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The map label for this gene is hisB

Identifier: 110680716

GI number: 110680716

Start: 3421094

End: 3421681

Strand: Direct

Name: hisB

Synonym: RD1_3556

Alternate gene names: 110680716

Gene position: 3421094-3421681 (Clockwise)

Preceding gene: 110680713

Following gene: 110680717

Centisome position: 82.77

GC content: 60.71

Gene sequence:

>588_bases
ATGCGCAGCCATTCCATCACCCGCAGCACAGCGGAAACCGACATCGAGGTGAGCGTTCAACTGGACGGCACCGGGCGCTA
TGACAATCAGACCGGCGTCGGTTTCTTTGACCACATGCTGGACCAGCTGGCGCGCCATTCGCTGATTGACCTGAGTGTCA
GGGCCAAGGGCGATCTGCATGTGGATGATCACCACACCGTCGAAGACACCGGCATCGCCCTCGGGCAAGCGCTGGCGGGC
GCATTGGGCGACAAACGCGGCATCGTGCGGTACGGGTCGTGTCTGTTGCCGATGGATGACGCGCTGGTGCGCTGTGCGCT
TGACCTGTCCGCACGTCCCTATCTGATCTGGAACGTCGATATGCCCACGGCCAAGATCGGCACCTTTGATACCGAACTGG
TGCGTGAATTCTTTACCGCACTCGCCACCCATGGCGGAATCACGCTGCACATCGACTTGCTGCACGGGATCAATTCCCAC
CATATCGCCGAGGCCACGTTCAAATCCGTCGCCCGTGCCCTGCGTCAAGCGGTTGAAACGGATCCGCGTAAGTCTGACGC
GATCCCGTCCACCAAAGGCGCACTCTGA

Upstream 100 bases:

>100_bases
TATCAGGCACAGGGGCCGCAATCCCTGAATGTGGCATCTTTTACTGCCGGGCAAGCCTGTTATAAGGGCCGCGACTTTGA
CAGGTGCGGAGACCGCTTCC

Downstream 100 bases:

>100_bases
GCGTGCTGACGGCGATTATCGATTACGAAAGCGGAAACCTGCATTCCGCGCATAAAGCCTTTGAACGCATGGCAAATGAA
ACCGGGGGCGGCGACGTGGT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MRSHSITRSTAETDIEVSVQLDGTGRYDNQTGVGFFDHMLDQLARHSLIDLSVRAKGDLHVDDHHTVEDTGIALGQALAG
ALGDKRGIVRYGSCLLPMDDALVRCALDLSARPYLIWNVDMPTAKIGTFDTELVREFFTALATHGGITLHIDLLHGINSH
HIAEATFKSVARALRQAVETDPRKSDAIPSTKGAL

Sequences:

>Translated_195_residues
MRSHSITRSTAETDIEVSVQLDGTGRYDNQTGVGFFDHMLDQLARHSLIDLSVRAKGDLHVDDHHTVEDTGIALGQALAG
ALGDKRGIVRYGSCLLPMDDALVRCALDLSARPYLIWNVDMPTAKIGTFDTELVREFFTALATHGGITLHIDLLHGINSH
HIAEATFKSVARALRQAVETDPRKSDAIPSTKGAL
>Mature_195_residues
MRSHSITRSTAETDIEVSVQLDGTGRYDNQTGVGFFDHMLDQLARHSLIDLSVRAKGDLHVDDHHTVEDTGIALGQALAG
ALGDKRGIVRYGSCLLPMDDALVRCALDLSARPYLIWNVDMPTAKIGTFDTELVREFFTALATHGGITLHIDLLHGINSH
HIAEATFKSVARALRQAVETDPRKSDAIPSTKGAL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=49.4845360824742, Blast_Score=191, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6324776, Length=214, Percent_Identity=40.6542056074766, Blast_Score=164, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_ROSDO (Q162Q6)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_683723.1
- ProteinModelPortal:   Q162Q6
- SMR:   Q162Q6
- STRING:   Q162Q6
- GeneID:   4196246
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_3556
- NMPDR:   fig|375451.6.peg.3305
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- PhylomeDB:   Q162Q6
- ProtClustDB:   PRK00951
- BioCyc:   RDEN375451:RD1_3556-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21209; Mature: 21209

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSHSITRSTAETDIEVSVQLDGTGRYDNQTGVGFFDHMLDQLARHSLIDLSVRAKGDLH
CCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCEE
VDDHHTVEDTGIALGQALAGALGDKRGIVRYGSCLLPMDDALVRCALDLSARPYLIWNVD
CCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCEECCHHHHHHHHHHCCCCCCEEEEECC
MPTAKIGTFDTELVREFFTALATHGGITLHIDLLHGINSHHIAEATFKSVARALRQAVET
CCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHC
DPRKSDAIPSTKGAL
CCCCCCCCCCCCCCC
>Mature Secondary Structure
MRSHSITRSTAETDIEVSVQLDGTGRYDNQTGVGFFDHMLDQLARHSLIDLSVRAKGDLH
CCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCCCEE
VDDHHTVEDTGIALGQALAGALGDKRGIVRYGSCLLPMDDALVRCALDLSARPYLIWNVD
CCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCEECCHHHHHHHHHHCCCCCCEEEEECC
MPTAKIGTFDTELVREFFTALATHGGITLHIDLLHGINSHHIAEATFKSVARALRQAVET
CCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHC
DPRKSDAIPSTKGAL
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA