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The map label for this gene is sdhA [H]

Identifier: 110678934

GI number: 110678934

Start: 1567480

End: 1569285

Strand: Direct

Name: sdhA [H]

Synonym: RD1_1628

Alternate gene names: 110678934

Gene position: 1567480-1569285 (Clockwise)

Preceding gene: 110678933

Following gene: 110678935

Centisome position: 37.93

GC content: 60.91

Gene sequence:

>1806_bases
ATGGCTGAATACGAATATGAAACACATGAATACGACGTTGTCGTCGTAGGAGCAGGCGGTGCTGGCCTGCGTGCGACTCT
CGGCATGGCCGAGCAGGGGCTTCGCACCGCCTGCGTCACCAAAGTATTCCCGACCCGCTCTCATACGGTTGCCGCGCAGG
GCGGGATCGCCGCCTCGCTGGCGAATATGGGGCCGGATAACTGGCAGTGGCATATGTATGACACGGTCAAAGGGTCGGAC
TGGCTGGGCGATACGGATGCGATGGAATACCTCGCCCGCGAAGCGCCCAAGGCGGTTTATGAGCTGGAACACTACGGTGT
CCCCTTCAGCCGGACAGAAGAGGGCAAGATTTACCAGCGCCCCTTCGGCGGCCACACCACCGAATTCGGCGAAGGCCCCG
CGGTGCAGCGGACCTGTGCCGCCGCCGACCGGACGGGCCACGCGATCCTGCACACGCTTTATGGGCAGTCGCTCAAGAAC
AACGCGGAATTCTACATCGAGTATTTCGCGATTGATCTGATCATGTCCGACGATGGCATCTGTCAGGGGGTGCTGTGCTG
GAAGCTGGACGACGGCACGCTGCACCTGTTCTCTTCGAAAATGGTGGTTCTGGCGACGGGTGGCTATGGCCGTGCCTATT
TCTCTGCAACGTCGGCGCATACCTGCACCGGGGATGGCGGCGGCATGACCGCGCGTGCGGGTCTGCCGTTGCAGGATATG
GAATTCGTTCAGTTCCACCCGACGGGCATCTACGGGGCAGGCTGCCTCATCACCGAAGGGGCGCGGGGCGAAGGCGGTTA
TCTGACCAATTCTGAGGGCGAACGCTTCATGGAACGCTATGCGCCGCAGTATAAGGACCTCGCGCCGCGCGATTATGTCA
GCCGCTGCATGACGATGGAAATCCGCGAAGGACGCGGCGTTGGCGCGAACGGCGATCACATTCACCTCAACCTGAACCAC
CTGCCGCCAGAAACGCTGAAACTGCGCCTGCCGGGTATTTCGGAAAGCGCGCGCGTCTTTGCGGGCGTGAACCTCAACAA
GGAACCAATCCCGGTTCTGCCGACGGTGCATTACAACATGGGCGGTATCCCGACGAATTACTGGGGTGAGGTGCTGGCGC
CGACACCGGACGATCCTGATCGTATCTCGCCCGGTTTGATGGCTGTGGGCGAAGCGGGCTGTGCCTCGGTTCACGGGGCC
AACCGGCTGGGGTCGAACTCCCTGATCGACCTTGTGGTCTTTGGGCGTGCGGCGGCGATCCGGGCGGGCAAGATTGTCGA
TCCCAACAGCCCGGTGCCAAGCCCGAACCAGAAATCCGTTGAGGCAGCACTCGATCGGTTCGACAACGCGCGCTACGCCA
AAGGGCATATGCCGACCGCCGCTTTGCGCCTTGAAATGCAGCAGACCATGCAAAAAGACGCCGCTGTTTTCCGTGCCAAC
GAAACCCTTGCCGAAGGCAAGAAGGCAATGGAAGAGGTTGCGGACAAATGGTCGGACGTTGGTGTCACCGACCGTAGCCT
TGTGTGGAATTCCGACCTGATGGAAACGCTCGAACTCGCCAACCTGATCCCCAACGCGGTGGCGACGATCACCGGGGCCG
AAGCCCGCAAGGAAAGCCGCGGCGCGCATGCGCATGAGGATTTCCCGGAGCGGGATGACGAGAACTGGCGCAAGCATTCA
CTGATCTGGTTCAAGGGCAACAAGGCGAGCCTTGGCTATCGCGGCGTGCATGAACAAGCGCTCACCAGCCACAATGATGG
CGGCATTGATCCCAAAAAGATCGCGCCCAAAAAACGGACGTTCTGA

Upstream 100 bases:

>100_bases
GCGGCCATGGGTTTTGGCCTTTACGCAGTTGTGCGGCTCGCATTGTAAAAATTATTCCGGCGCGCGCCTGTGTGCCAGCT
AGACTTCCGGGAGATACTCG

Downstream 100 bases:

>100_bases
GATGATACGAAACCTATCCCGCCTTGCCAAAGGCACTGGTCTTTTGGGGGCGGCTGTGGCGCTTTCGGCTTGCGCTGCGG
TGCAGGAAACCACGGACCAA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 601; Mature: 600

Protein sequence:

>601_residues
MAEYEYETHEYDVVVVGAGGAGLRATLGMAEQGLRTACVTKVFPTRSHTVAAQGGIAASLANMGPDNWQWHMYDTVKGSD
WLGDTDAMEYLAREAPKAVYELEHYGVPFSRTEEGKIYQRPFGGHTTEFGEGPAVQRTCAAADRTGHAILHTLYGQSLKN
NAEFYIEYFAIDLIMSDDGICQGVLCWKLDDGTLHLFSSKMVVLATGGYGRAYFSATSAHTCTGDGGGMTARAGLPLQDM
EFVQFHPTGIYGAGCLITEGARGEGGYLTNSEGERFMERYAPQYKDLAPRDYVSRCMTMEIREGRGVGANGDHIHLNLNH
LPPETLKLRLPGISESARVFAGVNLNKEPIPVLPTVHYNMGGIPTNYWGEVLAPTPDDPDRISPGLMAVGEAGCASVHGA
NRLGSNSLIDLVVFGRAAAIRAGKIVDPNSPVPSPNQKSVEAALDRFDNARYAKGHMPTAALRLEMQQTMQKDAAVFRAN
ETLAEGKKAMEEVADKWSDVGVTDRSLVWNSDLMETLELANLIPNAVATITGAEARKESRGAHAHEDFPERDDENWRKHS
LIWFKGNKASLGYRGVHEQALTSHNDGGIDPKKIAPKKRTF

Sequences:

>Translated_601_residues
MAEYEYETHEYDVVVVGAGGAGLRATLGMAEQGLRTACVTKVFPTRSHTVAAQGGIAASLANMGPDNWQWHMYDTVKGSD
WLGDTDAMEYLAREAPKAVYELEHYGVPFSRTEEGKIYQRPFGGHTTEFGEGPAVQRTCAAADRTGHAILHTLYGQSLKN
NAEFYIEYFAIDLIMSDDGICQGVLCWKLDDGTLHLFSSKMVVLATGGYGRAYFSATSAHTCTGDGGGMTARAGLPLQDM
EFVQFHPTGIYGAGCLITEGARGEGGYLTNSEGERFMERYAPQYKDLAPRDYVSRCMTMEIREGRGVGANGDHIHLNLNH
LPPETLKLRLPGISESARVFAGVNLNKEPIPVLPTVHYNMGGIPTNYWGEVLAPTPDDPDRISPGLMAVGEAGCASVHGA
NRLGSNSLIDLVVFGRAAAIRAGKIVDPNSPVPSPNQKSVEAALDRFDNARYAKGHMPTAALRLEMQQTMQKDAAVFRAN
ETLAEGKKAMEEVADKWSDVGVTDRSLVWNSDLMETLELANLIPNAVATITGAEARKESRGAHAHEDFPERDDENWRKHS
LIWFKGNKASLGYRGVHEQALTSHNDGGIDPKKIAPKKRTF
>Mature_600_residues
AEYEYETHEYDVVVVGAGGAGLRATLGMAEQGLRTACVTKVFPTRSHTVAAQGGIAASLANMGPDNWQWHMYDTVKGSDW
LGDTDAMEYLAREAPKAVYELEHYGVPFSRTEEGKIYQRPFGGHTTEFGEGPAVQRTCAAADRTGHAILHTLYGQSLKNN
AEFYIEYFAIDLIMSDDGICQGVLCWKLDDGTLHLFSSKMVVLATGGYGRAYFSATSAHTCTGDGGGMTARAGLPLQDME
FVQFHPTGIYGAGCLITEGARGEGGYLTNSEGERFMERYAPQYKDLAPRDYVSRCMTMEIREGRGVGANGDHIHLNLNHL
PPETLKLRLPGISESARVFAGVNLNKEPIPVLPTVHYNMGGIPTNYWGEVLAPTPDDPDRISPGLMAVGEAGCASVHGAN
RLGSNSLIDLVVFGRAAAIRAGKIVDPNSPVPSPNQKSVEAALDRFDNARYAKGHMPTAALRLEMQQTMQKDAAVFRANE
TLAEGKKAMEEVADKWSDVGVTDRSLVWNSDLMETLELANLIPNAVATITGAEARKESRGAHAHEDFPERDDENWRKHSL
IWFKGNKASLGYRGVHEQALTSHNDGGIDPKKIAPKKRTF

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=609, Percent_Identity=58.4564860426929, Blast_Score=691, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=553, Percent_Identity=52.9837251356239, Blast_Score=545, Evalue=1e-156,
Organism=Escherichia coli, GI1790597, Length=548, Percent_Identity=39.963503649635, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1788928, Length=559, Percent_Identity=32.0214669051878, Blast_Score=208, Evalue=9e-55,
Organism=Caenorhabditis elegans, GI17550100, Length=611, Percent_Identity=60.392798690671, Blast_Score=720, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=584, Percent_Identity=57.3630136986301, Blast_Score=682, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=593, Percent_Identity=62.0573355817875, Blast_Score=741, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=585, Percent_Identity=62.5641025641026, Blast_Score=738, Evalue=0.0,
Organism=Drosophila melanogaster, GI17137288, Length=598, Percent_Identity=60.8695652173913, Blast_Score=732, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=598, Percent_Identity=60.8695652173913, Blast_Score=732, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=598, Percent_Identity=60.8695652173913, Blast_Score=732, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=620, Percent_Identity=54.5161290322581, Blast_Score=678, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65454; Mature: 65323

