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The map label for this gene is fabF [H]

Identifier: 110680228

GI number: 110680228

Start: 2907056

End: 2908315

Strand: Reverse

Name: fabF [H]

Synonym: RD1_3036

Alternate gene names: 110680228

Gene position: 2908315-2907056 (Counterclockwise)

Preceding gene: 110680229

Following gene: 110680227

Centisome position: 70.37

GC content: 59.92

Gene sequence:

>1260_bases
ATGCGCAGAGTAGTTGTCACAGGCTTGGGTTTGGTCACACCATTGGCTGATGGTGTCGAGGAGAGCTGGTCGAGAATTCT
TGCGGGGAAATCCGGCGCGGGTCCCATTACGGGATTTGATGCGAGCCGGTTGGTCACGCAATACGCCTGCGAAGTACCCC
TTGGCGACGGTTCGGACGGGACATTCAACGCGGATACCTATCTGCCCGCGAAAGAGCAGCGCAAGGTTGATACCTTTATT
CTTTTCGGGCTGGCAGCGGCGGAGCAGGCGGTCAGGGATGCCGGTTGGGCACCTGAGGATCAAGAAAGCTTGGAGCGTAC
CGGCGTGCTGATCGGATCGGGGATCGGCGGATTGAATTCCATCGCCAATACCGCGGTGATGATGGCGGAAAAAGGCCCGC
GCCGGGTGTCGCCGTTCTTTGTGCCGGGGGCGCTGATCAACCTGATTTCCGGTCAGGTCAGCATCAAATACGGCTTCAAG
GGGCCGAACCATTCGGTCGTAACGGCCTGTTCGACCGGTGCCCATGCGATTGGCGACGCGAGCCGTTTGATCCAGCACGG
AGATGCGGATGTGATGATTGCGGGTGGTGCGGAAGCGGCGATCTGCGAGATTGGTATTGCCGGTTTCAATGCCTGCAAGG
CACTGAGCACCAAACGCGGCGATGATCCGCAAAAGGCAAGCCGGCCTTATGACAAGGACCGCGACGGTTTCGTGATGGGC
GAGGGAGCCGGTATCGTTGTGCTGGAAGAGTATGAGCATGCCAAGGCGCGTGGTGCGAGGATCTATGCCGAAGTTCTGGG
CTATGGGTTGTCTGGTGATGCCTATCACATTACCGCCCCGTCAGAAGATGGGGAAGGCGGCGAGCGGTCGATGCGCAACG
CGCTGCGGGGGGCGGGTCTGGCGCCCAAGGATATTGACTACATCAACGCGCATGGGACGTCGACCATGGCCGATACGATC
GAGTTGGGCGCGGTGGAACGGATGATGGGGGAACATGCCGGGAAGGTGACGATGTCGTCGACGAAATCGGCAACCGGGCA
TCTTTTGGGCGCGGCCGGCGCGATCGAGGCGATCTTTTCGATCCTTGCCATTCGTGATCAGGTGGCACCGCCGACGATCA
ATCTGGACAACCCGGCGGTTGAGACGGCGATTGACCTTGCGCCCAATGCCAAGCGCCCGCGTGAAATCAACGTCGCCCTC
AGCAACTCATTCGGGTTTGGGGGCACGAATGCGAGTGTTCTGTTCGGGAAGACCGACTGA

Upstream 100 bases:

>100_bases
GCCACAATAACGGGTATGACCGGGGGCGGGGTGCCAAGAGCCCTTGCACAGAAACAACTGCTCAAGGTAAGGGGGAGCAG
ATTTACACGGGGGTATTGCC

Downstream 100 bases:

>100_bases
TGTGGCGGCATATCGCTTCTAATGCAGTGACGATGTTGATTGTGCTGCTGTTTCTGGTGGGCGGCGTCATTCTGTGGGGC
AAATCCCAATACGATGGTGC

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MRRVVVTGLGLVTPLADGVEESWSRILAGKSGAGPITGFDASRLVTQYACEVPLGDGSDGTFNADTYLPAKEQRKVDTFI
LFGLAAAEQAVRDAGWAPEDQESLERTGVLIGSGIGGLNSIANTAVMMAEKGPRRVSPFFVPGALINLISGQVSIKYGFK
GPNHSVVTACSTGAHAIGDASRLIQHGDADVMIAGGAEAAICEIGIAGFNACKALSTKRGDDPQKASRPYDKDRDGFVMG
EGAGIVVLEEYEHAKARGARIYAEVLGYGLSGDAYHITAPSEDGEGGERSMRNALRGAGLAPKDIDYINAHGTSTMADTI
ELGAVERMMGEHAGKVTMSSTKSATGHLLGAAGAIEAIFSILAIRDQVAPPTINLDNPAVETAIDLAPNAKRPREINVAL
SNSFGFGGTNASVLFGKTD

Sequences:

>Translated_419_residues
MRRVVVTGLGLVTPLADGVEESWSRILAGKSGAGPITGFDASRLVTQYACEVPLGDGSDGTFNADTYLPAKEQRKVDTFI
LFGLAAAEQAVRDAGWAPEDQESLERTGVLIGSGIGGLNSIANTAVMMAEKGPRRVSPFFVPGALINLISGQVSIKYGFK
GPNHSVVTACSTGAHAIGDASRLIQHGDADVMIAGGAEAAICEIGIAGFNACKALSTKRGDDPQKASRPYDKDRDGFVMG
EGAGIVVLEEYEHAKARGARIYAEVLGYGLSGDAYHITAPSEDGEGGERSMRNALRGAGLAPKDIDYINAHGTSTMADTI
ELGAVERMMGEHAGKVTMSSTKSATGHLLGAAGAIEAIFSILAIRDQVAPPTINLDNPAVETAIDLAPNAKRPREINVAL
SNSFGFGGTNASVLFGKTD
>Mature_419_residues
MRRVVVTGLGLVTPLADGVEESWSRILAGKSGAGPITGFDASRLVTQYACEVPLGDGSDGTFNADTYLPAKEQRKVDTFI
LFGLAAAEQAVRDAGWAPEDQESLERTGVLIGSGIGGLNSIANTAVMMAEKGPRRVSPFFVPGALINLISGQVSIKYGFK
GPNHSVVTACSTGAHAIGDASRLIQHGDADVMIAGGAEAAICEIGIAGFNACKALSTKRGDDPQKASRPYDKDRDGFVMG
EGAGIVVLEEYEHAKARGARIYAEVLGYGLSGDAYHITAPSEDGEGGERSMRNALRGAGLAPKDIDYINAHGTSTMADTI
ELGAVERMMGEHAGKVTMSSTKSATGHLLGAAGAIEAIFSILAIRDQVAPPTINLDNPAVETAIDLAPNAKRPREINVAL
SNSFGFGGTNASVLFGKTD

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=49.2788461538462, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI223972627, Length=188, Percent_Identity=43.6170212765958, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI41872631, Length=428, Percent_Identity=25, Blast_Score=102, Evalue=9e-22,
Organism=Escherichia coli, GI1787337, Length=418, Percent_Identity=50.7177033492823, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI1788663, Length=423, Percent_Identity=38.2978723404255, Blast_Score=250, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI71983541, Length=423, Percent_Identity=39.7163120567376, Blast_Score=264, Evalue=6e-71,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=43.7735849056604, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI212642053, Length=433, Percent_Identity=26.0969976905312, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17550940, Length=264, Percent_Identity=27.6515151515151, Blast_Score=92, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6320904, Length=443, Percent_Identity=39.7291196388262, Blast_Score=301, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24644341, Length=420, Percent_Identity=48.0952380952381, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI19920632, Length=356, Percent_Identity=26.123595505618, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI221330659, Length=356, Percent_Identity=26.123595505618, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24581345, Length=356, Percent_Identity=24.1573033707865, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43492; Mature: 43492

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGLGLVTPLADGVEESWSRILAGKSGAGPITGFDASRLVTQYACEVPLGDGSDG
CCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
TFNADTYLPAKEQRKVDTFILFGLAAAEQAVRDAGWAPEDQESLERTGVLIGSGIGGLNS
CCCCCCCCCCHHHCCHHHHEEHHHHHHHHHHHHCCCCCCCHHHHHHCCEEEECCCCCHHH
IANTAVMMAEKGPRRVSPFFVPGALINLISGQVSIKYGFKGPNHSVVTACSTGAHAIGDA
HHHHEEEEECCCCCCCCCEECCHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCHHHHHH
SRLIQHGDADVMIAGGAEAAICEIGIAGFNACKALSTKRGDDPQKASRPYDKDRDGFVMG
HHHHHCCCCCEEEECCCCEEEEEECCCCHHHHHHHHCCCCCCHHHHCCCCCCCCCCEEEE
EGAGIVVLEEYEHAKARGARIYAEVLGYGLSGDAYHITAPSEDGEGGERSMRNALRGAGL
CCCCEEEEECCCHHHHCCCEEEHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCC
APKDIDYINAHGTSTMADTIELGAVERMMGEHAGKVTMSSTKSATGHLLGAAGAIEAIFS
CCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHEEHHHHHHHHHH
ILAIRDQVAPPTINLDNPAVETAIDLAPNAKRPREINVALSNSFGFGGTNASVLFGKTD
HHHHHHHCCCCEECCCCCHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEECCC
>Mature Secondary Structure
MRRVVVTGLGLVTPLADGVEESWSRILAGKSGAGPITGFDASRLVTQYACEVPLGDGSDG
CCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
TFNADTYLPAKEQRKVDTFILFGLAAAEQAVRDAGWAPEDQESLERTGVLIGSGIGGLNS
CCCCCCCCCCHHHCCHHHHEEHHHHHHHHHHHHCCCCCCCHHHHHHCCEEEECCCCCHHH
IANTAVMMAEKGPRRVSPFFVPGALINLISGQVSIKYGFKGPNHSVVTACSTGAHAIGDA
HHHHEEEEECCCCCCCCCEECCHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCHHHHHH
SRLIQHGDADVMIAGGAEAAICEIGIAGFNACKALSTKRGDDPQKASRPYDKDRDGFVMG
HHHHHCCCCCEEEECCCCEEEEEECCCCHHHHHHHHCCCCCCHHHHCCCCCCCCCCEEEE
EGAGIVVLEEYEHAKARGARIYAEVLGYGLSGDAYHITAPSEDGEGGERSMRNALRGAGL
CCCCEEEEECCCHHHHCCCEEEHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCC
APKDIDYINAHGTSTMADTIELGAVERMMGEHAGKVTMSSTKSATGHLLGAAGAIEAIFS
CCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCHHEEHHHHHHHHHH
ILAIRDQVAPPTINLDNPAVETAIDLAPNAKRPREINVALSNSFGFGGTNASVLFGKTD
HHHHHHHCCCCEECCCCCHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]