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The map label for this gene is lrp [H]

Identifier: 110679243

GI number: 110679243

Start: 1868895

End: 1869350

Strand: Direct

Name: lrp [H]

Synonym: RD1_1956

Alternate gene names: 110679243

Gene position: 1868895-1869350 (Clockwise)

Preceding gene: 110679242

Following gene: 110679244

Centisome position: 45.22

GC content: 62.06

Gene sequence:

>456_bases
ATGATCGAACTGGATGGTATTGACCGACGGCTTGTGCGCGCGCTTGCCGATGACGCGCTGCAAACTGCCGGCGCCTTGGG
GCGGCGGTTTGGCCTGTCACAGCCTGCCACATGGCGACGCATTCGCAAACTTGAGGCGGCGGGTGTGTTGCGGGGCCGCC
GCCTGCGCCTGAATGCGCAAAGCCTTGGTTTTGGGGTCACGGTCTTTCTGGGCGTAAAACTCGCCACCAAAGGGCGCGTC
AGCCTTGAGGATTTTGAGCGGGCAGTCAGCGCGATCCCCGAAGTGCAGCAGGTCGAGCATGTTCTGGGGCTTTATGATTA
TCGTCTGCGCGTCGTGGCGCGTGATCTGCCGGACTTTGAACGTGTGTTGCGGCGCCGGATCATGACACTGCCCGGCGCTG
GCGAGGTGGAGGCAAATGTCCTGCTGAGTGAAGAGCGCTTGCCCGGACCTCTTTAG

Upstream 100 bases:

>100_bases
ACGACATTTATCGCGACCGCATTCTGACCCTGCCGCATATCGCCGATATCGAAGCCCTGATGCAAATCGCCCGGATCAAA
TCCGAAGAGGCGCTGCCCAT

Downstream 100 bases:

>100_bases
GTGCTGTGCAGGAATGTGCAGGGGTGCGGCAAAGCAGGCTTTGCCCCTGATCACCGGACGCGTTAAAGGAGAAGTCAGGA
TTTTACAGGAGAATACAAAT

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 151; Mature: 151

Protein sequence:

>151_residues
MIELDGIDRRLVRALADDALQTAGALGRRFGLSQPATWRRIRKLEAAGVLRGRRLRLNAQSLGFGVTVFLGVKLATKGRV
SLEDFERAVSAIPEVQQVEHVLGLYDYRLRVVARDLPDFERVLRRRIMTLPGAGEVEANVLLSEERLPGPL

Sequences:

>Translated_151_residues
MIELDGIDRRLVRALADDALQTAGALGRRFGLSQPATWRRIRKLEAAGVLRGRRLRLNAQSLGFGVTVFLGVKLATKGRV
SLEDFERAVSAIPEVQQVEHVLGLYDYRLRVVARDLPDFERVLRRRIMTLPGAGEVEANVLLSEERLPGPL
>Mature_151_residues
MIELDGIDRRLVRALADDALQTAGALGRRFGLSQPATWRRIRKLEAAGVLRGRRLRLNAQSLGFGVTVFLGVKLATKGRV
SLEDFERAVSAIPEVQQVEHVLGLYDYRLRVVARDLPDFERVLRRRIMTLPGAGEVEANVLLSEERLPGPL

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87081742, Length=148, Percent_Identity=27.7027027027027, Blast_Score=77, Evalue=4e-16,
Organism=Escherichia coli, GI1787116, Length=142, Percent_Identity=29.5774647887324, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1790182, Length=142, Percent_Identity=26.056338028169, Blast_Score=66, Evalue=1e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 16854; Mature: 16854

Theoretical pI: Translated: 11.19; Mature: 11.19

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELDGIDRRLVRALADDALQTAGALGRRFGLSQPATWRRIRKLEAAGVLRGRRLRLNAQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEECHH
SLGFGVTVFLGVKLATKGRVSLEDFERAVSAIPEVQQVEHVLGLYDYRLRVVARDLPDFE
HHCCHHHHHHEEHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
RVLRRRIMTLPGAGEVEANVLLSEERLPGPL
HHHHHHHHCCCCCCCCHHHEEEECCCCCCCC
>Mature Secondary Structure
MIELDGIDRRLVRALADDALQTAGALGRRFGLSQPATWRRIRKLEAAGVLRGRRLRLNAQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEECHH
SLGFGVTVFLGVKLATKGRVSLEDFERAVSAIPEVQQVEHVLGLYDYRLRVVARDLPDFE
HHCCHHHHHHEEHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
RVLRRRIMTLPGAGEVEANVLLSEERLPGPL
HHHHHHHHCCCCCCCCHHHEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11157937; 11481430 [H]