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The map label for this gene is bcr [H]

Identifier: 110679957

GI number: 110679957

Start: 2615032

End: 2616252

Strand: Direct

Name: bcr [H]

Synonym: RD1_2745

Alternate gene names: 110679957

Gene position: 2615032-2616252 (Clockwise)

Preceding gene: 110679956

Following gene: 110679960

Centisome position: 63.27

GC content: 58.31

Gene sequence:

>1221_bases
TTGACGCAGACGACGCGCCATCTGCCCATTGCACGGGCTGAATTCATTGCCCTGATGGCGATGATGTTTGCGACAATCGC
TTTTTCGATTGATGCGATGCTGCCTGCGATGCCGGATATTGCAACGCAACTGACGCCGCTGGAGCCGACACGCGCCACGT
TGATCATCACGTCCTTTGTGCTTGGTATGGGGATCGGCACGTTCTTTGCCGGGCCGCTGTCGGATGCTTTCGGGCGGCGA
AACATCATGTTTCTGGGTGCCGGTCTTTATATTGCCGCTGCGGCTGTGGCCTGGGCCAGCCAGTCCCTCGAATTGATGTT
GATTGCCCGCGTGTTTCAGGGAATCGGCGCGTCAGGCCCGCGCGTGGTCTGCATTGCGATCGTGCGCGATCTCTTCTCGG
GGCGCGAAATGGCGCGGATCCTGTCGATCGTCATGATCATCTTCACCATTGTGCCAGCCTTTGCGCCCGCCATGGGCGTT
GTTATCATCCACGTTGCCGGCTGGCGCAGTATTTTTCTGGCCTTTGTCATATTCTCACTGATCTCGGCGGTGTGGTTGGG
CCTGCGCCTGCCCGAGACCTTGCCGGTGGAAAACAGACGCCCGCTGAAAATAGCGCTGATTGTGGATGCCGTGCGGCAAA
TGCTGCAACACCCGGTCGTGCGCATCTCGATCATGGTTCAAACACTTTCCATGGCCATGCTGTTTTCGCTACTGATGCTG
ATACAACCGGTTTACCAGTTTGTGTTCGACAAGCTTGAAACCTTCCCCTTCTGGTTCGGTGCCATTGCGCTGTCCTCGGC
GCTTTCCAGTTTTCTGAACGCCATGTTGGTCGTGCGTTTTGGCATGCGCCGCCTGATCACCATCGGTCTGGCCATGCAGA
TTGGTCTGTCAACGCTCGTTCTGATGACCAGTGGGAGCGCTGCCGGTCAGGGCTTTGCCGTTTTTGCGATCTGGCAGGCG
TTTGTGTTCTTTCAGGCCGGACTGTCCATTGGCAACCTCAATGCCATCGCGATGGAACCGATGGGCCATATCGCGGGCAT
GGCCGCGAGTGTGATCGGCGCGATTTCGACCGTGCTGGCCGCTGTGATCGCCTCGCCCGTCGGTCTGTTGTTTGACGGCA
CGATCAGACCGCTGGTTGGCACCATTTTGGTGCTGGCGCTGCTGGCCTTCCTGCTGATGATGTATATGGCGCGGGTTGAG
GCGCGCGCGCAAAGCGCCTAG

Upstream 100 bases:

>100_bases
GCCACACCAAGTGGCGATTGAAGAGGGTTCAACTCTAGGTTATGTCTGACGCCAAGTAGCGCCAAATTATGAACGCGCAG
AGTGAGACAAGGCCGGAAAC

Downstream 100 bases:

>100_bases
CCCGCCTTTGCTTTCTTGCGCTTTTTCTCGGCGATGACCTTTTCGGCGAGATCGCGCGCGATGGCAAACGCGCCTTTGAT
CTTGTCGGCATCCGCTTTCC

Product: MFS permease protein, putative

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MTQTTRHLPIARAEFIALMAMMFATIAFSIDAMLPAMPDIATQLTPLEPTRATLIITSFVLGMGIGTFFAGPLSDAFGRR
NIMFLGAGLYIAAAAVAWASQSLELMLIARVFQGIGASGPRVVCIAIVRDLFSGREMARILSIVMIIFTIVPAFAPAMGV
VIIHVAGWRSIFLAFVIFSLISAVWLGLRLPETLPVENRRPLKIALIVDAVRQMLQHPVVRISIMVQTLSMAMLFSLLML
IQPVYQFVFDKLETFPFWFGAIALSSALSSFLNAMLVVRFGMRRLITIGLAMQIGLSTLVLMTSGSAAGQGFAVFAIWQA
FVFFQAGLSIGNLNAIAMEPMGHIAGMAASVIGAISTVLAAVIASPVGLLFDGTIRPLVGTILVLALLAFLLMMYMARVE
ARAQSA

Sequences:

>Translated_406_residues
MTQTTRHLPIARAEFIALMAMMFATIAFSIDAMLPAMPDIATQLTPLEPTRATLIITSFVLGMGIGTFFAGPLSDAFGRR
NIMFLGAGLYIAAAAVAWASQSLELMLIARVFQGIGASGPRVVCIAIVRDLFSGREMARILSIVMIIFTIVPAFAPAMGV
VIIHVAGWRSIFLAFVIFSLISAVWLGLRLPETLPVENRRPLKIALIVDAVRQMLQHPVVRISIMVQTLSMAMLFSLLML
IQPVYQFVFDKLETFPFWFGAIALSSALSSFLNAMLVVRFGMRRLITIGLAMQIGLSTLVLMTSGSAAGQGFAVFAIWQA
FVFFQAGLSIGNLNAIAMEPMGHIAGMAASVIGAISTVLAAVIASPVGLLFDGTIRPLVGTILVLALLAFLLMMYMARVE
ARAQSA
>Mature_405_residues
TQTTRHLPIARAEFIALMAMMFATIAFSIDAMLPAMPDIATQLTPLEPTRATLIITSFVLGMGIGTFFAGPLSDAFGRRN
IMFLGAGLYIAAAAVAWASQSLELMLIARVFQGIGASGPRVVCIAIVRDLFSGREMARILSIVMIIFTIVPAFAPAMGVV
IIHVAGWRSIFLAFVIFSLISAVWLGLRLPETLPVENRRPLKIALIVDAVRQMLQHPVVRISIMVQTLSMAMLFSLLMLI
QPVYQFVFDKLETFPFWFGAIALSSALSSFLNAMLVVRFGMRRLITIGLAMQIGLSTLVLMTSGSAAGQGFAVFAIWQAF
VFFQAGLSIGNLNAIAMEPMGHIAGMAASVIGAISTVLAAVIASPVGLLFDGTIRPLVGTILVLALLAFLLMMYMARVEA
RAQSA

Specific function: Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=401, Percent_Identity=25.6857855361596, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1790146, Length=145, Percent_Identity=33.7931034482759, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI87082312, Length=173, Percent_Identity=28.9017341040462, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI48994889, Length=144, Percent_Identity=28.4722222222222, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43680; Mature: 43548

Theoretical pI: Translated: 11.38; Mature: 11.38

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.7 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.4 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQTTRHLPIARAEFIALMAMMFATIAFSIDAMLPAMPDIATQLTPLEPTRATLIITSFV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHH
LGMGIGTFFAGPLSDAFGRRNIMFLGAGLYIAAAAVAWASQSLELMLIARVFQGIGASGP
HHHHHHHHHCCHHHHHCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
RVVCIAIVRDLFSGREMARILSIVMIIFTIVPAFAPAMGVVIIHVAGWRSIFLAFVIFSL
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISAVWLGLRLPETLPVENRRPLKIALIVDAVRQMLQHPVVRISIMVQTLSMAMLFSLLML
HHHHHHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
IQPVYQFVFDKLETFPFWFGAIALSSALSSFLNAMLVVRFGMRRLITIGLAMQIGLSTLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LMTSGSAAGQGFAVFAIWQAFVFFQAGLSIGNLNAIAMEPMGHIAGMAASVIGAISTVLA
HEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHH
AVIASPVGLLFDGTIRPLVGTILVLALLAFLLMMYMARVEARAQSA
HHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]