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The map label for this gene is glmS [H]

Identifier: 110680485

GI number: 110680485

Start: 3166295

End: 3168115

Strand: Direct

Name: glmS [H]

Synonym: RD1_3305

Alternate gene names: 110680485

Gene position: 3166295-3168115 (Clockwise)

Preceding gene: 110680484

Following gene: 110680486

Centisome position: 76.61

GC content: 59.47

Gene sequence:

>1821_bases
ATGTGTGGTATTGTTGGCGTTCTGAGCAAACATGAAGCAGCCCCCATCCTCGTTGACGCGCTCAAGAGGCTGGAATATCG
CGGCTACGACAGCGCAGGTATCGCTACCGTCAACGCAGGCAAGCTGGATCGCCGCCGCGCGGTCGGCAAACTGGTGAACC
TGTCGGACCTGCTGGTCCATGAACCGCTGGTCGGCAAATCAGGCATTGGCCATACCCGCTGGGCCACACATGGCGCGCCG
AGTGTGAGCAACGCGCACCCCCATCAGGCGGGACCAGTCGCGGTTGTGCACAACGGCATCATCGAGAATTTCCGCGAATT
GCGCGCGGAACTGGCCGAAAACGGCATGCAATTCGTGACCGAAACGGATACGGAAACGGTCGCCCTTTTGACGCAGCACT
TCATGGCCCAAGGTCTCGGCCCTGTCGATGCGGCCTTTCATGCGCTGGACAAGCTGCGCGGGGCCTTTGCGCTTGCCTTT
CTCTTTGACGGTGAGGACGATCTGATCGTCGCCGCGCGCAAGGGCTCACCGCTGGCAATCGGACATGGCGCGGGTGAGAT
GTTCATCGGCTCCGATGCGATTGCGCTGGCCCCGATGACCAACGAAATCACCTATCTGGAAGAAGGCGACCGCGCTGTGC
TCACACGCACCAGCCTGCAGATCACCGACGCTGCGGGAAACCCTGCAACCCGCGCAGTCAAGACCATCCAGATCGACAAC
ACCCGCATCGACAAGGCCGGTCACAAACACTTCATGGCCAAGGAAATCGCTGAGCAACCCGGGGTGATTGCGCAGGCTCT
GGGGCATTACATTTCCAGCGACGGGCAAATCATCCTGCCCAAACCCGACATTGATTTTACCGCCATCGACCGGTTGACAA
TGGTGGCCTGTGGCACGGCCTATTACGCCTGCCTGACGGCGAAATACTGGTTCGAGCAGATTGCGCGCATCCCGGTCGAA
GTGGATGTGGCCTCCGAATTTCGCTACCGCGAGCCGCCGATCCCGGCGCGCTCGGCTGCGCTGTTCGTCAGCCAGTCCGG
TGAAACTGCCGATACGCTGGCCGCCCTGCGCTACTGCGCCGGCAAGAGCGATACGATCCTGTCCGTGATCAACGTCCCCG
AAAGTTCCATCGCGCGGGAAAGCGATCTGGTGCTGCCGATCCATGCGGGTGTCGAGGTTGGCGTCGCTTCCACAAAAGCG
TTCACATGCCAACTGACGGTCTTGTTGCTTCTGGCGCTGCGTGCCGCGCAGGACCGCGGTGAGGTGGATGCCAAAACGCT
CGCACGGCATCTGTCCGATCTGCGCGATCTGCCCAATATCGTCAGCACGGCACTCGGGGCCAATGCCGAAATGCATCAGG
CCGCGATCAAGCTGTCCGAGGCCCGCGATGTACTGTTTCTGGGGCGCGGACTGATGTACCCGCTCGCATTGGAAGGGGCA
TTAAAATTAAAGGAAATCAGCTATATACATGCCGAAGCCTATGCAGCAGGTGAACTCAAACATGGCCCTATCGCGCTGAT
TGACAAACATGTGCCCGTGGTCGTGATGGCACCCCGCGATGCGCTGTTTGAAAAGACCGTCAGCAACATGCAGGAGGTGA
TGGCGCGCAAAGGGCGGGTCATCCTTGTATCTGACGCCACCGGTATTGAAGAGTTCGGACAAGAGGCTTTCGCAACGATT
GAAATGCCGCAGATTTCATCGGTTTTGACACCCATCCTATACGCGATACCCGCCCAACTGCTGGCCTATCACACCGCTGT
GGCCAAAGGAACGGATGTGGATCAACCACGCAACCTGGCAAAGTCGGTGACGGTCGAGTAG

Upstream 100 bases:

>100_bases
CCCTTTCGCGCGCCCCGCAAATCGAAAAACCCGGCATGGCGACAAAAATCATTAACTTGCTGAGGGCCAAAAAGGCCAAG
CAACAGAGAGGCAGCTGACC

Downstream 100 bases:

>100_bases
CAAATCCGGCGCGCAGGCGTGTCGCCGCCCCGCGCAGGGTGCGATTTCAAATCGCTGCGGCCCCGCAACAGCCTGCAAAG
CCCAGCGATGACCTGAAAAA

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 606; Mature: 606

Protein sequence:

>606_residues
MCGIVGVLSKHEAAPILVDALKRLEYRGYDSAGIATVNAGKLDRRRAVGKLVNLSDLLVHEPLVGKSGIGHTRWATHGAP
SVSNAHPHQAGPVAVVHNGIIENFRELRAELAENGMQFVTETDTETVALLTQHFMAQGLGPVDAAFHALDKLRGAFALAF
LFDGEDDLIVAARKGSPLAIGHGAGEMFIGSDAIALAPMTNEITYLEEGDRAVLTRTSLQITDAAGNPATRAVKTIQIDN
TRIDKAGHKHFMAKEIAEQPGVIAQALGHYISSDGQIILPKPDIDFTAIDRLTMVACGTAYYACLTAKYWFEQIARIPVE
VDVASEFRYREPPIPARSAALFVSQSGETADTLAALRYCAGKSDTILSVINVPESSIARESDLVLPIHAGVEVGVASTKA
FTCQLTVLLLLALRAAQDRGEVDAKTLARHLSDLRDLPNIVSTALGANAEMHQAAIKLSEARDVLFLGRGLMYPLALEGA
LKLKEISYIHAEAYAAGELKHGPIALIDKHVPVVVMAPRDALFEKTVSNMQEVMARKGRVILVSDATGIEEFGQEAFATI
EMPQISSVLTPILYAIPAQLLAYHTAVAKGTDVDQPRNLAKSVTVE

Sequences:

>Translated_606_residues
MCGIVGVLSKHEAAPILVDALKRLEYRGYDSAGIATVNAGKLDRRRAVGKLVNLSDLLVHEPLVGKSGIGHTRWATHGAP
SVSNAHPHQAGPVAVVHNGIIENFRELRAELAENGMQFVTETDTETVALLTQHFMAQGLGPVDAAFHALDKLRGAFALAF
LFDGEDDLIVAARKGSPLAIGHGAGEMFIGSDAIALAPMTNEITYLEEGDRAVLTRTSLQITDAAGNPATRAVKTIQIDN
TRIDKAGHKHFMAKEIAEQPGVIAQALGHYISSDGQIILPKPDIDFTAIDRLTMVACGTAYYACLTAKYWFEQIARIPVE
VDVASEFRYREPPIPARSAALFVSQSGETADTLAALRYCAGKSDTILSVINVPESSIARESDLVLPIHAGVEVGVASTKA
FTCQLTVLLLLALRAAQDRGEVDAKTLARHLSDLRDLPNIVSTALGANAEMHQAAIKLSEARDVLFLGRGLMYPLALEGA
LKLKEISYIHAEAYAAGELKHGPIALIDKHVPVVVMAPRDALFEKTVSNMQEVMARKGRVILVSDATGIEEFGQEAFATI
EMPQISSVLTPILYAIPAQLLAYHTAVAKGTDVDQPRNLAKSVTVE
>Mature_606_residues
MCGIVGVLSKHEAAPILVDALKRLEYRGYDSAGIATVNAGKLDRRRAVGKLVNLSDLLVHEPLVGKSGIGHTRWATHGAP
SVSNAHPHQAGPVAVVHNGIIENFRELRAELAENGMQFVTETDTETVALLTQHFMAQGLGPVDAAFHALDKLRGAFALAF
LFDGEDDLIVAARKGSPLAIGHGAGEMFIGSDAIALAPMTNEITYLEEGDRAVLTRTSLQITDAAGNPATRAVKTIQIDN
TRIDKAGHKHFMAKEIAEQPGVIAQALGHYISSDGQIILPKPDIDFTAIDRLTMVACGTAYYACLTAKYWFEQIARIPVE
VDVASEFRYREPPIPARSAALFVSQSGETADTLAALRYCAGKSDTILSVINVPESSIARESDLVLPIHAGVEVGVASTKA
FTCQLTVLLLLALRAAQDRGEVDAKTLARHLSDLRDLPNIVSTALGANAEMHQAAIKLSEARDVLFLGRGLMYPLALEGA
LKLKEISYIHAEAYAAGELKHGPIALIDKHVPVVVMAPRDALFEKTVSNMQEVMARKGRVILVSDATGIEEFGQEAFATI
EMPQISSVLTPILYAIPAQLLAYHTAVAKGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=688, Percent_Identity=36.7732558139535, Blast_Score=406, Evalue=1e-113,
Organism=Homo sapiens, GI205277386, Length=687, Percent_Identity=36.8267831149927, Blast_Score=401, Evalue=1e-112,
Organism=Escherichia coli, GI1790167, Length=614, Percent_Identity=48.8599348534202, Blast_Score=546, Evalue=1e-156,
Organism=Escherichia coli, GI1788651, Length=217, Percent_Identity=30.4147465437788, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI87082251, Length=321, Percent_Identity=23.6760124610592, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17539970, Length=428, Percent_Identity=39.2523364485981, Blast_Score=295, Evalue=4e-80,
Organism=Caenorhabditis elegans, GI17532897, Length=430, Percent_Identity=39.0697674418605, Blast_Score=295, Evalue=5e-80,
Organism=Caenorhabditis elegans, GI17532899, Length=430, Percent_Identity=39.0697674418605, Blast_Score=295, Evalue=5e-80,
Organism=Saccharomyces cerevisiae, GI6322745, Length=448, Percent_Identity=38.1696428571429, Blast_Score=293, Evalue=4e-80,
Organism=Saccharomyces cerevisiae, GI6323731, Length=432, Percent_Identity=31.0185185185185, Blast_Score=204, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=36.5853658536585, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21357745, Length=690, Percent_Identity=36.9565217391304, Blast_Score=410, Evalue=1e-114,
Organism=Drosophila melanogaster, GI28573187, Length=141, Percent_Identity=32.6241134751773, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24659598, Length=123, Percent_Identity=36.5853658536585, Blast_Score=66, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 64966; Mature: 64966

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGVLSKHEAAPILVDALKRLEYRGYDSAGIATVNAGKLDRRRAVGKLVNLSDLLVH
CCCCHHHHCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHCCHHHHHHC
EPLVGKSGIGHTRWATHGAPSVSNAHPHQAGPVAVVHNGIIENFRELRAELAENGMQFVT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCEEEE
ETDTETVALLTQHFMAQGLGPVDAAFHALDKLRGAFALAFLFDGEDDLIVAARKGSPLAI
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEEECCCCEEE
GHGAGEMFIGSDAIALAPMTNEITYLEEGDRAVLTRTSLQITDAAGNPATRAVKTIQIDN
ECCCCCEEECCCCEEEECCCCCEEEEECCCEEEEEEEEEEEEECCCCCHHHEEEEEEECC
TRIDKAGHKHFMAKEIAEQPGVIAQALGHYISSDGQIILPKPDIDFTAIDRLTMVACGTA
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHH
YYACLTAKYWFEQIARIPVEVDVASEFRYREPPIPARSAALFVSQSGETADTLAALRYCA
HHHHHHHHHHHHHHHCCCEEEEEHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHC
GKSDTILSVINVPESSIARESDLVLPIHAGVEVGVASTKAFTCQLTVLLLLALRAAQDRG
CCCCCEEEEEECCCHHHCCCCCEEEEEECCCEECCCCCCHHHHHHHHHHHHHHHHHCCCC
EVDAKTLARHLSDLRDLPNIVSTALGANAEMHQAAIKLSEARDVLFLGRGLMYPLALEGA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECCCCCCCHHHHCCC
LKLKEISYIHAEAYAAGELKHGPIALIDKHVPVVVMAPRDALFEKTVSNMQEVMARKGRV
HHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHCCCE
ILVSDATGIEEFGQEAFATIEMPQISSVLTPILYAIPAQLLAYHTAVAKGTDVDQPRNLA
EEEECCCCHHHHCHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
KSVTVE
HHCCCC
>Mature Secondary Structure
MCGIVGVLSKHEAAPILVDALKRLEYRGYDSAGIATVNAGKLDRRRAVGKLVNLSDLLVH
CCCCHHHHCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHCCHHHHHHC
EPLVGKSGIGHTRWATHGAPSVSNAHPHQAGPVAVVHNGIIENFRELRAELAENGMQFVT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCEEEE
ETDTETVALLTQHFMAQGLGPVDAAFHALDKLRGAFALAFLFDGEDDLIVAARKGSPLAI
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEEECCCCEEE
GHGAGEMFIGSDAIALAPMTNEITYLEEGDRAVLTRTSLQITDAAGNPATRAVKTIQIDN
ECCCCCEEECCCCEEEECCCCCEEEEECCCEEEEEEEEEEEEECCCCCHHHEEEEEEECC
TRIDKAGHKHFMAKEIAEQPGVIAQALGHYISSDGQIILPKPDIDFTAIDRLTMVACGTA
CCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHH
YYACLTAKYWFEQIARIPVEVDVASEFRYREPPIPARSAALFVSQSGETADTLAALRYCA
HHHHHHHHHHHHHHHCCCEEEEEHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHC
GKSDTILSVINVPESSIARESDLVLPIHAGVEVGVASTKAFTCQLTVLLLLALRAAQDRG
CCCCCEEEEEECCCHHHCCCCCEEEEEECCCEECCCCCCHHHHHHHHHHHHHHHHHCCCC
EVDAKTLARHLSDLRDLPNIVSTALGANAEMHQAAIKLSEARDVLFLGRGLMYPLALEGA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECCCCCCCHHHHCCC
LKLKEISYIHAEAYAAGELKHGPIALIDKHVPVVVMAPRDALFEKTVSNMQEVMARKGRV
HHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHCCCE
ILVSDATGIEEFGQEAFATIEMPQISSVLTPILYAIPAQLLAYHTAVAKGTDVDQPRNLA
EEEECCCCHHHHCHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
KSVTVE
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]