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The map label for this gene is moaA [H]

Identifier: 110680487

GI number: 110680487

Start: 3168991

End: 3169998

Strand: Direct

Name: moaA [H]

Synonym: RD1_3307

Alternate gene names: 110680487

Gene position: 3168991-3169998 (Clockwise)

Preceding gene: 110680486

Following gene: 110680488

Centisome position: 76.67

GC content: 59.62

Gene sequence:

>1008_bases
ATGAATGCTCCGTTGATTGATCCCTTCGCCCGCGCGATCACATACCTGCGTGTTTCCGTAACCGATCGTTGCGATTTTCG
CTGCGTCTATTGCATGTCGGAAAACATGACGTTCCTGCCCAAGAAAGAGTTGCTGACGCTCGAAGAGCTTGACCGCATGT
GTTCGACCTTTGTGGGCCTCGGCGTGGAAAAGCTGCGGATCACCGGCGGGGAACCTTTGGTGCGCAAAGGCATCATGACT
TTTTTCCAAAGCATGTCGCGCCACCTTGATGCGGGCACCTTGAAAGAGTTGACGCTGACCACGAATGGCAGCCAACTCGA
ACGGTTTGCCGCAGACCTCTATGCGGCGGGTGTGCGGCGGGTCAATGTATCGCTTGACACGTTGGACGAACAGAAATTTG
CAGATATCACGCGCTGGGGACGCCTGCCTCAGGTACTGCGGGGCATTGATGCGGCTCTGGCGGTCGGCATGCGGGTCAAG
CTGAACGCTGTTGCGCTGAAGAACTTCAATGAAGATGAGTTGCCCACGATCACCGAGTGGTGCGCCGCGCGCGGCGTCGA
TCTGACGTGGATCGAGGTGATGCCGATGGGCGACATCGGAAACGAGGACCGGCTGGATCAGTATTGGTCGCTCAAAGACG
TGCGCGCACGTTATGCCGAACATTACACCGTCACCGATCTGGCCGAACGAACCGGCGGTCCTGCGCGCTATGTCAGGTTG
GAGGAGACAGGTCAGAAAATCGGCTTCATCACGCCGCTCAGCCACAATTTCTGCGAAAGCTGCAATCGCGTGCGCCTGAC
CTGCACCGGAGAATTGTTCATGTGCCTCGGCCAGGAAGACGCCGCCGATCTGCGCGCGCCGCTGCGCGCCCACCCGGAGG
ATGATGCCCCGCTGCAAGAGGCGATCCGCGCCGCCATCGCACGCAAGCCCAAGGGCCATGACTTTGACTACTCGCGCCAG
CGCCTTGACGGTCAGATGCCGCGCCACATGAGCCATACGGGCGGCTGA

Upstream 100 bases:

>100_bases
AGGGTAGGCCGTTTCAAACGCGGCGGGCGTGACACGATCGCACGCCACTTTTGACGTTATATGCTTGCCGCCCCGCGCGC
GGACCATTACTTGTTAATGC

Downstream 100 bases:

>100_bases
CCTGCGCCATGCGCCCCCCTTTGCTCTACCATCTCTATGTCGGTGCAACGGCGCTGCTCGTCCCGTTCTTTGCCTGGATT
GAAACCCGGAAATTGCGCGC

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MNAPLIDPFARAITYLRVSVTDRCDFRCVYCMSENMTFLPKKELLTLEELDRMCSTFVGLGVEKLRITGGEPLVRKGIMT
FFQSMSRHLDAGTLKELTLTTNGSQLERFAADLYAAGVRRVNVSLDTLDEQKFADITRWGRLPQVLRGIDAALAVGMRVK
LNAVALKNFNEDELPTITEWCAARGVDLTWIEVMPMGDIGNEDRLDQYWSLKDVRARYAEHYTVTDLAERTGGPARYVRL
EETGQKIGFITPLSHNFCESCNRVRLTCTGELFMCLGQEDAADLRAPLRAHPEDDAPLQEAIRAAIARKPKGHDFDYSRQ
RLDGQMPRHMSHTGG

Sequences:

>Translated_335_residues
MNAPLIDPFARAITYLRVSVTDRCDFRCVYCMSENMTFLPKKELLTLEELDRMCSTFVGLGVEKLRITGGEPLVRKGIMT
FFQSMSRHLDAGTLKELTLTTNGSQLERFAADLYAAGVRRVNVSLDTLDEQKFADITRWGRLPQVLRGIDAALAVGMRVK
LNAVALKNFNEDELPTITEWCAARGVDLTWIEVMPMGDIGNEDRLDQYWSLKDVRARYAEHYTVTDLAERTGGPARYVRL
EETGQKIGFITPLSHNFCESCNRVRLTCTGELFMCLGQEDAADLRAPLRAHPEDDAPLQEAIRAAIARKPKGHDFDYSRQ
RLDGQMPRHMSHTGG
>Mature_335_residues
MNAPLIDPFARAITYLRVSVTDRCDFRCVYCMSENMTFLPKKELLTLEELDRMCSTFVGLGVEKLRITGGEPLVRKGIMT
FFQSMSRHLDAGTLKELTLTTNGSQLERFAADLYAAGVRRVNVSLDTLDEQKFADITRWGRLPQVLRGIDAALAVGMRVK
LNAVALKNFNEDELPTITEWCAARGVDLTWIEVMPMGDIGNEDRLDQYWSLKDVRARYAEHYTVTDLAERTGGPARYVRL
EETGQKIGFITPLSHNFCESCNRVRLTCTGELFMCLGQEDAADLRAPLRAHPEDDAPLQEAIRAAIARKPKGHDFDYSRQ
RLDGQMPRHMSHTGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=339, Percent_Identity=35.1032448377581, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI22027536, Length=339, Percent_Identity=35.1032448377581, Blast_Score=182, Evalue=6e-46,
Organism=Escherichia coli, GI1786999, Length=338, Percent_Identity=34.9112426035503, Blast_Score=192, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17561210, Length=313, Percent_Identity=35.7827476038339, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI32566331, Length=313, Percent_Identity=35.7827476038339, Blast_Score=203, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI32566329, Length=313, Percent_Identity=35.7827476038339, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI28574490, Length=315, Percent_Identity=39.0476190476191, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI28574488, Length=315, Percent_Identity=39.0476190476191, Blast_Score=199, Evalue=2e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37782; Mature: 37782

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPLIDPFARAITYLRVSVTDRCDFRCVYCMSENMTFLPKKELLTLEELDRMCSTFVGL
CCCCCCCHHHHHHHHHEEEECCCCCCEEEEEECCCCEECCHHHHHHHHHHHHHHHHHHHC
GVEKLRITGGEPLVRKGIMTFFQSMSRHLDAGTLKELTLTTNGSQLERFAADLYAAGVRR
CCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHEE
VNVSLDTLDEQKFADITRWGRLPQVLRGIDAALAVGMRVKLNAVALKNFNEDELPTITEW
EEEEHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCHHHHH
CAARGVDLTWIEVMPMGDIGNEDRLDQYWSLKDVRARYAEHYTVTDLAERTGGPARYVRL
HHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEE
EETGQKIGFITPLSHNFCESCNRVRLTCTGELFMCLGQEDAADLRAPLRAHPEDDAPLQE
HHCCCEEEEECCCCHHHHHCCCCEEEEEECEEEEEECCCCHHHHHCCHHCCCCCCCCHHH
AIRAAIARKPKGHDFDYSRQRLDGQMPRHMSHTGG
HHHHHHHCCCCCCCCCHHHHHHCCCCCCHHCCCCC
>Mature Secondary Structure
MNAPLIDPFARAITYLRVSVTDRCDFRCVYCMSENMTFLPKKELLTLEELDRMCSTFVGL
CCCCCCCHHHHHHHHHEEEECCCCCCEEEEEECCCCEECCHHHHHHHHHHHHHHHHHHHC
GVEKLRITGGEPLVRKGIMTFFQSMSRHLDAGTLKELTLTTNGSQLERFAADLYAAGVRR
CCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHEE
VNVSLDTLDEQKFADITRWGRLPQVLRGIDAALAVGMRVKLNAVALKNFNEDELPTITEW
EEEEHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCHHHHH
CAARGVDLTWIEVMPMGDIGNEDRLDQYWSLKDVRARYAEHYTVTDLAERTGGPARYVRL
HHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEE
EETGQKIGFITPLSHNFCESCNRVRLTCTGELFMCLGQEDAADLRAPLRAHPEDDAPLQE
HHCCCEEEEECCCCHHHHHCCCCEEEEEECEEEEEECCCCHHHHHCCHHCCCCCCCCHHH
AIRAAIARKPKGHDFDYSRQRLDGQMPRHMSHTGG
HHHHHHHCCCCCCCCCHHHHHHCCCCCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA