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The map label for this gene is pdhB [H]

Identifier: 110680127

GI number: 110680127

Start: 2801326

End: 2803515

Strand: Reverse

Name: pdhB [H]

Synonym: RD1_2926

Alternate gene names: 110680127

Gene position: 2803515-2801326 (Counterclockwise)

Preceding gene: 110680128

Following gene: 110680126

Centisome position: 67.83

GC content: 63.33

Gene sequence:

>2190_bases
ATGGATCGTGCTGGGATCGTTCACGAGACCTTTCTGAAACGCGTCGCAGCGCATGATTTCCCGCAAGGACCCGCCGCGCG
GCGCGATGTGTCACCGGAAAAGATGGTCGAGATTTTCCGCGCGCAATGCCTGTCGCGCCAGCTCGACAGGACCAGCCGCG
CGATGCAAAAGGCCGGGCAGGGGTATTACACCATCGGCTCCAGCGGGCACGAGGGCATGGCGGCGGTTGCTGAAAGCCTG
CGCCCCACGGACATGGCTTTTCTGCACTACCGTGACGCCGCTTTTCAGATCCAGCGCGCGGCACAGGTGCCGGGGCAGAC
ACCCGCATGGGACATCCTGCTGAGCTTTGCCGCATCGCGCGATGATCCGATCTCTGGCGGGCGGCACAAGGTCTTGGGCT
CCAAGACGCTCAACATCCCGCCGCAGACCTCGACGATTGCAAGCCACCTGCCCAAGGCGATGGGGGTCGCCTATTCGATT
GGTCTGGCGCGTCGTCTGAAACCTGACCATTCCACGCTGCCCTATGATGCGGTGGTCATGTGTTCATTTGGCGATGCATC
GGCCAATCATTCCACGGCGCAGGGCGCAATCAACGCCGCCTGCTGGAGCAGTTATCAATCCGTACCCATGCCGCTGCTGC
TGGTCTGCGAAGACAATGGCATCGGCATTTCCACCCCAACACCCGAGGGGTGGATCGCGGCCAATTTTGCGCACCGTCCG
GGCCTGCGCTATTTCGCCTGCAATGGTCTGGATATGACCGAGACCCTCGCTGTTGCGGGGGCTGCGGCGGCATATGTGCG
GCGCCACCGCAAGCCTGCGTTTCTGCATCTGCGCACCGTGCGTCTTTATGGGCACGCCGGGTCAGATGTGGAGGCGACCT
ATCGCAGCCCGCAGGCGATTGCGGCGGATGAAGCCAATGACCCCCTGTTGCACAGCGTCCGCCTGATGCACGAGCGCGCG
GCCTGCGCACCGCAAGACGCGCTCGCCATCTATAATGAGGCAGACGCCGCCTGCACACGTATCGCGGCGCAAGCGGTGAC
GCGGCCGCGCCTGAAAACCCGCGAAGACGTCGCCGCCAGCCTGATCCCGCCCGCGCGGCAGGTCGTGCCAAGCAACGGGC
CGGATGCCAGCGAACGCCAGACATTGTTTGGCAGCGACATGCGCGCCATGACAGAGCCGCAGCCCATGGGGCGGCTGATC
AGCTGGGCGCTTGCGGATCTGATGCATGCACATAAGGAAATCATCGTCGCGGGAGAGGACGTCGGGCGCAAGGGCGGCGT
TTACGGTGCGACGCAAAAGCTGCAAGCGCGATTTGGCCCGGATCGGGTCATTGATACGCTGCTGGACGAACAGTCCATTC
TGGGCCTCGCATTGGGGCTGGCGCATAACGGTTTCATCCCGATCCCGGAAATCCAGTTCCTTGCCTATCTGCACAATGCA
GAGGATCAACTGCGCGGTGAGGCAGCGACGCTCAGCTTCTTTTCAAATGGGCAGTTTACCAACCCGATGGTGCTGCGGAT
CGCGGGGCTTGGGTATCAAAAAGGCTTTGGAGGGCATTTCCACAACGACAACAGCCTTGCCGTTCTGCGCGACATTCCGG
GGCTTGTGATCGCATGTCCGTCCAATGGGGCGGATGCCGCGATGATGCTGCGCGAGGCGGTGCGGCTGGCGCGCGAAGAA
CAGCGCGTGGTGGTCTTTATCGAGCCGATCGCACTTTACCCGATGCGCGACCTGCACGTGGCGGGTGACGGCGGATGGCT
GCACCACTACCCGGCACCGGATCAGCGGATCGCCCTTGGCGATGTGGGCGTGGCGGGGGATGGCACGGATATCGCGCTGG
TTTCCTATGGCAACGGGCGGTATCTGTCTGAACAGGCAGCCGCAATATTGGTAGATCAAGGCATTGCGGCCCGGGTCGTG
GACATCCGCTGGCTGGCCCCGCAGCCCGATGCGGCGATCCTTGCGGCCACGCAGGATTGTGCGTCGGTGCTTATCGTTGA
TGAGTGCCGCCGCACGGGCAGTCAGTCCGAGGCCTTGCTGAGCCTCTTTGCCGAATCGGGGCGGACCCGGGTGGCGCGGC
TCACAGCAGAGGATTGTTTTATCGCAACCGGGCCTGCCTATGCGGCGACGCTGCCTTCGGTCGAGGGGATCGTGTCTGCG
GCACTCGAACTGGCGCAGGGTGCATCATGA

Upstream 100 bases:

>100_bases
AGCGCTGTTTTCAGAACCTGCCATGCATGGACAATCGCCTCGAATCCCAGCAGGGTCTGCGCGGCAAAAACCGCCTGAAG
CCCGAACTGAGGATCAAAAG

Downstream 100 bases:

>100_bases
GCAAAACCGCCGTTGTGATTTGCCCCGGTCGCGGCACCTATACGAAATCCGAACTGGGATACCTTGCGCGCCATCACGGT
GACGCCATGGCGCACCTCGC

Product: pyruvate dehydrogenase E1 component, beta subunit, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 729; Mature: 729

Protein sequence:

>729_residues
MDRAGIVHETFLKRVAAHDFPQGPAARRDVSPEKMVEIFRAQCLSRQLDRTSRAMQKAGQGYYTIGSSGHEGMAAVAESL
RPTDMAFLHYRDAAFQIQRAAQVPGQTPAWDILLSFAASRDDPISGGRHKVLGSKTLNIPPQTSTIASHLPKAMGVAYSI
GLARRLKPDHSTLPYDAVVMCSFGDASANHSTAQGAINAACWSSYQSVPMPLLLVCEDNGIGISTPTPEGWIAANFAHRP
GLRYFACNGLDMTETLAVAGAAAAYVRRHRKPAFLHLRTVRLYGHAGSDVEATYRSPQAIAADEANDPLLHSVRLMHERA
ACAPQDALAIYNEADAACTRIAAQAVTRPRLKTREDVAASLIPPARQVVPSNGPDASERQTLFGSDMRAMTEPQPMGRLI
SWALADLMHAHKEIIVAGEDVGRKGGVYGATQKLQARFGPDRVIDTLLDEQSILGLALGLAHNGFIPIPEIQFLAYLHNA
EDQLRGEAATLSFFSNGQFTNPMVLRIAGLGYQKGFGGHFHNDNSLAVLRDIPGLVIACPSNGADAAMMLREAVRLAREE
QRVVVFIEPIALYPMRDLHVAGDGGWLHHYPAPDQRIALGDVGVAGDGTDIALVSYGNGRYLSEQAAAILVDQGIAARVV
DIRWLAPQPDAAILAATQDCASVLIVDECRRTGSQSEALLSLFAESGRTRVARLTAEDCFIATGPAYAATLPSVEGIVSA
ALELAQGAS

Sequences:

>Translated_729_residues
MDRAGIVHETFLKRVAAHDFPQGPAARRDVSPEKMVEIFRAQCLSRQLDRTSRAMQKAGQGYYTIGSSGHEGMAAVAESL
RPTDMAFLHYRDAAFQIQRAAQVPGQTPAWDILLSFAASRDDPISGGRHKVLGSKTLNIPPQTSTIASHLPKAMGVAYSI
GLARRLKPDHSTLPYDAVVMCSFGDASANHSTAQGAINAACWSSYQSVPMPLLLVCEDNGIGISTPTPEGWIAANFAHRP
GLRYFACNGLDMTETLAVAGAAAAYVRRHRKPAFLHLRTVRLYGHAGSDVEATYRSPQAIAADEANDPLLHSVRLMHERA
ACAPQDALAIYNEADAACTRIAAQAVTRPRLKTREDVAASLIPPARQVVPSNGPDASERQTLFGSDMRAMTEPQPMGRLI
SWALADLMHAHKEIIVAGEDVGRKGGVYGATQKLQARFGPDRVIDTLLDEQSILGLALGLAHNGFIPIPEIQFLAYLHNA
EDQLRGEAATLSFFSNGQFTNPMVLRIAGLGYQKGFGGHFHNDNSLAVLRDIPGLVIACPSNGADAAMMLREAVRLAREE
QRVVVFIEPIALYPMRDLHVAGDGGWLHHYPAPDQRIALGDVGVAGDGTDIALVSYGNGRYLSEQAAAILVDQGIAARVV
DIRWLAPQPDAAILAATQDCASVLIVDECRRTGSQSEALLSLFAESGRTRVARLTAEDCFIATGPAYAATLPSVEGIVSA
ALELAQGAS
>Mature_729_residues
MDRAGIVHETFLKRVAAHDFPQGPAARRDVSPEKMVEIFRAQCLSRQLDRTSRAMQKAGQGYYTIGSSGHEGMAAVAESL
RPTDMAFLHYRDAAFQIQRAAQVPGQTPAWDILLSFAASRDDPISGGRHKVLGSKTLNIPPQTSTIASHLPKAMGVAYSI
GLARRLKPDHSTLPYDAVVMCSFGDASANHSTAQGAINAACWSSYQSVPMPLLLVCEDNGIGISTPTPEGWIAANFAHRP
GLRYFACNGLDMTETLAVAGAAAAYVRRHRKPAFLHLRTVRLYGHAGSDVEATYRSPQAIAADEANDPLLHSVRLMHERA
ACAPQDALAIYNEADAACTRIAAQAVTRPRLKTREDVAASLIPPARQVVPSNGPDASERQTLFGSDMRAMTEPQPMGRLI
SWALADLMHAHKEIIVAGEDVGRKGGVYGATQKLQARFGPDRVIDTLLDEQSILGLALGLAHNGFIPIPEIQFLAYLHNA
EDQLRGEAATLSFFSNGQFTNPMVLRIAGLGYQKGFGGHFHNDNSLAVLRDIPGLVIACPSNGADAAMMLREAVRLAREE
QRVVVFIEPIALYPMRDLHVAGDGGWLHHYPAPDQRIALGDVGVAGDGTDIALVSYGNGRYLSEQAAAILVDQGIAARVV
DIRWLAPQPDAAILAATQDCASVLIVDECRRTGSQSEALLSLFAESGRTRVARLTAEDCFIATGPAYAATLPSVEGIVSA
ALELAQGAS

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=333, Percent_Identity=27.027027027027, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI34101272, Length=333, Percent_Identity=27.027027027027, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI156564403, Length=272, Percent_Identity=25.3676470588235, Blast_Score=84, Evalue=6e-16,
Organism=Homo sapiens, GI258645172, Length=304, Percent_Identity=25.3289473684211, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI11386135, Length=305, Percent_Identity=25.2459016393443, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI291084858, Length=272, Percent_Identity=23.8970588235294, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI4505685, Length=310, Percent_Identity=22.258064516129, Blast_Score=68, Evalue=4e-11,
Organism=Homo sapiens, GI291084742, Length=310, Percent_Identity=22.258064516129, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17538422, Length=257, Percent_Identity=28.4046692607004, Blast_Score=90, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17506935, Length=270, Percent_Identity=28.5185185185185, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI86563357, Length=324, Percent_Identity=24.3827160493827, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI86563355, Length=324, Percent_Identity=24.3827160493827, Blast_Score=76, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319698, Length=269, Percent_Identity=27.5092936802974, Blast_Score=94, Evalue=9e-20,
Organism=Drosophila melanogaster, GI21358145, Length=298, Percent_Identity=27.5167785234899, Blast_Score=93, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24650940, Length=298, Percent_Identity=27.5167785234899, Blast_Score=93, Evalue=7e-19,
Organism=Drosophila melanogaster, GI21355903, Length=289, Percent_Identity=26.643598615917, Blast_Score=91, Evalue=4e-18,
Organism=Drosophila melanogaster, GI160714832, Length=293, Percent_Identity=26.962457337884, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI160714828, Length=293, Percent_Identity=26.962457337884, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 78147; Mature: 78147

