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The map label for this gene is lpxD [H]

Identifier: 110679849

GI number: 110679849

Start: 2501890

End: 2502990

Strand: Direct

Name: lpxD [H]

Synonym: RD1_2620

Alternate gene names: 110679849

Gene position: 2501890-2502990 (Clockwise)

Preceding gene: 110679848

Following gene: 110679850

Centisome position: 60.53

GC content: 61.13

Gene sequence:

>1101_bases
ATGGCGCGTCAGGAATTCAGCGTTGCAGACATCGCGAAAGCCCTTGGCGCAGAAGCCTTTGGCGAGACTGCGCTGAAAAT
CGACGGTGTGGCGGAACCGCAATCCGCCGCGCCCACGCAGCTGGCGATGGCAACCAATGCCGAATACGCGGAAAAACTCG
GACAGGGACAGGCCGTCGCGGCGGTACTATGGCCCGGTGCGGATTGGTCCGCGCTGGGATTGAAGGCTGCGATCATACCG
ACGCGACCCCGGTATGCGATGTCGGGGCTCACACAACTGCTCGATCCCGGGCAGGGGTTTGCGCCCGGCATTCACCCAAG
CGCGATCATCGACCCCAGCGCCGAGATCGGTGCAAATGTGGCCATCGGCGCCTTGACGGTGATTGGCCCTGGTGCTGTCA
TCGGGGCGAATAGCACCATTGGTCCGCAGTGTTTTATCGGCTGGAACGCGCGTTTGGGGTCAAACGCGATGCTGCGTGAA
CAGGTCAGCATCGGTGCGCGTGTGACCATTGGCGCGCATTTTCATGCGCAGCCCGGTGTGCGCATCGGGGGGGACGGTTT
TTCCTTCGTGACCGAAGACAAATCGGGCATCGAAGCCGTGCGCGAAACGCTGGGGGATCCGCAGGATACGCAGGCTCAGG
GCTGGACGCGCATTCACTCGCTCGGGGCGGTGACAATCGGCGATCACGTCGATCTGGGGGCTTGCGTCAATATCGACAAC
GGCACCATCCGTGACACGCGGATTGGCGATGGCTGCAAAATGGATAACTTCGTGCACATCGGGCATAACGTGATCATCGG
CAAGGATTGCCTGATCTGTGGCCACTCCGGCGTTGCCGGGTCAACGGTCGTGGGGGACAATGTGGTGCTGGGCGGGATGA
CAGGTGTCAGCGACAACATCTTTATCGGGGATCGCGTCATCACAGGCGGCGGGACCAAGGTTTTATCCTCCATCCCGGCG
GGCCGCGTTGTTCTGGGCTACCCGGCCACCCGAATGGACAAGCAAATCGACATCTTCAAGGCGGTCCGGCGCTTGCCGCG
TCTGGTCATGGACGTCGCCGAATTGAAGAAAGCGGTTTTCAAATCTGGTGGCAGTGACTAA

Upstream 100 bases:

>100_bases
GTCGCGATGGTCGGATTTGGGAAGCGCTCTCACAGGCAGGGGTGGCGTTGCGCGGCGTTCAGGGCTAAGTCACACCCGTG
GCATCACCGGGAGCATCAGC

Downstream 100 bases:

>100_bases
ATCCTGCGCAGGCGTACAGTATAAGGGCAGACCGATGAGCACATTGGATCAGGTCATCGCAATCATCGCAGAGCATGCCG
TCCTCGACCCTGCGGATGTG

Product: UDP-3-O-3-hydroxymyristoyl glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MARQEFSVADIAKALGAEAFGETALKIDGVAEPQSAAPTQLAMATNAEYAEKLGQGQAVAAVLWPGADWSALGLKAAIIP
TRPRYAMSGLTQLLDPGQGFAPGIHPSAIIDPSAEIGANVAIGALTVIGPGAVIGANSTIGPQCFIGWNARLGSNAMLRE
QVSIGARVTIGAHFHAQPGVRIGGDGFSFVTEDKSGIEAVRETLGDPQDTQAQGWTRIHSLGAVTIGDHVDLGACVNIDN
GTIRDTRIGDGCKMDNFVHIGHNVIIGKDCLICGHSGVAGSTVVGDNVVLGGMTGVSDNIFIGDRVITGGGTKVLSSIPA
GRVVLGYPATRMDKQIDIFKAVRRLPRLVMDVAELKKAVFKSGGSD

Sequences:

>Translated_366_residues
MARQEFSVADIAKALGAEAFGETALKIDGVAEPQSAAPTQLAMATNAEYAEKLGQGQAVAAVLWPGADWSALGLKAAIIP
TRPRYAMSGLTQLLDPGQGFAPGIHPSAIIDPSAEIGANVAIGALTVIGPGAVIGANSTIGPQCFIGWNARLGSNAMLRE
QVSIGARVTIGAHFHAQPGVRIGGDGFSFVTEDKSGIEAVRETLGDPQDTQAQGWTRIHSLGAVTIGDHVDLGACVNIDN
GTIRDTRIGDGCKMDNFVHIGHNVIIGKDCLICGHSGVAGSTVVGDNVVLGGMTGVSDNIFIGDRVITGGGTKVLSSIPA
GRVVLGYPATRMDKQIDIFKAVRRLPRLVMDVAELKKAVFKSGGSD
>Mature_365_residues
ARQEFSVADIAKALGAEAFGETALKIDGVAEPQSAAPTQLAMATNAEYAEKLGQGQAVAAVLWPGADWSALGLKAAIIPT
RPRYAMSGLTQLLDPGQGFAPGIHPSAIIDPSAEIGANVAIGALTVIGPGAVIGANSTIGPQCFIGWNARLGSNAMLREQ
VSIGARVTIGAHFHAQPGVRIGGDGFSFVTEDKSGIEAVRETLGDPQDTQAQGWTRIHSLGAVTIGDHVDLGACVNIDNG
TIRDTRIGDGCKMDNFVHIGHNVIIGKDCLICGHSGVAGSTVVGDNVVLGGMTGVSDNIFIGDRVITGGGTKVLSSIPAG
RVVLGYPATRMDKQIDIFKAVRRLPRLVMDVAELKKAVFKSGGSD

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=354, Percent_Identity=32.7683615819209, Blast_Score=167, Evalue=8e-43,
Organism=Escherichia coli, GI1786378, Length=266, Percent_Identity=25.187969924812, Blast_Score=72, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 37737; Mature: 37605

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARQEFSVADIAKALGAEAFGETALKIDGVAEPQSAAPTQLAMATNAEYAEKLGQGQAVA
CCCCCCCHHHHHHHHCHHHHCCCEEEECCCCCCCCCCCCEEEEECCHHHHHHCCCCCEEE
AVLWPGADWSALGLKAAIIPTRPRYAMSGLTQLLDPGQGFAPGIHPSAIIDPSAEIGANV
EEEECCCCCHHHCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCEEECCCHHHCCCE
AIGALTVIGPGAVIGANSTIGPQCFIGWNARLGSNAMLREQVSIGARVTIGAHFHAQPGV
EEEEEEEECCCEEEECCCCCCCEEEEECCCCCCCCHHHHHHHCCCEEEEEEEEEECCCCC
RIGGDGFSFVTEDKSGIEAVRETLGDPQDTQAQGWTRIHSLGAVTIGDHVDLGACVNIDN
EECCCCCEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCEEEECCCCCCCEEEECCC
GTIRDTRIGDGCKMDNFVHIGHNVIIGKDCLICGHSGVAGSTVVGDNVVLGGMTGVSDNI
CEEEECCCCCCCCCCCEEEECCEEEECCCEEEECCCCCCCCEEECCCEEEECCCCCCCCE
FIGDRVITGGGTKVLSSIPAGRVVLGYPATRMDKQIDIFKAVRRLPRLVMDVAELKKAVF
EECCEEEECCCHHHHHCCCCCCEEECCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSGGSD
HCCCCC
>Mature Secondary Structure 
ARQEFSVADIAKALGAEAFGETALKIDGVAEPQSAAPTQLAMATNAEYAEKLGQGQAVA
CCCCCCHHHHHHHHCHHHHCCCEEEECCCCCCCCCCCCEEEEECCHHHHHHCCCCCEEE
AVLWPGADWSALGLKAAIIPTRPRYAMSGLTQLLDPGQGFAPGIHPSAIIDPSAEIGANV
EEEECCCCCHHHCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCEEECCCHHHCCCE
AIGALTVIGPGAVIGANSTIGPQCFIGWNARLGSNAMLREQVSIGARVTIGAHFHAQPGV
EEEEEEEECCCEEEECCCCCCCEEEEECCCCCCCCHHHHHHHCCCEEEEEEEEEECCCCC
RIGGDGFSFVTEDKSGIEAVRETLGDPQDTQAQGWTRIHSLGAVTIGDHVDLGACVNIDN
EECCCCCEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCEEEECCCCCCCEEEECCC
GTIRDTRIGDGCKMDNFVHIGHNVIIGKDCLICGHSGVAGSTVVGDNVVLGGMTGVSDNI
CEEEECCCCCCCCCCCEEEECCEEEECCCEEEECCCCCCCCEEECCCEEEECCCCCCCCE
FIGDRVITGGGTKVLSSIPAGRVVLGYPATRMDKQIDIFKAVRRLPRLVMDVAELKKAVF
EECCEEEECCCHHHHHCCCCCCEEECCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSGGSD
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA