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The map label for this gene is ppiB [H]

Identifier: 110680203

GI number: 110680203

Start: 2883787

End: 2884326

Strand: Reverse

Name: ppiB [H]

Synonym: RD1_3006

Alternate gene names: 110680203

Gene position: 2884326-2883787 (Counterclockwise)

Preceding gene: 110680204

Following gene: 110680202

Centisome position: 69.79

GC content: 61.11

Gene sequence:

>540_bases
ATGGCCACATTGGCCGCTGGACCTGCCATGGCGACGGGCATCGCGATCGAGGTCGCGGGCGAGGCCAACGGAACGATCAC
GATTGATCTGCTGGAGGATCTTGCCCCCGGCCATGTCGAGCGGATCACCATGCTCGCGGCCAGCGGTGCCTATGATGGTG
TGGTTTTTCACCGTGTCATTGACGGCTTCATGGCGCAGACCGGGGATGTCGAATTCGGCAAGATGGGCGGTGACATGCGG
CGCGCCGGCATGGGGGGGTCTGATCAGCCGGACCTGCCGCAGGAGTTTTCCGATGTGCCGTTTGACCGCGGTGTCGTGGG
CATGGCCCGGTCGCAAAATCCCAACAGCGCCAACAGTCAGTTTTTCATCATGTTCAGCGAAGGCTATTTTCTCAATGGCC
AATATACCGTGGTGGGTCGTGTGACTGACGGGCTTGAAGTGCTGGATGCAATCAAGCGCGGGCAGGGGCGCAACGGTGCC
GTGACCGGCCAGCCCGATGTGATGCAATCGGTACGCGTGATCGACGCGCCCACTGATTAA

Upstream 100 bases:

>100_bases
ATGGAACATGTGGACGCCATTACCCGGGGCGAGCCGCCTGCGGAGCCGGATCGCATGATCTCGGTGAAGGTTGCTGCCGA
TGTTTAAGGCAGCGGTATTC

Downstream 100 bases:

>100_bases
GTGACCATCGGTCACATCATGTGGCCGATCTGGAACGCAATTCGAGGGTCTCAACTGAGCAGTTTGCTCGGTTGAGACCC
TCAATAACCTGCCGCAGCTG

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin-type, putative

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 179; Mature: 178

Protein sequence:

>179_residues
MATLAAGPAMATGIAIEVAGEANGTITIDLLEDLAPGHVERITMLAASGAYDGVVFHRVIDGFMAQTGDVEFGKMGGDMR
RAGMGGSDQPDLPQEFSDVPFDRGVVGMARSQNPNSANSQFFIMFSEGYFLNGQYTVVGRVTDGLEVLDAIKRGQGRNGA
VTGQPDVMQSVRVIDAPTD

Sequences:

>Translated_179_residues
MATLAAGPAMATGIAIEVAGEANGTITIDLLEDLAPGHVERITMLAASGAYDGVVFHRVIDGFMAQTGDVEFGKMGGDMR
RAGMGGSDQPDLPQEFSDVPFDRGVVGMARSQNPNSANSQFFIMFSEGYFLNGQYTVVGRVTDGLEVLDAIKRGQGRNGA
VTGQPDVMQSVRVIDAPTD
>Mature_178_residues
ATLAAGPAMATGIAIEVAGEANGTITIDLLEDLAPGHVERITMLAASGAYDGVVFHRVIDGFMAQTGDVEFGKMGGDMRR
AGMGGSDQPDLPQEFSDVPFDRGVVGMARSQNPNSANSQFFIMFSEGYFLNGQYTVVGRVTDGLEVLDAIKRGQGRNGAV
TGQPDVMQSVRVIDAPTD

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=130, Percent_Identity=39.2307692307692, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI10863927, Length=157, Percent_Identity=31.8471337579618, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI24308049, Length=151, Percent_Identity=35.0993377483444, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI22547212, Length=138, Percent_Identity=31.8840579710145, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI7657473, Length=138, Percent_Identity=31.8840579710145, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI22547215, Length=138, Percent_Identity=31.8840579710145, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI310129267, Length=157, Percent_Identity=29.9363057324841, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI310120620, Length=157, Percent_Identity=29.9363057324841, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI310110104, Length=152, Percent_Identity=30.9210526315789, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310127646, Length=157, Percent_Identity=28.6624203821656, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI310114371, Length=157, Percent_Identity=28.6624203821656, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI310119221, Length=157, Percent_Identity=28.6624203821656, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI4505991, Length=151, Percent_Identity=33.112582781457, Blast_Score=64, Evalue=5e-11,
Organism=Escherichia coli, GI1786736, Length=157, Percent_Identity=33.7579617834395, Blast_Score=76, Evalue=1e-15,
Organism=Escherichia coli, GI1789763, Length=161, Percent_Identity=32.2981366459627, Blast_Score=67, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71980594, Length=154, Percent_Identity=35.0649350649351, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71980590, Length=132, Percent_Identity=37.8787878787879, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17506311, Length=132, Percent_Identity=37.8787878787879, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17559074, Length=161, Percent_Identity=32.2981366459627, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17566266, Length=162, Percent_Identity=31.4814814814815, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17539496, Length=136, Percent_Identity=33.0882352941176, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17565860, Length=160, Percent_Identity=30.625, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24652460, Length=133, Percent_Identity=38.3458646616541, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17986117, Length=129, Percent_Identity=36.4341085271318, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18817; Mature: 18686

Theoretical pI: Translated: 4.18; Mature: 4.18

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLAAGPAMATGIAIEVAGEANGTITIDLLEDLAPGHVERITMLAASGAYDGVVFHRVI
CCCCCCCCCHHCCEEEEEECCCCCEEEEEEHHHCCCCHHHEEEEEECCCCCCHHHHHHHH
DGFMAQTGDVEFGKMGGDMRRAGMGGSDQPDLPQEFSDVPFDRGVVGMARSQNPNSANSQ
HHHHHCCCCEEHHHCCCCHHHCCCCCCCCCCCCHHHHCCCCCCCEEEEECCCCCCCCCCE
FFIMFSEGYFLNGQYTVVGRVTDGLEVLDAIKRGQGRNGAVTGQPDVMQSVRVIDAPTD
EEEEECCCEEECCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCHHHHHHEEEEECCCC
>Mature Secondary Structure 
ATLAAGPAMATGIAIEVAGEANGTITIDLLEDLAPGHVERITMLAASGAYDGVVFHRVI
CCCCCCCCHHCCEEEEEECCCCCEEEEEEHHHCCCCHHHEEEEEECCCCCCHHHHHHHH
DGFMAQTGDVEFGKMGGDMRRAGMGGSDQPDLPQEFSDVPFDRGVVGMARSQNPNSANSQ
HHHHHCCCCEEHHHCCCCHHHCCCCCCCCCCCCHHHHCCCCCCCEEEEECCCCCCCCCCE
FFIMFSEGYFLNGQYTVVGRVTDGLEVLDAIKRGQGRNGAVTGQPDVMQSVRVIDAPTD
EEEEECCCEEECCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCHHHHHHEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA