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The map label for this gene is clpP [H]

Identifier: 110680063

GI number: 110680063

Start: 2726839

End: 2727465

Strand: Reverse

Name: clpP [H]

Synonym: RD1_2858

Alternate gene names: 110680063

Gene position: 2727465-2726839 (Counterclockwise)

Preceding gene: 110680065

Following gene: 110680062

Centisome position: 65.99

GC content: 55.18

Gene sequence:

>627_bases
ATGAAAGATCCGATTGAAACCTACATGAACCTTGTTCCCATGGTCGTGGAGCAAACCAGCAGGGGCGAGCGTGCATATGA
CATTTTCTCACGCCTCCTGAAGGAGCGGATCATCTTTCTGAACGGCCCTGTGCATGACGGCATGTCGTCGCTGATCGTGG
CGCAGCTTTTGCATCTTGAGGCAGAAAACCCGGCCAAAGAGATATCCATGTATATCAACAGCCCCGGCGGTGTCGTGACC
TCTGGGTTGTCGATCTATGACACGATGCAATACATCAAACCCAAGGTGTCGACCCTTGTGATCGGACAGGCGGCCTCGAT
GGGGTCCCTGCTGCTGACTGCGGGCGAGGCGGGCATGCGCTTTTCTCTGCCCAACAGCCGTGTGATGGTCCACCAGCCAT
CGGGCGGATATCAGGGGCAGGCGACCGACATCATGATCCACGCGGCCGAGACGCAGAAACTCAAGGACCGCCTGAACGAA
ATTTATGTCAAGCACACGGGTCAGACCATGAAGAAGGTCGTCGACGCGTTGGAGCGGGACAATTTCATGTCCCCGGAAGA
GGCGAAAGAGTTTGGCCTGATCGACGAGATTGTTGAAAATCGCAGCAAAGATGATGCCGAAACGTAA

Upstream 100 bases:

>100_bases
TTGTGCAGCCCCCCTTGCGGCTCCTGCGCGCCAACACTAATGTTCTGTCAACCGTTCGCAGGTATGGTCCTGACAACGAC
GCAGCAGACAGGCATTCCAC

Downstream 100 bases:

>100_bases
CGAGGCATTTGCCTGACGGCCCGTTTACCATTTAGCGATTGTGGACGGGCTGGGGCTGGCCTAAACTGATACTAAGGATG
GAGGGCGCACCAGATCGCTG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MKDPIETYMNLVPMVVEQTSRGERAYDIFSRLLKERIIFLNGPVHDGMSSLIVAQLLHLEAENPAKEISMYINSPGGVVT
SGLSIYDTMQYIKPKVSTLVIGQAASMGSLLLTAGEAGMRFSLPNSRVMVHQPSGGYQGQATDIMIHAAETQKLKDRLNE
IYVKHTGQTMKKVVDALERDNFMSPEEAKEFGLIDEIVENRSKDDAET

Sequences:

>Translated_208_residues
MKDPIETYMNLVPMVVEQTSRGERAYDIFSRLLKERIIFLNGPVHDGMSSLIVAQLLHLEAENPAKEISMYINSPGGVVT
SGLSIYDTMQYIKPKVSTLVIGQAASMGSLLLTAGEAGMRFSLPNSRVMVHQPSGGYQGQATDIMIHAAETQKLKDRLNE
IYVKHTGQTMKKVVDALERDNFMSPEEAKEFGLIDEIVENRSKDDAET
>Mature_208_residues
MKDPIETYMNLVPMVVEQTSRGERAYDIFSRLLKERIIFLNGPVHDGMSSLIVAQLLHLEAENPAKEISMYINSPGGVVT
SGLSIYDTMQYIKPKVSTLVIGQAASMGSLLLTAGEAGMRFSLPNSRVMVHQPSGGYQGQATDIMIHAAETQKLKDRLNE
IYVKHTGQTMKKVVDALERDNFMSPEEAKEFGLIDEIVENRSKDDAET

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=196, Percent_Identity=60.7142857142857, Blast_Score=258, Evalue=4e-69,
Organism=Escherichia coli, GI1786641, Length=201, Percent_Identity=64.1791044776119, Blast_Score=277, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=59.6774193548387, Blast_Score=234, Evalue=2e-62,
Organism=Drosophila melanogaster, GI20129427, Length=200, Percent_Identity=63.5, Blast_Score=271, Evalue=3e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23079; Mature: 23079

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDPIETYMNLVPMVVEQTSRGERAYDIFSRLLKERIIFLNGPVHDGMSSLIVAQLLHLE
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHC
AENPAKEISMYINSPGGVVTSGLSIYDTMQYIKPKVSTLVIGQAASMGSLLLTAGEAGMR
CCCCHHHEEEEECCCCCHHHCCHHHHHHHHHHCCHHHHEEEECCCCCCCEEEECCCCCEE
FSLPNSRVMVHQPSGGYQGQATDIMIHAAETQKLKDRLNEIYVKHTGQTMKKVVDALERD
EECCCCEEEEECCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHC
NFMSPEEAKEFGLIDEIVENRSKDDAET
CCCCHHHHHHHCHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKDPIETYMNLVPMVVEQTSRGERAYDIFSRLLKERIIFLNGPVHDGMSSLIVAQLLHLE
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHC
AENPAKEISMYINSPGGVVTSGLSIYDTMQYIKPKVSTLVIGQAASMGSLLLTAGEAGMR
CCCCHHHEEEEECCCCCHHHCCHHHHHHHHHHCCHHHHEEEECCCCCCCEEEECCCCCEE
FSLPNSRVMVHQPSGGYQGQATDIMIHAAETQKLKDRLNEIYVKHTGQTMKKVVDALERD
EECCCCEEEEECCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHC
NFMSPEEAKEFGLIDEIVENRSKDDAET
CCCCHHHHHHHCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA