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The map label for this gene is hisM [H]

Identifier: 110679185

GI number: 110679185

Start: 1811597

End: 1812343

Strand: Reverse

Name: hisM [H]

Synonym: RD1_1896

Alternate gene names: 110679185

Gene position: 1812343-1811597 (Counterclockwise)

Preceding gene: 110679186

Following gene: 110679184

Centisome position: 43.85

GC content: 56.09

Gene sequence:

>747_bases
TTGCTGCCCCGCGATGATTTCACACTGTGCCAACAGTTTACACTGATCGGCTCCGGCATGATCTGGAACATCTATTTCGG
TGTTGTTGCATTGATCTGCGGCTTTTTTCTGGCGACCGCCGTGGCTGTCGGCAAGGCGTCCCCTCGCAGGATTTTCCGCA
AACCATCTGAGTGGTTCATCTTTATCTTTCGCGGCTCGCCGCTGTTTATCCAGTTCTTTTTTGGCTACTTTCTCTTTCTG
AGCCTCAAATCGGTATCACCCATATTCGACCCCTTCACAGCCGCCTGGCTGGGAGCGTTGATCGTTCTGTTCCTCAACAC
GGCCGCCTATTCGGGCGAGATCTTTTACGGCGCGCTGCAGTCCATACCCAAGGGCGACACGGAGGCCGCAGATGCATACG
GCATGACCGGCTGGCCCCGGTTCCGGCGTGTGATCTGGCCCACCATGCTGCGGCTGGCATGGCCTGCCTACACCAATGAG
GCGATCTTTTTGTTTCATGCCACGGCGCTCGTTTTCCTGTCCGGCTTCCCGGCGTGGCAACAACGCGGCGATGCGCTTTA
TTACGCAAGCTACTTTGCCGATAAAACCTTCAATCCCTTTATCCCCTACCCGATCCTCGCGGGGTATTTCATCGTGCTCA
CGCTGATCGTTGTGGGGATATTCGGGCTGGTCAATGCGCGGCTGAACCGTCATTTGCCGCAGGACATCAGACCGAAATTG
AGGTTGCGTCCCAACCTGATCCGGTAG

Upstream 100 bases:

>100_bases
AGGCAACCGCCGCCGGTGAAGCGCAACGAAAGGCCGCCGCATGAGTTGCTGGCAAACCATTCAGGATTATGGCCTGCGCG
CGATCGGGATCGGGGAGCGG

Downstream 100 bases:

>100_bases
TATCCATAATTTGATCAAATTATCCGTGGCGCTGGCCGTGGTACGGGACGCCGCACCCTTATGACCAGCGCTCAAGACTG
GTGCTGTATGAACAATTGGC

Product: histidine ABC transporter, permease protein

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MLPRDDFTLCQQFTLIGSGMIWNIYFGVVALICGFFLATAVAVGKASPRRIFRKPSEWFIFIFRGSPLFIQFFFGYFLFL
SLKSVSPIFDPFTAAWLGALIVLFLNTAAYSGEIFYGALQSIPKGDTEAADAYGMTGWPRFRRVIWPTMLRLAWPAYTNE
AIFLFHATALVFLSGFPAWQQRGDALYYASYFADKTFNPFIPYPILAGYFIVLTLIVVGIFGLVNARLNRHLPQDIRPKL
RLRPNLIR

Sequences:

>Translated_248_residues
MLPRDDFTLCQQFTLIGSGMIWNIYFGVVALICGFFLATAVAVGKASPRRIFRKPSEWFIFIFRGSPLFIQFFFGYFLFL
SLKSVSPIFDPFTAAWLGALIVLFLNTAAYSGEIFYGALQSIPKGDTEAADAYGMTGWPRFRRVIWPTMLRLAWPAYTNE
AIFLFHATALVFLSGFPAWQQRGDALYYASYFADKTFNPFIPYPILAGYFIVLTLIVVGIFGLVNARLNRHLPQDIRPKL
RLRPNLIR
>Mature_248_residues
MLPRDDFTLCQQFTLIGSGMIWNIYFGVVALICGFFLATAVAVGKASPRRIFRKPSEWFIFIFRGSPLFIQFFFGYFLFL
SLKSVSPIFDPFTAAWLGALIVLFLNTAAYSGEIFYGALQSIPKGDTEAADAYGMTGWPRFRRVIWPTMLRLAWPAYTNE
AIFLFHATALVFLSGFPAWQQRGDALYYASYFADKTFNPFIPYPILAGYFIVLTLIVVGIFGLVNARLNRHLPQDIRPKL
RLRPNLIR

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4160

COG function: function code E; ABC-type arginine/histidine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788645, Length=218, Percent_Identity=31.651376146789, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1788226, Length=227, Percent_Identity=29.9559471365639, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787086, Length=117, Percent_Identity=32.4786324786325, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1787030, Length=171, Percent_Identity=29.8245614035088, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1787087, Length=231, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788646, Length=178, Percent_Identity=33.1460674157303, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786874, Length=209, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI87082239, Length=136, Percent_Identity=33.0882352941176, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1786873, Length=163, Percent_Identity=28.2208588957055, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 28265; Mature: 28265

Theoretical pI: Translated: 10.16; Mature: 10.16

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCC
>Mature Secondary Structure
MLPRDDFTLCQQFTLIGSGMIWNIYFGVVALICGFFLATAVAVGKASPRRIFRKPSEWFI
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCEEE
FIFRGSPLFIQFFFGYFLFLSLKSVSPIFDPFTAAWLGALIVLFLNTAAYSGEIFYGALQ
EEEECCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
SIPKGDTEAADAYGMTGWPRFRRVIWPTMLRLAWPAYTNEAIFLFHATALVFLSGFPAWQ
HCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHCCCHHH
QRGDALYYASYFADKTFNPFIPYPILAGYFIVLTLIVVGIFGLVNARLNRHLPQDIRPKL
HCCCEEEEHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCC
RLRPNLIR
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]