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The map label for this gene is purC

Identifier: 110679527

GI number: 110679527

Start: 2162753

End: 2163514

Strand: Direct

Name: purC

Synonym: RD1_2262

Alternate gene names: 110679527

Gene position: 2162753-2163514 (Clockwise)

Preceding gene: 110679522

Following gene: 110679528

Centisome position: 52.33

GC content: 57.35

Gene sequence:

>762_bases
ATGGCCCGGCGCAAGAAAATCTACGAAGGCAAAGCGAAAATCCTGTATGAAGGACCCGAACCGGGCACCATCGTGCAGTA
CTTCAAGGACGATGCCACCGCGTTCAATGCCGAAAAGAAGGCCGTGATCGAAGGCAAGGGGGTGTTGAACAACCGTTTGT
CCGAATTCTTCATGACCGGACTTGGCCATATCGGCGTGCCGACGCATTTCATCAAACGGCTCAACATGCGTGAACAGCTT
GTGCGCAGCGTGGACATCATCCCGCTCGAGATCATCGTGCGCAACTACGCCGCTGGCACCATGTCAAAGCGACTGGGGTT
GGAAGAGGGCACGCAACTGCCGCGCCCCATCGTTGAATATTGCTATAAGGATGACAAGCTGGGCGATCCGCTGGTCACAG
AAGAGCACATCGCGGCCTTTGGCTGGGCCAGCCAGCAGGATATGGATGACATGCTCAGCCTCGCGCTGCGGGTAAATGAT
TTCCTGTCGGGGCTGATGTTCGGCGTGGGCATTCGTCTGGTGGATTTCAAGATCGAAGTGGGCCGCGTCTATGACGGGGA
TTTCCAGCGTCTTGTTGTCGCCGATGAGATCAGCCCGGACAGTTGCCGCTTGTGGGACATCGAATCCGGTCGCAAGCTGG
ACAAGGACGTGTTCCGGCGCGATCTCGGCGATCTGGCCGATGCCTATACCGAAGTGGCGCAGCGTCTGGGCGTGATGCCC
AAGAACGCCACGCCGATCACAAAACCGACCCTGATCAACTAA

Upstream 100 bases:

>100_bases
CATTGCGCAAGATGCCTCGGCTTGCAGCGACGCAACCCTTCCACTAAGAGAGGCGCAGATAAGTCCCTGATCCTCAGGGC
TCAGTCTTGAAAGGACGCCC

Downstream 100 bases:

>100_bases
CCCCGGGAAACAGTGCGTCCGGGGCGCACAGAAGGACGAGACATGAAAGCACGAGTACATGTTATGCTGAAAAACGGTGT
GCTGGACCCGCAGGGCGAAG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MARRKKIYEGKAKILYEGPEPGTIVQYFKDDATAFNAEKKAVIEGKGVLNNRLSEFFMTGLGHIGVPTHFIKRLNMREQL
VRSVDIIPLEIIVRNYAAGTMSKRLGLEEGTQLPRPIVEYCYKDDKLGDPLVTEEHIAAFGWASQQDMDDMLSLALRVND
FLSGLMFGVGIRLVDFKIEVGRVYDGDFQRLVVADEISPDSCRLWDIESGRKLDKDVFRRDLGDLADAYTEVAQRLGVMP
KNATPITKPTLIN

Sequences:

>Translated_253_residues
MARRKKIYEGKAKILYEGPEPGTIVQYFKDDATAFNAEKKAVIEGKGVLNNRLSEFFMTGLGHIGVPTHFIKRLNMREQL
VRSVDIIPLEIIVRNYAAGTMSKRLGLEEGTQLPRPIVEYCYKDDKLGDPLVTEEHIAAFGWASQQDMDDMLSLALRVND
FLSGLMFGVGIRLVDFKIEVGRVYDGDFQRLVVADEISPDSCRLWDIESGRKLDKDVFRRDLGDLADAYTEVAQRLGVMP
KNATPITKPTLIN
>Mature_252_residues
ARRKKIYEGKAKILYEGPEPGTIVQYFKDDATAFNAEKKAVIEGKGVLNNRLSEFFMTGLGHIGVPTHFIKRLNMREQLV
RSVDIIPLEIIVRNYAAGTMSKRLGLEEGTQLPRPIVEYCYKDDKLGDPLVTEEHIAAFGWASQQDMDDMLSLALRVNDF
LSGLMFGVGIRLVDFKIEVGRVYDGDFQRLVVADEISPDSCRLWDIESGRKLDKDVFRRDLGDLADAYTEVAQRLGVMPK
NATPITKPTLIN

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=257, Percent_Identity=31.9066147859922, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI5453539, Length=257, Percent_Identity=31.9066147859922, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI119220559, Length=264, Percent_Identity=30.6818181818182, Blast_Score=94, Evalue=9e-20,
Organism=Escherichia coli, GI1788820, Length=238, Percent_Identity=41.1764705882353, Blast_Score=194, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17531275, Length=227, Percent_Identity=31.7180616740088, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI18860083, Length=254, Percent_Identity=31.1023622047244, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24583917, Length=249, Percent_Identity=26.5060240963855, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_ROSDO (Q167J5)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_682534.1
- ProteinModelPortal:   Q167J5
- SMR:   Q167J5
- STRING:   Q167J5
- GeneID:   4196492
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_2262
- NMPDR:   fig|375451.6.peg.2110
- eggNOG:   COG0152
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- PhylomeDB:   Q167J5
- ProtClustDB:   PRK09362
- BioCyc:   RDEN375451:RD1_2262-MONOMER
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 28514; Mature: 28383

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARRKKIYEGKAKILYEGPEPGTIVQYFKDDATAFNAEKKAVIEGKGVLNNRLSEFFMTG
CCCCCCHHCCCEEEEEECCCCCHHHHHHHCCHHHCCCCCCEEEECCCHHHHHHHHHHHHC
LGHIGVPTHFIKRLNMREQLVRSVDIIPLEIIVRNYAAGTMSKRLGLEEGTQLPRPIVEY
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
CYKDDKLGDPLVTEEHIAAFGWASQQDMDDMLSLALRVNDFLSGLMFGVGIRLVDFKIEV
HHCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEE
GRVYDGDFQRLVVADEISPDSCRLWDIESGRKLDKDVFRRDLGDLADAYTEVAQRLGVMP
CEEECCCCEEEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
KNATPITKPTLIN
CCCCCCCCCCCCC
>Mature Secondary Structure 
ARRKKIYEGKAKILYEGPEPGTIVQYFKDDATAFNAEKKAVIEGKGVLNNRLSEFFMTG
CCCCCHHCCCEEEEEECCCCCHHHHHHHCCHHHCCCCCCEEEECCCHHHHHHHHHHHHC
LGHIGVPTHFIKRLNMREQLVRSVDIIPLEIIVRNYAAGTMSKRLGLEEGTQLPRPIVEY
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
CYKDDKLGDPLVTEEHIAAFGWASQQDMDDMLSLALRVNDFLSGLMFGVGIRLVDFKIEV
HHCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEE
GRVYDGDFQRLVVADEISPDSCRLWDIESGRKLDKDVFRRDLGDLADAYTEVAQRLGVMP
CEEECCCCEEEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
KNATPITKPTLIN
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA