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The map label for this gene is lysA [H]

Identifier: 110678901

GI number: 110678901

Start: 1539099

End: 1540364

Strand: Direct

Name: lysA [H]

Synonym: RD1_1595

Alternate gene names: 110678901

Gene position: 1539099-1540364 (Clockwise)

Preceding gene: 110678900

Following gene: 110678902

Centisome position: 37.24

GC content: 59.0

Gene sequence:

>1266_bases
ATGGATCATTTTCTCTATCGCGATGGCGTGTTGCACGCCGAGGATGTATCGGTGCCCGAGATTGCGGCCGCCGTGGGCAC
GCCGTTTTATCTCTATTCCACTGCAACGCTTCTGAGGCATTTCCGCCTTTTTGATGAGGCGCTTGACGGGATGGACCACC
TCGTATGCTACGCCATGAAAGCGGCCAGCAATCAGGCGATCCTGAAGACCCTCGCTCAGGCGGGGGCGGGCATGGACGTG
GTGTCGGGGGGTGAGTATCTGCGGGCCAAGGCCGCCGGGGTGCCCGGCGACAAGATCGTGTTTTCAGGGGTGGGAAAGAC
AGCCGCCGAAATCCGCCTCGCGCTCGAAGGGGGCATTCGACAGTTCAATGTTGAGTCCGAGCCGGAGATGGAGGTGCTGA
ACGCCGCCGCGCTGGAGATGGGCGTTACCGCACCAATCACCATTCGCGTGAACCCCGATGTGGACGCCAAAACGCATGCA
AAGATCGCCACGGGCAAGTCCGAGAACAAATTCGGCATCCCGATTTCGCGCGCGCGCGAGGTCTATGCGCTCGCCGCTTC
GATGAAGGGGCTGGAGGTGATCGGCATTGATGTGCATATCGGCAGCCAGTTGACAGAGCTTGCCCCGTTCGAAGCCGCCT
ATGACAAGGTTGCGGAGTTGACAGAGCAGTTGCGCGCCGAAGGCCACAACATCCGGCGTCTGGACCTCGGTGGGGGTCTT
GGCATTCCCTATGCACGCGACAATCAGGCGCCGCCTTTACCCTCCGACTATGGCGCGATGATCAAGCGCAAGCTGGGGCA
TCTGGGCTGCGAGATCGAGATTGAGCCGGGTCGGCTGATCGTCGGGAACGCCGGTATCATGGTCTCTGAGGTGATTTACG
TGAAATCCGGTGAAGATCGCGATTTCCTGATCATTGACGGGGCGATGAATGACCTGATCCGCCCTGCCATGTACGAAGCC
TATCACGATATCATTCCGGTGGTTGAGCCTGATCCGGGGGTTGAACAGGTGAAATTCGATATCGTCGGCCCTGTGTGCGA
AACGGGCGATACATTCGCGCGCGCACGCATCATGCCGCCGGTCGCCGCCGGAGAACGCGTCGCCTTCCGCTCGGCCGGTG
CATATGGCGCAGTCATGAGCAGCGAGTACAATTCCCGCCCGCTTATTCCCGAAGTTTTGGTGCATGAAGATCAATTTGCG
GTTATTCGCCCACGTCCAACCTTTGACGAAATGATAAAACGAGATACCATTCCTACTTGGCTCTGA

Upstream 100 bases:

>100_bases
CAATCGTTGAGGTCTGCGGCTGGAACTGCCTGTTGGGCCGAAACGCCGCGCGCGGCAAAGGCTGATTGATCTTGGCTGCG
CTTTTGCGTAAAGCGCGCGC

Downstream 100 bases:

>100_bases
TCGTGCGCGTGCAAAGGGGCCATTGGCAACGGAGCATGACATATGGCGTCTTTTTCCCGGCATGATGCGGAAAAAACATT
GAAATCAGTGCGATGGCCCC

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MDHFLYRDGVLHAEDVSVPEIAAAVGTPFYLYSTATLLRHFRLFDEALDGMDHLVCYAMKAASNQAILKTLAQAGAGMDV
VSGGEYLRAKAAGVPGDKIVFSGVGKTAAEIRLALEGGIRQFNVESEPEMEVLNAAALEMGVTAPITIRVNPDVDAKTHA
KIATGKSENKFGIPISRAREVYALAASMKGLEVIGIDVHIGSQLTELAPFEAAYDKVAELTEQLRAEGHNIRRLDLGGGL
GIPYARDNQAPPLPSDYGAMIKRKLGHLGCEIEIEPGRLIVGNAGIMVSEVIYVKSGEDRDFLIIDGAMNDLIRPAMYEA
YHDIIPVVEPDPGVEQVKFDIVGPVCETGDTFARARIMPPVAAGERVAFRSAGAYGAVMSSEYNSRPLIPEVLVHEDQFA
VIRPRPTFDEMIKRDTIPTWL

Sequences:

>Translated_421_residues
MDHFLYRDGVLHAEDVSVPEIAAAVGTPFYLYSTATLLRHFRLFDEALDGMDHLVCYAMKAASNQAILKTLAQAGAGMDV
VSGGEYLRAKAAGVPGDKIVFSGVGKTAAEIRLALEGGIRQFNVESEPEMEVLNAAALEMGVTAPITIRVNPDVDAKTHA
KIATGKSENKFGIPISRAREVYALAASMKGLEVIGIDVHIGSQLTELAPFEAAYDKVAELTEQLRAEGHNIRRLDLGGGL
GIPYARDNQAPPLPSDYGAMIKRKLGHLGCEIEIEPGRLIVGNAGIMVSEVIYVKSGEDRDFLIIDGAMNDLIRPAMYEA
YHDIIPVVEPDPGVEQVKFDIVGPVCETGDTFARARIMPPVAAGERVAFRSAGAYGAVMSSEYNSRPLIPEVLVHEDQFA
VIRPRPTFDEMIKRDTIPTWL
>Mature_421_residues
MDHFLYRDGVLHAEDVSVPEIAAAVGTPFYLYSTATLLRHFRLFDEALDGMDHLVCYAMKAASNQAILKTLAQAGAGMDV
VSGGEYLRAKAAGVPGDKIVFSGVGKTAAEIRLALEGGIRQFNVESEPEMEVLNAAALEMGVTAPITIRVNPDVDAKTHA
KIATGKSENKFGIPISRAREVYALAASMKGLEVIGIDVHIGSQLTELAPFEAAYDKVAELTEQLRAEGHNIRRLDLGGGL
GIPYARDNQAPPLPSDYGAMIKRKLGHLGCEIEIEPGRLIVGNAGIMVSEVIYVKSGEDRDFLIIDGAMNDLIRPAMYEA
YHDIIPVVEPDPGVEQVKFDIVGPVCETGDTFARARIMPPVAAGERVAFRSAGAYGAVMSSEYNSRPLIPEVLVHEDQFA
VIRPRPTFDEMIKRDTIPTWL

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=371, Percent_Identity=25.6064690026954, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI16506287, Length=403, Percent_Identity=23.3250620347395, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1789203, Length=440, Percent_Identity=33.6363636363636, Blast_Score=186, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17562780, Length=415, Percent_Identity=22.8915662650602, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24586472, Length=359, Percent_Identity=23.3983286908078, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24586474, Length=360, Percent_Identity=23.6111111111111, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45586; Mature: 45586

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHFLYRDGVLHAEDVSVPEIAAAVGTPFYLYSTATLLRHFRLFDEALDGMDHLVCYAMK
CCCCEECCCCEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
AASNQAILKTLAQAGAGMDVVSGGEYLRAKAAGVPGDKIVFSGVGKTAAEIRLALEGGIR
HCCCHHHHHHHHHCCCCCEEECCCCEEEEECCCCCCCCEEEECCCCCHHHEEEEECCCCE
QFNVESEPEMEVLNAAALEMGVTAPITIRVNPDVDAKTHAKIATGKSENKFGIPISRARE
EECCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHH
VYALAASMKGLEVIGIDVHIGSQLTELAPFEAAYDKVAELTEQLRAEGHNIRRLDLGGGL
HHHHHHCCCCCEEEEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
GIPYARDNQAPPLPSDYGAMIKRKLGHLGCEIEIEPGRLIVGNAGIMVSEVIYVKSGEDR
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCEEEEECCCEEEEEEEEEECCCCC
DFLIIDGAMNDLIRPAMYEAYHDIIPVVEPDPGVEQVKFDIVGPVCETGDTFARARIMPP
CEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCHHEEEEEEECCCCCCCCHHHHHEECCC
VAAGERVAFRSAGAYGAVMSSEYNSRPLIPEVLVHEDQFAVIRPRPTFDEMIKRDTIPTW
CCCCCEEEEECCCCCHHEECCCCCCCCCCHHHHCCCCCEEEECCCCCHHHHHHHCCCCCC
L
C
>Mature Secondary Structure
MDHFLYRDGVLHAEDVSVPEIAAAVGTPFYLYSTATLLRHFRLFDEALDGMDHLVCYAMK
CCCCEECCCCEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
AASNQAILKTLAQAGAGMDVVSGGEYLRAKAAGVPGDKIVFSGVGKTAAEIRLALEGGIR
HCCCHHHHHHHHHCCCCCEEECCCCEEEEECCCCCCCCEEEECCCCCHHHEEEEECCCCE
QFNVESEPEMEVLNAAALEMGVTAPITIRVNPDVDAKTHAKIATGKSENKFGIPISRARE
EECCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEECCCCCCCCCCCHHHHHH
VYALAASMKGLEVIGIDVHIGSQLTELAPFEAAYDKVAELTEQLRAEGHNIRRLDLGGGL
HHHHHHCCCCCEEEEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
GIPYARDNQAPPLPSDYGAMIKRKLGHLGCEIEIEPGRLIVGNAGIMVSEVIYVKSGEDR
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCEEEEECCCEEEEEEEEEECCCCC
DFLIIDGAMNDLIRPAMYEAYHDIIPVVEPDPGVEQVKFDIVGPVCETGDTFARARIMPP
CEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCHHEEEEEEECCCCCCCCHHHHHEECCC
VAAGERVAFRSAGAYGAVMSSEYNSRPLIPEVLVHEDQFAVIRPRPTFDEMIKRDTIPTW
CCCCCEEEEECCCCCHHEECCCCCCCCCCHHHHCCCCCEEEECCCCCHHHHHHHCCCCCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]