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The map label for this gene is guaB [H]

Identifier: 110679931

GI number: 110679931

Start: 2585222

End: 2586670

Strand: Reverse

Name: guaB [H]

Synonym: RD1_2713

Alternate gene names: 110679931

Gene position: 2586670-2585222 (Counterclockwise)

Preceding gene: 110679935

Following gene: 110679930

Centisome position: 62.58

GC content: 63.77

Gene sequence:

>1449_bases
ATGGAGATTCGTGAGGCTCTGACCTTTGATGATGTATTGCTGGTGCCCGGTGCGTCCTCGGTGCTGCCATCGACGGCGGA
CACGCGCACCCGTGTCACGCGCAGCATTGCCATGAACATCCCGCTGCTCAGCTCTGCCATGGATACGGTGACCGAGGCGC
GCATGGCGATCGCGATGGCGCAGGCGGGCGGTATCGGTGTTGTCCACCGCAACCTTTCCGTTGAGGAACAGGCGCAGGAA
GTCCGGCGCGTCAAACGGTTCGAAAGCGGCATCGTCTACAACCCAATCACCCTGCGCCCCGAACAGACACTGGCCGATGC
CAAGGCGCTGCAGGAGCGATACCGCGTGACCGGCTTTCCGGTGGTGGACGAGAAGGGGCGCGTTCTGGGCATTGTCACAA
ATCGCGACATGCGCTTTGCCAGCGATGACCGCACGCCCGTCTCCGTGATGATGTCGGCCGAAAACCTCGCCATCCTGACT
GAACCTGCAGACCGTGAAGAGGCGATCAGCCTGATGAAATCCCGGCGCATCGAAAAGCTGCTGGTGACCGATGGGGAGGG
CAAGCTGACGGGCTTGCTCACCCTGAAAGACACCGAACAGGCGGTGCTGAACCCCACTGCCTGCAAGGATGAATTGGGCC
GCCTGCGTGTCGCCGCTGCCACCACGGTGGGGGATGCAGGGTTTGAACGCTCCGAGGCGCTGGTGGATGCGGGGGCGGAC
ATGATCGTGATCGACACCGCGCATGGCCATTCCGAGGGTGTCGCGGCGGCGGTCCGGCGCGCCAAGAGCCTCAGCAATGA
AGTACAGATCGTGGCGGGCAATGTCGCAACCGGCGAGGCCACCCGCGCGCTGATCGACGCGGGGGCGGATGCGGTCAAGG
TCGGGATCGGTCCGGGGTCGATCTGCACCACGCGCATGGTTGCAGGTGTCGGGGTGCCGCAACTTACCGCCATTATTGAT
TGCGCCGCCGCTGCCGGGGACGTGCCGGTCATCGCGGACGGGGGCATCAAGTTTTCGGGCGATTTTGCCAAGGCGATTGC
GGCGGGGGCTTCCTGCGCCATGGTCGGCAGCATGATCGCGGGCACCGACGAAAGCCCCGGCGAGGTGATCCTCTATCAGG
GGCGCAGCTTCAAAAGCTATCGCGGGATGGGCAGTCTTGGCGCCATGGCCAGCGGGTCGGCAGACCGGTATTTCCAGAAA
GACGCCGCGAGCGACAAGCTCGTCCCCGAAGGGATCGAAGGGCAGGTGGCCTACAAAGGGTCGGCCGGTGCCGTCATTCA
CCAACTCGTGGGTGGGCTGCGTGCGGCCATGGGCTATACGGGCTGTGCGACCGTCGACGAGATGCGCAGCAATTGCACAT
TCGTCAAGATCACCGGGGCGGGCCTCAAGGAAAGCCATGTTCATGATGTGCAGATCACGCGCGAAAGCCCGAATTATCGG
GTTGGCTAG

Upstream 100 bases:

>100_bases
ACCCGCATATGGGGTTGCGGAAAAATTTGCCCCTTTTCATTCTGCGGGACCCGTGAAATAGGAAACTGCCAAGTGAAACG
CTCCGATTGCGAGGTATGCC

Downstream 100 bases:

>100_bases
TCACGCCCCCGGTCTGAAGGAGAGGGCGCAATGACACCCGCCGCGCGCATTGCTGCCGCCATCGAGATTCTGGATGTGAT
CGCGCAAGGGGCCGCCGCCG

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MEIREALTFDDVLLVPGASSVLPSTADTRTRVTRSIAMNIPLLSSAMDTVTEARMAIAMAQAGGIGVVHRNLSVEEQAQE
VRRVKRFESGIVYNPITLRPEQTLADAKALQERYRVTGFPVVDEKGRVLGIVTNRDMRFASDDRTPVSVMMSAENLAILT
EPADREEAISLMKSRRIEKLLVTDGEGKLTGLLTLKDTEQAVLNPTACKDELGRLRVAAATTVGDAGFERSEALVDAGAD
MIVIDTAHGHSEGVAAAVRRAKSLSNEVQIVAGNVATGEATRALIDAGADAVKVGIGPGSICTTRMVAGVGVPQLTAIID
CAAAAGDVPVIADGGIKFSGDFAKAIAAGASCAMVGSMIAGTDESPGEVILYQGRSFKSYRGMGSLGAMASGSADRYFQK
DAASDKLVPEGIEGQVAYKGSAGAVIHQLVGGLRAAMGYTGCATVDEMRSNCTFVKITGAGLKESHVHDVQITRESPNYR
VG

Sequences:

>Translated_482_residues
MEIREALTFDDVLLVPGASSVLPSTADTRTRVTRSIAMNIPLLSSAMDTVTEARMAIAMAQAGGIGVVHRNLSVEEQAQE
VRRVKRFESGIVYNPITLRPEQTLADAKALQERYRVTGFPVVDEKGRVLGIVTNRDMRFASDDRTPVSVMMSAENLAILT
EPADREEAISLMKSRRIEKLLVTDGEGKLTGLLTLKDTEQAVLNPTACKDELGRLRVAAATTVGDAGFERSEALVDAGAD
MIVIDTAHGHSEGVAAAVRRAKSLSNEVQIVAGNVATGEATRALIDAGADAVKVGIGPGSICTTRMVAGVGVPQLTAIID
CAAAAGDVPVIADGGIKFSGDFAKAIAAGASCAMVGSMIAGTDESPGEVILYQGRSFKSYRGMGSLGAMASGSADRYFQK
DAASDKLVPEGIEGQVAYKGSAGAVIHQLVGGLRAAMGYTGCATVDEMRSNCTFVKITGAGLKESHVHDVQITRESPNYR
VG
>Mature_482_residues
MEIREALTFDDVLLVPGASSVLPSTADTRTRVTRSIAMNIPLLSSAMDTVTEARMAIAMAQAGGIGVVHRNLSVEEQAQE
VRRVKRFESGIVYNPITLRPEQTLADAKALQERYRVTGFPVVDEKGRVLGIVTNRDMRFASDDRTPVSVMMSAENLAILT
EPADREEAISLMKSRRIEKLLVTDGEGKLTGLLTLKDTEQAVLNPTACKDELGRLRVAAATTVGDAGFERSEALVDAGAD
MIVIDTAHGHSEGVAAAVRRAKSLSNEVQIVAGNVATGEATRALIDAGADAVKVGIGPGSICTTRMVAGVGVPQLTAIID
CAAAAGDVPVIADGGIKFSGDFAKAIAAGASCAMVGSMIAGTDESPGEVILYQGRSFKSYRGMGSLGAMASGSADRYFQK
DAASDKLVPEGIEGQVAYKGSAGAVIHQLVGGLRAAMGYTGCATVDEMRSNCTFVKITGAGLKESHVHDVQITRESPNYR
VG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=457, Percent_Identity=36.980306345733, Blast_Score=277, Evalue=2e-74,
Organism=Homo sapiens, GI34328928, Length=483, Percent_Identity=36.231884057971, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI156616279, Length=483, Percent_Identity=36.231884057971, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI34328930, Length=483, Percent_Identity=36.231884057971, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI66933016, Length=483, Percent_Identity=34.9896480331263, Blast_Score=275, Evalue=5e-74,
Organism=Homo sapiens, GI217035152, Length=477, Percent_Identity=36.2683438155136, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI217035148, Length=457, Percent_Identity=36.1050328227571, Blast_Score=263, Evalue=4e-70,
Organism=Homo sapiens, GI217035150, Length=480, Percent_Identity=33.5416666666667, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=38.4615384615385, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=38.4615384615385, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=38.4615384615385, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI50541956, Length=247, Percent_Identity=38.4615384615385, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI156104880, Length=247, Percent_Identity=38.0566801619433, Blast_Score=157, Evalue=3e-38,
Organism=Escherichia coli, GI1788855, Length=482, Percent_Identity=60.3734439834025, Blast_Score=556, Evalue=1e-159,
Organism=Escherichia coli, GI1786293, Length=262, Percent_Identity=36.6412213740458, Blast_Score=155, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI71994385, Length=479, Percent_Identity=36.5344467640919, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI71994389, Length=427, Percent_Identity=37.9391100702576, Blast_Score=242, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI17560440, Length=238, Percent_Identity=38.655462184874, Blast_Score=166, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6322012, Length=487, Percent_Identity=36.5503080082135, Blast_Score=300, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6323585, Length=460, Percent_Identity=37.3913043478261, Blast_Score=300, Evalue=4e-82,
Organism=Saccharomyces cerevisiae, GI6323464, Length=493, Percent_Identity=36.5111561866126, Blast_Score=292, Evalue=8e-80,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=36.8421052631579, Blast_Score=223, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6319353, Length=115, Percent_Identity=40.8695652173913, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24641071, Length=482, Percent_Identity=35.6846473029046, Blast_Score=279, Evalue=3e-75,
Organism=Drosophila melanogaster, GI24641073, Length=482, Percent_Identity=35.6846473029046, Blast_Score=279, Evalue=3e-75,
Organism=Drosophila melanogaster, GI28571163, Length=440, Percent_Identity=35.9090909090909, Blast_Score=249, Evalue=4e-66,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 50474; Mature: 50474

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIREALTFDDVLLVPGASSVLPSTADTRTRVTRSIAMNIPLLSSAMDTVTEARMAIAMA
CCHHHHCCCCCEEEECCCHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
QAGGIGVVHRNLSVEEQAQEVRRVKRFESGIVYNPITLRPEQTLADAKALQERYRVTGFP
CCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEECCEEECCHHHHHHHHHHHHHHCCCCCC
VVDEKGRVLGIVTNRDMRFASDDRTPVSVMMSAENLAILTEPADREEAISLMKSRRIEKL
EECCCCCEEEEEECCCCEECCCCCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHCCEEE
LVTDGEGKLTGLLTLKDTEQAVLNPTACKDELGRLRVAAATTVGDAGFERSEALVDAGAD
EEECCCCCEEEEEEECCCHHHHCCCCHHHHHHCCEEEEEEEECCCCCCCHHHHHHHCCCC
MIVIDTAHGHSEGVAAAVRRAKSLSNEVQIVAGNVATGEATRALIDAGADAVKVGIGPGS
EEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCC
ICTTRMVAGVGVPQLTAIIDCAAAAGDVPVIADGGIKFSGDFAKAIAAGASCAMVGSMIA
HHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEECCCEEECCHHHHHHHCCCHHHHHHHHHC
GTDESPGEVILYQGRSFKSYRGMGSLGAMASGSADRYFQKDAASDKLVPEGIEGQVAYKG
CCCCCCCCEEEECCCCCHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCEEEECC
SAGAVIHQLVGGLRAAMGYTGCATVDEMRSNCTFVKITGAGLKESHVHDVQITRESPNYR
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEEECCCCCCCCCEEEEEEECCCCCC
VG
CC
>Mature Secondary Structure
MEIREALTFDDVLLVPGASSVLPSTADTRTRVTRSIAMNIPLLSSAMDTVTEARMAIAMA
CCHHHHCCCCCEEEECCCHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
QAGGIGVVHRNLSVEEQAQEVRRVKRFESGIVYNPITLRPEQTLADAKALQERYRVTGFP
CCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEECCEEECCHHHHHHHHHHHHHHCCCCCC
VVDEKGRVLGIVTNRDMRFASDDRTPVSVMMSAENLAILTEPADREEAISLMKSRRIEKL
EECCCCCEEEEEECCCCEECCCCCCCEEEEEECCCEEEEECCCCHHHHHHHHHHHCCEEE
LVTDGEGKLTGLLTLKDTEQAVLNPTACKDELGRLRVAAATTVGDAGFERSEALVDAGAD
EEECCCCCEEEEEEECCCHHHHCCCCHHHHHHCCEEEEEEEECCCCCCCHHHHHHHCCCC
MIVIDTAHGHSEGVAAAVRRAKSLSNEVQIVAGNVATGEATRALIDAGADAVKVGIGPGS
EEEEECCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCC
ICTTRMVAGVGVPQLTAIIDCAAAAGDVPVIADGGIKFSGDFAKAIAAGASCAMVGSMIA
HHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEECCCEEECCHHHHHHHCCCHHHHHHHHHC
GTDESPGEVILYQGRSFKSYRGMGSLGAMASGSADRYFQKDAASDKLVPEGIEGQVAYKG
CCCCCCCCEEEECCCCCHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCEEEECC
SAGAVIHQLVGGLRAAMGYTGCATVDEMRSNCTFVKITGAGLKESHVHDVQITRESPNYR
CCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEEECCCCCCCCCEEEEEEECCCCCC
VG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]