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The map label for this gene is apt

Identifier: 110679422

GI number: 110679422

Start: 2045167

End: 2045697

Strand: Reverse

Name: apt

Synonym: RD1_2148

Alternate gene names: 110679422

Gene position: 2045697-2045167 (Counterclockwise)

Preceding gene: 110679423

Following gene: 110679408

Centisome position: 49.5

GC content: 59.13

Gene sequence:

>531_bases
ATGAAAACCGTACAAGACTACATCCGCACCATCGTCGATTTCCCCCACGAGGGGATCATGTTTCGCGATGTGACCACGCT
TTTCGCAGATCCACGCGGGTTTCGCATCGCGATTGACCAGATGTTGCACCCCTATGCGGGCTTGCAGATTGATAAGGTTG
TGGGGCTGGAGGCACGCGGGTTCATCCTCGGCGGCGCCATCGCGCACCAGTTGTCCAAGGGGTTCGTCCCAATCCGCAAG
AAAGGCAAGCTGCCGGGCAAAACCATCAGCGAAGCCTATACGCTGGAATATGGCGAGGCGATTGTCGAAATCCACGATGA
CGCCATCCAACCGGGCGAAAAGGTGCTGGTGGTCGATGATCTGCTCGCCACAGGCGGCACTGCCGAAGCGGGCATCAAGC
TTATCGAGCGGTTGGGAGGGGAGATCATCTCCACCTCCTTTATCATTGATCTGCCCGATCTTGGCGGGCGCGCGCGCCTT
GAGGCCATGGGCGTGGAGGTCAACGCGCTCTGCGCCTATGAGGGGCTGTGA

Upstream 100 bases:

>100_bases
CCGTCCTGACGTGGATCACCCGCGCAGGCGGCGCCACCCTGATTGGCATGGGCGTGCTGACCGCAACCCTGCGCCGCGCC
ACATAACCCTGAGAGACATT

Downstream 100 bases:

>100_bases
TCAACCCACAAGCGTTGGCCAGTTTGCATCCCCCGCAGCGATGTTGCCCGCGACGTCACGTTCCCATTTGCGTTGAATGC
GGCGTGAAAAGTTGAGGTAC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MKTVQDYIRTIVDFPHEGIMFRDVTTLFADPRGFRIAIDQMLHPYAGLQIDKVVGLEARGFILGGAIAHQLSKGFVPIRK
KGKLPGKTISEAYTLEYGEAIVEIHDDAIQPGEKVLVVDDLLATGGTAEAGIKLIERLGGEIISTSFIIDLPDLGGRARL
EAMGVEVNALCAYEGL

Sequences:

>Translated_176_residues
MKTVQDYIRTIVDFPHEGIMFRDVTTLFADPRGFRIAIDQMLHPYAGLQIDKVVGLEARGFILGGAIAHQLSKGFVPIRK
KGKLPGKTISEAYTLEYGEAIVEIHDDAIQPGEKVLVVDDLLATGGTAEAGIKLIERLGGEIISTSFIIDLPDLGGRARL
EAMGVEVNALCAYEGL
>Mature_176_residues
MKTVQDYIRTIVDFPHEGIMFRDVTTLFADPRGFRIAIDQMLHPYAGLQIDKVVGLEARGFILGGAIAHQLSKGFVPIRK
KGKLPGKTISEAYTLEYGEAIVEIHDDAIQPGEKVLVVDDLLATGGTAEAGIKLIERLGGEIISTSFIIDLPDLGGRARL
EAMGVEVNALCAYEGL

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=177, Percent_Identity=43.5028248587571, Blast_Score=147, Evalue=4e-36,
Organism=Homo sapiens, GI71773201, Length=128, Percent_Identity=47.65625, Blast_Score=124, Evalue=4e-29,
Organism=Escherichia coli, GI1786675, Length=175, Percent_Identity=54.2857142857143, Blast_Score=190, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17509087, Length=176, Percent_Identity=43.1818181818182, Blast_Score=136, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6323619, Length=154, Percent_Identity=42.8571428571429, Blast_Score=116, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320649, Length=165, Percent_Identity=37.5757575757576, Blast_Score=90, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136334, Length=174, Percent_Identity=39.6551724137931, Blast_Score=121, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_ROSDO (Q167V0)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_682429.1
- ProteinModelPortal:   Q167V0
- SMR:   Q167V0
- STRING:   Q167V0
- GeneID:   4196612
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_2148
- NMPDR:   fig|375451.6.peg.2004
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- PhylomeDB:   Q167V0
- ProtClustDB:   PRK02304
- BioCyc:   RDEN375451:RD1_2148-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19064; Mature: 19064

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVQDYIRTIVDFPHEGIMFRDVTTLFADPRGFRIAIDQMLHPYAGLQIDKVVGLEARG
CCCHHHHHHHHHHCCCCCEEHHHHHHHHCCCCCCEEEHHHHHCHHCCCEEEHEECCCCCC
FILGGAIAHQLSKGFVPIRKKGKLPGKTISEAYTLEYGEAIVEIHDDAIQPGEKVLVVDD
EEEHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEECCCCCCCCCEEEEEEH
LLATGGTAEAGIKLIERLGGEIISTSFIIDLPDLGGRARLEAMGVEVNALCAYEGL
HHHCCCCHHHHHHHHHHHCCCEEEEEEEEECCCCCCCEEEEEECCEEEEEEECCCC
>Mature Secondary Structure
MKTVQDYIRTIVDFPHEGIMFRDVTTLFADPRGFRIAIDQMLHPYAGLQIDKVVGLEARG
CCCHHHHHHHHHHCCCCCEEHHHHHHHHCCCCCCEEEHHHHHCHHCCCEEEHEECCCCCC
FILGGAIAHQLSKGFVPIRKKGKLPGKTISEAYTLEYGEAIVEIHDDAIQPGEKVLVVDD
EEEHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEECCCCCCCCCEEEEEEH
LLATGGTAEAGIKLIERLGGEIISTSFIIDLPDLGGRARLEAMGVEVNALCAYEGL
HHHCCCCHHHHHHHHHHHCCCEEEEEEEEECCCCCCCEEEEEECCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA