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The map label for this gene is ctaD [H]

Identifier: 110679254

GI number: 110679254

Start: 1879336

End: 1881006

Strand: Reverse

Name: ctaD [H]

Synonym: RD1_1967

Alternate gene names: 110679254

Gene position: 1881006-1879336 (Counterclockwise)

Preceding gene: 110679257

Following gene: 110679253

Centisome position: 45.51

GC content: 57.93

Gene sequence:

>1671_bases
ATGGCAGACGCAGCCATTCACGGGCACGACCATCAAGATGAGCGCGGGTTTTTCACCCGCTGGTTCATGTCCACAAACCA
CAAAGATATCGGTATTCTCTATCTGATCACATCCGCGTTCGTCGGATTCGTATCAGTTGCCTTTACCGTCTACATGCGCC
TCGAGCTGATGGAGCCGGGCGTTCAGTACATGTGTATGGAAGGCGCACGGATGTTCGCCAGCGATGCGCTCTGTACACCC
AACGGACACCTTTGGAATGTTTTGATCACCGGTCACGGTATCCTAATGATGTTCTTTGTTGTCATTCCGGCGCTTTTCGG
CGGATTTGGCAACTATTTCATGCCGTTGCAGATCGGCGCGCCGGATATGGCCTTCCCGCGGATGAACAACCTCAGCTTCT
GGATGTATGTTGCGGGCACCGCCTTGGCGATCTGTTCCGTCCTTGCACCGGGTGGCAATGACCAGTCGGGTTCTGGCGTG
GGCTGGGTGCTCTACCCACCGCTCTCCACGAATGAGGGCGGCTATTCGATGGACCTCGCGATCTTCGCGGTTCACGTCTC
GGGAGCCTCTTCGATCCTTGGCGCGATCAACATGATCACGACTTTCCTGAACATGCGTGCCCCCGGCATGACCCTGTTCA
AGGTGCCGCTGTTCTCATGGTCGATCTTTGTCACAAGCTGGTTGATCCTGCTGTCCCTGCCGGTTCTGGCGGGCGCGATC
ACCATGTTGCTGATGGACCGTAACTTCGGCTTTACCTTCTTTGATCCCGCAGGCGGGGGCGACCCCGTGCTCTACCAGCA
CATCCTGTGGTTCTTTGGCCACCCGGAGGTCTACATCATCATTCTGCCCGGCTTTGGCATCATCTCCCATGTGATCGCGA
CCTTCGCGCGCAAACCGATCTTCGGCTACCTGCCGATGGTCTGGGCGATCATCGCCATCGGTGCTTTGGGCTTCGTCGTC
TGGGCGCACCACATGTACACCGTGGGCATGTCGCTCAACCAGCAGGCCTATTTCATGCTGGCCACGATGGTCATCGCGGT
GCCCACAGGGGTCAAGGTCTTCAGCTGGATCGCGACCATGTGGGGCGGATCGGTGGAATTCAAAACGCCCATGCTCTGGG
CCTTTGGTTTCCTCTTCCTCTTCACCGTGGGCGGTGTGACCGGCATCGTGCTGTCGCAGGCCGCCGTGGACCGCTACTAT
CATGACACCTATTACGTTGTGGCGCACTTCCACTATGTGATGTCGCTCGGGGCCGTCTTTGCCATCTTCGCCGGGATCTA
CTTCTACTTCCCCAAGATGACGGGCAAGATGTATCCCGAATGGGCCGGCAAGCTGCACTTCTGGACGATGTTCATCGGGG
CAAACCTGACCTTCTTCCCGCAGCACTTCCTGGGCCGTCAGGGCATGCCACGTCGCTACATCGACTATCCTGAGGCTTTC
GCCTACTGGAACCTGTGGTCAAGCTGGGGCGCGTTCCTGTCCTTTGCCTCCTTCCTTTTCTTCTTTGGCGTCATGGCCTA
TGCCCTGCGCTACGGCAAGAAATGCACCGAGGCGAACCCATGGAACGAATACGCCGACACGCTGGAATGGACCCTGCCCT
CCCCACCGCCCGAGCACACGTTCGAGCAGCTTCCAAAGCAGGAAGACTGGGACAAGCAGCACAGCCACTAA

Upstream 100 bases:

>100_bases
GGATCATTGCTCCTTGGCACAACACACTCTAAAACCGTTGTGAATCTACGGTCGGAACGGGAACCCCGGCCTGGAGCAAC
ACACAATCAGGAGGCACCGC

Downstream 100 bases:

>100_bases
GGCGCGCGTCTGAAACACTCAGGAAAAGCCCCGCACCGTCGGGGCTTTTTCGCGTTCGGGATCATCCGAGGCGGGCCGCT
GAAAGCCCACAACCGGTTTT

Product: cytochrome c oxidase, subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1-beta; Cytochrome c oxidase polypeptide I-beta [H]

Number of amino acids: Translated: 556; Mature: 555

Protein sequence:

>556_residues
MADAAIHGHDHQDERGFFTRWFMSTNHKDIGILYLITSAFVGFVSVAFTVYMRLELMEPGVQYMCMEGARMFASDALCTP
NGHLWNVLITGHGILMMFFVVIPALFGGFGNYFMPLQIGAPDMAFPRMNNLSFWMYVAGTALAICSVLAPGGNDQSGSGV
GWVLYPPLSTNEGGYSMDLAIFAVHVSGASSILGAINMITTFLNMRAPGMTLFKVPLFSWSIFVTSWLILLSLPVLAGAI
TMLLMDRNFGFTFFDPAGGGDPVLYQHILWFFGHPEVYIIILPGFGIISHVIATFARKPIFGYLPMVWAIIAIGALGFVV
WAHHMYTVGMSLNQQAYFMLATMVIAVPTGVKVFSWIATMWGGSVEFKTPMLWAFGFLFLFTVGGVTGIVLSQAAVDRYY
HDTYYVVAHFHYVMSLGAVFAIFAGIYFYFPKMTGKMYPEWAGKLHFWTMFIGANLTFFPQHFLGRQGMPRRYIDYPEAF
AYWNLWSSWGAFLSFASFLFFFGVMAYALRYGKKCTEANPWNEYADTLEWTLPSPPPEHTFEQLPKQEDWDKQHSH

Sequences:

>Translated_556_residues
MADAAIHGHDHQDERGFFTRWFMSTNHKDIGILYLITSAFVGFVSVAFTVYMRLELMEPGVQYMCMEGARMFASDALCTP
NGHLWNVLITGHGILMMFFVVIPALFGGFGNYFMPLQIGAPDMAFPRMNNLSFWMYVAGTALAICSVLAPGGNDQSGSGV
GWVLYPPLSTNEGGYSMDLAIFAVHVSGASSILGAINMITTFLNMRAPGMTLFKVPLFSWSIFVTSWLILLSLPVLAGAI
TMLLMDRNFGFTFFDPAGGGDPVLYQHILWFFGHPEVYIIILPGFGIISHVIATFARKPIFGYLPMVWAIIAIGALGFVV
WAHHMYTVGMSLNQQAYFMLATMVIAVPTGVKVFSWIATMWGGSVEFKTPMLWAFGFLFLFTVGGVTGIVLSQAAVDRYY
HDTYYVVAHFHYVMSLGAVFAIFAGIYFYFPKMTGKMYPEWAGKLHFWTMFIGANLTFFPQHFLGRQGMPRRYIDYPEAF
AYWNLWSSWGAFLSFASFLFFFGVMAYALRYGKKCTEANPWNEYADTLEWTLPSPPPEHTFEQLPKQEDWDKQHSH
>Mature_555_residues
ADAAIHGHDHQDERGFFTRWFMSTNHKDIGILYLITSAFVGFVSVAFTVYMRLELMEPGVQYMCMEGARMFASDALCTPN
GHLWNVLITGHGILMMFFVVIPALFGGFGNYFMPLQIGAPDMAFPRMNNLSFWMYVAGTALAICSVLAPGGNDQSGSGVG
WVLYPPLSTNEGGYSMDLAIFAVHVSGASSILGAINMITTFLNMRAPGMTLFKVPLFSWSIFVTSWLILLSLPVLAGAIT
MLLMDRNFGFTFFDPAGGGDPVLYQHILWFFGHPEVYIIILPGFGIISHVIATFARKPIFGYLPMVWAIIAIGALGFVVW
AHHMYTVGMSLNQQAYFMLATMVIAVPTGVKVFSWIATMWGGSVEFKTPMLWAFGFLFLFTVGGVTGIVLSQAAVDRYYH
DTYYVVAHFHYVMSLGAVFAIFAGIYFYFPKMTGKMYPEWAGKLHFWTMFIGANLTFFPQHFLGRQGMPRRYIDYPEAFA
YWNLWSSWGAFLSFASFLFFFGVMAYALRYGKKCTEANPWNEYADTLEWTLPSPPPEHTFEQLPKQEDWDKQHSH

Specific function: Subunit I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). This cytochrome c oxidase shows proton pump activity across th

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=530, Percent_Identity=53.0188679245283, Blast_Score=533, Evalue=1e-151,
Organism=Escherichia coli, GI1786634, Length=537, Percent_Identity=38.7337057728119, Blast_Score=348, Evalue=4e-97,
Organism=Saccharomyces cerevisiae, GI6226519, Length=550, Percent_Identity=50.5454545454545, Blast_Score=542, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6226524, Length=340, Percent_Identity=54.7058823529412, Blast_Score=371, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6226523, Length=265, Percent_Identity=49.4339622641509, Blast_Score=231, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 62546; Mature: 62415

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.8 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADAAIHGHDHQDERGFFTRWFMSTNHKDIGILYLITSAFVGFVSVAFTVYMRLELMEPG
CCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VQYMCMEGARMFASDALCTPNGHLWNVLITGHGILMMFFVVIPALFGGFGNYFMPLQIGA
HHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEECC
PDMAFPRMNNLSFWMYVAGTALAICSVLAPGGNDQSGSGVGWVLYPPLSTNEGGYSMDLA
CCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEE
IFAVHVSGASSILGAINMITTFLNMRAPGMTLFKVPLFSWSIFVTSWLILLSLPVLAGAI
EEEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
TMLLMDRNFGFTFFDPAGGGDPVLYQHILWFFGHPEVYIIILPGFGIISHVIATFARKPI
HHHHEECCCCEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCH
FGYLPMVWAIIAIGALGFVVWAHHMYTVGMSLNQQAYFMLATMVIAVPTGVKVFSWIATM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
WGGSVEFKTPMLWAFGFLFLFTVGGVTGIVLSQAAVDRYYHDTYYVVAHFHYVMSLGAVF
HCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
AIFAGIYFYFPKMTGKMYPEWAGKLHFWTMFIGANLTFFPQHFLGRQGMPRRYIDYPEAF
HHHHHHHHHHHHHCCCCCHHHCCCCEEEEEECCCCCEECCHHHHCCCCCCCHHCCCCHHH
AYWNLWSSWGAFLSFASFLFFFGVMAYALRYGKKCTEANPWNEYADTLEWTLPSPPPEHT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCEEECCCCCCCCHH
FEQLPKQEDWDKQHSH
HHHCCCCCCCCCCCCC
>Mature Secondary Structure 
ADAAIHGHDHQDERGFFTRWFMSTNHKDIGILYLITSAFVGFVSVAFTVYMRLELMEPG
CCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VQYMCMEGARMFASDALCTPNGHLWNVLITGHGILMMFFVVIPALFGGFGNYFMPLQIGA
HHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEECC
PDMAFPRMNNLSFWMYVAGTALAICSVLAPGGNDQSGSGVGWVLYPPLSTNEGGYSMDLA
CCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEE
IFAVHVSGASSILGAINMITTFLNMRAPGMTLFKVPLFSWSIFVTSWLILLSLPVLAGAI
EEEEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
TMLLMDRNFGFTFFDPAGGGDPVLYQHILWFFGHPEVYIIILPGFGIISHVIATFARKPI
HHHHEECCCCEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCH
FGYLPMVWAIIAIGALGFVVWAHHMYTVGMSLNQQAYFMLATMVIAVPTGVKVFSWIATM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
WGGSVEFKTPMLWAFGFLFLFTVGGVTGIVLSQAAVDRYYHDTYYVVAHFHYVMSLGAVF
HCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
AIFAGIYFYFPKMTGKMYPEWAGKLHFWTMFIGANLTFFPQHFLGRQGMPRRYIDYPEAF
HHHHHHHHHHHHHCCCCCHHHCCCCEEEEEECCCCCEECCHHHHCCCCCCCHHCCCCHHH
AYWNLWSSWGAFLSFASFLFFFGVMAYALRYGKKCTEANPWNEYADTLEWTLPSPPPEHT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCEEECCCCCCCCHH
FEQLPKQEDWDKQHSH
HHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2155830; 7651515; 9380672; 10338009; 8794157 [H]