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The map label for this gene is hemB [H]

Identifier: 110679960

GI number: 110679960

Start: 2620395

End: 2621393

Strand: Direct

Name: hemB [H]

Synonym: RD1_2749

Alternate gene names: 110679960

Gene position: 2620395-2621393 (Clockwise)

Preceding gene: 110679957

Following gene: 110679961

Centisome position: 63.4

GC content: 61.46

Gene sequence:

>999_bases
ATGCGCCCGACACAAGCCCCCTTTCCCGCCACCCGTCTGCGCCGCCTGCGCCAAAGCCCGGCCATCCGTGCTTTGACGCG
GCAGAACACGCTTACGGTGGATGATTTTATCTGGCCGGTTTTCGTGCGCGCCGGTGAGGGGATCAAGGAGGAGATCCCCT
CGATGCCGGGTGTCTTTCGCCGGTCGGTCGATCAACTGGTGGAGGCTGCGCGCGAGGCGGCAGATCTGGGCATCCCCGCG
ATCTGCATCTTTCCCTATACCGGCATAGAAGAGCGTACAGAGGATTGCGCGGGCGCGTGGGATCCGGAAAACCACGTCAA
TCGGGCCATCCGCGCCATCAAACAGGCGGTGCCGGATATTGCGGTGATGACCGATGTGGCGCTGGATACCTATAACATCA
ACGGGCATGACGGCTTTGTCGAAAACGGAGAGATCGTCAACGACCGCACGGTCGAGGCGCTGGTCAAGATGACGCTGGCG
CAGGCTGAGGCGGGCGCGGATATCATCGGCCCGTCGGATATGATGGATGGGCGGATCGGTGCGATGCGCGAAGGACTTGA
AGCGGCGGGGCATCAGCGGGTCATGATCCTGAGCTATTCGGCGAAATATGCCTCCGCCTTTTACGGACCCTTCCGCGATG
CGGTGGGGGCATCCGGTGCCTTGAGCGGTGACAAGAAGACCTACCAGATGGACCCCGGCAATTCCGATGAAGCCCTGCGT
CTGATCGAACGCGATCTGCGCGAAGGGGCGGATATGGTCATGGTCAAACCCGGCATGCCCTATCTCGACATCTGCCGCCG
GGTCAAAGATGCCTTTGGGGCGCCGACCTATGCCTATCAGGTGTCGGGCGAATACGCGATGATCCAGAGTGCGGCGGCCA
ATGGCTGGATCGACGGGGACAAGGTCATGATGGAAAGCCTGATGGCGTTCAAACGCGCGGGCTGTGATGGCATTCTGACC
TATTTTGCCCCGGCAGCGGCACGTATCCTCAACCCGTAG

Upstream 100 bases:

>100_bases
TCTTTCGGCACTCTTAGCGGGGCAATGTGGCAATTCCTAGCCTTGGCTTGGGGAAAAATACGTGGCAATCAGGATGTGTA
ACACAAAATGGACATTTGCG

Downstream 100 bases:

>100_bases
CGAATTGCCGCTGAACACACCGCTTGCGCGTGACTTTGGTCTGCAATGCGCGTATTGTCCCGCATAAGTCGGGCAAACCG
GCAGCAGAGCAATCAGATAC

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MRPTQAPFPATRLRRLRQSPAIRALTRQNTLTVDDFIWPVFVRAGEGIKEEIPSMPGVFRRSVDQLVEAAREAADLGIPA
ICIFPYTGIEERTEDCAGAWDPENHVNRAIRAIKQAVPDIAVMTDVALDTYNINGHDGFVENGEIVNDRTVEALVKMTLA
QAEAGADIIGPSDMMDGRIGAMREGLEAAGHQRVMILSYSAKYASAFYGPFRDAVGASGALSGDKKTYQMDPGNSDEALR
LIERDLREGADMVMVKPGMPYLDICRRVKDAFGAPTYAYQVSGEYAMIQSAAANGWIDGDKVMMESLMAFKRAGCDGILT
YFAPAAARILNP

Sequences:

>Translated_332_residues
MRPTQAPFPATRLRRLRQSPAIRALTRQNTLTVDDFIWPVFVRAGEGIKEEIPSMPGVFRRSVDQLVEAAREAADLGIPA
ICIFPYTGIEERTEDCAGAWDPENHVNRAIRAIKQAVPDIAVMTDVALDTYNINGHDGFVENGEIVNDRTVEALVKMTLA
QAEAGADIIGPSDMMDGRIGAMREGLEAAGHQRVMILSYSAKYASAFYGPFRDAVGASGALSGDKKTYQMDPGNSDEALR
LIERDLREGADMVMVKPGMPYLDICRRVKDAFGAPTYAYQVSGEYAMIQSAAANGWIDGDKVMMESLMAFKRAGCDGILT
YFAPAAARILNP
>Mature_332_residues
MRPTQAPFPATRLRRLRQSPAIRALTRQNTLTVDDFIWPVFVRAGEGIKEEIPSMPGVFRRSVDQLVEAAREAADLGIPA
ICIFPYTGIEERTEDCAGAWDPENHVNRAIRAIKQAVPDIAVMTDVALDTYNINGHDGFVENGEIVNDRTVEALVKMTLA
QAEAGADIIGPSDMMDGRIGAMREGLEAAGHQRVMILSYSAKYASAFYGPFRDAVGASGALSGDKKTYQMDPGNSDEALR
LIERDLREGADMVMVKPGMPYLDICRRVKDAFGAPTYAYQVSGEYAMIQSAAANGWIDGDKVMMESLMAFKRAGCDGILT
YFAPAAARILNP

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=316, Percent_Identity=42.0886075949367, Blast_Score=232, Evalue=4e-61,
Organism=Escherichia coli, GI87081728, Length=313, Percent_Identity=44.7284345047923, Blast_Score=243, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6321398, Length=312, Percent_Identity=36.8589743589744, Blast_Score=186, Evalue=4e-48,
Organism=Drosophila melanogaster, GI21358291, Length=291, Percent_Identity=37.8006872852234, Blast_Score=214, Evalue=6e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36233; Mature: 36233

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPTQAPFPATRLRRLRQSPAIRALTRQNTLTVDDFIWPVFVRAGEGIKEEIPSMPGVFR
CCCCCCCCCHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHCCCCCHHHH
RSVDQLVEAAREAADLGIPAICIFPYTGIEERTEDCAGAWDPENHVNRAIRAIKQAVPDI
HHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCH
AVMTDVALDTYNINGHDGFVENGEIVNDRTVEALVKMTLAQAEAGADIIGPSDMMDGRIG
HHHHHHHHEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCHHH
AMREGLEAAGHQRVMILSYSAKYASAFYGPFRDAVGASGALSGDKKTYQMDPGNSDEALR
HHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHH
LIERDLREGADMVMVKPGMPYLDICRRVKDAFGAPTYAYQVSGEYAMIQSAAANGWIDGD
HHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCCCHH
KVMMESLMAFKRAGCDGILTYFAPAAARILNP
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRPTQAPFPATRLRRLRQSPAIRALTRQNTLTVDDFIWPVFVRAGEGIKEEIPSMPGVFR
CCCCCCCCCHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHCCCCCHHHH
RSVDQLVEAAREAADLGIPAICIFPYTGIEERTEDCAGAWDPENHVNRAIRAIKQAVPDI
HHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCH
AVMTDVALDTYNINGHDGFVENGEIVNDRTVEALVKMTLAQAEAGADIIGPSDMMDGRIG
HHHHHHHHEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCHHH
AMREGLEAAGHQRVMILSYSAKYASAFYGPFRDAVGASGALSGDKKTYQMDPGNSDEALR
HHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHH
LIERDLREGADMVMVKPGMPYLDICRRVKDAFGAPTYAYQVSGEYAMIQSAAANGWIDGD
HHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHCCCCCCHH
KVMMESLMAFKRAGCDGILTYFAPAAARILNP
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7784513 [H]