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The map label for this gene is prs [H]

Identifier: 110680689

GI number: 110680689

Start: 3389090

End: 3390109

Strand: Direct

Name: prs [H]

Synonym: RD1_3528

Alternate gene names: 110680689

Gene position: 3389090-3390109 (Clockwise)

Preceding gene: 110680686

Following gene: 110680699

Centisome position: 82.0

GC content: 56.27

Gene sequence:

>1020_bases
ATGCCACACGTCCAAGAACCCAAGCTGATTTCTGGAAATGCAAATATGCCCCTCGCGCAGGGTATCGCGCGACGCATGAG
CATGCACCGTGGCGTCCCTGTCGGACTGGTCGACGCGCGGGTTGAGCGGTTCAATGACGGAGAGATTTTTGTCGAAGTGT
TCGAGAATGTGCGCGGCGAGGATATGTTCATCCTTCAATCCACGTCCAACCCGGCCAATGACAACCTGATGGAATTGTTG
ATCATGGCGGATGCCCTGCGACGCTCTTCCGCGGCGCGGGTCACGGCGGTGCTGCCCTATTTCGGCTATGCGCGGCAAGA
TCGCCGAACCAAGGCGCGCACGCCCATTACCGCGAAACTGGTGGCCAACATGCTGGTCGGGACAGGTATCGAGCGGGTTT
TGACCATGGACCTGCATGCCGCGCAAATTCAGGGGTTTTTCGATATACCGGTTGATAACCTTTATGCCTCGCCCATCTTT
GCCCTTGATATCAAGAGTGAGTTCAAAGGCCGGATGGATGAACTCATGATTGTTTCCCCCGACGTGGGCGGGGTCGCGCG
TGCACGGGAGCTGGCCAAACGCATCAATTCCCCGCTTGCGATCGTAGACAAGCGACGCGAAAAGCCTGGCGAAATTGCCG
AGATGAAAGTGATTGGCGATGTGACAGGCAAAACCTGCATCATCGTCGACGACATGTGTGACACGGCGGGTACGCTGTGC
AAGGCCGCGCAGGTGCTGATCGAACATGGCGCAAAAGAGGTGCATTCCTACATCACGCATGGCATCATGTCCGGACCGGC
GGTTGAGCGCGTCACGAATTCTGTAATGAAATCGCTTGTGATCACAGACACCATCGCACCCACAGATGCCGTGAAAGAGG
CAACCAATATCAGGATCGTGCCAACAGCACCTGTTTTTGCGCAAGCCATCCTGAACATTTGGAACGGCACGTCCGTATCG
TCGCTGTTTGAAGCGGAAACGCTCGGCCCGATCTACGATGGAATGTACGCGGCCGAATAG

Upstream 100 bases:

>100_bases
GTGGCCTTGGGTTCTTTGCCGATTGGTAAGGCCGTGTTAGGTGAAGTCAACATCACGAATCTGTCACAATTCCCTCTTCC
TAATCTCGGAAACACCTCCC

Downstream 100 bases:

>100_bases
GGTCGCAAAGTCGGTCGGGGCTTAACGCGGGGCGCTGCCGGCCTCGCGCGCTATTTTCGCCTGGTATTTGCGTTCCAGAA
CAAGCTGCTGCGGCTCCCAG

Product: ribose-phosphate pyrophosphokinase putative

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MPHVQEPKLISGNANMPLAQGIARRMSMHRGVPVGLVDARVERFNDGEIFVEVFENVRGEDMFILQSTSNPANDNLMELL
IMADALRRSSAARVTAVLPYFGYARQDRRTKARTPITAKLVANMLVGTGIERVLTMDLHAAQIQGFFDIPVDNLYASPIF
ALDIKSEFKGRMDELMIVSPDVGGVARARELAKRINSPLAIVDKRREKPGEIAEMKVIGDVTGKTCIIVDDMCDTAGTLC
KAAQVLIEHGAKEVHSYITHGIMSGPAVERVTNSVMKSLVITDTIAPTDAVKEATNIRIVPTAPVFAQAILNIWNGTSVS
SLFEAETLGPIYDGMYAAE

Sequences:

>Translated_339_residues
MPHVQEPKLISGNANMPLAQGIARRMSMHRGVPVGLVDARVERFNDGEIFVEVFENVRGEDMFILQSTSNPANDNLMELL
IMADALRRSSAARVTAVLPYFGYARQDRRTKARTPITAKLVANMLVGTGIERVLTMDLHAAQIQGFFDIPVDNLYASPIF
ALDIKSEFKGRMDELMIVSPDVGGVARARELAKRINSPLAIVDKRREKPGEIAEMKVIGDVTGKTCIIVDDMCDTAGTLC
KAAQVLIEHGAKEVHSYITHGIMSGPAVERVTNSVMKSLVITDTIAPTDAVKEATNIRIVPTAPVFAQAILNIWNGTSVS
SLFEAETLGPIYDGMYAAE
>Mature_338_residues
PHVQEPKLISGNANMPLAQGIARRMSMHRGVPVGLVDARVERFNDGEIFVEVFENVRGEDMFILQSTSNPANDNLMELLI
MADALRRSSAARVTAVLPYFGYARQDRRTKARTPITAKLVANMLVGTGIERVLTMDLHAAQIQGFFDIPVDNLYASPIFA
LDIKSEFKGRMDELMIVSPDVGGVARARELAKRINSPLAIVDKRREKPGEIAEMKVIGDVTGKTCIIVDDMCDTAGTLCK
AAQVLIEHGAKEVHSYITHGIMSGPAVERVTNSVMKSLVITDTIAPTDAVKEATNIRIVPTAPVFAQAILNIWNGTSVSS
LFEAETLGPIYDGMYAAE

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=326, Percent_Identity=46.319018404908, Blast_Score=294, Evalue=8e-80,
Organism=Homo sapiens, GI4506129, Length=315, Percent_Identity=46.3492063492063, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI84875539, Length=318, Percent_Identity=45.9119496855346, Blast_Score=287, Evalue=8e-78,
Organism=Homo sapiens, GI28557709, Length=323, Percent_Identity=44.5820433436532, Blast_Score=281, Evalue=6e-76,
Organism=Homo sapiens, GI4506133, Length=349, Percent_Identity=34.6704871060172, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI194018537, Length=348, Percent_Identity=33.6206896551724, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI310128524, Length=147, Percent_Identity=32.6530612244898, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI310115209, Length=147, Percent_Identity=32.6530612244898, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI310118259, Length=147, Percent_Identity=32.6530612244898, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI310119946, Length=147, Percent_Identity=32.6530612244898, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI1787458, Length=319, Percent_Identity=53.2915360501567, Blast_Score=331, Evalue=4e-92,
Organism=Caenorhabditis elegans, GI17554704, Length=317, Percent_Identity=44.4794952681388, Blast_Score=280, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI25149168, Length=323, Percent_Identity=44.2724458204334, Blast_Score=280, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI17554702, Length=323, Percent_Identity=44.2724458204334, Blast_Score=280, Evalue=8e-76,
Organism=Caenorhabditis elegans, GI71989924, Length=323, Percent_Identity=44.2724458204334, Blast_Score=278, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17570245, Length=348, Percent_Identity=31.0344827586207, Blast_Score=164, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6321776, Length=318, Percent_Identity=44.3396226415094, Blast_Score=272, Evalue=7e-74,
Organism=Saccharomyces cerevisiae, GI6319403, Length=318, Percent_Identity=45.9119496855346, Blast_Score=270, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6320946, Length=318, Percent_Identity=44.6540880503145, Blast_Score=265, Evalue=8e-72,
Organism=Saccharomyces cerevisiae, GI6322667, Length=207, Percent_Identity=38.1642512077295, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6324511, Length=111, Percent_Identity=38.7387387387387, Blast_Score=85, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21355239, Length=326, Percent_Identity=47.239263803681, Blast_Score=286, Evalue=1e-77,
Organism=Drosophila melanogaster, GI45551540, Length=349, Percent_Identity=44.1260744985673, Blast_Score=274, Evalue=5e-74,
Organism=Drosophila melanogaster, GI24651458, Length=363, Percent_Identity=32.2314049586777, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24651456, Length=363, Percent_Identity=32.2314049586777, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI281362873, Length=363, Percent_Identity=32.2314049586777, Blast_Score=177, Evalue=7e-45,
Organism=Drosophila melanogaster, GI24651454, Length=363, Percent_Identity=32.2314049586777, Blast_Score=177, Evalue=7e-45,
Organism=Drosophila melanogaster, GI24651462, Length=382, Percent_Identity=31.151832460733, Blast_Score=167, Evalue=8e-42,
Organism=Drosophila melanogaster, GI24651464, Length=382, Percent_Identity=31.151832460733, Blast_Score=167, Evalue=8e-42,
Organism=Drosophila melanogaster, GI45552010, Length=382, Percent_Identity=30.8900523560209, Blast_Score=165, Evalue=3e-41,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 36953; Mature: 36822

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHVQEPKLISGNANMPLAQGIARRMSMHRGVPVGLVDARVERFNDGEIFVEVFENVRGE
CCCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCHHHHHHHHCCCCC
DMFILQSTSNPANDNLMELLIMADALRRSSAARVTAVLPYFGYARQDRRTKARTPITAKL
EEEEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHEEHHHHHCCHHHHCHHHCCCCHHHHH
VANMLVGTGIERVLTMDLHAAQIQGFFDIPVDNLYASPIFALDIKSEFKGRMDELMIVSP
HHHHHHHCCHHHHHHHHHHHHHHCCEEECCHHHHHCCCEEEEECCHHHCCCCCCEEEECC
DVGGVARARELAKRINSPLAIVDKRREKPGEIAEMKVIGDVTGKTCIIVDDMCDTAGTLC
CCCHHHHHHHHHHHHCCCEEEHHHHCCCCCCCEEEEEEECCCCCEEEEEECHHHHHHHHH
KAAQVLIEHGAKEVHSYITHGIMSGPAVERVTNSVMKSLVITDTIAPTDAVKEATNIRIV
HHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCEEEE
PTAPVFAQAILNIWNGTSVSSLFEAETLGPIYDGMYAAE
ECCHHHHHHHHHHHCCCCHHHHHHHHHCCHHHCCCCCCC
>Mature Secondary Structure 
PHVQEPKLISGNANMPLAQGIARRMSMHRGVPVGLVDARVERFNDGEIFVEVFENVRGE
CCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCHHHHHHHHCCCCC
DMFILQSTSNPANDNLMELLIMADALRRSSAARVTAVLPYFGYARQDRRTKARTPITAKL
EEEEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHEEHHHHHCCHHHHCHHHCCCCHHHHH
VANMLVGTGIERVLTMDLHAAQIQGFFDIPVDNLYASPIFALDIKSEFKGRMDELMIVSP
HHHHHHHCCHHHHHHHHHHHHHHCCEEECCHHHHHCCCEEEEECCHHHCCCCCCEEEECC
DVGGVARARELAKRINSPLAIVDKRREKPGEIAEMKVIGDVTGKTCIIVDDMCDTAGTLC
CCCHHHHHHHHHHHHCCCEEEHHHHCCCCCCCEEEEEEECCCCCEEEEEECHHHHHHHHH
KAAQVLIEHGAKEVHSYITHGIMSGPAVERVTNSVMKSLVITDTIAPTDAVKEATNIRIV
HHHHHHHHHCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCEEEE
PTAPVFAQAILNIWNGTSVSSLFEAETLGPIYDGMYAAE
ECCHHHHHHHHHHHCCCCHHHHHHHHHCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA