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The map label for this gene is hisE

Identifier: 110680722

GI number: 110680722

Start: 3425324

End: 3425641

Strand: Direct

Name: hisE

Synonym: RD1_3562

Alternate gene names: 110680722

Gene position: 3425324-3425641 (Clockwise)

Preceding gene: 110680721

Following gene: 110680738

Centisome position: 82.88

GC content: 55.97

Gene sequence:

>318_bases
ATGACACTTGACGCTCTGTTCGCCACCATTCTGGACCGAAAAACTGCCGATCCCGCCAGCAGCTGGACGGCGCAACTTCT
CTCCAAAGGACCGGAAAAATGCGCGGAAAAATTCGGAGAAGAGGCGGTTGAGGCCATAATCGAAGCTGTCAAGGGCGACC
GCGACGCCCTGACTGGCGAGGCCGCGGATGTGCTGTATCATTTGCTGGTCATGCTTGCAGCCTGCGATGTGGACTTGAAA
GACGTCCTGGCGGAACTTGAGCGGCGACAAAATACATCTGGGATCGCTGAAAAACAGGGCAGATTCAAGGCGCCGTAA

Upstream 100 bases:

>100_bases
CATCCGCGGTCCTCGCCGCATCGATCTTCCATTTCGGGGATTACACGATCGCTCAGGCCAAACAGCACATGTCGGACGCT
GGCATCCCCATGAGGCTCAT

Downstream 100 bases:

>100_bases
CCGTCAGCCTCAGGTCAGGCGCGAGGATATCATGCCGGTCGAAAAGCCACCCATGCGCAATTCGCCGAACAACCTTTGAT
ATTCAATCTTGGGGCAGCGG

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 105; Mature: 104

Protein sequence:

>105_residues
MTLDALFATILDRKTADPASSWTAQLLSKGPEKCAEKFGEEAVEAIIEAVKGDRDALTGEAADVLYHLLVMLAACDVDLK
DVLAELERRQNTSGIAEKQGRFKAP

Sequences:

>Translated_105_residues
MTLDALFATILDRKTADPASSWTAQLLSKGPEKCAEKFGEEAVEAIIEAVKGDRDALTGEAADVLYHLLVMLAACDVDLK
DVLAELERRQNTSGIAEKQGRFKAP
>Mature_104_residues
TLDALFATILDRKTADPASSWTAQLLSKGPEKCAEKFGEEAVEAIIEAVKGDRDALTGEAADVLYHLLVMLAACDVDLKD
VLAELERRQNTSGIAEKQGRFKAP

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=79, Percent_Identity=45.5696202531646, Blast_Score=75, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_ROSDO (Q162Q0)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_683729.1
- ProteinModelPortal:   Q162Q0
- SMR:   Q162Q0
- STRING:   Q162Q0
- GeneID:   4195793
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_3562
- NMPDR:   fig|375451.6.peg.3311
- eggNOG:   COG0140
- HOGENOM:   HBG646527
- OMA:   ETVMAAK
- ProtClustDB:   PRK00400
- BioCyc:   RDEN375451:RD1_3562-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 11362; Mature: 11231

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDALFATILDRKTADPASSWTAQLLSKGPEKCAEKFGEEAVEAIIEAVKGDRDALTGE
CCHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCH
AADVLYHLLVMLAACDVDLKDVLAELERRQNTSGIAEKQGRFKAP
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHCCCCCCC
>Mature Secondary Structure 
TLDALFATILDRKTADPASSWTAQLLSKGPEKCAEKFGEEAVEAIIEAVKGDRDALTGE
CHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCH
AADVLYHLLVMLAACDVDLKDVLAELERRQNTSGIAEKQGRFKAP
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA