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The map label for this gene is thrS

Identifier: 110679173

GI number: 110679173

Start: 1797934

End: 1799880

Strand: Reverse

Name: thrS

Synonym: RD1_1883

Alternate gene names: 110679173

Gene position: 1799880-1797934 (Counterclockwise)

Preceding gene: 110679177

Following gene: 110679171

Centisome position: 43.55

GC content: 58.91

Gene sequence:

>1947_bases
ATGGCCCAAATCTCTCTCACCTTTCCTGATGGCAGCACACGCGAATTCGATGCAGGCGTGACCGCTGGCGATGTCGCAGC
GAGCATTTCAACCTCCCTGCGCAAAAAGGCGATCAGCGCCACCGTCGGCGGTGCGCATTATGACCTTGCCTGGCCCATCC
ATGCGGATGCCACGATCGCGATCCACACGATGCAGGACGAAGAGCAGGCCAACGAATTGGTGCGCCACGACCTGGCGCAT
ATCATGGCGCGCGCCGTGCAGGAAATCTGGCCCGAAACCAAGGTGACAATCGGTCCTGTGATCAAGGACGGCTGGTACTA
TGACTTTGACCGCGCCGAGGCGTTCTCTCCCGAAGATCTCGGTCTGATCGAGAAAAAGATGAAGGAGATCATCAACAAAC
GCGACCCTGTGCGCACGGAAGTATGGGATCGCGCGCGCGCCATCGCGCATTACGAGGCGAACGACGAACCATATAAGGTC
GAATTGATCAACGCCATTCCCGGCGATGAACCCTTGCGGATGTATTGGCACGGGGATTGGCAGGACCTGTGCCGCGGCCC
GCATCTGCAACATACCGGGCAGGTGCCCGGCGATGCGTTCAAACTCATGTCCATCGCGGGCGCGTATTGGCGCGGTGACA
GTGACCGCGCGATGCTGCAGCGTATTTACGGCGTGGCCTTTACCGGCAAGGAAAAGCTCAAGGCGCATCTGACCATGCTG
GAGGAAGCGGCCAAACGCGACCACCGCAAGCTGGGCCGCGAGATGGACCTGTTCCACATGCAGGAAGAAGCCCCGGGGCA
GGTCTTCTGGCATCCAAATGGCTGGTCGATCTACACGACGCTGCAGGATTACATGCGCCGCAAGCAGCGCGCGGCAGGCT
ATCAGGAGGTCAACACCCCCCAGGTGGTTGATCGCAAACTGTGGGAAGCGTCCGGCCATTGGGACAAATATCAGGAACAT
ATGTTCATCGTCGAAGTGGACGAGGATCACGCGCGCGAAAAAGCGGTCAATGCGCTCAAACCCATGAACTGCCCCTGCCA
CGTGCAGATCTTCAATCAGGGGCTCAAATCCTACCGCGACCTGCCCTTGCGCATGGCTGAATTCGGCTCATGCAACCGCT
ATGAGCCATCCGGAGCGTTGCATGGCATCATGCGGGTGCGCGGCTTTACGCAAGACGATGGCCACACCTTCTGCCGCGAG
GACCAGATCGAGGCGGAATGCGCGGCCTTCATCACCTATCTGTCGTCCGTCTATCAGGATCTCGGATTCGAGAAATTCGA
AATCATGTTTGCCACACGGCCCGAAAAGCGCGTGGGCTCAGAGGAAAGCTGGGACCACGTCGAGGCCGCACTGGAAAACG
CGATCAAGGCAACCGGGCACCCCTATACGCTGGACGAAGGCGAAGGCGCATTTTACGGGCCCAAACTGGATTTCAAACTC
ACGGATGCGATTGGCCGCGAATGGCAATGCGGCACCTTTCAGGTTGATCCGAACCTGCCCGAGCGGCTGGATGCGACCTA
TATCGGTCAGGACGGCGCCAAGCATCGGCCTTACATGTTGCACCGGGCCTGCCTTGGGTCTTTTGAACGCTTCATCGGAA
TCCTGATCGAAAACTCTGCCGGAAAGTTGCCCTTCTGGCTGGCCCCGCGTCAGGTCGTTGTCGCTTCGATCATTTCGGAT
GCGGATGACTACGTTCTGGAGGTGGTTGAGAAACTGCAGGCGGCGGGCGTGCGCGCCGAAGCTGATGTGCGCAACGAGAA
GATCAACTACAAAGTGCGCGAACACTCGGTTGGAAAGGTCCCGGTCATTCTGGCTGTGGGTGCCCGCGAGGTCGAAGAGA
AAACAGTCACCCTGCGCCGGCTCGGAGAGAAAAAGACCAGCGTCGAGACACTGGACGCTGTAACACAAGCCTTGGGACGC
GAGGCAACGCCACCCGACCTTTTGTAA

Upstream 100 bases:

>100_bases
CGCCTCGCTTGACACGACCGGCTCAGAGGTTCATCAGCGCCACCAAACCAACCCGCAACCGGGCGTCTCGTAGGCGCCAA
ACTGACGAGGAGCGCCCAAG

Downstream 100 bases:

>100_bases
CAAAATACGCTGTTTTCAGCCCTGAACCGGAATACACCGCAGATATTGAAACAATTCTGCGGCGTTTTGCGTGTTTTCTC
GCCCCTTGGTCACCATTTGC

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 648; Mature: 647

Protein sequence:

>648_residues
MAQISLTFPDGSTREFDAGVTAGDVAASISTSLRKKAISATVGGAHYDLAWPIHADATIAIHTMQDEEQANELVRHDLAH
IMARAVQEIWPETKVTIGPVIKDGWYYDFDRAEAFSPEDLGLIEKKMKEIINKRDPVRTEVWDRARAIAHYEANDEPYKV
ELINAIPGDEPLRMYWHGDWQDLCRGPHLQHTGQVPGDAFKLMSIAGAYWRGDSDRAMLQRIYGVAFTGKEKLKAHLTML
EEAAKRDHRKLGREMDLFHMQEEAPGQVFWHPNGWSIYTTLQDYMRRKQRAAGYQEVNTPQVVDRKLWEASGHWDKYQEH
MFIVEVDEDHAREKAVNALKPMNCPCHVQIFNQGLKSYRDLPLRMAEFGSCNRYEPSGALHGIMRVRGFTQDDGHTFCRE
DQIEAECAAFITYLSSVYQDLGFEKFEIMFATRPEKRVGSEESWDHVEAALENAIKATGHPYTLDEGEGAFYGPKLDFKL
TDAIGREWQCGTFQVDPNLPERLDATYIGQDGAKHRPYMLHRACLGSFERFIGILIENSAGKLPFWLAPRQVVVASIISD
ADDYVLEVVEKLQAAGVRAEADVRNEKINYKVREHSVGKVPVILAVGAREVEEKTVTLRRLGEKKTSVETLDAVTQALGR
EATPPDLL

Sequences:

>Translated_648_residues
MAQISLTFPDGSTREFDAGVTAGDVAASISTSLRKKAISATVGGAHYDLAWPIHADATIAIHTMQDEEQANELVRHDLAH
IMARAVQEIWPETKVTIGPVIKDGWYYDFDRAEAFSPEDLGLIEKKMKEIINKRDPVRTEVWDRARAIAHYEANDEPYKV
ELINAIPGDEPLRMYWHGDWQDLCRGPHLQHTGQVPGDAFKLMSIAGAYWRGDSDRAMLQRIYGVAFTGKEKLKAHLTML
EEAAKRDHRKLGREMDLFHMQEEAPGQVFWHPNGWSIYTTLQDYMRRKQRAAGYQEVNTPQVVDRKLWEASGHWDKYQEH
MFIVEVDEDHAREKAVNALKPMNCPCHVQIFNQGLKSYRDLPLRMAEFGSCNRYEPSGALHGIMRVRGFTQDDGHTFCRE
DQIEAECAAFITYLSSVYQDLGFEKFEIMFATRPEKRVGSEESWDHVEAALENAIKATGHPYTLDEGEGAFYGPKLDFKL
TDAIGREWQCGTFQVDPNLPERLDATYIGQDGAKHRPYMLHRACLGSFERFIGILIENSAGKLPFWLAPRQVVVASIISD
ADDYVLEVVEKLQAAGVRAEADVRNEKINYKVREHSVGKVPVILAVGAREVEEKTVTLRRLGEKKTSVETLDAVTQALGR
EATPPDLL
>Mature_647_residues
AQISLTFPDGSTREFDAGVTAGDVAASISTSLRKKAISATVGGAHYDLAWPIHADATIAIHTMQDEEQANELVRHDLAHI
MARAVQEIWPETKVTIGPVIKDGWYYDFDRAEAFSPEDLGLIEKKMKEIINKRDPVRTEVWDRARAIAHYEANDEPYKVE
LINAIPGDEPLRMYWHGDWQDLCRGPHLQHTGQVPGDAFKLMSIAGAYWRGDSDRAMLQRIYGVAFTGKEKLKAHLTMLE
EAAKRDHRKLGREMDLFHMQEEAPGQVFWHPNGWSIYTTLQDYMRRKQRAAGYQEVNTPQVVDRKLWEASGHWDKYQEHM
FIVEVDEDHAREKAVNALKPMNCPCHVQIFNQGLKSYRDLPLRMAEFGSCNRYEPSGALHGIMRVRGFTQDDGHTFCRED
QIEAECAAFITYLSSVYQDLGFEKFEIMFATRPEKRVGSEESWDHVEAALENAIKATGHPYTLDEGEGAFYGPKLDFKLT
DAIGREWQCGTFQVDPNLPERLDATYIGQDGAKHRPYMLHRACLGSFERFIGILIENSAGKLPFWLAPRQVVVASIISDA
DDYVLEVVEKLQAAGVRAEADVRNEKINYKVREHSVGKVPVILAVGAREVEEKTVTLRRLGEKKTSVETLDAVTQALGRE
ATPPDLL

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=641, Percent_Identity=39.0015600624025, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI38570111, Length=620, Percent_Identity=38.0645161290323, Blast_Score=439, Evalue=1e-123,
Organism=Homo sapiens, GI20070344, Length=642, Percent_Identity=36.6043613707165, Blast_Score=407, Evalue=1e-113,
Organism=Escherichia coli, GI1788013, Length=639, Percent_Identity=48.8262910798122, Blast_Score=627, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984184, Length=619, Percent_Identity=38.610662358643, Blast_Score=448, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI71984192, Length=619, Percent_Identity=38.610662358643, Blast_Score=447, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6322112, Length=635, Percent_Identity=38.4251968503937, Blast_Score=433, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6322654, Length=406, Percent_Identity=35.9605911330049, Blast_Score=276, Evalue=7e-75,
Organism=Drosophila melanogaster, GI24583842, Length=621, Percent_Identity=39.9355877616747, Blast_Score=455, Evalue=1e-128,
Organism=Drosophila melanogaster, GI28574141, Length=621, Percent_Identity=39.9355877616747, Blast_Score=455, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24583839, Length=621, Percent_Identity=39.9355877616747, Blast_Score=454, Evalue=1e-128,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_ROSDO (Q168U9)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_682180.1
- ProteinModelPortal:   Q168U9
- SMR:   Q168U9
- STRING:   Q168U9
- GeneID:   4196825
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_1883
- NMPDR:   fig|375451.6.peg.1760
- eggNOG:   COG0441
- HOGENOM:   HBG352811
- OMA:   TAKDPEC
- PhylomeDB:   Q168U9
- ProtClustDB:   PRK00413
- BioCyc:   RDEN375451:RD1_1883-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 73401; Mature: 73270

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQISLTFPDGSTREFDAGVTAGDVAASISTSLRKKAISATVGGAHYDLAWPIHADATIA
CCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEE
IHTMQDEEQANELVRHDLAHIMARAVQEIWPETKVTIGPVIKDGWYYDFDRAEAFSPEDL
EEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEEECCCEEECCCCCCCCCCHH
GLIEKKMKEIINKRDPVRTEVWDRARAIAHYEANDEPYKVELINAIPGDEPLRMYWHGDW
HHHHHHHHHHHCCCCCCHHHHHHHHHHHEEECCCCCCEEEEEEECCCCCCCEEEEECCCH
QDLCRGPHLQHTGQVPGDAFKLMSIAGAYWRGDSDRAMLQRIYGVAFTGKEKLKAHLTML
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCEECCHHHHHHHHHHH
EEAAKRDHRKLGREMDLFHMQEEAPGQVFWHPNGWSIYTTLQDYMRRKQRAAGYQEVNTP
HHHHHHHHHHHCCCCHHHHHHCCCCCEEEECCCCCEEHHHHHHHHHHHHHHCCCCCCCCH
QVVDRKLWEASGHWDKYQEHMFIVEVDEDHAREKAVNALKPMNCPCHVQIFNQGLKSYRD
HHHHHHHHHCCCCHHHHHCCEEEEEECCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHC
LPLRMAEFGSCNRYEPSGALHGIMRVRGFTQDDGHTFCREDQIEAECAAFITYLSSVYQD
CCHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LGFEKFEIMFATRPEKRVGSEESWDHVEAALENAIKATGHPYTLDEGEGAFYGPKLDFKL
CCCCEEEEEEECCCHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCEECCCCCEEE
TDAIGREWQCGTFQVDPNLPERLDATYIGQDGAKHRPYMLHRACLGSFERFIGILIENSA
HHHCCCCCCCCEEEECCCCHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHHEEEEECCC
GKLPFWLAPRQVVVASIISDADDYVLEVVEKLQAAGVRAEADVRNEKINYKVREHSVGKV
CCCCEEECCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCC
PVILAVGAREVEEKTVTLRRLGEKKTSVETLDAVTQALGREATPPDLL
EEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
AQISLTFPDGSTREFDAGVTAGDVAASISTSLRKKAISATVGGAHYDLAWPIHADATIA
CEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEE
IHTMQDEEQANELVRHDLAHIMARAVQEIWPETKVTIGPVIKDGWYYDFDRAEAFSPEDL
EEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEEECCCEEECCCCCCCCCCHH
GLIEKKMKEIINKRDPVRTEVWDRARAIAHYEANDEPYKVELINAIPGDEPLRMYWHGDW
HHHHHHHHHHHCCCCCCHHHHHHHHHHHEEECCCCCCEEEEEEECCCCCCCEEEEECCCH
QDLCRGPHLQHTGQVPGDAFKLMSIAGAYWRGDSDRAMLQRIYGVAFTGKEKLKAHLTML
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCEECCHHHHHHHHHHH
EEAAKRDHRKLGREMDLFHMQEEAPGQVFWHPNGWSIYTTLQDYMRRKQRAAGYQEVNTP
HHHHHHHHHHHCCCCHHHHHHCCCCCEEEECCCCCEEHHHHHHHHHHHHHHCCCCCCCCH
QVVDRKLWEASGHWDKYQEHMFIVEVDEDHAREKAVNALKPMNCPCHVQIFNQGLKSYRD
HHHHHHHHHCCCCHHHHHCCEEEEEECCHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHC
LPLRMAEFGSCNRYEPSGALHGIMRVRGFTQDDGHTFCREDQIEAECAAFITYLSSVYQD
CCHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LGFEKFEIMFATRPEKRVGSEESWDHVEAALENAIKATGHPYTLDEGEGAFYGPKLDFKL
CCCCEEEEEEECCCHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCEECCCCCEEE
TDAIGREWQCGTFQVDPNLPERLDATYIGQDGAKHRPYMLHRACLGSFERFIGILIENSA
HHHCCCCCCCCEEEECCCCHHHCCCEEECCCCCCCCCHHHHHHHHHHHHHHHEEEEECCC
GKLPFWLAPRQVVVASIISDADDYVLEVVEKLQAAGVRAEADVRNEKINYKVREHSVGKV
CCCCEEECCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCC
PVILAVGAREVEEKTVTLRRLGEKKTSVETLDAVTQALGREATPPDLL
EEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA