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The map label for this gene is lpxB [H]

Identifier: 110679828

GI number: 110679828

Start: 2480896

End: 2482056

Strand: Direct

Name: lpxB [H]

Synonym: RD1_2598

Alternate gene names: 110679828

Gene position: 2480896-2482056 (Clockwise)

Preceding gene: 110679827

Following gene: 110679830

Centisome position: 60.03

GC content: 60.38

Gene sequence:

>1161_bases
GTGAAACGGGCGTTTATCATCGCGGGCGAGCCGTCAGGGGACAAGCTGGGCGGTGCGTTGATGGTTGGGCTCAAAACGCT
GTCGCCGGGAATCGCATTTGATGGTGTCGGCGGACCCTTGATGCAGGCCCAGGGGCTGGAAAGCCGCTTTCCCATGGATG
AGCTTAGCGTGATGGGGATTACAGAGGTTTTGCCAAAATACCGCGCCTTGAAAGCGCGCATACGTGAGACGGCGCAGGCG
GTGATCGCGAGTAACCCAGACGTGCTTATCACCATAGATTCGCCTGATTTTTGTTTTCGGGTGGCCAAGCTGGTGAAAAA
ATCCAGCAGCATCCGGACGGTGCATTATGTGGCCCCGACCGTCTGGGCGTGGCGGCCCGGCCGCGCGGCCAAGATATCGA
AATTTGTTGATCACCTGTTGGCGTTGTTTCCATTCGAACCTGCCTATTTCACACCTCATGGCATGGCGTGTGATTTCGTG
GGCCATCCGGTGGTCGCCGAACCTGTCGCGACACAAGATGAGGCGGAAGCGTTCCGGGCAGAGCATGACATCGGATCCGC
GCCGCTTTTGATGGTTTTGCCTGGCTCAAGGCGGGGGGAGGTTGCGCGTCTGGCGGATGTTTTCGGGGGTGCGATCTCAC
CCGTTCTGGCGCGGCACCCGGGACTGAAAGTGGTCGTGCCCGCCGCCAGACCCGTGGCGCAGCAGGTCAAGGAAGCCGTC
GCACAGTGGCCGGTGGCGCCGGTTGTGATTGATCCTCGCGACATGGCCTCAGAAGATGCAGCTTGTGCGAAAAGTGCCGC
GTTTCGTGCTGCCGATATTGCCCTTGCGGCCTCGGGTACCGTGTCGCTGGAACTGGCCGCGTCACGCACGCCGATGGTCG
TGGCCTACCGCATGCATTGGCTCAGCTACAGGCTGATCCGCGCGATGGCTTTGGTGGATACGGTGACCTTGGTCAATCTG
GTATCGGACACGCGTTTCGTGCCTGAATTTCTTGGTCCGGACTGTGAGAGTTCTGCTATCGGACAGGCTTTGATAGATGT
GCTGAAAACCCCGTCTGATCAGGTGGAGGCCATGCAGATTACCATGGAGCGGTTGGGTCATCGGGGGGAGGCACCCGGGC
TGCGGGCCGCCCGCGCGATCCTTCATCGAGCGGGGGTGTAA

Upstream 100 bases:

>100_bases
GCATCGTGATCCAAGCCGGGGCGATGATCTTGCTTGATCCCGAAGCCACCATTGCGGGCGCGAACAAGACAGGGCTGGTC
CTGTGGTCGCGCGCAAGCGC

Downstream 100 bases:

>100_bases
TCCCAAGGACACGCTGCGCGTGACACGATCTGAGCCGCCCTCACGGGCGGGATTGGCGCCGGTTCATCCCTTGTGAATCC
ATCCGCCGCCGTAGATCCGG

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MKRAFIIAGEPSGDKLGGALMVGLKTLSPGIAFDGVGGPLMQAQGLESRFPMDELSVMGITEVLPKYRALKARIRETAQA
VIASNPDVLITIDSPDFCFRVAKLVKKSSSIRTVHYVAPTVWAWRPGRAAKISKFVDHLLALFPFEPAYFTPHGMACDFV
GHPVVAEPVATQDEAEAFRAEHDIGSAPLLMVLPGSRRGEVARLADVFGGAISPVLARHPGLKVVVPAARPVAQQVKEAV
AQWPVAPVVIDPRDMASEDAACAKSAAFRAADIALAASGTVSLELAASRTPMVVAYRMHWLSYRLIRAMALVDTVTLVNL
VSDTRFVPEFLGPDCESSAIGQALIDVLKTPSDQVEAMQITMERLGHRGEAPGLRAARAILHRAGV

Sequences:

>Translated_386_residues
MKRAFIIAGEPSGDKLGGALMVGLKTLSPGIAFDGVGGPLMQAQGLESRFPMDELSVMGITEVLPKYRALKARIRETAQA
VIASNPDVLITIDSPDFCFRVAKLVKKSSSIRTVHYVAPTVWAWRPGRAAKISKFVDHLLALFPFEPAYFTPHGMACDFV
GHPVVAEPVATQDEAEAFRAEHDIGSAPLLMVLPGSRRGEVARLADVFGGAISPVLARHPGLKVVVPAARPVAQQVKEAV
AQWPVAPVVIDPRDMASEDAACAKSAAFRAADIALAASGTVSLELAASRTPMVVAYRMHWLSYRLIRAMALVDTVTLVNL
VSDTRFVPEFLGPDCESSAIGQALIDVLKTPSDQVEAMQITMERLGHRGEAPGLRAARAILHRAGV
>Mature_386_residues
MKRAFIIAGEPSGDKLGGALMVGLKTLSPGIAFDGVGGPLMQAQGLESRFPMDELSVMGITEVLPKYRALKARIRETAQA
VIASNPDVLITIDSPDFCFRVAKLVKKSSSIRTVHYVAPTVWAWRPGRAAKISKFVDHLLALFPFEPAYFTPHGMACDFV
GHPVVAEPVATQDEAEAFRAEHDIGSAPLLMVLPGSRRGEVARLADVFGGAISPVLARHPGLKVVVPAARPVAQQVKEAV
AQWPVAPVVIDPRDMASEDAACAKSAAFRAADIALAASGTVSLELAASRTPMVVAYRMHWLSYRLIRAMALVDTVTLVNL
VSDTRFVPEFLGPDCESSAIGQALIDVLKTPSDQVEAMQITMERLGHRGEAPGLRAARAILHRAGV

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=334, Percent_Identity=37.125748502994, Blast_Score=194, Evalue=9e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 41280; Mature: 41280

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRAFIIAGEPSGDKLGGALMVGLKTLSPGIAFDGVGGPLMQAQGLESRFPMDELSVMGI
CCCEEEEECCCCCCCCCHHHEEEHHHCCCCCEECCCCCCHHHHCCCCCCCCHHHHHHHHH
TEVLPKYRALKARIRETAQAVIASNPDVLITIDSPDFCFRVAKLVKKSSSIRTVHYVAPT
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCC
VWAWRPGRAAKISKFVDHLLALFPFEPAYFTPHGMACDFVGHPVVAEPVATQDEAEAFRA
EEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHH
EHDIGSAPLLMVLPGSRRGEVARLADVFGGAISPVLARHPGLKVVVPAARPVAQQVKEAV
HCCCCCCCEEEEECCCCCCHHHHHHHHHCHHHHHHHHCCCCCEEEECCCCHHHHHHHHHH
AQWPVAPVVIDPRDMASEDAACAKSAAFRAADIALAASGTVSLELAASRTPMVVAYRMHW
HHCCCCCEEECCHHHCCCHHHHHHHHHHHHHHEEEEECCCEEEEEECCCCCEEHHHHHHH
LSYRLIRAMALVDTVTLVNLVSDTRFVPEFLGPDCESSAIGQALIDVLKTPSDQVEAMQI
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHH
TMERLGHRGEAPGLRAARAILHRAGV
HHHHHCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MKRAFIIAGEPSGDKLGGALMVGLKTLSPGIAFDGVGGPLMQAQGLESRFPMDELSVMGI
CCCEEEEECCCCCCCCCHHHEEEHHHCCCCCEECCCCCCHHHHCCCCCCCCHHHHHHHHH
TEVLPKYRALKARIRETAQAVIASNPDVLITIDSPDFCFRVAKLVKKSSSIRTVHYVAPT
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCC
VWAWRPGRAAKISKFVDHLLALFPFEPAYFTPHGMACDFVGHPVVAEPVATQDEAEAFRA
EEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHH
EHDIGSAPLLMVLPGSRRGEVARLADVFGGAISPVLARHPGLKVVVPAARPVAQQVKEAV
HCCCCCCCEEEEECCCCCCHHHHHHHHHCHHHHHHHHCCCCCEEEECCCCHHHHHHHHHH
AQWPVAPVVIDPRDMASEDAACAKSAAFRAADIALAASGTVSLELAASRTPMVVAYRMHW
HHCCCCCEEECCHHHCCCHHHHHHHHHHHHHHEEEEECCCEEEEEECCCCCEEHHHHHHH
LSYRLIRAMALVDTVTLVNLVSDTRFVPEFLGPDCESSAIGQALIDVLKTPSDQVEAMQI
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHH
TMERLGHRGEAPGLRAARAILHRAGV
HHHHHCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA