEEEECCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA