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The map label for this gene is qacE [H]

Identifier: 110679924

GI number: 110679924

Start: 2574906

End: 2575241

Strand: Direct

Name: qacE [H]

Synonym: RD1_2706

Alternate gene names: 110679924

Gene position: 2574906-2575241 (Clockwise)

Preceding gene: 110679922

Following gene: 110679925

Centisome position: 62.3

GC content: 56.85

Gene sequence:

>336_bases
ATGCCACTGCACTATCTCTATCTGATCCTCGCCGTCCTGTTTGAAACGATCGGCACCACCGCCCTTCAGGCCAGCCAGCA
GTTCACCCGCACAGGCCCCACCATCGTCGTTGTGATCGCCTATGGGCTGGCTTTCTTCCTGCTGGGCCTGACGCTCAAAT
ACATGCCCGTCGGTGTGGTCTATGCGATCTGGTCGGGTCTGGGCATCGTCTTTATCGCCTGCATCGGTTTCGTGGTGTTT
GGTCAACGGCTCGACCTGCCCGCGATCATCGGGTTGGGTCTGATTCTGTCCGGTATTCTGGTCATTCACCTGCTGTCAAA
TACCACGCAGCATTAA

Upstream 100 bases:

>100_bases
ATCCGGCGTGTGGCCTTGTCTGATATGTCTGCCAGCCTCGTGATGGCGCAGACCAAAGACACGCACTGTCTGCCGGTCTT
ACGCCAGAAGGGCCGCTGCC

Downstream 100 bases:

>100_bases
CTCTGCACCCGCCTTGGGCGATTATCGCTGGCTTTCTGGCAGGCTGCGCGGTATGCGGCCCCCAAAGCGGCGCCGGGAGG
CGCGCATATTCAGTCAAATC

Product: quaternary ammonium compound-resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Quaternary ammonium determinant E [H]

Number of amino acids: Translated: 111; Mature: 110

Protein sequence:

>111_residues
MPLHYLYLILAVLFETIGTTALQASQQFTRTGPTIVVVIAYGLAFFLLGLTLKYMPVGVVYAIWSGLGIVFIACIGFVVF
GQRLDLPAIIGLGLILSGILVIHLLSNTTQH

Sequences:

>Translated_111_residues
MPLHYLYLILAVLFETIGTTALQASQQFTRTGPTIVVVIAYGLAFFLLGLTLKYMPVGVVYAIWSGLGIVFIACIGFVVF
GQRLDLPAIIGLGLILSGILVIHLLSNTTQH
>Mature_110_residues
PLHYLYLILAVLFETIGTTALQASQQFTRTGPTIVVVIAYGLAFFLLGLTLKYMPVGVVYAIWSGLGIVFIACIGFVVFG
QRLDLPAIIGLGLILSGILVIHLLSNTTQH

Specific function: Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=107, Percent_Identity=53.2710280373832, Blast_Score=112, Evalue=4e-27,
Organism=Escherichia coli, GI87082378, Length=102, Percent_Identity=31.3725490196078, Blast_Score=59, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 11992; Mature: 11861

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLHYLYLILAVLFETIGTTALQASQQFTRTGPTIVVVIAYGLAFFLLGLTLKYMPVGVV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YAIWSGLGIVFIACIGFVVFGQRLDLPAIIGLGLILSGILVIHLLSNTTQH
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PLHYLYLILAVLFETIGTTALQASQQFTRTGPTIVVVIAYGLAFFLLGLTLKYMPVGVV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YAIWSGLGIVFIACIGFVVFGQRLDLPAIIGLGLILSGILVIHLLSNTTQH
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8494372 [H]