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The map label for this gene is uppS [H]

Identifier: 110679818

GI number: 110679818

Start: 2471371

End: 2472147

Strand: Direct

Name: uppS [H]

Synonym: RD1_2587

Alternate gene names: 110679818

Gene position: 2471371-2472147 (Clockwise)

Preceding gene: 110679817

Following gene: 110679819

Centisome position: 59.79

GC content: 59.97

Gene sequence:

>777_bases
GTGGCCTCACGGCGGGCGTGTTCGGAGGAATTAGTCATCGAGCCCGAAAGACAGCCCGACCTCAATCAAGTCCCCGGATG
CCCGCGACACGTTGCGATTATAATGGATGGTAACGGCCGATGGGCCACGCAACGCGGTCGTCCGCGGCTCTTTGGCCATC
ATGCCGGGGCGCGTCGCGTGCGCGAAATCGTTGAGGCCTGCCCGTCAGTTGGCGTCAAATACCTTACAATATTTGCTTTT
TCGACCGAAAACTGGAAGCGGACGCAGGCGGAGGTCGCCGGGCTGATGAGCCTATTCAAGCGCTACATCACGCGCGAGAC
CCGCGAGTTGAATACCTATGGCGTCAGGGTGCGCTTTATCGGGGATCGCACGCGGCTGGACGCGACGCTGGCGCGGCTCA
TGACCGAATTGGAAAACGCGACGGCCGGGAACACCAATATGCATCTGACCATCGCGATCAATTACGGCGGGCGTGACGAG
GTGGCGCGCGCCACGAAACGACTGGCGCAGGATGTGGCTAACGGCATGCTCAAGCCCGAGGATGTGGACGAGGAAACACT
GCCGAAATACCTTGATACCTATGTTCTGCCGGACCCGGATCTTGTGATCCGCACAAGTGGCGAGGCGCGGATATCGAATT
TCCTGCTCTGGCAATCGGCCTATTCGGAATATGAATTCATCGACACGCTTTGGCCGGACTTCACGCGCAGCGAATTTGAG
GAAGTCTGCACCGCCTACGGCGGGCGCGAGCGGCGCTATGGCGGCGTGAAGGCATAG

Upstream 100 bases:

>100_bases
CCCTGCTTTGGCCGCGTTAAAGGTGATTTTAAAGATTTTAAGTAGTCATGGTTACTGACTCTGTGTCACAAGGACACAGA
CGTAAGACAAATGGAGCGCG

Downstream 100 bases:

>100_bases
CCTGTCATGGGGGCGGAGAGCGAAAAATGGGCTGATCTGGCAGTCCGGCTCACTTCAGGCGCTGCGATGGTTCTGCTGGG
CCTTTGGGGTGTGTGGATGG

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MASRRACSEELVIEPERQPDLNQVPGCPRHVAIIMDGNGRWATQRGRPRLFGHHAGARRVREIVEACPSVGVKYLTIFAF
STENWKRTQAEVAGLMSLFKRYITRETRELNTYGVRVRFIGDRTRLDATLARLMTELENATAGNTNMHLTIAINYGGRDE
VARATKRLAQDVANGMLKPEDVDEETLPKYLDTYVLPDPDLVIRTSGEARISNFLLWQSAYSEYEFIDTLWPDFTRSEFE
EVCTAYGGRERRYGGVKA

Sequences:

>Translated_258_residues
MASRRACSEELVIEPERQPDLNQVPGCPRHVAIIMDGNGRWATQRGRPRLFGHHAGARRVREIVEACPSVGVKYLTIFAF
STENWKRTQAEVAGLMSLFKRYITRETRELNTYGVRVRFIGDRTRLDATLARLMTELENATAGNTNMHLTIAINYGGRDE
VARATKRLAQDVANGMLKPEDVDEETLPKYLDTYVLPDPDLVIRTSGEARISNFLLWQSAYSEYEFIDTLWPDFTRSEFE
EVCTAYGGRERRYGGVKA
>Mature_257_residues
ASRRACSEELVIEPERQPDLNQVPGCPRHVAIIMDGNGRWATQRGRPRLFGHHAGARRVREIVEACPSVGVKYLTIFAFS
TENWKRTQAEVAGLMSLFKRYITRETRELNTYGVRVRFIGDRTRLDATLARLMTELENATAGNTNMHLTIAINYGGRDEV
ARATKRLAQDVANGMLKPEDVDEETLPKYLDTYVLPDPDLVIRTSGEARISNFLLWQSAYSEYEFIDTLWPDFTRSEFEE
VCTAYGGRERRYGGVKA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=211, Percent_Identity=38.8625592417062, Blast_Score=162, Evalue=2e-40,
Organism=Homo sapiens, GI45580738, Length=211, Percent_Identity=38.8625592417062, Blast_Score=162, Evalue=2e-40,
Organism=Escherichia coli, GI1786371, Length=242, Percent_Identity=48.3471074380165, Blast_Score=238, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI71993029, Length=213, Percent_Identity=35.6807511737089, Blast_Score=147, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6319474, Length=212, Percent_Identity=39.622641509434, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=219, Percent_Identity=30.5936073059361, Blast_Score=106, Evalue=4e-24,
Organism=Drosophila melanogaster, GI18857969, Length=226, Percent_Identity=37.6106194690265, Blast_Score=146, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 29370; Mature: 29238

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASRRACSEELVIEPERQPDLNQVPGCPRHVAIIMDGNGRWATQRGRPRLFGHHAGARRV
CCCCCCCCCCCEECCCCCCCCCCCCCCCCEEEEEECCCCCEECCCCCCCEECCCHHHHHH
REIVEACPSVGVKYLTIFAFSTENWKRTQAEVAGLMSLFKRYITRETRELNTYGVRVRFI
HHHHHHHHCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
GDRTRLDATLARLMTELENATAGNTNMHLTIAINYGGRDEVARATKRLAQDVANGMLKPE
CCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCC
DVDEETLPKYLDTYVLPDPDLVIRTSGEARISNFLLWQSAYSEYEFIDTLWPDFTRSEFE
CCCHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
EVCTAYGGRERRYGGVKA
HHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
ASRRACSEELVIEPERQPDLNQVPGCPRHVAIIMDGNGRWATQRGRPRLFGHHAGARRV
CCCCCCCCCCEECCCCCCCCCCCCCCCCEEEEEECCCCCEECCCCCCCEECCCHHHHHH
REIVEACPSVGVKYLTIFAFSTENWKRTQAEVAGLMSLFKRYITRETRELNTYGVRVRFI
HHHHHHHHCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEE
GDRTRLDATLARLMTELENATAGNTNMHLTIAINYGGRDEVARATKRLAQDVANGMLKPE
CCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCC
DVDEETLPKYLDTYVLPDPDLVIRTSGEARISNFLLWQSAYSEYEFIDTLWPDFTRSEFE
CCCHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
EVCTAYGGRERRYGGVKA
HHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]