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The map label for this gene is purE [H]

Identifier: 110680671

GI number: 110680671

Start: 3373658

End: 3374146

Strand: Direct

Name: purE [H]

Synonym: RD1_3510

Alternate gene names: 110680671

Gene position: 3373658-3374146 (Clockwise)

Preceding gene: 110680668

Following gene: 110680672

Centisome position: 81.63

GC content: 62.58

Gene sequence:

>489_bases
ATGACACCTCCCTCTGTCGGAATAATCATGGGCAGCCAGTCGGATTGGCCAACCCTGCGTGAGGCCGCACTGGTGCTGGA
TGATCTTGGCGTTGCGTATGAAAAACGTATCGTTTCGGCCCATCGCACACCGGATCGGCTCTGGGACTATGGCGTCACCG
CCGTGGACCGGGGCTTGCAGGTGATCATCGCCGGTGCCGGGGGCGCGGCCCATCTGCCCGGCATGATGGCATCAAAAACG
CGCGTGCCGGTCATCGGGGTCCCTGTGCAGACACAGGCCCTGTCCGGTGTTGATTCGCTTTATTCGATCCTGCAGATGCC
GCGCGGCTATCCGGTCGCGACAATGGCAATCGGGGCCGCCGGTGCCAAGAACGCCGGGCTGATGGCCGCAGGAATCCTTG
CGCTCAACGATGCCGACCTTGCGGCACGTCTGGACGCATGGCGCGCTGCACTTTCTGCCTCCATCCCTGAGGAACCCGTT
GATGAATGA

Upstream 100 bases:

>100_bases
CCCGGATATCATCGCCTGAGGCATGCCCGGTGCATTGCGCACCCCATCCGTTTGATTATAGTCCGGATTTAGAAATATCA
GGCGCAAGGGGCCCTTTTCA

Downstream 100 bases:

>100_bases
ACCCTTGAAGACCGGATCCACCATCGGGATCCTGGGTGGCGGGCAGCTGGGCCGGATGCTGGCCGTGGCGGCGGCCCGTC
TTGGCCTCAAGACACATGTC

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 162; Mature: 161

Protein sequence:

>162_residues
MTPPSVGIIMGSQSDWPTLREAALVLDDLGVAYEKRIVSAHRTPDRLWDYGVTAVDRGLQVIIAGAGGAAHLPGMMASKT
RVPVIGVPVQTQALSGVDSLYSILQMPRGYPVATMAIGAAGAKNAGLMAAGILALNDADLAARLDAWRAALSASIPEEPV
DE

Sequences:

>Translated_162_residues
MTPPSVGIIMGSQSDWPTLREAALVLDDLGVAYEKRIVSAHRTPDRLWDYGVTAVDRGLQVIIAGAGGAAHLPGMMASKT
RVPVIGVPVQTQALSGVDSLYSILQMPRGYPVATMAIGAAGAKNAGLMAAGILALNDADLAARLDAWRAALSASIPEEPV
DE
>Mature_161_residues
TPPSVGIIMGSQSDWPTLREAALVLDDLGVAYEKRIVSAHRTPDRLWDYGVTAVDRGLQVIIAGAGGAAHLPGMMASKTR
VPVIGVPVQTQALSGVDSLYSILQMPRGYPVATMAIGAAGAKNAGLMAAGILALNDADLAARLDAWRAALSASIPEEPVD
E

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=158, Percent_Identity=59.4936708860759, Blast_Score=162, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6324702, Length=147, Percent_Identity=54.421768707483, Blast_Score=156, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16802; Mature: 16670

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPPSVGIIMGSQSDWPTLREAALVLDDLGVAYEKRIVSAHRTPDRLWDYGVTAVDRGLQ
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHCCEE
VIIAGAGGAAHLPGMMASKTRVPVIGVPVQTQALSGVDSLYSILQMPRGYPVATMAIGAA
EEEECCCCHHHCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHEEECCC
GAKNAGLMAAGILALNDADLAARLDAWRAALSASIPEEPVDE
CCCCCCCEEHHEEEECCCHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TPPSVGIIMGSQSDWPTLREAALVLDDLGVAYEKRIVSAHRTPDRLWDYGVTAVDRGLQ
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHCCEE
VIIAGAGGAAHLPGMMASKTRVPVIGVPVQTQALSGVDSLYSILQMPRGYPVATMAIGAA
EEEECCCCHHHCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCCHHEEECCC
GAKNAGLMAAGILALNDADLAARLDAWRAALSASIPEEPVDE
CCCCCCCEEHHEEEECCCHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]