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The map label for this gene is acdA [H]

Identifier: 110679512

GI number: 110679512

Start: 2147387

End: 2148535

Strand: Direct

Name: acdA [H]

Synonym: RD1_2243

Alternate gene names: 110679512

Gene position: 2147387-2148535 (Clockwise)

Preceding gene: 110679511

Following gene: 110679513

Centisome position: 51.96

GC content: 57.88

Gene sequence:

>1149_bases
ATGGATTTTTCGCTCACCGAGGAACAGCAAGCGATTTTCGACATGGCCTATGCTTTTGGCCAGGAAAACATCGCACCCTT
TGCCCAGGAGTGGGAAGCCGCCGGGACCATCCCAAAGGCGCTGTGGCCCAAGGTCGCTGAACTTGGCCTTGCCGGGATTT
ATGTGTCCGAAGAACACGGCGGCTCAGGGCTTTCCCGGCTTGATGCGACGCTGGTTTTTGAAGCACTGGCAATGGCTTGC
CCGTCGGTCGGGTCCTTTCTGTCGATCCACAACATGTGCGGCGGCATGATCGACACCTATGGTTCTGACGCCATGAAAAC
ACACTGGTTGCCCAAGCTGTGTACCATGGAAACCGTATTCTCTTATTGCCTGACCGAACCCGGGTCAGGATCTGATGCCG
CTGCCCTGCGCACGCGGGCGCAGCGCAGCAACTCAGGCTATGTGTTGAACGGCACCAAGGCGTTCATTTCGGGTGGCGGA
TATTCCGATGTCTACCTCACGATGGTGCGCACGGGGGATGCAGGCCCCAAGGGTATTTCCGCCGTACTGATTGAAAACGG
GCGCGAAGGTCTGTCTTTTGGCGCCCTCGAAAACAAGATGGGATGGCGCGCGCAACCCACGGCACAGGTGCAGTTTGATG
ACTGCGCGATCCCGGCGGACAATCTGGTCGGGCAGGAAGGGCAGGGGTTTGCCTACGCGATGGCGGGCCTTGACGGGGGG
CGATTGAACATCGCCGCATCCGCCCTTGGTGGCGCGCAGGCGGCGCTGAACGCTGCCCTGTCCTATACCGCGGAGCGCAA
GGCATTCGGGCAACGGCTGGATCAGTTTCAGGCGCTGCAATTCAAACTGGCGGATATGGAAGTCAAGTTGCAGACCGCGC
GGATATTCCTGCGTCAGGCCGCGTCCAAACTGGATGCTAAAGCTGCGGATGCCACAAAATATTGTGCAATGGCAAAGCTT
TACGTGACAGATGTTGCATTTGATGTGGCCAATCAGGCGCTGCAACTGCACGGCGGATACGGCTATCTTGCAGACTACGG
GATCGAAAAAATCGTGCGGGATTTGCGCGTGCACCAGATTCTGGAAGGCACAAACGAAGTCATGCGTGTCATTATTTCGC
GCCAGATGATCGCTGAACACGGGGCCTGA

Upstream 100 bases:

>100_bases
CTTGAGATGACGGGCTACTGAGCGACCCCTTGCAGCGTCCGACCGGGATGATATGCCTTGGGCCGGGCTGCTTGGGCCGC
ACGATCATTTGAGGATGCCG

Downstream 100 bases:

>100_bases
CGGGCGTTTCACCGCTTTTTAGGGACTGCGATGCACGACCATTAAGGCTCAATTTACATCTGTGCGGCATGTTTGGACAA
GTGCGTGTCACATCAGGCAT

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MDFSLTEEQQAIFDMAYAFGQENIAPFAQEWEAAGTIPKALWPKVAELGLAGIYVSEEHGGSGLSRLDATLVFEALAMAC
PSVGSFLSIHNMCGGMIDTYGSDAMKTHWLPKLCTMETVFSYCLTEPGSGSDAAALRTRAQRSNSGYVLNGTKAFISGGG
YSDVYLTMVRTGDAGPKGISAVLIENGREGLSFGALENKMGWRAQPTAQVQFDDCAIPADNLVGQEGQGFAYAMAGLDGG
RLNIAASALGGAQAALNAALSYTAERKAFGQRLDQFQALQFKLADMEVKLQTARIFLRQAASKLDAKAADATKYCAMAKL
YVTDVAFDVANQALQLHGGYGYLADYGIEKIVRDLRVHQILEGTNEVMRVIISRQMIAEHGA

Sequences:

>Translated_382_residues
MDFSLTEEQQAIFDMAYAFGQENIAPFAQEWEAAGTIPKALWPKVAELGLAGIYVSEEHGGSGLSRLDATLVFEALAMAC
PSVGSFLSIHNMCGGMIDTYGSDAMKTHWLPKLCTMETVFSYCLTEPGSGSDAAALRTRAQRSNSGYVLNGTKAFISGGG
YSDVYLTMVRTGDAGPKGISAVLIENGREGLSFGALENKMGWRAQPTAQVQFDDCAIPADNLVGQEGQGFAYAMAGLDGG
RLNIAASALGGAQAALNAALSYTAERKAFGQRLDQFQALQFKLADMEVKLQTARIFLRQAASKLDAKAADATKYCAMAKL
YVTDVAFDVANQALQLHGGYGYLADYGIEKIVRDLRVHQILEGTNEVMRVIISRQMIAEHGA
>Mature_382_residues
MDFSLTEEQQAIFDMAYAFGQENIAPFAQEWEAAGTIPKALWPKVAELGLAGIYVSEEHGGSGLSRLDATLVFEALAMAC
PSVGSFLSIHNMCGGMIDTYGSDAMKTHWLPKLCTMETVFSYCLTEPGSGSDAAALRTRAQRSNSGYVLNGTKAFISGGG
YSDVYLTMVRTGDAGPKGISAVLIENGREGLSFGALENKMGWRAQPTAQVQFDDCAIPADNLVGQEGQGFAYAMAGLDGG
RLNIAASALGGAQAALNAALSYTAERKAFGQRLDQFQALQFKLADMEVKLQTARIFLRQAASKLDAKAADATKYCAMAKL
YVTDVAFDVANQALQLHGGYGYLADYGIEKIVRDLRVHQILEGTNEVMRVIISRQMIAEHGA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7656849, Length=375, Percent_Identity=51.7333333333333, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI4557231, Length=383, Percent_Identity=34.7258485639687, Blast_Score=244, Evalue=9e-65,
Organism=Homo sapiens, GI187960098, Length=383, Percent_Identity=34.7258485639687, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI4501859, Length=379, Percent_Identity=36.4116094986807, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI4557233, Length=375, Percent_Identity=37.3333333333333, Blast_Score=240, Evalue=1e-63,
Organism=Homo sapiens, GI4501857, Length=363, Percent_Identity=36.0881542699724, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI226958412, Length=381, Percent_Identity=34.9081364829396, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI76496475, Length=354, Percent_Identity=34.4632768361582, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI4557235, Length=354, Percent_Identity=34.4632768361582, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI226958414, Length=345, Percent_Identity=35.0724637681159, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI21361497, Length=356, Percent_Identity=34.2696629213483, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI4503943, Length=378, Percent_Identity=28.042328042328, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI7669494, Length=352, Percent_Identity=28.4090909090909, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI38505218, Length=322, Percent_Identity=27.0186335403727, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI211971008, Length=336, Percent_Identity=24.4047619047619, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI48976061, Length=336, Percent_Identity=24.4047619047619, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1786223, Length=389, Percent_Identity=28.2776349614396, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI87081958, Length=392, Percent_Identity=30.3571428571429, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI87082384, Length=288, Percent_Identity=26.7361111111111, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87081702, Length=303, Percent_Identity=22.7722772277228, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17533517, Length=377, Percent_Identity=47.2148541114058, Blast_Score=384, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17569725, Length=382, Percent_Identity=32.9842931937173, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=33.2460732984293, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17506239, Length=381, Percent_Identity=33.3333333333333, Blast_Score=228, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17508101, Length=378, Percent_Identity=32.8042328042328, Blast_Score=226, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17570075, Length=384, Percent_Identity=31.25, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI71985184, Length=381, Percent_Identity=33.3333333333333, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17538396, Length=386, Percent_Identity=33.419689119171, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI71990804, Length=279, Percent_Identity=35.1254480286738, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17551932, Length=360, Percent_Identity=32.2222222222222, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI32563615, Length=233, Percent_Identity=37.7682403433476, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17505929, Length=371, Percent_Identity=31.8059299191375, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI71985192, Length=277, Percent_Identity=36.101083032491, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=30.2919708029197, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17534353, Length=381, Percent_Identity=28.6089238845144, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17562446, Length=326, Percent_Identity=25.4601226993865, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17531909, Length=240, Percent_Identity=25.8333333333333, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI86563383, Length=331, Percent_Identity=27.7945619335347, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI86563381, Length=331, Percent_Identity=27.7945619335347, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17531913, Length=171, Percent_Identity=26.9005847953216, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=34.9206349206349, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI21355753, Length=384, Percent_Identity=35.15625, Blast_Score=234, Evalue=6e-62,
Organism=Drosophila melanogaster, GI21356377, Length=381, Percent_Identity=34.6456692913386, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24646207, Length=381, Percent_Identity=35.6955380577428, Blast_Score=215, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24666513, Length=380, Percent_Identity=32.8947368421053, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI281363737, Length=347, Percent_Identity=34.5821325648415, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI19920834, Length=379, Percent_Identity=26.9129287598945, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 40912; Mature: 40912

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFSLTEEQQAIFDMAYAFGQENIAPFAQEWEAAGTIPKALWPKVAELGLAGIYVSEEHG
CCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEECCCC
GSGLSRLDATLVFEALAMACPSVGSFLSIHNMCGGMIDTYGSDAMKTHWLPKLCTMETVF
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHCCCCHHHHHCCHHHHHHHHHH
SYCLTEPGSGSDAAALRTRAQRSNSGYVLNGTKAFISGGGYSDVYLTMVRTGDAGPKGIS
HHHHCCCCCCCCHHHHHHHHHCCCCCEEEECCEEEECCCCCCCEEEEEEEECCCCCCCEE
AVLIENGREGLSFGALENKMGWRAQPTAQVQFDDCAIPADNLVGQEGQGFAYAMAGLDGG
EEEEECCCCCCCCCCHHCCCCCCCCCCCEEEECCCCCCHHHHCCCCCCCEEEEEECCCCC
RLNIAASALGGAQAALNAALSYTAERKAFGQRLDQFQALQFKLADMEVKLQTARIFLRQA
CEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
ASKLDAKAADATKYCAMAKLYVTDVAFDVANQALQLHGGYGYLADYGIEKIVRDLRVHQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHH
LEGTNEVMRVIISRQMIAEHGA
HHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDFSLTEEQQAIFDMAYAFGQENIAPFAQEWEAAGTIPKALWPKVAELGLAGIYVSEEHG
CCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEECCCC
GSGLSRLDATLVFEALAMACPSVGSFLSIHNMCGGMIDTYGSDAMKTHWLPKLCTMETVF
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHCCCCHHHHHCCHHHHHHHHHH
SYCLTEPGSGSDAAALRTRAQRSNSGYVLNGTKAFISGGGYSDVYLTMVRTGDAGPKGIS
HHHHCCCCCCCCHHHHHHHHHCCCCCEEEECCEEEECCCCCCCEEEEEEEECCCCCCCEE
AVLIENGREGLSFGALENKMGWRAQPTAQVQFDDCAIPADNLVGQEGQGFAYAMAGLDGG
EEEEECCCCCCCCCCHHCCCCCCCCCCCEEEECCCCCCHHHHCCCCCCCEEEEEECCCCC
RLNIAASALGGAQAALNAALSYTAERKAFGQRLDQFQALQFKLADMEVKLQTARIFLRQA
CEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
ASKLDAKAADATKYCAMAKLYVTDVAFDVANQALQLHGGYGYLADYGIEKIVRDLRVHQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHH
LEGTNEVMRVIISRQMIAEHGA
HHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]