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The map label for this gene is lpxA [H]

Identifier: 110679826

GI number: 110679826

Start: 2479323

End: 2480108

Strand: Direct

Name: lpxA [H]

Synonym: RD1_2596

Alternate gene names: 110679826

Gene position: 2479323-2480108 (Clockwise)

Preceding gene: 110679825

Following gene: 110679827

Centisome position: 59.99

GC content: 60.18

Gene sequence:

>786_bases
TTGATGGGCAACATTCACCCCAGTGCTGTCATCGACCCCGGCGCGCAGATCGACCCGAGCGCAAGGGTCGGCCCGTTTTG
TGTGGTGGGTGCGCAGGTCACGCTGGCCGCGGGGGTGGAACTGAAAAGCCACGTCGTGGTCACGGGGCGGACCTCCATCG
GGGATGATACGGTCGTTTTTCCCTTTGCCGTCGTCGGTGAAATCCCGCAGGATCTGAAATTCAAGGGTGAGGCGACCCGG
CTGGTGATTGGCCAGCGCAACCGTATTCGTGAACATGTCACCATCAATTGCGGCACAGAAGGCGGCGGTGGGGTGACGCG
CATTGGCGATGACGGGCTGTTCATGGCAGGGTGTCACGTGGCCCATGATGCTGTGATCGGGAACCGCGTTATTCTGGTCA
ATTCGGTCGCCATTGCCGGGCATTGCATCCTTGAGGATGATGTGATCGTCGGCGGATTGTCCGGCGTGCATCAATTTGTG
CGCATTGGCCGCGGGGCGATCATCGGGGCGGTCAGCATGGTGACCAATGACGTGATTCCCTATGGTCTGGTGCAGGGTCC
ACGGGGTGAACTGGATGGTCTGAACCTTGTCGGTCTGAAACGTCGCGGCGTGGAGCGGGCAGATATCACGGCCCTGCGCG
CCGCCTTTCAGATGCTGGCGCAGGGAGAGGGCACCTTTCAGAGCCGCGCGCAGCGCCTCAAGGAAGAAACATCCAGTGAC
TATGTACGTGAGATTGTCGAATTCATCACATCCGACAGTGACCGTCATTTCCTGACGCCACGCTGA

Upstream 100 bases:

>100_bases
ACCCGGCGGCAAAGTCTGGCGCTTTGGCGGTGTCGCATCGGTTGAGGGCGAGATGGCCGCCGAAGTCGAGTTTACCGCCA
TGATGGACATGGGCTGATCG

Downstream 100 bases:

>100_bases
TGCTGGCGCTGATCACAGGACGCGGGGGGCTTCCGGCGCGGGTGGCAGCGGCACAGACCGCACGCCCGCTGGTCTGTGTG
CTGGAGGGTTTCGCCCCAGA

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MMGNIHPSAVIDPGAQIDPSARVGPFCVVGAQVTLAAGVELKSHVVVTGRTSIGDDTVVFPFAVVGEIPQDLKFKGEATR
LVIGQRNRIREHVTINCGTEGGGGVTRIGDDGLFMAGCHVAHDAVIGNRVILVNSVAIAGHCILEDDVIVGGLSGVHQFV
RIGRGAIIGAVSMVTNDVIPYGLVQGPRGELDGLNLVGLKRRGVERADITALRAAFQMLAQGEGTFQSRAQRLKEETSSD
YVREIVEFITSDSDRHFLTPR

Sequences:

>Translated_261_residues
MMGNIHPSAVIDPGAQIDPSARVGPFCVVGAQVTLAAGVELKSHVVVTGRTSIGDDTVVFPFAVVGEIPQDLKFKGEATR
LVIGQRNRIREHVTINCGTEGGGGVTRIGDDGLFMAGCHVAHDAVIGNRVILVNSVAIAGHCILEDDVIVGGLSGVHQFV
RIGRGAIIGAVSMVTNDVIPYGLVQGPRGELDGLNLVGLKRRGVERADITALRAAFQMLAQGEGTFQSRAQRLKEETSSD
YVREIVEFITSDSDRHFLTPR
>Mature_261_residues
MMGNIHPSAVIDPGAQIDPSARVGPFCVVGAQVTLAAGVELKSHVVVTGRTSIGDDTVVFPFAVVGEIPQDLKFKGEATR
LVIGQRNRIREHVTINCGTEGGGGVTRIGDDGLFMAGCHVAHDAVIGNRVILVNSVAIAGHCILEDDVIVGGLSGVHQFV
RIGRGAIIGAVSMVTNDVIPYGLVQGPRGELDGLNLVGLKRRGVERADITALRAAFQMLAQGEGTFQSRAQRLKEETSSD
YVREIVEFITSDSDRHFLTPR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=231, Percent_Identity=46.7532467532467, Blast_Score=220, Evalue=7e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 27685; Mature: 27685

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMGNIHPSAVIDPGAQIDPSARVGPFCVVGAQVTLAAGVELKSHVVVTGRTSIGDDTVVF
CCCCCCCCCEECCCCCCCCCCCCCCEEEECCEEEEEECCEEECEEEEEECCCCCCCEEEE
PFAVVGEIPQDLKFKGEATRLVIGQRNRIREHVTINCGTEGGGGVTRIGDDGLFMAGCHV
HHHHHCCCCCCCEECCCEEEEEECCCCCCCEEEEEECCCCCCCCEEEECCCCEEEECCHH
AHDAVIGNRVILVNSVAIAGHCILEDDVIVGGLSGVHQFVRIGRGAIIGAVSMVTNDVIP
HHHHHHCCEEEEEEEEEEEEEEEEECCEEEECHHHHHHHHHHCCCHHHHHHHHHHHCCCC
YGLVQGPRGELDGLNLVGLKRRGVERADITALRAAFQMLAQGEGTFQSRAQRLKEETSSD
CCCCCCCCCCCCCCEEEEHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHH
YVREIVEFITSDSDRHFLTPR
HHHHHHHHHHCCCCCEECCCC
>Mature Secondary Structure
MMGNIHPSAVIDPGAQIDPSARVGPFCVVGAQVTLAAGVELKSHVVVTGRTSIGDDTVVF
CCCCCCCCCEECCCCCCCCCCCCCCEEEECCEEEEEECCEEECEEEEEECCCCCCCEEEE
PFAVVGEIPQDLKFKGEATRLVIGQRNRIREHVTINCGTEGGGGVTRIGDDGLFMAGCHV
HHHHHCCCCCCCEECCCEEEEEECCCCCCCEEEEEECCCCCCCCEEEECCCCEEEECCHH
AHDAVIGNRVILVNSVAIAGHCILEDDVIVGGLSGVHQFVRIGRGAIIGAVSMVTNDVIP
HHHHHHCCEEEEEEEEEEEEEEEEECCEEEECHHHHHHHHHHCCCHHHHHHHHHHHCCCC
YGLVQGPRGELDGLNLVGLKRRGVERADITALRAAFQMLAQGEGTFQSRAQRLKEETSSD
CCCCCCCCCCCCCCEEEEHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHH
YVREIVEFITSDSDRHFLTPR
HHHHHHHHHHCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA