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The map label for this gene is purK [H]

Identifier: 110680672

GI number: 110680672

Start: 3374139

End: 3375206

Strand: Direct

Name: purK [H]

Synonym: RD1_3511

Alternate gene names: 110680672

Gene position: 3374139-3375206 (Clockwise)

Preceding gene: 110680671

Following gene: 110680675

Centisome position: 81.64

GC content: 59.08

Gene sequence:

>1068_bases
ATGAATGAACCCTTGAAGACCGGATCCACCATCGGGATCCTGGGTGGCGGGCAGCTGGGCCGGATGCTGGCCGTGGCGGC
GGCCCGTCTTGGCCTCAAGACACATGTCTTTGAGCCCGGTGCTGAGCCCCCCGCAAGCCACACCGCGCACCGGCTGACAA
CCGCAGCTTACAGTGACACGGAAGCGTTGATCGCATTTGCACGCTCCGTTGATGTGGTCACATATGAGTTCGAGAACATC
CCCACCGACGCGCTGGATACGATCGAGGCCATCACCCCGATAAGACCGGAACGCGAAGCCCTGCGCGTCAGTCAGGACCG
CCTGATCGAAAAGGCATATCTTGAGGGTCTGGGCTTGCAAGTGGCTCCCTTTGCGCCGGTGAACGATGCTGCGAGCCTGC
AAAAGGCGGTCGATCAGATCGGCACCCCCTCAATCCTCAAAACATGTCGCTTTGGCTATGATGGCAAAGGTCAGGCCAAG
CTGAACACGCCTGACGACCAGCCTGCGGCACTGGCGGCGATGGCAGATCAGCCTGCCGTGCTCGAAGGGTTTGTGACCTT
CAGCCGCGAAGTCTCCGTCATTGCCGCGCGCAGCGTCAATGGCGATGTGGCCTGTTTCGATCCCGGCGAAAACATCCACA
AAAACGGCATTCTGCACACGACGACCGTCCCTGCATCCCTTAGCGCCACACAGCGCACAGATGCCGTATTGATGGCCGCG
AAGATATTGAACGCTCTCGATTATGTTGGCGTGTTGGGGGTTGAGCTTTTCGTGACGCCCCAAGGTCTGATCGTGAATGA
AATTGCACCACGGGTGCATAATTCGGGGCATTGGACGCAGAACGGCTGCGCCATCGACCAGTTTGAACAGCATATCCGCG
CGATCGCAGGCTGGCCTTTGGGCGACGGAACGCGCCATTCGGATGTGGTCATGGAAAACCTGATCGGCGACGATATGGAC
CGCGTCGCAGAAATTGCACGCGAAAGCGGCGCAGCCTTACATCTTTATGGCAAGGCTGACGTCAAACCGGGGCGCAAAAT
GGGCCATGTGAACCGTATCGCACGCTGA

Upstream 100 bases:

>100_bases
ATGGCCGCAGGAATCCTTGCGCTCAACGATGCCGACCTTGCGGCACGTCTGGACGCATGGCGCGCTGCACTTTCTGCCTC
CATCCCTGAGGAACCCGTTG

Downstream 100 bases:

>100_bases
TCGCTCAGGCGGCGAAAAATCGGGTCGCGACATCGCCTGCCATATGGCTGATTCGCCCTTTGACCAGCGTCGCCGCGACG
CGCCGGGTTTCTCTGTCAAG

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MNEPLKTGSTIGILGGGQLGRMLAVAAARLGLKTHVFEPGAEPPASHTAHRLTTAAYSDTEALIAFARSVDVVTYEFENI
PTDALDTIEAITPIRPEREALRVSQDRLIEKAYLEGLGLQVAPFAPVNDAASLQKAVDQIGTPSILKTCRFGYDGKGQAK
LNTPDDQPAALAAMADQPAVLEGFVTFSREVSVIAARSVNGDVACFDPGENIHKNGILHTTTVPASLSATQRTDAVLMAA
KILNALDYVGVLGVELFVTPQGLIVNEIAPRVHNSGHWTQNGCAIDQFEQHIRAIAGWPLGDGTRHSDVVMENLIGDDMD
RVAEIARESGAALHLYGKADVKPGRKMGHVNRIAR

Sequences:

>Translated_355_residues
MNEPLKTGSTIGILGGGQLGRMLAVAAARLGLKTHVFEPGAEPPASHTAHRLTTAAYSDTEALIAFARSVDVVTYEFENI
PTDALDTIEAITPIRPEREALRVSQDRLIEKAYLEGLGLQVAPFAPVNDAASLQKAVDQIGTPSILKTCRFGYDGKGQAK
LNTPDDQPAALAAMADQPAVLEGFVTFSREVSVIAARSVNGDVACFDPGENIHKNGILHTTTVPASLSATQRTDAVLMAA
KILNALDYVGVLGVELFVTPQGLIVNEIAPRVHNSGHWTQNGCAIDQFEQHIRAIAGWPLGDGTRHSDVVMENLIGDDMD
RVAEIARESGAALHLYGKADVKPGRKMGHVNRIAR
>Mature_355_residues
MNEPLKTGSTIGILGGGQLGRMLAVAAARLGLKTHVFEPGAEPPASHTAHRLTTAAYSDTEALIAFARSVDVVTYEFENI
PTDALDTIEAITPIRPEREALRVSQDRLIEKAYLEGLGLQVAPFAPVNDAASLQKAVDQIGTPSILKTCRFGYDGKGQAK
LNTPDDQPAALAAMADQPAVLEGFVTFSREVSVIAARSVNGDVACFDPGENIHKNGILHTTTVPASLSATQRTDAVLMAA
KILNALDYVGVLGVELFVTPQGLIVNEIAPRVHNSGHWTQNGCAIDQFEQHIRAIAGWPLGDGTRHSDVVMENLIGDDMD
RVAEIARESGAALHLYGKADVKPGRKMGHVNRIAR

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=341, Percent_Identity=37.2434017595308, Blast_Score=198, Evalue=4e-52,
Organism=Escherichia coli, GI1788155, Length=361, Percent_Identity=27.9778393351801, Blast_Score=106, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324702, Length=363, Percent_Identity=33.8842975206612, Blast_Score=204, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 37862; Mature: 37862

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEPLKTGSTIGILGGGQLGRMLAVAAARLGLKTHVFEPGAEPPASHTAHRLTTAAYSDT
CCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCHHEEECCCCCCCCCHHHHHHHHHHCCCH
EALIAFARSVDVVTYEFENIPTDALDTIEAITPIRPEREALRVSQDRLIEKAYLEGLGLQ
HHHHHHHHHCEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCE
VAPFAPVNDAASLQKAVDQIGTPSILKTCRFGYDGKGQAKLNTPDDQPAALAAMADQPAV
EECCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEECCCCCCCCHHHHHHCCCCHH
LEGFVTFSREVSVIAARSVNGDVACFDPGENIHKNGILHTTTVPASLSATQRTDAVLMAA
HHHHHHHCCCEEEEEEECCCCCEEEECCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHH
KILNALDYVGVLGVELFVTPQGLIVNEIAPRVHNSGHWTQNGCAIDQFEQHIRAIAGWPL
HHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCC
GDGTRHSDVVMENLIGDDMDRVAEIARESGAALHLYGKADVKPGRKMGHVNRIAR
CCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MNEPLKTGSTIGILGGGQLGRMLAVAAARLGLKTHVFEPGAEPPASHTAHRLTTAAYSDT
CCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCHHEEECCCCCCCCCHHHHHHHHHHCCCH
EALIAFARSVDVVTYEFENIPTDALDTIEAITPIRPEREALRVSQDRLIEKAYLEGLGLQ
HHHHHHHHHCEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCE
VAPFAPVNDAASLQKAVDQIGTPSILKTCRFGYDGKGQAKLNTPDDQPAALAAMADQPAV
EECCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEECCCCCCCCHHHHHHCCCCHH
LEGFVTFSREVSVIAARSVNGDVACFDPGENIHKNGILHTTTVPASLSATQRTDAVLMAA
HHHHHHHCCCEEEEEEECCCCCEEEECCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHH
KILNALDYVGVLGVELFVTPQGLIVNEIAPRVHNSGHWTQNGCAIDQFEQHIRAIAGWPL
HHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCC
GDGTRHSDVVMENLIGDDMDRVAEIARESGAALHLYGKADVKPGRKMGHVNRIAR
CCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]