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The map label for this gene is garR [H]

Identifier: 110679776

GI number: 110679776

Start: 2429638

End: 2430582

Strand: Direct

Name: garR [H]

Synonym: RD1_2540

Alternate gene names: 110679776

Gene position: 2429638-2430582 (Clockwise)

Preceding gene: 110679769

Following gene: 110679779

Centisome position: 58.78

GC content: 60.21

Gene sequence:

>945_bases
ATGAAAGTCGGGTTTATCGGGCTGGGCAATGTGGGCGGCAAGCTCAGCGGGTCTTTGTTGCGCAATGGGACGGCCCTTTG
GGTGCATGACCTGAACCCGGATTTCGTGGCGCAAAAGGTTGCACTGGGTGCGCAGGATGGCGGCACGCCGGCACAGATGA
TGCAGGACTGTGACGCCTTGATCACCTGCCTGCCAAGCCCTGAAGCCTCTGCCGCCGTGCTGGCCGAGATGATGCCGCAT
GTGGGCCCGGGCAAAATCTGGATGGAAATGTCGACCACCGATGCACAAGAGGTCAAAAGGATCGGCGCGCAGGTCATCGC
GGCGGGTGGGGCGGCGGTCGATTGTCCCGTCTCGGGCGGATGCCACCGGGCGGACACGGGCAATATCTCGATCTATGCAG
GATGCGATCGCCCGACGTTTGAGCGCATTTTGCCGTTGCTGACGCTCATGGGGCGGCGCGTGCTGCACACTGGCCCGCTG
GGCAGTGCAAGTGTTTTGAAAGTCATGACAAATTATCTGGCCACCGCCAATCTGCTGACCCTGTGCGAAGCGTTGACGGT
GATGAAGGCTGCCGGGATGGATCTGGGCACGACCTTTGAGGCGATCAGCATCTCGTCGGGCACGTCGTTCGTGCATGAAA
CCGAAAGCCAGTTGCTGTTGTCGGGATCGCGTGATGTGAATTTCACCATGGACCTTGTGCAAAAGGACATCGGCCTGTTT
CAGAAACTGGCTGAGACGCACGCCGTGCCGTTGGAAATCTCACCGCTGATCATCGAAATGATGCGCGACGGGCAGCGCCG
CTATGGCGCGCAGGCACAATCGGATCGCATGATCGAACGGCTTGAGGAGGCAACTGGGCTTGATATCCACGCGCCGGGTT
TCCCCGACGCGCTGATTGATGATGAGCCCGAAGAGCGCGGGTATGAAGTGCACCCGAACCGCTAG

Upstream 100 bases:

>100_bases
TATCCCGCAAGACAGGCCTGCGCGGCGGCAGGTCGCAAACAGGCGCGACAGGTCGTATGCGCCCCCTAGCTTTGCGTAAA
ACAACGGGTGGGAGCGTGGG

Downstream 100 bases:

>100_bases
CCAAGGTCGAGGTCAGACCAGCGTGCCCTCAGCGCTCAGCACGGTCTTGCCACCGAGATAGCCCGCAAGGACCGGCGGCA
GAACCACGGACCCATCTGCT

Product: 2-hydroxy-3-oxopropionate reductase, putative

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MKVGFIGLGNVGGKLSGSLLRNGTALWVHDLNPDFVAQKVALGAQDGGTPAQMMQDCDALITCLPSPEASAAVLAEMMPH
VGPGKIWMEMSTTDAQEVKRIGAQVIAAGGAAVDCPVSGGCHRADTGNISIYAGCDRPTFERILPLLTLMGRRVLHTGPL
GSASVLKVMTNYLATANLLTLCEALTVMKAAGMDLGTTFEAISISSGTSFVHETESQLLLSGSRDVNFTMDLVQKDIGLF
QKLAETHAVPLEISPLIIEMMRDGQRRYGAQAQSDRMIERLEEATGLDIHAPGFPDALIDDEPEERGYEVHPNR

Sequences:

>Translated_314_residues
MKVGFIGLGNVGGKLSGSLLRNGTALWVHDLNPDFVAQKVALGAQDGGTPAQMMQDCDALITCLPSPEASAAVLAEMMPH
VGPGKIWMEMSTTDAQEVKRIGAQVIAAGGAAVDCPVSGGCHRADTGNISIYAGCDRPTFERILPLLTLMGRRVLHTGPL
GSASVLKVMTNYLATANLLTLCEALTVMKAAGMDLGTTFEAISISSGTSFVHETESQLLLSGSRDVNFTMDLVQKDIGLF
QKLAETHAVPLEISPLIIEMMRDGQRRYGAQAQSDRMIERLEEATGLDIHAPGFPDALIDDEPEERGYEVHPNR
>Mature_314_residues
MKVGFIGLGNVGGKLSGSLLRNGTALWVHDLNPDFVAQKVALGAQDGGTPAQMMQDCDALITCLPSPEASAAVLAEMMPH
VGPGKIWMEMSTTDAQEVKRIGAQVIAAGGAAVDCPVSGGCHRADTGNISIYAGCDRPTFERILPLLTLMGRRVLHTGPL
GSASVLKVMTNYLATANLLTLCEALTVMKAAGMDLGTTFEAISISSGTSFVHETESQLLLSGSRDVNFTMDLVQKDIGLF
QKLAETHAVPLEISPLIIEMMRDGQRRYGAQAQSDRMIERLEEATGLDIHAPGFPDALIDDEPEERGYEVHPNR

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=255, Percent_Identity=26.2745098039216, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI23308751, Length=271, Percent_Identity=28.0442804428044, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI145693186, Length=267, Percent_Identity=32.2097378277154, Blast_Score=131, Evalue=5e-32,
Organism=Escherichia coli, GI1786719, Length=285, Percent_Identity=28.7719298245614, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1790315, Length=265, Percent_Identity=30.188679245283, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1789092, Length=282, Percent_Identity=25.531914893617, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17557316, Length=273, Percent_Identity=27.4725274725275, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24655230, Length=263, Percent_Identity=25.4752851711027, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19922568, Length=263, Percent_Identity=25.4752851711027, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI28574115, Length=267, Percent_Identity=20.5992509363296, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 33489; Mature: 33489

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGFIGLGNVGGKLSGSLLRNGTALWVHDLNPDFVAQKVALGAQDGGTPAQMMQDCDAL
CEEEEEEECCCCCCCCCHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
ITCLPSPEASAAVLAEMMPHVGPGKIWMEMSTTDAQEVKRIGAQVIAAGGAAVDCPVSGG
HEECCCCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHEECCCCEEECCCCCC
CHRADTGNISIYAGCDRPTFERILPLLTLMGRRVLHTGPLGSASVLKVMTNYLATANLLT
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCHHEECCCCCHHHHHHHHHHHHHHHHHHH
LCEALTVMKAAGMDLGTTFEAISISSGTSFVHETESQLLLSGSRDVNFTMDLVQKDIGLF
HHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHCCHHHEECCCCCCCHHHHHHHHHHHHH
QKLAETHAVPLEISPLIIEMMRDGQRRYGAQAQSDRMIERLEEATGLDIHAPGFPDALID
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEECCCCCCHHCC
DEPEERGYEVHPNR
CCHHHCCCCCCCCC
>Mature Secondary Structure
MKVGFIGLGNVGGKLSGSLLRNGTALWVHDLNPDFVAQKVALGAQDGGTPAQMMQDCDAL
CEEEEEEECCCCCCCCCHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
ITCLPSPEASAAVLAEMMPHVGPGKIWMEMSTTDAQEVKRIGAQVIAAGGAAVDCPVSGG
HEECCCCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHEECCCCEEECCCCCC
CHRADTGNISIYAGCDRPTFERILPLLTLMGRRVLHTGPLGSASVLKVMTNYLATANLLT
CCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCHHEECCCCCHHHHHHHHHHHHHHHHHHH
LCEALTVMKAAGMDLGTTFEAISISSGTSFVHETESQLLLSGSRDVNFTMDLVQKDIGLF
HHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHCCHHHEECCCCCCCHHHHHHHHHHHHH
QKLAETHAVPLEISPLIIEMMRDGQRRYGAQAQSDRMIERLEEATGLDIHAPGFPDALID
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEECCCCCCHHCC
DEPEERGYEVHPNR
CCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]