Click here to switch to the map view.

The map label for this gene is envZ [H]

Identifier: 110679517

GI number: 110679517

Start: 2153976

End: 2155301

Strand: Direct

Name: envZ [H]

Synonym: RD1_2250

Alternate gene names: 110679517

Gene position: 2153976-2155301 (Clockwise)

Preceding gene: 110679514

Following gene: 110679518

Centisome position: 52.12

GC content: 60.48

Gene sequence:

>1326_bases
ATGTTCTTTGGGTGGCTCAAACAATATATGCCGCGCAGCCTGTATGTGCGGGCGGTTCTGATCCTGCTGTTGCCGGTGGT
TTTCCTGCAACTGGTGGTGACGGTGCTGTTTCTGACCCGACATTTCGAAGACGTCACGCAGCAAATGGTAACGGCCGTTT
CCCGCGAGATTCTGCTGGTTCTCGATATTGTTGATACCGCGCCGGATGCAGGCTCCGTGCCAACGCAAGTGGTGGCTCAG
GCCAGTCAACTGGCGTTGACGGCCACGCCTGTATCGCCCGACGCTGTGCCGAGCCAGATGTTGCGCCACTGGTATGACTT
TTCCGGGCGCGTGATCGTGGCGCGTTTGCCGTCGCGCGTTGCGCAAATCGAAACCATAGATCTGTTGAACGACCAGCGGG
TCCATGTTTATGCGCAAACCCGCCATGGCCCGGTCCGCATAAGTTTTGACCGCGATCGCGTCTCGGCCAAGAATCCGCAT
CAGCTTTTTGTGAACATGATCTTCTTCGGTGGGCTGGTGACCGTTATCGCCATCCTCTACTTGCGCAATCAGTTGCGGCC
GATCAAGCGGTTGGCGCGCGCGGCAGAGGCGTTTGGACGGGGAAGGCATGAGCCCTACACCCCGGCCGGTGCGTCCGAAG
TCAGGGCGGCGGGCAATGCGTTTCTGGATATGCGCAACCGGATCGAACGCCAGATCGAACAACGCACCTTGATGCTGTCG
GGGGTAAGTCATGATTTGCGCACCCCGCTCACGCGCATGCGGCTCAGCCTGTCCATGCTGGAGGATGCCGAGAGAATACC
GCTTGAGCAGGATGTCAACGACATGCAGGAGATGCTTGATGCCTTTCTCAGCTTTGCCAAGGGCGAAGGAGAGGGCGAGC
CCGAAGCTGTCGATCCACGCGCATTGGTCAGTGCTGTGGTTGAGGACGCAAAAAGGGCAGGGCGCGATGTCACGCTGGTG
GCGCAGGAGGGCGAGGGGACGGGCACTGTCCAACTGAATGTGCTGGCCATAAGGCGCGCGCTGGACAACCTGATTTCCAA
TGCGGTGCGCTATGGAACGCGCGCGCAGGTGTCCGTCTTGCTCACGGATAAAACCCTGCGGCTGCGGGTTGAAGACGATG
GACCGGGCATTCCGGAAAAGCGGCGGGCAGAGGCGACGCGCCCCTTTACCCGTCTGGATGCAGCGCGCAATCAGGATCAG
GGCAGTGGCGTTGGTCTGGGCCTCGCGATCACCAGTGACATCGCGCGCGCGCACGGCGGTATGCTGAGGCTTGGCAAATC
TGAACGTCTGGGCGGCCTCAGTGCCGACATCGTCATCGCGCGCTAA

Upstream 100 bases:

>100_bases
CCGGCTCTATTGATTGCGGGACGCCGATGGGCGGGTCGAAATCATCTGCCATGGTCATTCAGTCTTTCTAATGCTGGGGG
GCACCGTTAGGGTCTACCGC

Downstream 100 bases:

>100_bases
AGCGTCACGCGAAAACAGTGTCAGTTGGTTTGGCCCATGTGCAGGGTTTGGAATTCATGGCGGTCATGGTAGGCCCGGCA
GGACTTGAACCCGCAACCAA

Product: sensor histidine kinase, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MFFGWLKQYMPRSLYVRAVLILLLPVVFLQLVVTVLFLTRHFEDVTQQMVTAVSREILLVLDIVDTAPDAGSVPTQVVAQ
ASQLALTATPVSPDAVPSQMLRHWYDFSGRVIVARLPSRVAQIETIDLLNDQRVHVYAQTRHGPVRISFDRDRVSAKNPH
QLFVNMIFFGGLVTVIAILYLRNQLRPIKRLARAAEAFGRGRHEPYTPAGASEVRAAGNAFLDMRNRIERQIEQRTLMLS
GVSHDLRTPLTRMRLSLSMLEDAERIPLEQDVNDMQEMLDAFLSFAKGEGEGEPEAVDPRALVSAVVEDAKRAGRDVTLV
AQEGEGTGTVQLNVLAIRRALDNLISNAVRYGTRAQVSVLLTDKTLRLRVEDDGPGIPEKRRAEATRPFTRLDAARNQDQ
GSGVGLGLAITSDIARAHGGMLRLGKSERLGGLSADIVIAR

Sequences:

>Translated_441_residues
MFFGWLKQYMPRSLYVRAVLILLLPVVFLQLVVTVLFLTRHFEDVTQQMVTAVSREILLVLDIVDTAPDAGSVPTQVVAQ
ASQLALTATPVSPDAVPSQMLRHWYDFSGRVIVARLPSRVAQIETIDLLNDQRVHVYAQTRHGPVRISFDRDRVSAKNPH
QLFVNMIFFGGLVTVIAILYLRNQLRPIKRLARAAEAFGRGRHEPYTPAGASEVRAAGNAFLDMRNRIERQIEQRTLMLS
GVSHDLRTPLTRMRLSLSMLEDAERIPLEQDVNDMQEMLDAFLSFAKGEGEGEPEAVDPRALVSAVVEDAKRAGRDVTLV
AQEGEGTGTVQLNVLAIRRALDNLISNAVRYGTRAQVSVLLTDKTLRLRVEDDGPGIPEKRRAEATRPFTRLDAARNQDQ
GSGVGLGLAITSDIARAHGGMLRLGKSERLGGLSADIVIAR
>Mature_441_residues
MFFGWLKQYMPRSLYVRAVLILLLPVVFLQLVVTVLFLTRHFEDVTQQMVTAVSREILLVLDIVDTAPDAGSVPTQVVAQ
ASQLALTATPVSPDAVPSQMLRHWYDFSGRVIVARLPSRVAQIETIDLLNDQRVHVYAQTRHGPVRISFDRDRVSAKNPH
QLFVNMIFFGGLVTVIAILYLRNQLRPIKRLARAAEAFGRGRHEPYTPAGASEVRAAGNAFLDMRNRIERQIEQRTLMLS
GVSHDLRTPLTRMRLSLSMLEDAERIPLEQDVNDMQEMLDAFLSFAKGEGEGEPEAVDPRALVSAVVEDAKRAGRDVTLV
AQEGEGTGTVQLNVLAIRRALDNLISNAVRYGTRAQVSVLLTDKTLRLRVEDDGPGIPEKRRAEATRPFTRLDAARNQDQ
GSGVGLGLAITSDIARAHGGMLRLGKSERLGGLSADIVIAR

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=447, Percent_Identity=31.7673378076063, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1787894, Length=277, Percent_Identity=32.4909747292419, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790346, Length=260, Percent_Identity=31.5384615384615, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1790551, Length=287, Percent_Identity=28.5714285714286, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI87082128, Length=285, Percent_Identity=29.1228070175439, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787374, Length=334, Percent_Identity=27.2455089820359, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788393, Length=269, Percent_Identity=26.7657992565056, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786600, Length=226, Percent_Identity=28.7610619469027, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790861, Length=302, Percent_Identity=27.8145695364238, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87081816, Length=229, Percent_Identity=25.764192139738, Blast_Score=62, Evalue=8e-11,
Organism=Escherichia coli, GI1786783, Length=230, Percent_Identity=27.8260869565217, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48791; Mature: 48791

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFGWLKQYMPRSLYVRAVLILLLPVVFLQLVVTVLFLTRHFEDVTQQMVTAVSREILLV
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
LDIVDTAPDAGSVPTQVVAQASQLALTATPVSPDAVPSQMLRHWYDFSGRVIVARLPSRV
EEEHHCCCCCCCCHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHCCCCCEEEEECHHHH
AQIETIDLLNDQRVHVYAQTRHGPVRISFDRDRVSAKNPHQLFVNMIFFGGLVTVIAILY
HHHHHHCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LRNQLRPIKRLARAAEAFGRGRHEPYTPAGASEVRAAGNAFLDMRNRIERQIEQRTLMLS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVSHDLRTPLTRMRLSLSMLEDAERIPLEQDVNDMQEMLDAFLSFAKGEGEGEPEAVDPR
CCCHHHHCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
ALVSAVVEDAKRAGRDVTLVAQEGEGTGTVQLNVLAIRRALDNLISNAVRYGTRAQVSVL
HHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEE
LTDKTLRLRVEDDGPGIPEKRRAEATRPFTRLDAARNQDQGSGVGLGLAITSDIARAHGG
EECCEEEEEECCCCCCCCCHHHHHHCCCHHHHHHHCCCCCCCCCEEEHHHHHHHHHHCCC
MLRLGKSERLGGLSADIVIAR
EEEECCCCCCCCCCCCEEEEC
>Mature Secondary Structure
MFFGWLKQYMPRSLYVRAVLILLLPVVFLQLVVTVLFLTRHFEDVTQQMVTAVSREILLV
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
LDIVDTAPDAGSVPTQVVAQASQLALTATPVSPDAVPSQMLRHWYDFSGRVIVARLPSRV
EEEHHCCCCCCCCHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHCCCCCEEEEECHHHH
AQIETIDLLNDQRVHVYAQTRHGPVRISFDRDRVSAKNPHQLFVNMIFFGGLVTVIAILY
HHHHHHCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LRNQLRPIKRLARAAEAFGRGRHEPYTPAGASEVRAAGNAFLDMRNRIERQIEQRTLMLS
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVSHDLRTPLTRMRLSLSMLEDAERIPLEQDVNDMQEMLDAFLSFAKGEGEGEPEAVDPR
CCCHHHHCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
ALVSAVVEDAKRAGRDVTLVAQEGEGTGTVQLNVLAIRRALDNLISNAVRYGTRAQVSVL
HHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEE
LTDKTLRLRVEDDGPGIPEKRRAEATRPFTRLDAARNQDQGSGVGLGLAITSDIARAHGG
EECCEEEEEECCCCCCCCCHHHHHHCCCHHHHHHHCCCCCCCCCEEEHHHHHHHHHHCCC
MLRLGKSERLGGLSADIVIAR
EEEECCCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]