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEYEYETHEYDVVVVGAGGAGLRATLGMAEQGLRTACVTKVFPTRSHTVAAQGGIAASL
CCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCHHHHHHHHCCCCCCCEEEECCCHHHHH
ANMGPDNWQWHMYDTVKGSDWLGDTDAMEYLAREAPKAVYELEHYGVPFSRTEEGKIYQR
HHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCEEEC
PFGGHTTEFGEGPAVQRTCAAADRTGHAILHTLYGQSLKNNAEFYIEYFAIDLIMSDDGI
CCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEEEEEEEECCCCC
CQGVLCWKLDDGTLHLFSSKMVVLATGGYGRAYFSATSAHTCTGDGGGMTARAGLPLQDM
CCEEEEEEECCCEEEEECCCEEEEEECCCCEEEEECCCCCEECCCCCCEEEECCCCCCCC
EFVQFHPTGIYGAGCLITEGARGEGGYLTNSEGERFMERYAPQYKDLAPRDYVSRCMTME
CEEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCHHHCCCCHHHHHHHHEEE
IREGRGVGANGDHIHLNLNHLPPETLKLRLPGISESARVFAGVNLNKEPIPVLPTVHYNM
ECCCCCCCCCCCEEEEEECCCCCCCEEEECCCCCCCCEEEEECCCCCCCCCCCCEEECCC
GGIPTNYWGEVLAPTPDDPDRISPGLMAVGEAGCASVHGANRLGSNSLIDLVVFGRAAAI
CCCCCCCCCCEECCCCCCHHHCCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEECCHHHE
RAGKIVDPNSPVPSPNQKSVEAALDRFDNARYAKGHMPTAALRLEMQQTMQKDAAVFRAN
ECCCEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEECC
ETLAEGKKAMEEVADKWSDVGVTDRSLVWNSDLMETLELANLIPNAVATITGAEARKESR
HHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHCCHHHHHCCCHHHHHHHC
GAHAHEDFPERDDENWRKHSLIWFKGNKASLGYRGVHEQALTSHNDGGIDPKKIAPKKRT
CCCCCCCCCCCCCCCCHHEEEEEEECCCCCCCCCCCHHHHHHCCCCCCCCHHHCCCCCCC
F
C
>Mature Secondary Structure 
AEYEYETHEYDVVVVGAGGAGLRATLGMAEQGLRTACVTKVFPTRSHTVAAQGGIAASL
CCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCHHHHHHHHCCCCCCCEEEECCCHHHHH
ANMGPDNWQWHMYDTVKGSDWLGDTDAMEYLAREAPKAVYELEHYGVPFSRTEEGKIYQR
HHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCEEEC
PFGGHTTEFGEGPAVQRTCAAADRTGHAILHTLYGQSLKNNAEFYIEYFAIDLIMSDDGI
CCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEEEEEEEECCCCC
CQGVLCWKLDDGTLHLFSSKMVVLATGGYGRAYFSATSAHTCTGDGGGMTARAGLPLQDM
CCEEEEEEECCCEEEEECCCEEEEEECCCCEEEEECCCCCEECCCCCCEEEECCCCCCCC
EFVQFHPTGIYGAGCLITEGARGEGGYLTNSEGERFMERYAPQYKDLAPRDYVSRCMTME
CEEEECCCCEEECCEEEECCCCCCCCEEECCCHHHHHHHHCCHHHCCCCHHHHHHHHEEE
IREGRGVGANGDHIHLNLNHLPPETLKLRLPGISESARVFAGVNLNKEPIPVLPTVHYNM
ECCCCCCCCCCCEEEEEECCCCCCCEEEECCCCCCCCEEEEECCCCCCCCCCCCEEECCC
GGIPTNYWGEVLAPTPDDPDRISPGLMAVGEAGCASVHGANRLGSNSLIDLVVFGRAAAI
CCCCCCCCCCEECCCCCCHHHCCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEECCHHHE
RAGKIVDPNSPVPSPNQKSVEAALDRFDNARYAKGHMPTAALRLEMQQTMQKDAAVFRAN
ECCCEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHEECC
ETLAEGKKAMEEVADKWSDVGVTDRSLVWNSDLMETLELANLIPNAVATITGAEARKESR
HHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHHCCHHHHHCCCHHHHHHHC
GAHAHEDFPERDDENWRKHSLIWFKGNKASLGYRGVHEQALTSHNDGGIDPKKIAPKKRT
CCCCCCCCCCCCCCCCHHEEEEEEECCCCCCCCCCCHHHHHHCCCCCCCCHHHCCCCCCC
F
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA