Click here to switch to the map view.

The map label for this gene is fabH

Identifier: 110680343

GI number: 110680343

Start: 3029430

End: 3030401

Strand: Direct

Name: fabH

Synonym: RD1_3156

Alternate gene names: 110680343

Gene position: 3029430-3030401 (Clockwise)

Preceding gene: 110680342

Following gene: 110680344

Centisome position: 73.3

GC content: 62.65

Gene sequence:

>972_bases
GTGACGCTGCGTGCCGTTGTAACGGGTGTCGGACATTACCTGCCCGACCGTATCGTGCCCAATTCCGAGTTCGAAAAGAC
GCTGGATACCAATGACGAATGGATTCGCGCACGCTCCGGCATTGAACGTCGGCATTTCGCCGCCGAGGGTGAGACAACCG
CGAGCATGGCCGCCGCCGCCAGCCGCGCCGCACTCAGCATGGCAGGGGCAGAGGCGCAGGATGTGGATGCGATCATCGTC
GCAACCTCGACGGCGGATCTGACCTTTCCCTCCGCGGCAACCATGGTGCAGGCCGAGCTTGGCATGACGCGCGGGTTTGC
CTTTGACGTGCAGGCCGTCTGCGCAGGCTTTGTCTTCGCGCTGAGCAATGCCAATGCGCTGATCCTCTCCGGTCAGGCCA
GACGGGTGCTGGTAATTGGTGCCGAGGCCTTCAGCCGCATCATGGACTGGACGGATCGCTCGACCTGCGTGCTCTTTGGC
GACGGCGCGGGCGCTGTGCTGCTCGAAGCGCAGGACGGCACGGGCACCTCTGCGGATCGTGGTATTCTGTCTACCGATCT
GAATTCCGACGGGCGACACAAGGATTTGCTCTATGTGGATGGCGGTGTCTCGACGGGCACGACCGGATATCTGCGCATGC
AGGGCAATCAGGTGTTCCGCCATGCGGTTGAAAAACTGGCCGCCACCGCGACCACAGCGCTTGAGCGCGCAGGCGTGAGC
GCGTCAGATGTGGACTGGGTCGTGCCGCATCAGGCGAACATCCGCATCATTCAGGGCACCGCCAAAAAACTTGGCGTGTC
CATGGATCGGGTCGTGGTCACCGTGCAGGATCACGGTAATACCTCTGCCGCATCGATTCCCCTTGCCCTGTCGGTGGGCC
ATGCACGCGGGCAGATCAAACAGGGCGATCTGGTGGTCACCGAAGCCATTGGCGGAGGATTGGCCTGGGGTGCGGTTGTC
CTGCGCTGGTAA

Upstream 100 bases:

>100_bases
TGTCATCCGCAATCAAACTCGCGGCACAACTGGCGCATATCCAGTTCACCGACAAACTTGCGGCCCGCGTTGCCGGTCTG
CCCGCAGAGGAGAAAACCCA

Downstream 100 bases:

>100_bases
AGCGGGTTATTTTCGCTCATCCGCCTTTGAGCAAGTCATTGATATTGACTCGTAAAAATGCATGGACGTACAGTCGCTGA
AAAAGAAAGGGACGGAGATG

Product: 3-oxoacyl-(acyl-carrier-protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MTLRAVVTGVGHYLPDRIVPNSEFEKTLDTNDEWIRARSGIERRHFAAEGETTASMAAAASRAALSMAGAEAQDVDAIIV
ATSTADLTFPSAATMVQAELGMTRGFAFDVQAVCAGFVFALSNANALILSGQARRVLVIGAEAFSRIMDWTDRSTCVLFG
DGAGAVLLEAQDGTGTSADRGILSTDLNSDGRHKDLLYVDGGVSTGTTGYLRMQGNQVFRHAVEKLAATATTALERAGVS
ASDVDWVVPHQANIRIIQGTAKKLGVSMDRVVVTVQDHGNTSAASIPLALSVGHARGQIKQGDLVVTEAIGGGLAWGAVV
LRW

Sequences:

>Translated_323_residues
MTLRAVVTGVGHYLPDRIVPNSEFEKTLDTNDEWIRARSGIERRHFAAEGETTASMAAAASRAALSMAGAEAQDVDAIIV
ATSTADLTFPSAATMVQAELGMTRGFAFDVQAVCAGFVFALSNANALILSGQARRVLVIGAEAFSRIMDWTDRSTCVLFG
DGAGAVLLEAQDGTGTSADRGILSTDLNSDGRHKDLLYVDGGVSTGTTGYLRMQGNQVFRHAVEKLAATATTALERAGVS
ASDVDWVVPHQANIRIIQGTAKKLGVSMDRVVVTVQDHGNTSAASIPLALSVGHARGQIKQGDLVVTEAIGGGLAWGAVV
LRW
>Mature_322_residues
TLRAVVTGVGHYLPDRIVPNSEFEKTLDTNDEWIRARSGIERRHFAAEGETTASMAAAASRAALSMAGAEAQDVDAIIVA
TSTADLTFPSAATMVQAELGMTRGFAFDVQAVCAGFVFALSNANALILSGQARRVLVIGAEAFSRIMDWTDRSTCVLFGD
GAGAVLLEAQDGTGTSADRGILSTDLNSDGRHKDLLYVDGGVSTGTTGYLRMQGNQVFRHAVEKLAATATTALERAGVSA
SDVDWVVPHQANIRIIQGTAKKLGVSMDRVVVTVQDHGNTSAASIPLALSVGHARGQIKQGDLVVTEAIGGGLAWGAVVL
RW

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=319, Percent_Identity=46.3949843260188, Blast_Score=281, Evalue=4e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_ROSDO (Q164C9)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_683350.1
- ProteinModelPortal:   Q164C9
- SMR:   Q164C9
- STRING:   Q164C9
- GeneID:   4198624
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_3156
- NMPDR:   fig|375451.6.peg.2931
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   ICATSTP
- PhylomeDB:   Q164C9
- ProtClustDB:   CLSK933877
- BioCyc:   RDEN375451:RD1_3156-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 33842; Mature: 33710

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: ACT_SITE 114-114 ACT_SITE 250-250 ACT_SITE 280-280

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRAVVTGVGHYLPDRIVPNSEFEKTLDTNDEWIRARSGIERRHFAAEGETTASMAAAA
CCHHHHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHCCCCHHHCCCCCCCHHHHHHHH
SRAALSMAGAEAQDVDAIIVATSTADLTFPSAATMVQAELGMTRGFAFDVQAVCAGFVFA
HHHHHHHCCCCCCCCCEEEEEECCCCEECCCHHHHHHHHHCCCCCCEEEHHHHHHHHHHE
LSNANALILSGQARRVLVIGAEAFSRIMDWTDRSTCVLFGDGAGAVLLEAQDGTGTSADR
ECCCCEEEEECCCCEEEEECHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCCCCCC
GILSTDLNSDGRHKDLLYVDGGVSTGTTGYLRMQGNQVFRHAVEKLAATATTALERAGVS
CEEEECCCCCCCCCEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCC
ASDVDWVVPHQANIRIIQGTAKKLGVSMDRVVVTVQDHGNTSAASIPLALSVGHARGQIK
CCCCEEECCCCCCEEEEECCHHHHCCCEEEEEEEEECCCCCCCEEEEEEEEECCCCCCCC
QGDLVVTEAIGGGLAWGAVVLRW
CCCEEEEECCCCCEEEEEEEEEC
>Mature Secondary Structure 
TLRAVVTGVGHYLPDRIVPNSEFEKTLDTNDEWIRARSGIERRHFAAEGETTASMAAAA
CHHHHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHCCCCHHHCCCCCCCHHHHHHHH
SRAALSMAGAEAQDVDAIIVATSTADLTFPSAATMVQAELGMTRGFAFDVQAVCAGFVFA
HHHHHHHCCCCCCCCCEEEEEECCCCEECCCHHHHHHHHHCCCCCCEEEHHHHHHHHHHE
LSNANALILSGQARRVLVIGAEAFSRIMDWTDRSTCVLFGDGAGAVLLEAQDGTGTSADR
ECCCCEEEEECCCCEEEEECHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCCCCCC
GILSTDLNSDGRHKDLLYVDGGVSTGTTGYLRMQGNQVFRHAVEKLAATATTALERAGVS
CEEEECCCCCCCCCEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCC
ASDVDWVVPHQANIRIIQGTAKKLGVSMDRVVVTVQDHGNTSAASIPLALSVGHARGQIK
CCCCEEECCCCCCEEEEECCHHHHCCCEEEEEEEEECCCCCCCEEEEEEEEECCCCCCCC
QGDLVVTEAIGGGLAWGAVVLRW
CCCEEEEECCCCCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA