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The map label for this gene is serS

Identifier: 110679777

GI number: 110679777

Start: 2430595

End: 2431887

Strand: Reverse

Name: serS

Synonym: RD1_2541

Alternate gene names: 110679777

Gene position: 2431887-2430595 (Counterclockwise)

Preceding gene: 110679778

Following gene: 110679775

Centisome position: 58.84

GC content: 60.87

Gene sequence:

>1293_bases
ATGCACGATATCCGCGCAATCCGAGAGAACCCGGCAGCCTTTGACGCAGCTTTGGCGCGACGTGGGGAGGCACCGATGTC
GCAGGCGATCCTCGCGCTGGACACAGCACGGCGCGCCAAGATCAACGCGGCGGAAAACGCTCAGGCCGAACAGAACAAAG
CTTCCAAAGAGGTCGGACAGGCCAAGGCACAGGGCGATGAAGCGACGTTTGAGAAACTGCGCGCGCTCGTCTCCGAAAAA
AAGGCGCTGGTGGCTGAGATGCAGGCCGATGCCAAGGCGCTGGACGCAGAGTTGACGGAAAAACTGTCGTGGATTGCCAA
CATCCCGGCCGATGACGTGCCCGACGGTGCCGACGAAGATGACAACGTCGAGGTGCGCCGCTGGGGGCATCTGCCCGATT
TCGAGTTCACACCCAAGGAACACTACGAAATCGGTGGCGTTGCCGCTTCGATGGATTTTGACACGGCCGCCAAGACATCA
GGTGCGCGTTTCGTGATGCTGAAGGGTGCGGTTGCCCGGATCCATCGTGCCTTGTCGCAATTCATGATCGACACCCATGT
GGATCACAACGGGCTGACCGAAATCAACAGCCCTGTTCTGGTGCGTGACGATGCGATGTATGGCACGGACAAACTGCCGA
AATTTGCCGAGGACAGCTACCAGACCACCAATGGCTGGTGGCTTGTGTCCACATCGGAAATCCCCCTGACCTATACGGTC
GCTGGTGATATCCTTGACGCTGCCGCCCTGCCGATCCGGCTGACGGCGCATACGCTGTGTTTCCGCTCCGAAGCGGGCAG
CGCGGGGCGCGACACGGCGGGTATGCTGCGCCAGCACCAGTTCGAAAAGGTGGAGATGGTTTCCATCACCGAACCGGACC
AGTCCGAGGCGGAACAACAACGCATGCTGCGCTGTGCCGAGGATATTCTGGAACGTCTTGGCCTGCCCTATCGCACGGTA
TTGCTTTGCACGGGCGACATGGGGTTCGGGGCGCGGCGCACCTTTGACATCGAAGCCTGGTTGCCCGGTCAGAACAATTA
TCGCGAGATATCTTCGGTTTCGACGACCGGGGATTTTCAGGCGCGGCGCATGAATGCGCGCTACAAACCCGCCGATGGGG
GCAAGCCGCAGTTCGTGCATACGCTGAACGGTTCGGGCCTTGCCGTGGGGCGCTGCCTGATTGCCGTGTTGGAAAACGGG
CAGCAAGCAGATGGGTCCGTGGTTCTGCCGCCGGTCCTTGCGGGCTATCTCGGTGGCAAGACCGTGCTGAGCGCTGAGGG
CACGCTGGTCTGA

Upstream 100 bases:

>100_bases
TGCGCAAATAACAGCCCCCGACGGGCCACGCGGCGCTTACGATCCATTCAACTTTCGGTCATAAGCAGAGCCAGAAACGA
GTCAGACCCAAGGACCAGAC

Downstream 100 bases:

>100_bases
CCTCGACCTTGGCTAGCGGTTCGGGTGCACTTCATACCCGCGCTCTTCGGGCTCATCATCAATCAGCGCGTCGGGGAAAC
CCGGCGCGTGGATATCAAGC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MHDIRAIRENPAAFDAALARRGEAPMSQAILALDTARRAKINAAENAQAEQNKASKEVGQAKAQGDEATFEKLRALVSEK
KALVAEMQADAKALDAELTEKLSWIANIPADDVPDGADEDDNVEVRRWGHLPDFEFTPKEHYEIGGVAASMDFDTAAKTS
GARFVMLKGAVARIHRALSQFMIDTHVDHNGLTEINSPVLVRDDAMYGTDKLPKFAEDSYQTTNGWWLVSTSEIPLTYTV
AGDILDAAALPIRLTAHTLCFRSEAGSAGRDTAGMLRQHQFEKVEMVSITEPDQSEAEQQRMLRCAEDILERLGLPYRTV
LLCTGDMGFGARRTFDIEAWLPGQNNYREISSVSTTGDFQARRMNARYKPADGGKPQFVHTLNGSGLAVGRCLIAVLENG
QQADGSVVLPPVLAGYLGGKTVLSAEGTLV

Sequences:

>Translated_430_residues
MHDIRAIRENPAAFDAALARRGEAPMSQAILALDTARRAKINAAENAQAEQNKASKEVGQAKAQGDEATFEKLRALVSEK
KALVAEMQADAKALDAELTEKLSWIANIPADDVPDGADEDDNVEVRRWGHLPDFEFTPKEHYEIGGVAASMDFDTAAKTS
GARFVMLKGAVARIHRALSQFMIDTHVDHNGLTEINSPVLVRDDAMYGTDKLPKFAEDSYQTTNGWWLVSTSEIPLTYTV
AGDILDAAALPIRLTAHTLCFRSEAGSAGRDTAGMLRQHQFEKVEMVSITEPDQSEAEQQRMLRCAEDILERLGLPYRTV
LLCTGDMGFGARRTFDIEAWLPGQNNYREISSVSTTGDFQARRMNARYKPADGGKPQFVHTLNGSGLAVGRCLIAVLENG
QQADGSVVLPPVLAGYLGGKTVLSAEGTLV
>Mature_430_residues
MHDIRAIRENPAAFDAALARRGEAPMSQAILALDTARRAKINAAENAQAEQNKASKEVGQAKAQGDEATFEKLRALVSEK
KALVAEMQADAKALDAELTEKLSWIANIPADDVPDGADEDDNVEVRRWGHLPDFEFTPKEHYEIGGVAASMDFDTAAKTS
GARFVMLKGAVARIHRALSQFMIDTHVDHNGLTEINSPVLVRDDAMYGTDKLPKFAEDSYQTTNGWWLVSTSEIPLTYTV
AGDILDAAALPIRLTAHTLCFRSEAGSAGRDTAGMLRQHQFEKVEMVSITEPDQSEAEQQRMLRCAEDILERLGLPYRTV
LLCTGDMGFGARRTFDIEAWLPGQNNYREISSVSTTGDFQARRMNARYKPADGGKPQFVHTLNGSGLAVGRCLIAVLENG
QQADGSVVLPPVLAGYLGGKTVLSAEGTLV

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=368, Percent_Identity=31.5217391304348, Blast_Score=178, Evalue=9e-45,
Organism=Homo sapiens, GI8923421, Length=380, Percent_Identity=32.3684210526316, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI225579074, Length=342, Percent_Identity=33.9181286549708, Blast_Score=172, Evalue=4e-43,
Organism=Escherichia coli, GI1787120, Length=427, Percent_Identity=49.6487119437939, Blast_Score=415, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17539260, Length=355, Percent_Identity=31.830985915493, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17542084, Length=332, Percent_Identity=31.3253012048193, Blast_Score=141, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6320226, Length=389, Percent_Identity=30.5912596401028, Blast_Score=182, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6321799, Length=288, Percent_Identity=30.5555555555556, Blast_Score=158, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24581334, Length=458, Percent_Identity=28.6026200873362, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI17737985, Length=360, Percent_Identity=30, Blast_Score=141, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_ROSDO (Q166J5)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_682784.1
- ProteinModelPortal:   Q166J5
- SMR:   Q166J5
- STRING:   Q166J5
- GeneID:   4198875
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_2541
- NMPDR:   fig|375451.6.peg.2362
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   ENGYTEV
- PhylomeDB:   Q166J5
- ProtClustDB:   PRK05431
- BioCyc:   RDEN375451:RD1_2541-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 46790; Mature: 46790

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 285-285 BINDING 385-385

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDIRAIRENPAAFDAALARRGEAPMSQAILALDTARRAKINAAENAQAEQNKASKEVGQ
CCCCHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHH
AKAQGDEATFEKLRALVSEKKALVAEMQADAKALDAELTEKLSWIANIPADDVPDGADED
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
DNVEVRRWGHLPDFEFTPKEHYEIGGVAASMDFDTAAKTSGARFVMLKGAVARIHRALSQ
CCEEEEEECCCCCCCCCCHHCCEECCEEEECCCCHHHCCCCCEEEEEHHHHHHHHHHHHH
FMIDTHVDHNGLTEINSPVLVRDDAMYGTDKLPKFAEDSYQTTNGWWLVSTSEIPLTYTV
HHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHCCCCCCCCCEEEEECCCCCEEEEE
AGDILDAAALPIRLTAHTLCFRSEAGSAGRDTAGMLRQHQFEKVEMVSITEPDQSEAEQQ
HHHHHHHHCCCEEEHHHHHEEECCCCCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHH
RMLRCAEDILERLGLPYRTVLLCTGDMGFGARRTFDIEAWLPGQNNYREISSVSTTGDFQ
HHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEEEEECCCCCCHHHHCCCCCCCCH
ARRMNARYKPADGGKPQFVHTLNGSGLAVGRCLIAVLENGQQADGSVVLPPVLAGYLGGK
HHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCEECHHHHHHHCCCC
TVLSAEGTLV
EEEECCCCCC
>Mature Secondary Structure
MHDIRAIRENPAAFDAALARRGEAPMSQAILALDTARRAKINAAENAQAEQNKASKEVGQ
CCCCHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHH
AKAQGDEATFEKLRALVSEKKALVAEMQADAKALDAELTEKLSWIANIPADDVPDGADED
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
DNVEVRRWGHLPDFEFTPKEHYEIGGVAASMDFDTAAKTSGARFVMLKGAVARIHRALSQ
CCEEEEEECCCCCCCCCCHHCCEECCEEEECCCCHHHCCCCCEEEEEHHHHHHHHHHHHH
FMIDTHVDHNGLTEINSPVLVRDDAMYGTDKLPKFAEDSYQTTNGWWLVSTSEIPLTYTV
HHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHCCCCCCCCCEEEEECCCCCEEEEE
AGDILDAAALPIRLTAHTLCFRSEAGSAGRDTAGMLRQHQFEKVEMVSITEPDQSEAEQQ
HHHHHHHHCCCEEEHHHHHEEECCCCCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHH
RMLRCAEDILERLGLPYRTVLLCTGDMGFGARRTFDIEAWLPGQNNYREISSVSTTGDFQ
HHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEEEEECCCCCCHHHHCCCCCCCCH
ARRMNARYKPADGGKPQFVHTLNGSGLAVGRCLIAVLENGQQADGSVVLPPVLAGYLGGK
HHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCEECHHHHHHHCCCC
TVLSAEGTLV
EEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA