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The map label for this gene is dxr [H]

Identifier: 110679820

GI number: 110679820

Start: 2472956

End: 2474128

Strand: Direct

Name: dxr [H]

Synonym: RD1_2590

Alternate gene names: 110679820

Gene position: 2472956-2474128 (Clockwise)

Preceding gene: 110679819

Following gene: 110679821

Centisome position: 59.83

GC content: 60.27

Gene sequence:

>1173_bases
ATGCGCAGCGTCAGTATATTCGGGGCAACCGGGTCGATTGGACAAAACACGATTGACCTGATCGCGCGTGACCCGCAGGC
GTATGATGTCGTGGCTCTGACCGGTGCAGGCAATATCAAACAATTGGCGCATGATGCCCGTCGTCTCAAGGCGGATATTG
CAGTCACTGCACATGATGCCCTTCTGCCCGAACTGCGCGCGGCGCTCGATGGCTCCGGCGTGGTGGCGGCTGCGGGGGCA
CAGGCCCTGAATGATGCCGCCTGCCGACCCGCCGATTGGGTTATGTCCGCAATTGTGGGGGCCGCCGGGCTGGCACCCGG
CCTCAGGGCATTGGAACAAGGTGCAACGCTTGCGCTGGCCAACAAGGAATCGCTGGTCTGTGCCGGGGCGTTGATGCTGG
ACACGGCCCGGGCAAACAAGGCGCGTCTGTTGCCGGTCGACAGCGAACATTCCGCTGTTTTCCAAGCGCTGACCGGCGAG
GATATCGCATCGGTGGAACGCATCATCATCACGGCAAGTGGTGGCGCGTTTCGCGACTGGCCCATTGAAAAACTGGCCGG
CGCGACCTTGGCGGAGGCCTCAAGCCACCCGAATTGGGATATGGGGCAGCGGATCACGATAGACTCTGCATCAATGTTTA
ATAAAGCCATGGAGCTTATTGAAACGAAAGAGTATTTCGGTGTTGAGCCTTCAAGAATTGAAGCCCTTGTACACCCGGAA
TCGCTCATCCACGCCATGGTCGGGTTTCGGGATGGCGCTTTGATGGCTCATGTCGGGCCGCATGACATGCGGCACGCGAT
CGGCTACGCGCTGCATTGGCCGGACCGCAAAACCCTCCCGGTTGAGCGCCTTGATCTGGCATCCATTGCGCAGTTGACGT
TCCGCGCACCCTGTGAGCAGCGCTGGCCCGCCTTGCGCCTTGCCCGGGAAGTGATGGAAACCGGCGGTATGGCCGGGGCG
ATTTTCAACGCCTCCAAGGAAATTGCGCTCGACGGATTTATCGACGGGCAGCTGCGATTCACGGACATGGCGGGCATCGT
CGAAGACGTCCTGACCCATTTCTCGGGCGAACCGGGTCACATTAACGCGGCCATGACCCTTGATAACGTGGCCCGGATAG
ACCATCTCGCCCGGGAAGAGGCGCGCAGGTTTATCAACAAGAGAGCAGGCTGA

Upstream 100 bases:

>100_bases
GGGCTGCTTGATCGTTTTGATGGTATGTTGGGAGCGGCGGTTTTCCTGCTGATTATCGGACCGTTCATTGCCTTCCCGCC
GGGAATTGGGTGACACACAG

Downstream 100 bases:

>100_bases
CATTGGATATTATGACCTTGATCCCGCAGTTTGGCGGGCTGATCTGGACGATTGCGGCCTTCATTCTGGCCTTGTCGGTG
ATCGTGGCCATCCACGAATA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MRSVSIFGATGSIGQNTIDLIARDPQAYDVVALTGAGNIKQLAHDARRLKADIAVTAHDALLPELRAALDGSGVVAAAGA
QALNDAACRPADWVMSAIVGAAGLAPGLRALEQGATLALANKESLVCAGALMLDTARANKARLLPVDSEHSAVFQALTGE
DIASVERIIITASGGAFRDWPIEKLAGATLAEASSHPNWDMGQRITIDSASMFNKAMELIETKEYFGVEPSRIEALVHPE
SLIHAMVGFRDGALMAHVGPHDMRHAIGYALHWPDRKTLPVERLDLASIAQLTFRAPCEQRWPALRLAREVMETGGMAGA
IFNASKEIALDGFIDGQLRFTDMAGIVEDVLTHFSGEPGHINAAMTLDNVARIDHLAREEARRFINKRAG

Sequences:

>Translated_390_residues
MRSVSIFGATGSIGQNTIDLIARDPQAYDVVALTGAGNIKQLAHDARRLKADIAVTAHDALLPELRAALDGSGVVAAAGA
QALNDAACRPADWVMSAIVGAAGLAPGLRALEQGATLALANKESLVCAGALMLDTARANKARLLPVDSEHSAVFQALTGE
DIASVERIIITASGGAFRDWPIEKLAGATLAEASSHPNWDMGQRITIDSASMFNKAMELIETKEYFGVEPSRIEALVHPE
SLIHAMVGFRDGALMAHVGPHDMRHAIGYALHWPDRKTLPVERLDLASIAQLTFRAPCEQRWPALRLAREVMETGGMAGA
IFNASKEIALDGFIDGQLRFTDMAGIVEDVLTHFSGEPGHINAAMTLDNVARIDHLAREEARRFINKRAG
>Mature_390_residues
MRSVSIFGATGSIGQNTIDLIARDPQAYDVVALTGAGNIKQLAHDARRLKADIAVTAHDALLPELRAALDGSGVVAAAGA
QALNDAACRPADWVMSAIVGAAGLAPGLRALEQGATLALANKESLVCAGALMLDTARANKARLLPVDSEHSAVFQALTGE
DIASVERIIITASGGAFRDWPIEKLAGATLAEASSHPNWDMGQRITIDSASMFNKAMELIETKEYFGVEPSRIEALVHPE
SLIHAMVGFRDGALMAHVGPHDMRHAIGYALHWPDRKTLPVERLDLASIAQLTFRAPCEQRWPALRLAREVMETGGMAGA
IFNASKEIALDGFIDGQLRFTDMAGIVEDVLTHFSGEPGHINAAMTLDNVARIDHLAREEARRFINKRAG

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=403, Percent_Identity=39.9503722084367, Blast_Score=282, Evalue=3e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 41627; Mature: 41627

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSVSIFGATGSIGQNTIDLIARDPQAYDVVALTGAGNIKQLAHDARRLKADIAVTAHDA
CCCEEEEECCCCCCCCCEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHEEEEHHHH
LLPELRAALDGSGVVAAAGAQALNDAACRPADWVMSAIVGAAGLAPGLRALEQGATLALA
HHHHHHHHCCCCCEEEECCHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCEEEEE
NKESLVCAGALMLDTARANKARLLPVDSEHSAVFQALTGEDIASVERIIITASGGAFRDW
CCCCEEEEHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCHHHCEEEEEEEECCCCCCCC
PIEKLAGATLAEASSHPNWDMGQRITIDSASMFNKAMELIETKEYFGVEPSRIEALVHPE
CHHHHCCCHHHHCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHEEECHH
SLIHAMVGFRDGALMAHVGPHDMRHAIGYALHWPDRKTLPVERLDLASIAQLTFRAPCEQ
HHHHHHHCCCCCCEEEECCHHHHHHHHCEEEECCCCCCCCHHHHHHHHHHHHHHCCCHHH
RWPALRLAREVMETGGMAGAIFNASKEIALDGFIDGQLRFTDMAGIVEDVLTHFSGEPGH
CCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCEEEEHHHHHHHHHHHHHCCCCCCE
INAAMTLDNVARIDHLAREEARRFINKRAG
EEEEEEHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRSVSIFGATGSIGQNTIDLIARDPQAYDVVALTGAGNIKQLAHDARRLKADIAVTAHDA
CCCEEEEECCCCCCCCCEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHEEEEHHHH
LLPELRAALDGSGVVAAAGAQALNDAACRPADWVMSAIVGAAGLAPGLRALEQGATLALA
HHHHHHHHCCCCCEEEECCHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCEEEEE
NKESLVCAGALMLDTARANKARLLPVDSEHSAVFQALTGEDIASVERIIITASGGAFRDW
CCCCEEEEHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCHHHCEEEEEEEECCCCCCCC
PIEKLAGATLAEASSHPNWDMGQRITIDSASMFNKAMELIETKEYFGVEPSRIEALVHPE
CHHHHCCCHHHHCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHEEECHH
SLIHAMVGFRDGALMAHVGPHDMRHAIGYALHWPDRKTLPVERLDLASIAQLTFRAPCEQ
HHHHHHHCCCCCCEEEECCHHHHHHHHCEEEECCCCCCCCHHHHHHHHHHHHHHCCCHHH
RWPALRLAREVMETGGMAGAIFNASKEIALDGFIDGQLRFTDMAGIVEDVLTHFSGEPGH
CCHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCEEEEHHHHHHHHHHHHHCCCCCCE
INAAMTLDNVARIDHLAREEARRFINKRAG
EEEEEEHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA