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The map label for this gene is ppi [H]

Identifier: 110680204

GI number: 110680204

Start: 2884340

End: 2884846

Strand: Reverse

Name: ppi [H]

Synonym: RD1_3007

Alternate gene names: 110680204

Gene position: 2884846-2884340 (Counterclockwise)

Preceding gene: 110680210

Following gene: 110680203

Centisome position: 69.8

GC content: 59.57

Gene sequence:

>507_bases
ATGGCCGAAATTACCGACCCCGAAAACACGATCTTGATGGAGCTCAAAGGCGGGACCGTCACCATCCAGCTGCTGCCGGA
TGTCGCGCCCCAGCATGTCGCACGGATGAAAGAGCTGGCGCGTGCGGGCCATTATGACAACGTCGCCTTTCACCGGGTGA
TCGACGGTTTCATGGCGCAAACCGGCGATGTGCAGCATGGTGACATGGAAGATGGCTTCAATCTGCGCATGGCGGGCACC
GGCGGGTCCGATCTGCCGAATGTACCTGCGGAGTTTTCCAAAGTGCCCCATGCGCGCGGGTCGCTGGGCGCGGCGCGTTC
CTCCAACCCGGACAGCGCGAACAGCCAGTTCTTCATCAACTTCAAGGACAATGATTTCCTGAACGGTCAATACACGGTCT
ATGGTCAGGTGATCGAGGGGATGGAACATGTGGACGCCATTACCCGGGGCGAGCCGCCTGCGGAGCCGGATCGCATGATC
TCGGTGAAGGTTGCTGCCGATGTTTAA

Upstream 100 bases:

>100_bases
CCGTGTTTTGCGCTTATCGTCGCTGAGGTCAACCGAGCGGCTTGGCATTCCTGATCGCAGCGCGTAGGTAATTCGCAAAG
TTTTCAACAGGAGTGCCCAG

Downstream 100 bases:

>100_bases
GGCAGCGGTATTCATGGCCACATTGGCCGCTGGACCTGCCATGGCGACGGGCATCGCGATCGAGGTCGCGGGCGAGGCCA
ACGGAACGATCACGATTGAT

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin-type, putative

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 168; Mature: 167

Protein sequence:

>168_residues
MAEITDPENTILMELKGGTVTIQLLPDVAPQHVARMKELARAGHYDNVAFHRVIDGFMAQTGDVQHGDMEDGFNLRMAGT
GGSDLPNVPAEFSKVPHARGSLGAARSSNPDSANSQFFINFKDNDFLNGQYTVYGQVIEGMEHVDAITRGEPPAEPDRMI
SVKVAADV

Sequences:

>Translated_168_residues
MAEITDPENTILMELKGGTVTIQLLPDVAPQHVARMKELARAGHYDNVAFHRVIDGFMAQTGDVQHGDMEDGFNLRMAGT
GGSDLPNVPAEFSKVPHARGSLGAARSSNPDSANSQFFINFKDNDFLNGQYTVYGQVIEGMEHVDAITRGEPPAEPDRMI
SVKVAADV
>Mature_167_residues
AEITDPENTILMELKGGTVTIQLLPDVAPQHVARMKELARAGHYDNVAFHRVIDGFMAQTGDVQHGDMEDGFNLRMAGTG
GSDLPNVPAEFSKVPHARGSLGAARSSNPDSANSQFFINFKDNDFLNGQYTVYGQVIEGMEHVDAITRGEPPAEPDRMIS
VKVAADV

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI4505991, Length=135, Percent_Identity=34.0740740740741, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI7706339, Length=140, Percent_Identity=27.8571428571429, Blast_Score=68, Evalue=4e-12,
Organism=Escherichia coli, GI1786736, Length=138, Percent_Identity=36.231884057971, Blast_Score=85, Evalue=2e-18,
Organism=Escherichia coli, GI1789763, Length=181, Percent_Identity=33.7016574585635, Blast_Score=83, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71980590, Length=142, Percent_Identity=31.6901408450704, Blast_Score=73, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71980594, Length=142, Percent_Identity=31.6901408450704, Blast_Score=73, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17552780, Length=163, Percent_Identity=32.5153374233129, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17539498, Length=157, Percent_Identity=28.0254777070064, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17551284, Length=141, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17551282, Length=159, Percent_Identity=31.4465408805031, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17506311, Length=157, Percent_Identity=29.9363057324841, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17559074, Length=159, Percent_Identity=28.3018867924528, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17539496, Length=153, Percent_Identity=25.4901960784314, Blast_Score=62, Evalue=9e-11,
Organism=Drosophila melanogaster, GI17986117, Length=186, Percent_Identity=30.1075268817204, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17136360, Length=135, Percent_Identity=32.5925925925926, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI20130249, Length=135, Percent_Identity=31.8518518518519, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18184; Mature: 18052

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEITDPENTILMELKGGTVTIQLLPDVAPQHVARMKELARAGHYDNVAFHRVIDGFMAQ
CCCCCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
TGDVQHGDMEDGFNLRMAGTGGSDLPNVPAEFSKVPHARGSLGAARSSNPDSANSQFFIN
CCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEE
FKDNDFLNGQYTVYGQVIEGMEHVDAITRGEPPAEPDRMISVKVAADV
ECCCCEECCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECC
>Mature Secondary Structure 
AEITDPENTILMELKGGTVTIQLLPDVAPQHVARMKELARAGHYDNVAFHRVIDGFMAQ
CCCCCCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
TGDVQHGDMEDGFNLRMAGTGGSDLPNVPAEFSKVPHARGSLGAARSSNPDSANSQFFIN
CCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEE
FKDNDFLNGQYTVYGQVIEGMEHVDAITRGEPPAEPDRMISVKVAADV
ECCCCEECCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA