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The map label for this gene is icd [H]

Identifier: 110679922

GI number: 110679922

Start: 2573354

End: 2574568

Strand: Direct

Name: icd [H]

Synonym: RD1_2704

Alternate gene names: 110679922

Gene position: 2573354-2574568 (Clockwise)

Preceding gene: 110679921

Following gene: 110679924

Centisome position: 62.26

GC content: 55.88

Gene sequence:

>1215_bases
GTGACGAAGATCAAAGTGCAAAACCCCGTTGTGGAACTCGATGGGGATGAAATGACCCGCATTATCTGGGATTTCATCAA
GCAGAAATTGATCCTGCCCTATCTGGATATTGATCTGAAATACTATGATCTGGGTATGGAATCCCGCGATGCCACGGACG
ATCAGATCACCGTGGATGCAGCCCATGCGATCAAGGAACACGGTGTCGGTGTCAAATGCGCGACGATCACGCCGGATGAA
GCCCGCGTCGAAGAGTTCGGCCTGAAACAGATGTGGCGCTCGCCCAATGGCACGATCCGCAACATTCTGGGCGGGGTGAT
CTTTCGCCAGCCGATCATTTGCCGGAACGTGCCGCGCCTCGTGCCCGGGTGGACAAAACCCATCGTTGTGGGGCGTCACG
CCTATGGCGATCAATACCGCGCGACAGATTTCAAATTTCCCGGCAAGGGCAAGCTGACCCTCAAATTTGTCGGTGAAGAC
GGCACGGAGATTGAGCGCGAGGTCTTTGACGCGCCCGACAGCGGTGTTGTGATGGCGATGTACAACCTCGACAAATCCAT
CATCGATTTTGCGCGCGCATCCTTCAATTATGGCCTCACTCTGGGCTGGCCCGTCTATCTGTCCACGAAAAACACCATTC
TGAAACAATATGACGGGCGGTTCCTCGAACTCTTCGCGCAGGTTTTCGAGGCGGAATTCAAGGAGAAATTCGACGCCGCC
GGTATCTGGTACGAACACCGCCTGATTGATGACATGGTCGCCTCTGCCATGAAGTGGTCGGGTGGATATGTCTGGGCCTG
CAAGAATTATGATGGCGATGTGCAGTCGGACACGGTTGCGCAGGGCTTTGGATCACTGGGGCTGATGGCATCGGTGTTGA
TGACACCGGACGGACAGGTCGTCGAATCCGAAGCCGCGCATGGCACCGTCACCCGCCATTATCGCCAGCACCAGAAAGGC
GAAGCGACCTCGACCAATTCCATTGCCTCGATCTATGCCTGGACAGGCGGGCTGAAGCACCGTGCCAAGCTTGACGACAA
TGACGCCTTGCTCAATTTTGCCGAAACGCTGGAAAAAGTGGTCGTGGATACGGTGGAAAGCGGGTTTATGACCAAAGACC
TTGCGCTGCTCGTGGGGCCGGATCAGGGCTGGCTGACAACGCAGGGGTTCCTGGAAAAGATCAGCGAGAACCTCAACACG
GCGCTTGCAGGCTGA

Upstream 100 bases:

>100_bases
GCGCCGCAGATTGGTATACATTTGTATACTTAATCCTTTGCAGCCCCCATGAATTGCGCTAAGGCCACCGTGACACCCAG
CCAGAACGCAGGAGATTCCG

Downstream 100 bases:

>100_bases
CCGGACAGGCGAACCGCCGGGCTTGGTTTGCGGTTTTGTCAGCCTCATGCGCGTCTGTTGCTGCGGCTGCGCAGCGAAGC
CGAAGCGCACCGACATCCAA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MTKIKVQNPVVELDGDEMTRIIWDFIKQKLILPYLDIDLKYYDLGMESRDATDDQITVDAAHAIKEHGVGVKCATITPDE
ARVEEFGLKQMWRSPNGTIRNILGGVIFRQPIICRNVPRLVPGWTKPIVVGRHAYGDQYRATDFKFPGKGKLTLKFVGED
GTEIEREVFDAPDSGVVMAMYNLDKSIIDFARASFNYGLTLGWPVYLSTKNTILKQYDGRFLELFAQVFEAEFKEKFDAA
GIWYEHRLIDDMVASAMKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMASVLMTPDGQVVESEAAHGTVTRHYRQHQKG
EATSTNSIASIYAWTGGLKHRAKLDDNDALLNFAETLEKVVVDTVESGFMTKDLALLVGPDQGWLTTQGFLEKISENLNT
ALAG

Sequences:

>Translated_404_residues
MTKIKVQNPVVELDGDEMTRIIWDFIKQKLILPYLDIDLKYYDLGMESRDATDDQITVDAAHAIKEHGVGVKCATITPDE
ARVEEFGLKQMWRSPNGTIRNILGGVIFRQPIICRNVPRLVPGWTKPIVVGRHAYGDQYRATDFKFPGKGKLTLKFVGED
GTEIEREVFDAPDSGVVMAMYNLDKSIIDFARASFNYGLTLGWPVYLSTKNTILKQYDGRFLELFAQVFEAEFKEKFDAA
GIWYEHRLIDDMVASAMKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMASVLMTPDGQVVESEAAHGTVTRHYRQHQKG
EATSTNSIASIYAWTGGLKHRAKLDDNDALLNFAETLEKVVVDTVESGFMTKDLALLVGPDQGWLTTQGFLEKISENLNT
ALAG
>Mature_403_residues
TKIKVQNPVVELDGDEMTRIIWDFIKQKLILPYLDIDLKYYDLGMESRDATDDQITVDAAHAIKEHGVGVKCATITPDEA
RVEEFGLKQMWRSPNGTIRNILGGVIFRQPIICRNVPRLVPGWTKPIVVGRHAYGDQYRATDFKFPGKGKLTLKFVGEDG
TEIEREVFDAPDSGVVMAMYNLDKSIIDFARASFNYGLTLGWPVYLSTKNTILKQYDGRFLELFAQVFEAEFKEKFDAAG
IWYEHRLIDDMVASAMKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMASVLMTPDGQVVESEAAHGTVTRHYRQHQKGE
ATSTNSIASIYAWTGGLKHRAKLDDNDALLNFAETLEKVVVDTVESGFMTKDLALLVGPDQGWLTTQGFLEKISENLNTA
LAG

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178825, Length=410, Percent_Identity=63.4146341463415, Blast_Score=551, Evalue=1e-157,
Organism=Homo sapiens, GI28178832, Length=407, Percent_Identity=63.8820638820639, Blast_Score=550, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI17540874, Length=407, Percent_Identity=64.3734643734644, Blast_Score=550, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI17550822, Length=403, Percent_Identity=63.7717121588089, Blast_Score=548, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6320137, Length=407, Percent_Identity=62.1621621621622, Blast_Score=525, Evalue=1e-150,
Organism=Saccharomyces cerevisiae, GI6324319, Length=407, Percent_Identity=59.2137592137592, Blast_Score=516, Evalue=1e-147,
Organism=Saccharomyces cerevisiae, GI6323203, Length=404, Percent_Identity=60.6435643564356, Blast_Score=516, Evalue=1e-147,
Organism=Drosophila melanogaster, GI21356561, Length=407, Percent_Identity=62.6535626535627, Blast_Score=541, Evalue=1e-154,
Organism=Drosophila melanogaster, GI221330987, Length=407, Percent_Identity=62.6535626535627, Blast_Score=540, Evalue=1e-154,
Organism=Drosophila melanogaster, GI221330985, Length=407, Percent_Identity=62.6535626535627, Blast_Score=540, Evalue=1e-154,
Organism=Drosophila melanogaster, GI28574947, Length=407, Percent_Identity=62.6535626535627, Blast_Score=540, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24660849, Length=407, Percent_Identity=62.6535626535627, Blast_Score=540, Evalue=1e-154,
Organism=Drosophila melanogaster, GI221330983, Length=407, Percent_Identity=62.6535626535627, Blast_Score=540, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24660856, Length=407, Percent_Identity=62.6535626535627, Blast_Score=540, Evalue=1e-154,
Organism=Drosophila melanogaster, GI24660868, Length=407, Percent_Identity=62.6535626535627, Blast_Score=539, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24660860, Length=407, Percent_Identity=62.6535626535627, Blast_Score=539, Evalue=1e-153,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45090; Mature: 44959

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIKVQNPVVELDGDEMTRIIWDFIKQKLILPYLDIDLKYYDLGMESRDATDDQITVDA
CCEEEECCCEEEECCHHHHHHHHHHHHHHHCCCEEECEEEEEECCCCCCCCCCCEEEEHH
AHAIKEHGVGVKCATITPDEARVEEFGLKQMWRSPNGTIRNILGGVIFRQPIICRNVPRL
HHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHCCCCCC
VPGWTKPIVVGRHAYGDQYRATDFKFPGKGKLTLKFVGEDGTEIEREVFDAPDSGVVMAM
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHCCCCCCEEEEE
YNLDKSIIDFARASFNYGLTLGWPVYLSTKNTILKQYDGRFLELFAQVFEAEFKEKFDAA
ECCCHHHHHHHHHHCCCCEEECCEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
GIWYEHRLIDDMVASAMKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMASVLMTPDGQV
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCE
VESEAAHGTVTRHYRQHQKGEATSTNSIASIYAWTGGLKHRAKLDDNDALLNFAETLEKV
EECCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
VVDTVESGFMTKDLALLVGPDQGWLTTQGFLEKISENLNTALAG
HHHHHHCCCCEECEEEEECCCCCCEEHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TKIKVQNPVVELDGDEMTRIIWDFIKQKLILPYLDIDLKYYDLGMESRDATDDQITVDA
CEEEECCCEEEECCHHHHHHHHHHHHHHHCCCEEECEEEEEECCCCCCCCCCCEEEEHH
AHAIKEHGVGVKCATITPDEARVEEFGLKQMWRSPNGTIRNILGGVIFRQPIICRNVPRL
HHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHCCCCCC
VPGWTKPIVVGRHAYGDQYRATDFKFPGKGKLTLKFVGEDGTEIEREVFDAPDSGVVMAM
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHCCCCCCEEEEE
YNLDKSIIDFARASFNYGLTLGWPVYLSTKNTILKQYDGRFLELFAQVFEAEFKEKFDAA
ECCCHHHHHHHHHHCCCCEEECCEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
GIWYEHRLIDDMVASAMKWSGGYVWACKNYDGDVQSDTVAQGFGSLGLMASVLMTPDGQV
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCE
VESEAAHGTVTRHYRQHQKGEATSTNSIASIYAWTGGLKHRAKLDDNDALLNFAETLEKV
EECCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHH
VVDTVESGFMTKDLALLVGPDQGWLTTQGFLEKISENLNTALAG
HHHHHHCCCCEECEEEEECCCCCCEEHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626059 [H]