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRAGIVHETFLKRVAAHDFPQGPAARRDVSPEKMVEIFRAQCLSRQLDRTSRAMQKAGQ
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GYYTIGSSGHEGMAAVAESLRPTDMAFLHYRDAAFQIQRAAQVPGQTPAWDILLSFAASR
CEEEECCCCCCHHHHHHHHCCCCCEEEEEECHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
DDPISGGRHKVLGSKTLNIPPQTSTIASHLPKAMGVAYSIGLARRLKPDHSTLPYDAVVM
CCCCCCCCEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEE
CSFGDASANHSTAQGAINAACWSSYQSVPMPLLLVCEDNGIGISTPTPEGWIAANFAHRP
EECCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCEECCCCCCCCCEEECCCCCC
GLRYFACNGLDMTETLAVAGAAAAYVRRHRKPAFLHLRTVRLYGHAGSDVEATYRSPQAI
CCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCHHHCCCCCEE
AADEANDPLLHSVRLMHERAACAPQDALAIYNEADAACTRIAAQAVTRPRLKTREDVAAS
ECCCCCCHHHHHHHHHHHHHCCCCCHHHEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHH
LIPPARQVVPSNGPDASERQTLFGSDMRAMTEPQPMGRLISWALADLMHAHKEIIVAGED
CCCCHHHHCCCCCCCCHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHCCEEEEECCC
VGRKGGVYGATQKLQARFGPDRVIDTLLDEQSILGLALGLAHNGFIPIPEIQFLAYLHNA
CCCCCCCCCCHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCC
EDQLRGEAATLSFFSNGQFTNPMVLRIAGLGYQKGFGGHFHNDNSLAVLRDIPGLVIACP
HHHHCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEEECC
SNGADAAMMLREAVRLAREEQRVVVFIEPIALYPMRDLHVAGDGGWLHHYPAPDQRIALG
CCCCHHHHHHHHHHHHHHCCCEEEEEEECCEECCCCEEEEECCCCEECCCCCCCCEEEEE
DVGVAGDGTDIALVSYGNGRYLSEQAAAILVDQGIAARVVDIRWLAPQPDAAILAATQDC
CCCCCCCCCCEEEEECCCCCEECHHHHEEEECCCCEEEEEEEEEECCCCCCEEEEECHHH
ASVLIVDECRRTGSQSEALLSLFAESGRTRVARLTAEDCFIATGPAYAATLPSVEGIVSA
HHEEEHHHHHCCCCHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCHHHHCCCHHHHHHH
ALELAQGAS
HHHHHCCCC
>Mature Secondary Structure
MDRAGIVHETFLKRVAAHDFPQGPAARRDVSPEKMVEIFRAQCLSRQLDRTSRAMQKAGQ
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GYYTIGSSGHEGMAAVAESLRPTDMAFLHYRDAAFQIQRAAQVPGQTPAWDILLSFAASR
CEEEECCCCCCHHHHHHHHCCCCCEEEEEECHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
DDPISGGRHKVLGSKTLNIPPQTSTIASHLPKAMGVAYSIGLARRLKPDHSTLPYDAVVM
CCCCCCCCEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEE
CSFGDASANHSTAQGAINAACWSSYQSVPMPLLLVCEDNGIGISTPTPEGWIAANFAHRP
EECCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCEECCCCCCCCCEEECCCCCC
GLRYFACNGLDMTETLAVAGAAAAYVRRHRKPAFLHLRTVRLYGHAGSDVEATYRSPQAI
CCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCHHHCCCCCEE
AADEANDPLLHSVRLMHERAACAPQDALAIYNEADAACTRIAAQAVTRPRLKTREDVAAS
ECCCCCCHHHHHHHHHHHHHCCCCCHHHEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHH
LIPPARQVVPSNGPDASERQTLFGSDMRAMTEPQPMGRLISWALADLMHAHKEIIVAGED
CCCCHHHHCCCCCCCCHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHCCEEEEECCC
VGRKGGVYGATQKLQARFGPDRVIDTLLDEQSILGLALGLAHNGFIPIPEIQFLAYLHNA
CCCCCCCCCCHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCC
EDQLRGEAATLSFFSNGQFTNPMVLRIAGLGYQKGFGGHFHNDNSLAVLRDIPGLVIACP
HHHHCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEEECC
SNGADAAMMLREAVRLAREEQRVVVFIEPIALYPMRDLHVAGDGGWLHHYPAPDQRIALG
CCCCHHHHHHHHHHHHHHCCCEEEEEEECCEECCCCEEEEECCCCEECCCCCCCCEEEEE
DVGVAGDGTDIALVSYGNGRYLSEQAAAILVDQGIAARVVDIRWLAPQPDAAILAATQDC
CCCCCCCCCCEEEEECCCCCEECHHHHEEEECCCCEEEEEEEEEECCCCCCEEEEECHHH
ASVLIVDECRRTGSQSEALLSLFAESGRTRVARLTAEDCFIATGPAYAATLPSVEGIVSA
HHEEEHHHHHCCCCHHHHHHHHHHHCCCCEEEEEECCCEEEECCCCHHHHCCCHHHHHHH
ALELAQGAS
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2200674; 2253629 [H]