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The map label for this gene is pepQ [H]

Identifier: 110680519

GI number: 110680519

Start: 3206207

End: 3207997

Strand: Direct

Name: pepQ [H]

Synonym: RD1_3341

Alternate gene names: 110680519

Gene position: 3206207-3207997 (Clockwise)

Preceding gene: 110680518

Following gene: 110680520

Centisome position: 77.57

GC content: 64.15

Gene sequence:

>1791_bases
ATGTTTCAGTCATTTGAAGTCACAGCCCGCCCGGAACAGGGCCCCCCGCGTCTCGCTGCACTGCGCGACCGTATGGCAGA
GGCCGCGTTGGACGGCTTTCTGGTGCCGCGGGCGGATGCGCATCAGGGCGAATATGTAGGACCGCATGACGAACGGCTTG
CATGGCTGACAGGCTTCACCGGCTCCGCCGGATTCTGCGCGGTTTTGCAGGCCGTCGCAGGCGTGTTCATCGACGGGCGC
TATCGCACGCAGGTCAAGGCGCAGGTCGCGGCAGACTTCACCCCCGTGCCCTGGCCCGACGTATCCTTGGGCGACTGGCT
GAAAGAGCAGATGCCCAGTGGCGGTATCGTCGGATTTGACCCGTGGCTGCACACGCCCGGTGAAATCGAAACGCTGGAAA
AGGCGCTGAAAAACAGCGGTATCACCTTGCAGCCTAGCCCCAATCTGGTGGATGCGATCTGGCATGACCAACCCGCGCCG
CCAATGGCCCCTGCCAAAGTGCACCCCCTTGAATTTGCGGGCGAAAGCCACGGTGACAAATGCGCGCGCCTCGGTGCGAC
CCTGAAAGAGGCGGGTGAAGCGGCAGCGCTGATCACCCTGCCCGACGCCCTGTGCTGGCTGTTGAACATTCGCGGTGCGG
ATATCGCGCGCAACCCTGTCGCGCAGGGGTTTGCCGTGTTGATGGCGGATGGTCATGTGCATCTGTTCATGGCCGAGGCC
AAGCTGAGCGAGGTGCGCGCGCATCTCGGCGACGGCGTGACGATCCACGCACCGGACAGCCTGCCGGGCTTTCTGGACGA
TCTTGCAGGGCCGGTGCGCGCCCACAAAGCGACCGTGCCGCTTTATCTGGCGGAACGTCTTGGGGACCGCGTGGTCTGGG
GGGATGACCCCTGCGCGCTGCCCAAAGCCTGCAAGAATGAGGCCGAAATCGAAGGGGCGGCGGCGGCCCATCTGCGCGAT
GGTGCGGCTGTGGTGGAACTGCTGGCGTGGCTTGATCAGCAAGCACCGGGGAGCATCACGGAAACGCAGGTGGTCACGCG
GCTTGAAACGCTGCGGCGCAGTGACAACGCCCTGCAGGACATCAGTTTTGAAACCATTGCGGGCACCGGGCCAAACGGGG
CCATCATGCATTACCGCGTCACCGAGGAAACCGACAGCCTGCTGGAGGAGGGTCAGTTGATCGTGCTCGACAGTGGGGGC
CAATACCTTGACGGCACCACCGATATCACCCGCACAATCCCCATCGGCGAGCCGCCCCGCGCTGCTGCCGAAGCCTTTAC
CCGCGTGTTGCAGGGCATGATCGCCATGAGCCGCCTGCGCTGGCCCGTCGGTCTTGCCGGGCGCGAGATCGAGGCGGTGG
GACGCGTGCCGCTCTGGCTGGCCGGGCAGGATTTTAACCACGGGCTGGGCCATGGTGTCGGCGCCTATCTGAGCGTGCAC
GAGGGACCACAACGGCTGAGCCGGGTGAGTTCGGTGCCCCTGCAACCCGGTATGATCCTGTCGAACGAACCGGGCTATTA
CCGCGAAGGCGCGTTCGGCATCCGGCTCGAAAACCTGATTGTCGTGATCAAGGCCCCCGCGCTGCCGGACGGCGATGCCG
AACGCGAGATGCTGGAATGGCGCACCCTGACCTATGCCCCGATTGACCGTCGCCTGATCGTCAAGGAGATGATGACAGGC
CCGGAAATCGACTGGATCAACAGCTATCACGCAGATGTGGCCGAAAAGATCGGCCCGCGGGTCAGTGCAGATACGCGCAA
ATGGCTTGAGGCTGCGACCGCACCTCTCTGA

Upstream 100 bases:

>100_bases
GACAGCGACCCGCGCGCACGCGCGCGCGTCATGGGCATGCGCCGCGCAGGCTAAACCCGGCTCCAGTTCTATCGCGGCAC
AATCAAAGGGATCCATCGCT

Downstream 100 bases:

>100_bases
ACGCGGTCCCCGGATGCCGCGTTTACAATCATGTGGTGTGAAAATAGGGTGACGCACAGCACGGAAGGAAACAAGATGGC
GCAACATATAACGATACGAA

Product: M24 family metallopeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 596; Mature: 596

Protein sequence:

>596_residues
MFQSFEVTARPEQGPPRLAALRDRMAEAALDGFLVPRADAHQGEYVGPHDERLAWLTGFTGSAGFCAVLQAVAGVFIDGR
YRTQVKAQVAADFTPVPWPDVSLGDWLKEQMPSGGIVGFDPWLHTPGEIETLEKALKNSGITLQPSPNLVDAIWHDQPAP
PMAPAKVHPLEFAGESHGDKCARLGATLKEAGEAAALITLPDALCWLLNIRGADIARNPVAQGFAVLMADGHVHLFMAEA
KLSEVRAHLGDGVTIHAPDSLPGFLDDLAGPVRAHKATVPLYLAERLGDRVVWGDDPCALPKACKNEAEIEGAAAAHLRD
GAAVVELLAWLDQQAPGSITETQVVTRLETLRRSDNALQDISFETIAGTGPNGAIMHYRVTEETDSLLEEGQLIVLDSGG
QYLDGTTDITRTIPIGEPPRAAAEAFTRVLQGMIAMSRLRWPVGLAGREIEAVGRVPLWLAGQDFNHGLGHGVGAYLSVH
EGPQRLSRVSSVPLQPGMILSNEPGYYREGAFGIRLENLIVVIKAPALPDGDAEREMLEWRTLTYAPIDRRLIVKEMMTG
PEIDWINSYHADVAEKIGPRVSADTRKWLEAATAPL

Sequences:

>Translated_596_residues
MFQSFEVTARPEQGPPRLAALRDRMAEAALDGFLVPRADAHQGEYVGPHDERLAWLTGFTGSAGFCAVLQAVAGVFIDGR
YRTQVKAQVAADFTPVPWPDVSLGDWLKEQMPSGGIVGFDPWLHTPGEIETLEKALKNSGITLQPSPNLVDAIWHDQPAP
PMAPAKVHPLEFAGESHGDKCARLGATLKEAGEAAALITLPDALCWLLNIRGADIARNPVAQGFAVLMADGHVHLFMAEA
KLSEVRAHLGDGVTIHAPDSLPGFLDDLAGPVRAHKATVPLYLAERLGDRVVWGDDPCALPKACKNEAEIEGAAAAHLRD
GAAVVELLAWLDQQAPGSITETQVVTRLETLRRSDNALQDISFETIAGTGPNGAIMHYRVTEETDSLLEEGQLIVLDSGG
QYLDGTTDITRTIPIGEPPRAAAEAFTRVLQGMIAMSRLRWPVGLAGREIEAVGRVPLWLAGQDFNHGLGHGVGAYLSVH
EGPQRLSRVSSVPLQPGMILSNEPGYYREGAFGIRLENLIVVIKAPALPDGDAEREMLEWRTLTYAPIDRRLIVKEMMTG
PEIDWINSYHADVAEKIGPRVSADTRKWLEAATAPL
>Mature_596_residues
MFQSFEVTARPEQGPPRLAALRDRMAEAALDGFLVPRADAHQGEYVGPHDERLAWLTGFTGSAGFCAVLQAVAGVFIDGR
YRTQVKAQVAADFTPVPWPDVSLGDWLKEQMPSGGIVGFDPWLHTPGEIETLEKALKNSGITLQPSPNLVDAIWHDQPAP
PMAPAKVHPLEFAGESHGDKCARLGATLKEAGEAAALITLPDALCWLLNIRGADIARNPVAQGFAVLMADGHVHLFMAEA
KLSEVRAHLGDGVTIHAPDSLPGFLDDLAGPVRAHKATVPLYLAERLGDRVVWGDDPCALPKACKNEAEIEGAAAAHLRD
GAAVVELLAWLDQQAPGSITETQVVTRLETLRRSDNALQDISFETIAGTGPNGAIMHYRVTEETDSLLEEGQLIVLDSGG
QYLDGTTDITRTIPIGEPPRAAAEAFTRVLQGMIAMSRLRWPVGLAGREIEAVGRVPLWLAGQDFNHGLGHGVGAYLSVH
EGPQRLSRVSSVPLQPGMILSNEPGYYREGAFGIRLENLIVVIKAPALPDGDAEREMLEWRTLTYAPIDRRLIVKEMMTG
PEIDWINSYHADVAEKIGPRVSADTRKWLEAATAPL

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=613, Percent_Identity=34.584013050571, Blast_Score=353, Evalue=3e-97,
Organism=Homo sapiens, GI93141226, Length=608, Percent_Identity=34.046052631579, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI264681565, Length=613, Percent_Identity=33.278955954323, Blast_Score=326, Evalue=4e-89,
Organism=Escherichia coli, GI1788728, Length=192, Percent_Identity=32.2916666666667, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1789275, Length=197, Percent_Identity=32.48730964467, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17509539, Length=594, Percent_Identity=34.1750841750842, Blast_Score=325, Evalue=5e-89,
Organism=Caenorhabditis elegans, GI25149105, Length=623, Percent_Identity=26.645264847512, Blast_Score=207, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6322999, Length=651, Percent_Identity=30.4147465437788, Blast_Score=289, Evalue=9e-79,
Organism=Drosophila melanogaster, GI17137632, Length=614, Percent_Identity=32.8990228013029, Blast_Score=311, Evalue=7e-85,
Organism=Drosophila melanogaster, GI161078230, Length=594, Percent_Identity=30.976430976431, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI21357287, Length=594, Percent_Identity=30.976430976431, Blast_Score=263, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 64376; Mature: 64376

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQSFEVTARPEQGPPRLAALRDRMAEAALDGFLVPRADAHQGEYVGPHDERLAWLTGFT
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCC
GSAGFCAVLQAVAGVFIDGRYRTQVKAQVAADFTPVPWPDVSLGDWLKEQMPSGGIVGFD
CCCHHHHHHHHHHHEEECCCCHHEEEEHHHCCCCCCCCCCCCHHHHHHHHCCCCCEEEEC
PWLHTPGEIETLEKALKNSGITLQPSPNLVDAIWHDQPAPPMAPAKVHPLEFAGESHGDK
CCCCCCCHHHHHHHHHHCCCCEECCCCCHHHHHHCCCCCCCCCCCCCCCHHCCCCCCCHH
CARLGATLKEAGEAAALITLPDALCWLLNIRGADIARNPVAQGFAVLMADGHVHLFMAEA
HHHHHHHHHHCCCEEEEEECHHHHHHHHHCCCCCCCCCHHHCCEEEEEECCCEEEEEEHH
KLSEVRAHLGDGVTIHAPDSLPGFLDDLAGPVRAHKATVPLYLAERLGDRVVWGDDPCAL
HHHHHHHHHCCCEEEECCCCCCHHHHHHCCCHHHHCCCCHHHHHHHHCCEEEECCCCCCC
PKACKNEAEIEGAAAAHLRDGAAVVELLAWLDQQAPGSITETQVVTRLETLRRSDNALQD
CHHHCCCHHCCCHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHH
ISFETIAGTGPNGAIMHYRVTEETDSLLEEGQLIVLDSGGQYLDGTTDITRTIPIGEPPR
CCEEEEECCCCCCCEEEEEECCHHHHHHHCCCEEEECCCCCCCCCCCCCEEECCCCCCCH
AAAEAFTRVLQGMIAMSRLRWPVGLAGREIEAVGRVPLWLAGQDFNHGLGHGVGAYLSVH
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCEEEEECCCCCCCCCCCCCCEEEEC
EGPQRLSRVSSVPLQPGMILSNEPGYYREGAFGIRLENLIVVIKAPALPDGDAEREMLEW
CCHHHHHHHHCCCCCCCEEECCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCHHHHHHHH
RTLTYAPIDRRLIVKEMMTGPEIDWINSYHADVAEKIGPRVSADTRKWLEAATAPL
HHEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MFQSFEVTARPEQGPPRLAALRDRMAEAALDGFLVPRADAHQGEYVGPHDERLAWLTGFT
CCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCC
GSAGFCAVLQAVAGVFIDGRYRTQVKAQVAADFTPVPWPDVSLGDWLKEQMPSGGIVGFD
CCCHHHHHHHHHHHEEECCCCHHEEEEHHHCCCCCCCCCCCCHHHHHHHHCCCCCEEEEC
PWLHTPGEIETLEKALKNSGITLQPSPNLVDAIWHDQPAPPMAPAKVHPLEFAGESHGDK
CCCCCCCHHHHHHHHHHCCCCEECCCCCHHHHHHCCCCCCCCCCCCCCCHHCCCCCCCHH
CARLGATLKEAGEAAALITLPDALCWLLNIRGADIARNPVAQGFAVLMADGHVHLFMAEA
HHHHHHHHHHCCCEEEEEECHHHHHHHHHCCCCCCCCCHHHCCEEEEEECCCEEEEEEHH
KLSEVRAHLGDGVTIHAPDSLPGFLDDLAGPVRAHKATVPLYLAERLGDRVVWGDDPCAL
HHHHHHHHHCCCEEEECCCCCCHHHHHHCCCHHHHCCCCHHHHHHHHCCEEEECCCCCCC
PKACKNEAEIEGAAAAHLRDGAAVVELLAWLDQQAPGSITETQVVTRLETLRRSDNALQD
CHHHCCCHHCCCHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHH
ISFETIAGTGPNGAIMHYRVTEETDSLLEEGQLIVLDSGGQYLDGTTDITRTIPIGEPPR
CCEEEEECCCCCCCEEEEEECCHHHHHHHCCCEEEECCCCCCCCCCCCCEEECCCCCCCH
AAAEAFTRVLQGMIAMSRLRWPVGLAGREIEAVGRVPLWLAGQDFNHGLGHGVGAYLSVH
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCEEEEECCCCCCCCCCCCCCEEEEC
EGPQRLSRVSSVPLQPGMILSNEPGYYREGAFGIRLENLIVVIKAPALPDGDAEREMLEW
CCHHHHHHHHCCCCCCCEEECCCCCCCCCCCCEEEEEEEEEEEECCCCCCCCHHHHHHHH
RTLTYAPIDRRLIVKEMMTGPEIDWINSYHADVAEKIGPRVSADTRKWLEAATAPL
HHEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]