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The map label for this gene is hmrR [H]

Identifier: 110679563

GI number: 110679563

Start: 2201200

End: 2201601

Strand: Direct

Name: hmrR [H]

Synonym: RD1_2304

Alternate gene names: 110679563

Gene position: 2201200-2201601 (Clockwise)

Preceding gene: 110679560

Following gene: 110679564

Centisome position: 53.26

GC content: 58.71

Gene sequence:

>402_bases
ATGAATATCGCAGAGGTGTCGCGCGTCAGTGGATTGCCGACAAAGACCATCAGATACTACGAAGACATCGGCCTTGTGAC
GCCAGCGCGCAGGGCCAACGGTTATCGCGATTTCAGCGCGCAGGACGGGCACAAGCTGGCCTTTCTCGGGCGGTCGCGCT
CGCTCGGCTTCTCTATTGAGGAATGCCGCACGCTTTTGTCGCTTTACGAAGACCGCGACCGCGCCAGCGCCGACGTCAAG
AGCGTTGCCGCCAAACATCTGGAACGTGTCGCGAAAAAGATAAAGGAACTGGAGGCGATGAAATCGACACTCGAAACGCT
TGTCACGCGCTGTCACGGGGATGACCGCCCGGATTGCCCGATCCTGAATGATCTCGCTGGTGGTGAGGGGGCAACTGCAT
GA

Upstream 100 bases:

>100_bases
ACACATAGGGCCTCCAGCAACTGGAAGGTCAAGGGGAAATATGCTATTGACTCTCCAGTAGCTGGAAGCCGTAAACGAAC
GCTCAGGAGGTGCCTTGCAC

Downstream 100 bases:

>100_bases
TCGTTGCATCCGAGATATGTTCTGGCACCGCTCCCCTTGCTCCCCCGTCGGTGGGCTGTGATAGGGCTGTGACCTTGGAC
AGCACCGGACCGCTCAAGAG

Product: HTH-type transcriptional regulator hmrR, putative

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 133; Mature: 133

Protein sequence:

>133_residues
MNIAEVSRVSGLPTKTIRYYEDIGLVTPARRANGYRDFSAQDGHKLAFLGRSRSLGFSIEECRTLLSLYEDRDRASADVK
SVAAKHLERVAKKIKELEAMKSTLETLVTRCHGDDRPDCPILNDLAGGEGATA

Sequences:

>Translated_133_residues
MNIAEVSRVSGLPTKTIRYYEDIGLVTPARRANGYRDFSAQDGHKLAFLGRSRSLGFSIEECRTLLSLYEDRDRASADVK
SVAAKHLERVAKKIKELEAMKSTLETLVTRCHGDDRPDCPILNDLAGGEGATA
>Mature_133_residues
MNIAEVSRVSGLPTKTIRYYEDIGLVTPARRANGYRDFSAQDGHKLAFLGRSRSLGFSIEECRTLLSLYEDRDRASADVK
SVAAKHLERVAKKIKELEAMKSTLETLVTRCHGDDRPDCPILNDLAGGEGATA

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=128, Percent_Identity=42.1875, Blast_Score=115, Evalue=8e-28,
Organism=Escherichia coli, GI1789687, Length=130, Percent_Identity=31.5384615384615, Blast_Score=65, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 14655; Mature: 14655

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIAEVSRVSGLPTKTIRYYEDIGLVTPARRANGYRDFSAQDGHKLAFLGRSRSLGFSIE
CCHHHHHHHCCCCHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCEEEEEECCCCCCCCHH
ECRTLLSLYEDRDRASADVKSVAAKHLERVAKKIKELEAMKSTLETLVTRCHGDDRPDCP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
ILNDLAGGEGATA
CHHHCCCCCCCCC
>Mature Secondary Structure
MNIAEVSRVSGLPTKTIRYYEDIGLVTPARRANGYRDFSAQDGHKLAFLGRSRSLGFSIE
CCHHHHHHHCCCCHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCEEEEEECCCCCCCCHH
ECRTLLSLYEDRDRASADVKSVAAKHLERVAKKIKELEAMKSTLETLVTRCHGDDRPDCP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
ILNDLAGGEGATA
CHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]