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The map label for this gene is hisN [H]

Identifier: 110679289

GI number: 110679289

Start: 1913306

End: 1914130

Strand: Direct

Name: hisN [H]

Synonym: RD1_2006

Alternate gene names: 110679289

Gene position: 1913306-1914130 (Clockwise)

Preceding gene: 110679288

Following gene: 110679290

Centisome position: 46.29

GC content: 61.7

Gene sequence:

>825_bases
ATGGCATTTGCTCCGGCTATGACCTTGCCGGAAACTGACCTCACTGAAATTGACGCGGTTGCGAACCGTCTGGCCGACGC
CGCGCGCGCGGCCATCCTGCCGTTTTTCCGATCACCTTCCCTGACGCAGGACAATAAGCTGGCTGCGGGGTATGACCCTG
TGACAGAAGCGGATCGCGCGGCAGAGCAGGAAATGCGCAGCCTCTTGGCCCGGATGCGCCCGGACGACGCCATTCTGGGA
GAAGAACTGGGCGACAAACCCGGCACCAGCGGGCTCACATGGGTGCTGGACCCGATTGACGGGACGCGCGGATTTGTCAG
CGGCACGCCCACATGGGGCGTTCTGATTGCGGTGCGCGATGCAAAAGGGCCGTTTTACGGGCTGATTGATCAACCCTACA
TCGGTGAAAGGTTCATTGGCGCCCCCGCGCATGCGCATATGACAGGCCCCATGGGCCACAGGGACTTATCAACAGCGCCA
CCGCGTGCCTTGGCGCAAGCCACCGTCTTTACCACCTTCCCCGAAGTTGGCAGCCCGGCAGAGCAAGAGGCTTTTCACAA
CGTGGCACGTCAGGCAAAACTCACGCGGTACGGCATGGATTGCTATGCCTATGCCTTGCTTGCAAGCGGCCAGATTGACC
TCGTGATCGAAGCGGGCTTGCAACCCTATGACATTCAGGCGCCGATCGCGGTGGTGCAGGCAGCGGGCGGAATTGTCACC
GATTGGATGGGTGAACCGGCCCATGACGGGGGGCGAGCAATCGCCGCTGCCAATGCGGACATCCACAAGGAGGCGCTTGC
CATCCTGAAACGTGCCGGTCCGTGA

Upstream 100 bases:

>100_bases
TTGTTTGAACTGGCGCGTGTGTTGAGCGATGTAGCGTAAAACGGCTGAACATGTTTGCGAAGAAACCACCTGCGCCGCCC
CTTGCGAGGGGCGGTGTTAG

Downstream 100 bases:

>100_bases
CGATCCGGGCGATCAGGAATGCGGATGTGATCGTCACGATGGACGATGCGCGCCGAAAACTGGCAAGGGCGGATATCGTC
ATCAAGGGCGGTGCAATCGA

Product: inositol monophosphatase family protein

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MAFAPAMTLPETDLTEIDAVANRLADAARAAILPFFRSPSLTQDNKLAAGYDPVTEADRAAEQEMRSLLARMRPDDAILG
EELGDKPGTSGLTWVLDPIDGTRGFVSGTPTWGVLIAVRDAKGPFYGLIDQPYIGERFIGAPAHAHMTGPMGHRDLSTAP
PRALAQATVFTTFPEVGSPAEQEAFHNVARQAKLTRYGMDCYAYALLASGQIDLVIEAGLQPYDIQAPIAVVQAAGGIVT
DWMGEPAHDGGRAIAAANADIHKEALAILKRAGP

Sequences:

>Translated_274_residues
MAFAPAMTLPETDLTEIDAVANRLADAARAAILPFFRSPSLTQDNKLAAGYDPVTEADRAAEQEMRSLLARMRPDDAILG
EELGDKPGTSGLTWVLDPIDGTRGFVSGTPTWGVLIAVRDAKGPFYGLIDQPYIGERFIGAPAHAHMTGPMGHRDLSTAP
PRALAQATVFTTFPEVGSPAEQEAFHNVARQAKLTRYGMDCYAYALLASGQIDLVIEAGLQPYDIQAPIAVVQAAGGIVT
DWMGEPAHDGGRAIAAANADIHKEALAILKRAGP
>Mature_273_residues
AFAPAMTLPETDLTEIDAVANRLADAARAAILPFFRSPSLTQDNKLAAGYDPVTEADRAAEQEMRSLLARMRPDDAILGE
ELGDKPGTSGLTWVLDPIDGTRGFVSGTPTWGVLIAVRDAKGPFYGLIDQPYIGERFIGAPAHAHMTGPMGHRDLSTAPP
RALAQATVFTTFPEVGSPAEQEAFHNVARQAKLTRYGMDCYAYALLASGQIDLVIEAGLQPYDIQAPIAVVQAAGGIVTD
WMGEPAHDGGRAIAAANADIHKEALAILKRAGP

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine (Probable) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI7657236, Length=226, Percent_Identity=29.2035398230088, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1788882, Length=259, Percent_Identity=29.3436293436293, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI193202572, Length=284, Percent_Identity=25.7042253521127, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21357329, Length=231, Percent_Identity=29.004329004329, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24664922, Length=243, Percent_Identity=27.1604938271605, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357303, Length=225, Percent_Identity=28, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 29058; Mature: 28927

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFAPAMTLPETDLTEIDAVANRLADAARAAILPFFRSPSLTQDNKLAAGYDPVTEADRA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHH
AEQEMRSLLARMRPDDAILGEELGDKPGTSGLTWVLDPIDGTRGFVSGTPTWGVLIAVRD
HHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEEC
AKGPFYGLIDQPYIGERFIGAPAHAHMTGPMGHRDLSTAPPRALAQATVFTTFPEVGSPA
CCCCEEECCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCH
EQEAFHNVARQAKLTRYGMDCYAYALLASGQIDLVIEAGLQPYDIQAPIAVVQAAGGIVT
HHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHCCCCHH
DWMGEPAHDGGRAIAAANADIHKEALAILKRAGP
HCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AFAPAMTLPETDLTEIDAVANRLADAARAAILPFFRSPSLTQDNKLAAGYDPVTEADRA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHH
AEQEMRSLLARMRPDDAILGEELGDKPGTSGLTWVLDPIDGTRGFVSGTPTWGVLIAVRD
HHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEEC
AKGPFYGLIDQPYIGERFIGAPAHAHMTGPMGHRDLSTAPPRALAQATVFTTFPEVGSPA
CCCCEEECCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCH
EQEAFHNVARQAKLTRYGMDCYAYALLASGQIDLVIEAGLQPYDIQAPIAVVQAAGGIVT
HHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHCCCCHH
DWMGEPAHDGGRAIAAANADIHKEALAILKRAGP
HCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]