Click here to switch to the map view.

The map label for this gene is apt [H]

Identifier: 110679624

GI number: 110679624

Start: 2264331

End: 2264951

Strand: Reverse

Name: apt [H]

Synonym: RD1_2373

Alternate gene names: 110679624

Gene position: 2264951-2264331 (Counterclockwise)

Preceding gene: 110679625

Following gene: 110679622

Centisome position: 54.8

GC content: 57.49

Gene sequence:

>621_bases
ATGGCTCACGACAAAGGACCCAGAGACGACCGTTGGTACTTCTCGCTCATGGCGCCCAACACCAAGGGCGACAAATTTGC
ATGGCTGGACCCGACCTCCATCTACATCAATGGCAAAGCCTATCACGATCTGCTCGACGATCTGTGCAATGATCTGGACG
CGGATGAAATAGACGTCGTCGCAGGGCTGGACGCGATGGGGTTCGTGCTGGCTGCAGGTATCGCGGCGCGCATCGGACGT
GGGTTTTTGCCCATCCGCAAGCCCGGCAAGCTGTGTGTGGACACGGACAGCGCGTCGATGACAAACTATTCCGGCCAGAC
GCAATCGATGGAAATGCGCACGCCTGCCTTTGCGCCCGGAACACGGGTTTTGCTGGTGGATCAATGGGTTGAAACCGGCG
GCACGATGCATGGCGCGGTGCAGCTTGTCGAACAACAGCAGGGCAAGGTCGCCGGCATGGTCGCCATTGTCATGGAAGAA
AACGACAACACCGCTGAATACCGCAAGAAATACAAATGCGTCACGGCCATTCAGCCCGGCACCGAATGGCAGCGCCAGGC
AAATGCGCAGTACCTTGAAAGCTTCAAGACCTATAAGCCCGAGATGGCGTTCCCCGTTTAA

Upstream 100 bases:

>100_bases
TGGCGACAGGCATCAACTTTGACGGGGATTTTTACAATATCGACCCTGACCGCCTCAAGCACCTCATGGACCTCACATCG
AACTAAGGGAGAATTCAAGA

Downstream 100 bases:

>100_bases
GGTCAGGGCACGACGCTCATTCAGCTTGGGCGCGCGCCCGTTTCGGCGTGCCCCGCTTGCGTTGGAAAGCGAGTGCTGCA
CGCGACGGGCGTTTCGCAAG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MAHDKGPRDDRWYFSLMAPNTKGDKFAWLDPTSIYINGKAYHDLLDDLCNDLDADEIDVVAGLDAMGFVLAAGIAARIGR
GFLPIRKPGKLCVDTDSASMTNYSGQTQSMEMRTPAFAPGTRVLLVDQWVETGGTMHGAVQLVEQQQGKVAGMVAIVMEE
NDNTAEYRKKYKCVTAIQPGTEWQRQANAQYLESFKTYKPEMAFPV

Sequences:

>Translated_206_residues
MAHDKGPRDDRWYFSLMAPNTKGDKFAWLDPTSIYINGKAYHDLLDDLCNDLDADEIDVVAGLDAMGFVLAAGIAARIGR
GFLPIRKPGKLCVDTDSASMTNYSGQTQSMEMRTPAFAPGTRVLLVDQWVETGGTMHGAVQLVEQQQGKVAGMVAIVMEE
NDNTAEYRKKYKCVTAIQPGTEWQRQANAQYLESFKTYKPEMAFPV
>Mature_205_residues
AHDKGPRDDRWYFSLMAPNTKGDKFAWLDPTSIYINGKAYHDLLDDLCNDLDADEIDVVAGLDAMGFVLAAGIAARIGRG
FLPIRKPGKLCVDTDSASMTNYSGQTQSMEMRTPAFAPGTRVLLVDQWVETGGTMHGAVQLVEQQQGKVAGMVAIVMEEN
DNTAEYRKKYKCVTAIQPGTEWQRQANAQYLESFKTYKPEMAFPV

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=101, Percent_Identity=39.6039603960396, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI1786675, Length=149, Percent_Identity=34.8993288590604, Blast_Score=79, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17509087, Length=96, Percent_Identity=39.5833333333333, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17136334, Length=137, Percent_Identity=35.7664233576642, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 22837; Mature: 22706

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHDKGPRDDRWYFSLMAPNTKGDKFAWLDPTSIYINGKAYHDLLDDLCNDLDADEIDVV
CCCCCCCCCCCEEEEEECCCCCCCEEEEECCCEEEECCHHHHHHHHHHHHHCCCCCCCEE
AGLDAMGFVLAAGIAARIGRGFLPIRKPGKLCVDTDSASMTNYSGQTQSMEMRTPAFAPG
ECCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEECCCCCCCC
TRVLLVDQWVETGGTMHGAVQLVEQQQGKVAGMVAIVMEENDNTAEYRKKYKCVTAIQPG
CEEEEEECHHHCCCCHHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHEEEEEECCC
TEWQRQANAQYLESFKTYKPEMAFPV
HHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AHDKGPRDDRWYFSLMAPNTKGDKFAWLDPTSIYINGKAYHDLLDDLCNDLDADEIDVV
CCCCCCCCCCEEEEEECCCCCCCEEEEECCCEEEECCHHHHHHHHHHHHHCCCCCCCEE
AGLDAMGFVLAAGIAARIGRGFLPIRKPGKLCVDTDSASMTNYSGQTQSMEMRTPAFAPG
ECCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEECCCCCCCC
TRVLLVDQWVETGGTMHGAVQLVEQQQGKVAGMVAIVMEENDNTAEYRKKYKCVTAIQPG
CEEEEEECHHHCCCCHHHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHEEEEEECCC
TEWQRQANAQYLESFKTYKPEMAFPV
HHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA