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The map label for this gene is lipB [H]

Identifier: 110679257

GI number: 110679257

Start: 1881912

End: 1882664

Strand: Reverse

Name: lipB [H]

Synonym: RD1_1970

Alternate gene names: 110679257

Gene position: 1882664-1881912 (Counterclockwise)

Preceding gene: 110679260

Following gene: 110679254

Centisome position: 45.55

GC content: 60.82

Gene sequence:

>753_bases
TTGCATTTTTCCGAAATCGAAAGATACGGACAGGCCTTTGCGCGCCCGATCTGCTGCGCTATGGCTGCGCATATGGTGGA
TTGGATCATCTCTGAGGGGCTGACCGACTTTCGCGCGGCGGAACGCTGGATGGAAAGGCGGGCGGCGGACATTGCGCAGG
GCCGCGCGGCGGAATGTATCTGGCTGGTGGAACACCCACCGCTATACACCGCCGGGACCAGTGCCAGGCAAAAGGATCTG
ATCGAACCGGACCGCTTTCCTGTGTATCCGACCAAACGGGGCGGGCAATATACCTACCATGGGCCCGGTCAGCGCGTGGC
TTACACTCTGCTGGATGTGGGCGCGCGCGGGCGGGATGTGCGGCTCTTTGTCCAACAGCTGGAAAGCTGGGTGATTTCAA
CGCTTGCACAGTTCAACGTCACCGGTGAAATCAGGCAGGGCCGCGTCGGCGTCTGGGTAGAGCGCCCGGACAAACCAAAG
ACCGCGACGGGCGCCCTTGCCGAAGACAAGATCGCCGCCATCGGCATCCGGTTGCGCAAATGGATTTCCTTTCACGGCGT
GTCCATCAACGTCGAACCGGATCTGAGCCATTTCAACGGGATCGTGCCCTGCGGCATTGCCGAGCACGGGGTCACCAGCC
TTGTGGATCTGGGTTTGCCCGTGACGATGCATGATCTCGATATCGCGCTGATGCAGGCATTCGCCAAGGTCTTCGGCAGC
GTCCCGAAACCGGCGCCGTGGATCGATTCGTAA

Upstream 100 bases:

>100_bases
CCACAGCGACCTCAACGCTGCGCGTCTACCATTCCGCCACATCCGCACGATAATGGTTCGCGGTCTTTAGCCTGCCGCGC
CAGCCTTGTGAAGAGTGATT

Downstream 100 bases:

>100_bases
CTGCGCCCAGGCCCGCAGATGAACATACCCGAAAACGCCGCGTGCCACACAAGACTACGCACCTGATAGCTGCGCGGCAT
TGCCCCTATCGGCCAACTGC

Product: lipoyltransferase

Products: NA

Alternate protein names: Lipoate-protein ligase B; Lipoyl/octanoyl transferase; Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase [H]

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MHFSEIERYGQAFARPICCAMAAHMVDWIISEGLTDFRAAERWMERRAADIAQGRAAECIWLVEHPPLYTAGTSARQKDL
IEPDRFPVYPTKRGGQYTYHGPGQRVAYTLLDVGARGRDVRLFVQQLESWVISTLAQFNVTGEIRQGRVGVWVERPDKPK
TATGALAEDKIAAIGIRLRKWISFHGVSINVEPDLSHFNGIVPCGIAEHGVTSLVDLGLPVTMHDLDIALMQAFAKVFGS
VPKPAPWIDS

Sequences:

>Translated_250_residues
MHFSEIERYGQAFARPICCAMAAHMVDWIISEGLTDFRAAERWMERRAADIAQGRAAECIWLVEHPPLYTAGTSARQKDL
IEPDRFPVYPTKRGGQYTYHGPGQRVAYTLLDVGARGRDVRLFVQQLESWVISTLAQFNVTGEIRQGRVGVWVERPDKPK
TATGALAEDKIAAIGIRLRKWISFHGVSINVEPDLSHFNGIVPCGIAEHGVTSLVDLGLPVTMHDLDIALMQAFAKVFGS
VPKPAPWIDS
>Mature_250_residues
MHFSEIERYGQAFARPICCAMAAHMVDWIISEGLTDFRAAERWMERRAADIAQGRAAECIWLVEHPPLYTAGTSARQKDL
IEPDRFPVYPTKRGGQYTYHGPGQRVAYTLLDVGARGRDVRLFVQQLESWVISTLAQFNVTGEIRQGRVGVWVERPDKPK
TATGALAEDKIAAIGIRLRKWISFHGVSINVEPDLSHFNGIVPCGIAEHGVTSLVDLGLPVTMHDLDIALMQAFAKVFGS
VPKPAPWIDS

Specific function: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate

COG id: COG0321

COG function: function code H; Lipoate-protein ligase B

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lipB family [H]

Homologues:

Organism=Homo sapiens, GI221554520, Length=213, Percent_Identity=31.924882629108, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI87081767, Length=148, Percent_Identity=41.8918918918919, Blast_Score=119, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323268, Length=225, Percent_Identity=28.4444444444444, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355483, Length=185, Percent_Identity=35.6756756756757, Blast_Score=103, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004143
- InterPro:   IPR000544
- InterPro:   IPR020605 [H]

Pfam domain/function: PF03099 BPL_LipA_LipB [H]

EC number: =2.3.1.181 [H]

Molecular weight: Translated: 27793; Mature: 27793

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS01313 LIPB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFSEIERYGQAFARPICCAMAAHMVDWIISEGLTDFRAAERWMERRAADIAQGRAAECI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEE
WLVEHPPLYTAGTSARQKDLIEPDRFPVYPTKRGGQYTYHGPGQRVAYTLLDVGARGRDV
EEECCCCCEECCCCHHHHCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHCCCCCHH
RLFVQQLESWVISTLAQFNVTGEIRQGRVGVWVERPDKPKTATGALAEDKIAAIGIRLRK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
WISFHGVSINVEPDLSHFNGIVPCGIAEHGVTSLVDLGLPVTMHDLDIALMQAFAKVFGS
HHHHCCEEEEECCCHHHHCCCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCC
VPKPAPWIDS
CCCCCCCCCC
>Mature Secondary Structure
MHFSEIERYGQAFARPICCAMAAHMVDWIISEGLTDFRAAERWMERRAADIAQGRAAECI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEE
WLVEHPPLYTAGTSARQKDLIEPDRFPVYPTKRGGQYTYHGPGQRVAYTLLDVGARGRDV
EEECCCCCEECCCCHHHHCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHCCCCCHH
RLFVQQLESWVISTLAQFNVTGEIRQGRVGVWVERPDKPKTATGALAEDKIAAIGIRLRK
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
WISFHGVSINVEPDLSHFNGIVPCGIAEHGVTSLVDLGLPVTMHDLDIALMQAFAKVFGS
HHHHCCEEEEECCCHHHHCCCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCC
VPKPAPWIDS
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA